Presence of New Delhi metallo-β-lactamase gene (NDM-1) in a clinical isolate of Acinetobacter junii in Argentina

Here we report the presence of a clinically significant A. junii blaNDM-1 positive in a 38-year-old woman who was admitted to the emergency department with a fever and leg ulcers with signs of infection. The NDM-1 carbapenemase has been dramatically spread among Gram-negative bacilli, thus imposing a new challenge on the health system to fight bacterial infections.These data expand the number of Acinetobacter species harbouring blaNDM-1. The wide existence of Acinetobacter harbouring and dispersing this carbapenemase emphasizes the importance of non-previously recognized pathogens as reservoirs of dangerous resistance determinants. These resistance determinants can be later easily transferred to other menacing pathogens.Fil: Montaña, Sabrina Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Cittadini, Roxana. Sanatorio Mater Dei; ArgentinaFil: Del Castillo M,. Sanatorio Mater Dei; ArgentinaFil: Uong, S.. California State University; Estados UnidosFil: Lazzaro, T.. California State University; Estados UnidosFil: Almuzara, Marisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Barberis, Claudia. Sanatorio Mater Dei; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Vay, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Ramírez, M. S.. California State University; Estados Unido

The SCUBA-2 Cosmology Legacy Survey: The EGS deep field -- III. The evolution of faint submillimeter galaxies at z<4z<4

We present a demographic analysis of the physical and morphological properties of $450/850~\mu\rm m$-selected galaxies from the deep observations of the SCUBA-2 Cosmology Legacy Survey in the Extended Groth Strip that are detected below the classical submillimeter-galaxy regime ($S_{850 \mu\rm m}\lesssim 6~\rm mJy$/beam) and compare them with a sample of optically-selected star-forming galaxies detected in the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey in the same field. We derive the evolution of the main sequence of star-forming galaxies, finding a steeper specific star formation rate versus stellar mass at $z>2.5$ than previous studies. Most faint submillimeter-galaxies fall within $3\sigma$ of the main sequence, but 40~per cent are classified as starbursts. Faint submillimeter galaxies have 50~per cent larger sizes at $2<z<3$ than optically-selected star-forming galaxies of the same mass range. This is also the redshift bin where we find the largest fraction of starbursts, and hence we could be witnessing merging processes, as confirmed by the preference for visual-morphology classifications of these systems as irregular disk galaxies and mergers. Both populations show an increment towards lower redshifts ($z<2$) of their concentration in $H$-band morphology, but faint submillimeter galaxies on average show larger concentration values at later times. These findings support the claim that faint submillimeter galaxies are mostly a population of massive dust-obscured disk-like galaxies that develop larger bulge components at later epochs. While the similarities are great, the median sizes, starburst numbers and $H$-band concentration of faint submillimeter galaxies differ from those of optically-selected star-forming galaxies of the same stellar mass.Comment: Accepted for publication in MNRA

Mapping the potential use of endectocide-treated cattle to reduce malaria transmission

Treating cattle with endectocide is a longstanding veterinary practice to reduce the load of endo and ectoparasites, but has the potential to be added to the malaria control and elimination toolbox, as it also kills malaria mosquitoes feeding on the animals. Here we used openly available data to map the areas of the African continent where high malaria prevalence in 2-10 year old children coincides with a high density of cattle and high density of the partly zoophilic malaria vector Anopheles arabiensis. That is, mapping the areas where treating cattle with endectocide would potentially have the greatest impact on reducing malaria transmission. In regions of Africa that are not dominated by rainforest nor desert, the map shows a scatter of areas in several countries where this intervention shows potential, including central and eastern sub-Saharan Africa. The savanna region underneath the Sahel in West Africa appears as the climatic block that would benefit to the largest extent from this intervention, encompassing several countries. West Africa currently presents the highest under-10 malaria prevalence and elimination within the next twenty years cannot be contemplated there with currently available interventions alone, making the use of endectocide treated cattle as a complementary intervention highly appealing

Genomics helps to decipher the resistance mechanisms present in a Pseudomonas chlororaphis strain recovered in an HIV patient

Fil: Montaña, Sabrina Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Lazzaro, T.. California State University; Estados UnidosFil: Uong, S.. California State University; Estados UnidosFil: Place, K.. California State University; Estados UnidosFil: Iriarte, A.. Universidad de la República; UruguayFil: Ocampo, C. V.. Sanatorio Mater Dei; ArgentinaFil: Vay, C.. Sanatorio Mater Dei; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Ramírez, M. S.. California State University; Estados Unido

The Casiquiare river acts as a corridor between the Amazonas and Orinoco river basins: biogeographic analysis of the genus Cichla

