Speciation through entrepreneurial spin-off: The Acorn-ARM story

Can the concept of speciation explain evidence on how technologies branch and advance? Can evidence on innovation through spin-off usefully inform the concept of speciation? These questions are addressed through a case study of detailed processes enabling the shift of technology to new domains of application. An innovative IT firm developed its own semiconductor technology to remedy supplier deficiencies but it required a joint venture with a completely new business model to adapt and move the technology into new market domains. We propose the concept of techno-organizational speciation to delineate this phenomenon. Competing perspectives on speciation (compatibility, niche and lineage approaches) are found to illuminate the evidence, while complementarities between these conceptual dimensions are revealed by the case. Causal processes uncovered include the following: (1) Techno-organizational speciation through spin-off may be needed to launch a dominant technical standard, compatible with multiple applications. (2) This can be achieved through niche creation from which develops a new business ecosystem. (3) Inherited knowledge together with organizationally based learning foster the branching and renewal of technological lineage

Scoping review and bibliometric analysis of Big Data applications for Medication adherence: An explorative methodological study to enhance consistency in literature

Background: Medication adherence has been studied in different settings, with different approaches, and applying different methodologies. Nevertheless, our knowledge and efficacy are quite limited in terms of measuring and evaluating all the variables and components that affect the management of medication adherence regimes as a complex phenomenon. The study aim is mapping the state-of-the-art of medication adherence measurement and assessment methods applied in chronic conditions. Specifically, we are interested in what methods and assessment procedures are currently used to tackle medication adherence. We explore whether Big Data techniques are adopted to improve decision-making procedures regarding patients' adherence, and the possible role of digital technologies in supporting interventions for improving patient adherence and avoiding waste or harm. Methods: A scoping literature review and bibliometric analysis were used. Arksey and O'Malley's framework was adopted to scope the review process, and a bibliometric analysis was applied to observe the evolution of the scientific literature and identify specific characteristics of the related knowledge domain. Results: A total of 533 articles were retrieved from the Scopus academic database and selected for the bibliometric analysis. Sixty-one studies were identified and included in the final analysis. The Morisky medication adherence scale (36%) was the most frequently adopted baseline measurement tool, and cardiovascular/hypertension disease, the most investigated illness (38%). Heterogeneous findings emerged from the types of study design and the statistical methodologies used to assess and compare the results. Conclusions: Our findings reveal a lack of Big Data applications currently deployed to address or measure medication adherence in chronic conditions. Our study proposes a general framework to select the methods, measurements and the corpus of variables in which the treatment regime can be analyzed

Process issues in alliance management: A panel discussion.

The purpose in this series of papers is to examine different perspectives on the evolution of the process of collaboration and the management challenges therein by focusing on a single case experience. The literature on alliance and collaboration has grown immensely in the last few years. Much attention has been given to the economic rationale for intermediate organizational forms, the so-called «swollen middle» (Hennart, 1993) that lies between market and hierarchical solutions, and to the conditions under which such structures are optimal (Hennart, 1988; Balakrishnan & Koza, 1993; Buckley and Casson, 1996). More recently, there has been a virtual explosion in the treatment of the managerial challenges involved in inter-firm collaboration, ranging from issues of negotiation and conflict resolution to the role of strategic intent or prior experience, as well as numerous attempts to conceptualize and measure that most ephemeral and over-abused concept, trust. The initial paper in the series introduces the specifics of the case on which our discussion is based, and presents a view on the role that perceptions of efficiency and equity between the partners within a relationship have on the evolution of their collaboration. As elaborated in the paper, efficiency perceptions refer to the partners' views on the potential for value creation within the alliance, relative to other organizational choices. Equity perceptions relate to the expected balance between the partners' relative costs and benefits in the alliance, that is, the potential for fairness in value appropriation. The paper starts by summarizing the facts of a failed international joint venture, and chronicles the process of its disintegration through a series of events in its 3-year history. The concepts of efficiency and equity are then defined and formalized. Next, the authors provide their own interpretation of the case data and propose a structure for the analysis of the inter-partner relationship. Finally, they offer a model of the evolution of collaboration that is driven by the maintenance of relational quality among the partners, including the accommodation of changes in both the business environment and the strategies of the partners over time. The three other papers in the series elaborate on this interpretation and bring a broader set of concerns derived from each author's own research trajectory. Since two of these were responsible for earlier models on which the initial case analysis was based, they have a unique opportunity to revisit their original thinking and reinterpret it in view of the facts presented. They take a more dynamic view and incorporate more recent theoretical insights from the management process literature to the collaborative process. The last paper ventures beyond the dyadic framework of the original analysis to examine the lessons that can be drawn for broader networks of collaborative alliances. A final section on conclusions summarizes the arguments and suggests where there may be convergence, as well as proposing new avenues for research.alliances; evolution process collaboration; management challenges;

