Effectiveness of carnosine on disturbed electrolytes homeostasis induced by cisplatin

We aimed to assess the effect of well known antioxidant carnosine on disturbed plasma and intraerythrocytes electrolytes and Na+-K+-ATPase activity by cisplatin. 24 male albino Wistar rats were selected and divided into 4 groups: Group I = untreated control; Group II = cisplatin control (received cisplatin at a dose of 3 mg/ kg body weight; i.p. for 13 alternate days); Group III = carnosine alone (treated group at a dose of 10 mg/kg body weight; i.p. for 13 consecutive days); Group IV = carnosine + cisplatin pretreated group. Carnosine was administered 30 min prior to cisplatin. Carnosine significantly restored the intra – erythrocytes Na+, K+ and Na+-K+-ATPase level which consequently affect the plasma Na+, Ca++, and Mg++ level. Effective role conferred by carnosine exhibits its protective activity.Key words: Cisplatin, carnosine, electrolytes, Na+-K+-ATPase

Electron spin manipulation and resonator readout in a double quantum dot nano-electromechanical system

Magnetically coupling a nano-mechanical resonator to a double quantum dot confining two electrons can enable the manipulation of a single electron spin and the readout of the resonator's natural frequency. When the Larmor frequency matches the resonator frequency, the electron spin in one of the dots can be selectively flipped by the magnetised resonator. By simultaneously measuring the charge state of the two-electron double quantum dots, this transition can be detected thus enabling the natural frequency of the mechanical resonator to be determined.Comment: 7 pages, fixed typos, updated figures 4 and

Noise based transmitted reference modulation for wireless sensor networks

Recent advances in the underlying technologies of wireless sensor networks (WSNs) have led to its use in different applications, from fields as diverse as battlefield applications to temperature control to healthcare. Research in the different aspects of WSNs is therefore in full swing, in both academia and the industry. In the Wireless Ad-hoc Links using robust Noise-based Ultra-wideband Transmission (WALNUT) project, modulation concepts (and relevant MAC protocols) are intended to be explored which allow for robust ad-hoc radio links with radio nodes implemented on a single CMOS chip

Genetic Alterations of RET: Possible Implications and Clinical Correlations in Thyroid Carcinogenesis

Thyroid cancers are malignant tumors in the thyroid gland. DNA polymorphisms are playing a decisive role in unscrambling the genomic basis of tumor formation and development in cancer. Thyroid cancer is influenced in a polygenic and low-penetrance manner by RET gene polymorphisms and this part of the world (North India) has not recorded any study regarding RET alterations in this very cancer. We assessed RET G691S (rs1799939), L769L (rs1800861) and S904S (rs1800863) polymorphisms by restriction fragment length polymorphism (RFLP) in order to explain their potential role in the diagnosis and prognosis of Papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC). In RET G691S polymorphism, the total dissemination of variant alleles (GA + AA) was 62.9% in cases as related to 44.5% in controls (P < 0.05). RET L769L variant alleles (TG + GG) was 70% in cases versus 88% in controls (P < 0.05). In RET S904S, occurrence of variant alleles (CG + GG) was 56% in cases versus 44% in controls (P < 0.05). G691S and L769L polymorphism advocate a “Dominant mode of inheritance”. The S904S polymorphism approves an “Additive mode of inheritance”. In conclusion, there was an over-representation of RET G691S/S904S polymorphisms and under-representation of L769L polymorphism in PTC and FTC patients. Additionally, our data suggest that some haplotypes (A T G, G T G and A T C) of RET may act as low penetrance alleles for predisposition of thyroid cancer

Surface structure of the Ag-In-(rare earth) complex intermetallics

We present a study of the surface structure of the Ag-In-RE (RE: rare-earth elements Gd, Tb, and Yb) complex intermetallics using scanning tunneling microscopy and low-energy electron diffraction. The surface of the Ag-In-Yb approximant prepared by sputter-annealing methods under ultrahigh-vacuum conditions produces a flat (100) surface with no facets. However, the Ag-In-Gd and Ag-In-Tb 1/1 approximants, which have a surface miscut of about 12∘ relative to the (100) plane, develop surface facets along various crystallographic directions. The structure of each facet can be explained as a truncation of the rhombic triacontahedral clusters, i.e., the main building blocks of these systems. Despite their differences in atomic structure, symmetry, and density, the facets show common features. The facet planes are In rich. The analysis of the nearest-neighbor atom distances suggests that In atoms form bonds with the RE atoms, which we suggest is a key factor that stabilizes even low-density facet planes