15,782 research outputs found
Magnetohydrodynamic normal mode analysis of plasma with equilibrium pressure anisotropy
In this work, we generalise linear magnetohydrodynamic (MHD) stability theory
to include equilibrium pressure anisotropy in the fluid part of the analysis. A
novel 'single-adiabatic' (SA) fluid closure is presented which is complementary
to the usual 'double-adiabatic' (CGL) model and has the advantage of naturally
reproducing exactly the MHD spectrum in the isotropic limit. As with MHD and
CGL, the SA model neglects the anisotropic perturbed pressure and thus loses
non-local fast-particle stabilisation present in the kinetic approach. Another
interesting aspect of this new approach is that the stabilising terms appear
naturally as separate viscous corrections leaving the isotropic SA closure
unchanged. After verifying the self-consistency of the SA model, we re-derive
the projected linear MHD set of equations required for stability analysis of
tokamaks in the MISHKA code. The cylindrical wave equation is derived
analytically as done previously in the spectral theory of MHD and clear
predictions are made for the modification to fast-magnetosonic and slow ion
sound speeds due to equilibrium anisotropy.Comment: 19 pages. This is an author-created, un-copyedited version of an
article submitted for publication in Plasma Physics and Controlled Fusion.
IOP Publishing Ltd is not responsible for any errors or omissions in this
version of the manuscript or any version derived from i
Recommended from our members
Identifying sources of error in cross-national questionnaires: Application of an error source typology to cognitive interview data
This article evaluates a Cross National Error Source Typology that was developed as a tool for making cross-national questionnaire design more effective. Cross-national questionnaire design has a number of potential error sources that are either not present or are less common in single nation studies. Tools that help to identify these error sources better inform the survey researcher when improving a source questionnaire that serves as the basis for translation. This article outlines the theoretical and practical development of the typology and evaluates an attempt to apply it to cross-national cognitive interviewing findings from the European Social Survey
Cortical activity evoked by inoculation needle prick in infants up to one-year old
Inoculation is one of the first and most common experiences of procedural pain in infancy. However, little is known about how needle puncture pain is processed by the central nervous system in children. In this study, we describe for the first time the event-related activity in the infant brain during routine inoculation using electroencephalography. Fifteen healthy term-born infants aged 1 to 2 months (n = 12) or 12 months (n = 5) were studied in an outpatient clinic. Pain behavior was scored using the Modified Behavioral Pain Scale. A distinct inoculation event-related vertex potential, consisting of 2 late negative-positive complexes, was observable in single trials after needle contact with the skin. The amplitude of both negative-positive components was significantly greater in the 12-month group. Both inoculation event-related potential amplitude and behavioral pain scores increased with age but the 2 measures were not correlated with each other. These components are the first recordings of brain activity in response to real-life needle pain in infants up to a year old. They provide new evidence of postnatal nociceptive processing and, combined with more traditional behavioral pain scores, offer a potentially more sensitive measure for testing the efficacy of analgesic protocols in this age group
Cortical pain responses in human infants
Despite the recent increase in our understanding of the development of pain processing, it is still not known whether premature infants are capable of processing pain at a cortical level. In this study, changes in cerebral oxygenation over the somatosensory cortex were measured in response to noxious stimulation using real-time near-infrared spectroscopy in 18 infants aged between 25 and 45 weeks postmenstrual age. The noxious stimuli were heel lances performed for routine blood sampling; no blood tests were performed solely for the purpose of the study. Noxious stimulation produced a clear cortical response, measured as an increase in total hemoglobin concentration [HbT] in the contralateral somatosensory cortex, from 25 weeks (mean Delta[HbT] = 7.74 mu mol/L; SE, 1.10). Cortical responses were significantly greater in awake compared with sleeping infants, with a mean difference of 6.63 mu mol/L [95% confidence interval (CI) limits: 2.35, 10.91 mu mol/L; mean age, 35.2 weeks]. In awake infants, the response in the contralateral somatosensory cortex increased with age ( regression coefficient, 0.698 mu mol/L/week; 95% CI limits: 0.132, 1.265 mu mol/L/week) and the latency decreased with age (regression coefficient, -0.9861 mu mol/L/week; 95% CI limits: -1.5361, -0.4361 mu mol/L/week; age range, 25-38 weeks). The response was modality specific because no response was detected after non-noxious stimulation of the heel, even when accompanied by reflex withdrawal of the foot. We conclude that noxious information is transmitted to the preterm infant cortex from 25 weeks, highlighting the potential for both higher-level pain processing and pain-induced plasticity in the human brain from a very early age
Theory and Simulation of the diffusion of kinks on dislocations in bcc metals
Isolated kinks on thermally fluctuating (1/2) screw, edge and
(1/2) edge dislocations in bcc iron are simulated under zero stress
conditions using molecular dynamics (MD). Kinks are seen to perform stochastic
motion in a potential landscape that depends on the dislocation character and
geometry, and their motion provides fresh insight into the coupling of
dislocations to a heat bath. The kink formation energy, migration barrier and
friction parameter are deduced from the simulations. A discrete
Frenkel-Kontorova-Langevin (FKL) model is able to reproduce the coarse grained
data from MD at a fraction of the computational cost, without assuming an a
priori temperature dependence beyond the fluctuation-dissipation theorem.