Anchor entrepreneurship and industry catalysis: The rise of the Italian Biomedical Valley

Accounting for the rise of the medical device industry in the Emilia-Romagna town of Mirandola from a once depressed agricultural area in 1962 to a world-manufacturing center for dialysis equipment and disposable plastic medical devices, requires in large measure mapping the methods of the local entrepreneur who spearheaded its development. Reworking Agrawal and Cockburn's anchor-tenant hypothesis highlighting the role of large organizations in fostering agglomerations, this paper privileges the Schumpeterian entrepreneur as the dynamic force driving new industrial formations. This anchor-entrepreneur with no prior experience in manufacturing medical devices and without any public financing or large private backers founded six firms. Each of these would be sold off fairly quickly to a different large multinational corporation. Placing the anchor-entrepreneur at the center stage advances understanding of early industry evolution, spelling out how first-mover pioneers shape the environment to establish the first markets needed to attract new resources and capabilities. Underpinning our argument are 61 fine-grain interviews with key medical device industry informants in addition to extensive secondary sources and historical records. We draw on this material to induce a stylized model of anchor-entrepreneurship and industry catalysis that rests on three generative processes: bricolage, second-hand imprinting and beaconing

Anchor entrepreneurship and industry catalysis: The rise of the Italian Biomedical Valley

Accounting for the rise of the medical device industry in the Emilia-Romagna town of Mirandola from a once depressed agricultural area in 1962 to a world-manufacturing center for dialysis equipment and disposable plastic medical devices, requires in large measure mapping the methods of the local entrepreneur who spearheaded its development. Reworking Agrawal and Cockburn's anchor-tenant hypothesis highlighting the role of large organizations in fostering agglomerations, this paper privileges the Schumpeterian entrepreneur as the dynamic force driving new industrial formations. This anchor-entrepreneur with no prior experience in manufacturing medical devices and without any public financing or large private backers founded six firms. Each of these would be sold off fairly quickly to a different large multinational corporation. Placing the anchor-entrepreneur at the center stage advances understanding of early industry evolution, spelling out how first-mover pioneers shape the environment to establish the first markets needed to attract new resources and capabilities. Underpinning our argument are 61 fine-grain interviews with key medical device industry informants in addition to extensive secondary sources and historical records. We draw on this material to induce a stylized model of anchor-entrepreneurship and industry catalysis that rests on three generative processes: bricolage, second-hand imprinting and beaconing

Evaluation of drinking patterns and their impact on alcohol-related aggression: a national survey of adolescent behaviours