The Casiquiare River is a unique biogeographic corridor between the Orinoco and Amazonas basins. We investigated the importance of this connection for Neotropical fishes using peacock cichlids ( Cichla spp.) as a model system. We tested whether the Casiquiare provides a conduit for gene flow between contemporary populations, and investigated the origin of biogeographic distributions that span the Casiquiare. Using sequences from the mitochondrial control region of three focal species ( C. temensis , C. monoculus , and C. orinocensis ) whose distributions include the Amazonas, Orinoco, and Casiquiare, we constructed maximum likelihood phylograms of haplotypes and analyzed the populations under an isolation-with-migration coalescent model. Our analyses suggest that populations of all three species have experienced some degree of gene flow via the Casiquiare. We also generated a mitochondrial genealogy of all Cichla species using >2000 bp and performed a dispersal-vicariance analysis (DIVA) to reconstruct the historical biogeography of the genus. This analysis, when combined with the intraspecific results, supports two instances of dispersal from the Amazonas to the Orinoco. Thus, our results support the idea that the Casiquiare connection is important across temporal scales, facilitating both gene flow and the dispersal and range expansion of species.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79059/1/j.1365-294X.2010.04540.x.pd

Early Science with the Large Millimetre Telescope: Molecules in the Extreme Outflow of a proto-Planetary Nebula

Extremely high velocity emission likely related to jets is known to occur in some proto-Planetary Nebulae. However, the molecular complexity of this kinematic component is largely unknown. We observed the known extreme outflow from the proto-Planetary Nebula IRAS 16342-3814, a prototype water fountain, in the full frequency range from 73 to 111 GHz with the RSR receiver on the Large Millimetre Telescope. We detected the molecules SiO, HCN, SO, and $^{13}$CO. All molecular transitions, with the exception of the latter are detected for the first time in this source, and all present emission with velocities up to a few hundred km s$^{-1}$. IRAS 16342-3814 is therefore the only source of this kind presenting extreme outflow activity simultaneously in all these molecules, with SO and SiO emission showing the highest velocities found of these species in proto-Planetary Nebulae. To be confirmed is a tentative weak SO component with a FWHM $\sim$ 700 km s$^{-1}$. The extreme outflow gas consists of dense gas (n$_{\rm H_2} >$ 10$^{4.8}$--10$^{5.7}$ cm$^{-3}$), with a mass larger than $\sim$ 0.02--0.15 M$_{\odot}$. The relatively high abundances of SiO and SO may be an indication of an oxygen-rich extreme high velocity gas.Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Society Letter

AzTEC 1.1 mm observations of high-z protocluster environments : SMG overdensities and misalignment between AGN jets and SMG distribution

We present observations at 1.1 mm towards 16 powerful radio galaxies and a radio-quiet quasar at 0.5 > z > 6.3 acquired with the AzTEC camera mounted at the James Clerk Maxwell Telescope and Atacama Submillimeter Telescope Experiment to study the spatial distribution of submillimetre galaxies (SMGs) towards possible protocluster regions. The survey covers a total area of 1.01 sq deg with rms depths of 0.52-1.44 mJy and detects 728 sources above 3σ. We find overdensities of a factor of ~2 in the source counts of three individual fields (4C+23.56, PKS1138-262, and MRC0355-037) over areas of ~200 sq deg. When combining all fields, the source-count analysis finds an overdensity that reaches a factor ≳ 3 at S 1.1mm = 4mJy covering a 1.5-arcmin-radius area centred on the active galactic nucleus. The large size of our maps allows us to establish that beyond a radius of 1.5 arcmin, the radial surface density of SMGs falls to that of a blank field. In addition, we find a trend for SMGs to align closely to a perpendicular direction with respect to the radio jets of the powerful central radio galaxies (73 -14 +13 deg). This misalignment is found over projected comoving scales of 4-20 Mpc, departs from perfect alignment (0 deg) by ~5σ, and apparently has no dependence on SMG luminosity. Under the assumption that the AzTEC sources are at the redshift of the central radio galaxy, the misalignment reported here can be interpreted as SMGs preferentially inhabiting mass-dominant filaments funnelling material towards the protoclusters, which are also the parent structures of the radio galaxies.Peer reviewe

Molecular characterization of KPC-2–positive Klebsiella pneumoniae isolates from a neurosurgical centre in Argentina

Carbapenem-resistant Enterobacteriaceae is a growing concern worldwide. Klebsiella pneumoniae is an important nosocomial pathogen with a high capacity for nosocomial spread. We described the occurrence of plasmid-encoded KPC-2–harbouring K. pneumoniae isolates recovered from a neurosurgical centre in Argentina. The blaKPC-2 gene was surrounded by ISkpn6 and ISkpn7.Fil: Montaña, Sabrina Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Hernandez, M.. California State University; Estados UnidosFil: Fernandez, J. S.. California State University; Estados UnidosFil: Penini, M.. Stamboulian Servicios de Salud; ArgentinaFil: Centron, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Sucari, A.. Stamboulian Servicios de Salud; ArgentinaFil: Iriarte, A.. Universidad de la República; UruguayFil: Ramirez, Maria Soledad. California State University; Estados Unido