Analytic results reveal that discreteness effects play an essential r\^ole in
thermally activated dislocation glide, revealing the existence of a crucial
intermediate length scale between molecular and dislocation dynamics. The model
is used to investigate dislocation motion under the vanishingly small stress
levels found in the evolution of dislocation microstructures in irradiated
materials
Lung Epithelial Cell Transcriptional Regulation as a Factor in COVID-19 Associated Coagulopathies
SARS-CoV-2 has rapidly become a global pandemic. In addition to the acute pulmonary symptoms of COVID-19 (the disease associated with SARS-CoV-2 infection), pulmonary and distal coagulopathies have caused morbidity and mortality in many patients. Currently, the molecular pathogenesis underlying COVID-19 associated coagulopathies are unknown. Identifying the molecular basis of how SARS-CoV-2 drives coagulation is essential to mitigating short and long term thrombotic risks of sick and recovered COVID-19 patients. We aimed to perform coagulation focused transcriptome analysis of in vitro infected primary respiratory epithelial cells, patient derived bronchial alveolar lavage (BALF) cells, and circulating immune cells during SARS-CoV-2 infection. Our objective was to identify transcription mediated signaling networks driving coagulopathies associated with COVID-19. We analyzed recently published experimentally and clinically derived bulk or single cell RNA sequencing datasets of SARS-CoV-2 infection to identify changes in transcriptional regulation of blood coagulation. We also confirmed that the transcriptional expression of a key coagulation regulator was recapitulated at the protein level. We specifically focused our analysis on lung tissue expressed genes regulating the extrinsic coagulation cascade and the plasminogen activation system. Analyzing transcriptomic data of in vitro infected normal human bronchial epithelial (NHBE) cells and patient derived BALF samples revealed that SARS-CoV-2 infection induces the extrinsic blood coagulation cascade and suppresses the plasminogen activation system. We also performed in vitro SARS-CoV-2 infection experiments on primary human lung epithelial cells to confirm that transcriptional upregulation of Tissue Factor, the extrinsic coagulation cascade master regulator, manifested at the protein level. Further, infection of NHBEs with influenza A virus (IAV) did not drive key regulators of blood coagulation in a similar manner as SARS-CoV-2. Additionally, peripheral blood mononuclear cells (PBMCs) did not differentially express genes regulating the extrinsic coagulation cascade or plasminogen activation system during SARS-CoV-2 infection, suggesting that they are not directly inducing coagulopathy through these pathways. The hyper-activation of the extrinsic blood coagulation cascade and the suppression of the plasminogen activation system in SARS-CoV-2 infected epithelial cells may drive diverse coagulopathies in the lung and distal organ systems. Understanding how hosts drive such transcriptional changes with SARS-CoV-2 infection may enable the design of host-directed therapeutic strategies to treat COVID-19 and other coronaviruses inducing hyper-coagulation
The planetary nebula Abell 48 and its [WN] nucleus
We have conducted a detailed multi-wavelength study of the peculiar nebula
Abell 48 and its central star. We classify the nucleus as a helium-rich,
hydrogen-deficient star of type [WN4-5]. The evidence for either a massive WN
or a low-mass [WN] interpretation is critically examined, and we firmly
conclude that Abell 48 is a planetary nebula (PN) around an evolved low-mass
star, rather than a Population I ejecta nebula. Importantly, the surrounding
nebula has a morphology typical of PNe, and is not enriched in nitrogen, and
thus not the `peeled atmosphere' of a massive star. We estimate a distance of
1.6 kpc and a reddening, E(B-V) = 1.90 mag, the latter value clearly showing