BACKGROUND: Although there have been a wide range of epidemiological studies examining the impact of patterns of alcohol consumption among adolescents, there remains considerable variability in both defining these patterns and the ability to comprehensively evaluate their relationship to behavioural patterns. This study explores a new procedure for defining and evaluating drinking patterns and integrating well-established indicators. The composite measure is then used to estimate the impact of these patterns on alcohol-related aggressive behaviour among Italian adolescents. METHODS: Data were collected as part of the 2011 European School Survey Project on Alcohol and other Drugs (ESPAD). A national sample of 14,199 students aged 15–19 years was collected using an anonymous, self-administered questionnaire completed in a classroom setting. Drinking patterns were established using principal component analysis. Alcohol-related aggression was analysed as to its relationship to patterns of drinking, behaviour of friends towards alcohol use, substance use/abuse, school performance, family relationships and leisure activities. RESULTS: Several specific drinking patterns were identified: “Drinking to Excess” (DE), “Drinking with Intoxication” (DI) and “Drinking but Not to Excess” (DNE). A higher percentage of males were involved in alcohol-related aggression compared with females. In males, the DE and DI patterns significantly increased the likelihood of alcohol-related aggression, whereas the DNE pattern was negatively associated. Similar results were found in females, although the DI pattern was not significantly associated with alcohol-related aggression. Overall, cigarette smoking, illegal drug use, truancy, limited parental monitoring, frequent evenings spent outside of the home and peer influence associated strongly with alcohol-related aggression. CONCLUSIONS: Our findings suggest that drinking patterns, as uniquely monitored with an integrated metric, can: 1) explain drinking habits better than commonly used indicators of alcohol use and 2) provide a better understanding of behavioural risks such as alcohol-related aggression. Environmental background also appears to strongly associate with this type of aggressive behaviour

A 3-component extension of the Camassa-Holm hierarchy

We introduce a bi-Hamiltonian hierarchy on the loop-algebra of sl(2) endowed with a suitable Poisson pair. It gives rise to the usual CH hierarchy by means of a bi-Hamiltonian reduction, and its first nontrivial flow provides a 3-component extension of the CH equation.Comment: 15 pages; minor changes; to appear in Letters in Mathematical Physic

Topic modeling and user network analysis on twitter during world lupus awareness day

Twitter is increasingly used by individuals and organizations to broadcast their feelings and practices, providing access to samples of spontaneously expressed opinions on all sorts of themes. Social media offers an additional source of data to unlock information supporting new insights disclosures, particularly for public health purposes. Systemic lupus erythematosus (SLE) is a complex, systemic autoimmune disease that remains a major challenge in therapeutic diagnostic and treatment management. When supporting patients with such a complex disease, sharing information through social media can play an important role in creating better healthcare services. This study explores the nature of topics posted by users and organizations on Twitter during world Lupus day to extract latent topics that occur in tweet texts and to identify what information is most commonly discussed among users. We identified online influencers and opinion leaders who discussed different topics. During this analysis, we found two different types of influencers that employed different narratives about the communities they belong to. Therefore, this study identifies hidden information for healthcare decision-makers and provides a detailed model of the implications for healthcare organizations to detect, understand, and define hidden content behind large collections of text

Past and Present Environmental Factors Differentially Influence Genetic and Morphological Traits of Italian Barbels (Pisces: Cyprinidae)

Local adaptation and phenotypic plasticity can lead to environment-related morphological and genetic variations in freshwater fish. Studying the responses of fish to environmental changes is crucial to understand their vulnerability to human-induced changes. Here, we used a latitudinal gradient as a proxy for past and present environmental factors and tested its influences on both genetic and morphological patterns. We selected as a suitable biogeographic model, the barbels, which inhabit 17 Adriatic basins of the central-southern Italian Peninsula, and explored association among attributes from genetic, morphological, and environmental analyses. The analysis of the mitochondrial DNA control region evidenced a southward significant increase in the number of private haplotypes, supporting the isolation of the southernmost populations related to the Mio-Pleistocene events. In contrast, morphology was mainly affected by changes in the present environmental conditions. Particularly, the number of scales and fish coloration were clearly associated to latitude, and thus thermal and hydrological conditions. Other morphometric and functional traits varied under the selective pressure of other environmental factors like elevation and distance from headwater. These results highlight the sensitivity of barbels to climate changes, which can serve as a basis for future eco-evolutionary and conservation studies

Flat bidifferential ideals and semihamiltonian PDEs

In this paper we consider a class of semihamiltonian systems characterized by the existence of a special conservation law. The density and the current of this conservation law satisfy a second order system of PDEs which has a natural interpretation in the theory of flat bifferential ideals. The class of systems we consider contains important well-known examples of semihamiltonian systems. Other examples, like genus 1 Whitham modulation equations for KdV, are related to this class by a reciprocal trasformation.Comment: 18 pages. v5: formula (36) corrected; minor change