the nebula lies on the near side of the Galactic bar, and cannot be a massive
WN star. The ionized mass (~0.3 M_Sun) and electron density (700 cm^-3) are
typical of middle-aged PNe. The observed stellar spectrum was compared to a
grid of models from the Potsdam Wolf-Rayet (PoWR) grid. The best fit
temperature is 71 kK, and the atmospheric composition is dominated by helium
with an upper limit on the hydrogen abundance of 10 per cent. Our results are
in very good agreement with the recent study of Todt et al., who determined a
hydrogen fraction of 10 per cent and an unusually large nitrogen fraction of ~5
per cent. This fraction is higher than any other low-mass H-deficient star, and
is not readily explained by current post-AGB models. We give a discussion of
the implications of this discovery for the late-stage evolution of
intermediate-mass stars. There is now tentative evidence for two distinct
helium-dominated post-AGB lineages, separate to the helium and carbon dominated
surface compositions produced by a late thermal pulse. Further theoretical work
is needed to explain these recent discoveries.Comment: 19 pages, 10 figures, to appear in MNRAS. Version 3 incorporates
proof correction
Recommended from our members
Effect of elevated CO2 and high temperature on seed-set and grain quality of rice
Hybrid vigour may help overcome the negative effects of climate change in rice. A popular rice hybrid (IR75217H), a heat-tolerant check (N22), and a mega-variety (IR64) were tested for tolerance of seed-set and grain quality to high-temperature stress at anthesis at ambient and elevated [CO2]. Under an ambient air temperature of 29 °C (tissue temperature 28.3 °C), elevated [CO2] increased vegetative and reproductive growth, including seed yield in all three genotypes. Seed-set was reduced by high temperature in all three genotypes, with the hybrid and IR64 equally affected and twice as sensitive as the tolerant cultivar N22. No interaction occurred between temperature and [CO2] for seed-set. The hybrid had significantly more anthesed spikelets at all temperatures than IR64 and at 29 °C this resulted in a large yield advantage. At 35 °C (tissue temperature 32.9 °C) the hybrid had a higher seed yield than IR64 due to the higher spikelet number, but at 38 °C (tissue temperature 34–35 °C) there was no yield advantage. Grain gel consistency in the hybrid and IR64 was reduced by high temperatures only at elevated [CO2], while the percentage of broken grains increased from 10% at 29 °C to 35% at 38 °C in the hybrid. It is concluded that seed-set of hybrids is susceptible to short episodes of high temperature during anthesis, but that at intermediate tissue temperatures of 32.9 °C higher spikelet number (yield potential) of the hybrid can compensate to some extent. If the heat tolerance from N22 or other tolerant donors could be transferred into hybrids, yield could be maintained under the higher temperatures predicted with climate change
Photometric and proper motion study of neglected open cluster NGC 2215
Optical UBVRI photometric measurements using the Faulkes Telescope North were
taken in early 2011 and combined with 2MASS JHK and WISE infrared
photometry as well as UCAC4 proper motion data in order to estimate the main
parameters of the galactic open cluster NGC 2215 of which large uncertainty
exists in the current literature. Fitting a King model we estimate a core
radius of 1.120.04 (0.240.01pc) and a limiting radius of
0.5 (0.940.11pc) for the cluster. The results of isochrone
fits indicates an age of with a distance of
pc, a metallicity of dex and a reddening of
. A proportion of the work in this study was undertaken by
Australian and Canadian upper secondary school students involved in the Space
to Grow astronomy education project, and is the first scientific publication to
have utilized our star cluster photometry curriculum materials.Comment: 10 pages, 9 Figures, 3 Table
- …