Extension of Operational Life-Time of WWER-440/213 Type Units at Paks Nuclear Power Plant

Operational license of WWER-440/213 units at Paks NPP, Hungary is limited to the design lifetime of 30 years. Prolongation by additional 20 years of the operational lifetime is feasible. Moreover, enhancement of the reactor thermal power by 8% will increase both the net power output and the competitiveness of the plant. Paks NPP is a pioneer considering the power up-rate and preparation of long-term operation of WWER-440/213 design. Systematic preparatory work for longterm operation of Paks NPP has been started in 2000. A regulatory framework and a comprehensive engineering practice have been developed. According to the authors view, creation of a gapless engineering system via consequent application of best practices, and feed-back of experiences together with proper consideration of WWER-440/V213 features are the decisive elements of ensuring the safety of long-term operation. That systematic engineering approach is in the focus of recent paper. Key elements of justification and measures for ensuring the safety of long-term operation of Paks NPP WWER-440/213 units are identified and discussed. These are the assessment of plant condition and review of adequacy of ageing management programmes, also the review, validation and reconstitution of time limited ageing analyses as core tasks of licence renewal

Monetary costs of agitation in older adults with Alzheimer's disease in the UK: prospective cohort study

While nearly half of all people with Alzheimer's disease (AD) have agitation symptoms every month, little is known about the costs of agitation in AD. We calculated the monetary costs associated with agitation in older adults with AD in the UK from a National Health Service and personal social services perspective

On the Construction and the Structure of Off-Shell Supermultiplet Quotients

Recent efforts to classify representations of supersymmetry with no central charge have focused on supermultiplets that are aptly depicted by Adinkras, wherein every supersymmetry generator transforms each component field into precisely one other component field or its derivative. Herein, we study gauge-quotients of direct sums of Adinkras by a supersymmetric image of another Adinkra and thus solve a puzzle from Ref.[2]: The so-defined supermultiplets do not produce Adinkras but more general types of supermultiplets, each depicted as a connected network of Adinkras. Iterating this gauge-quotient construction then yields an indefinite sequence of ever larger supermultiplets, reminiscent of Weyl's construction that is known to produce all finite-dimensional unitary representations in Lie algebras.Comment: 20 pages, revised to clarify the problem addressed and solve

Interdiffusion along grain boundaries: Diffusion induced grain boundary migration, low temperature homogenization and reactions in nanostructured thin films

LBK

Újabb szenzációs őslénytani leletek a pulai alginitbányából = Further remarkable palaeontological finds at the alginite quarry in Pula

Remains of a volcanic crater from the Pliocene (4 million years ago), fi lled with alginite,were discovered near the village of Pula, Veszprém County, in 1973. Paleontological research begun at the Pula alginite mine in 2003 has yielded several hundred specimens for the collections at the Bakony Museum of the Hungarian Natural History Museum. The latest collections have yielded large numbers of insects (mayfl y larvae, dragonfl ies, bugs, mosquitoes, grasshoppers, fl ies, wasps, beetles, etc.) and specimens of moss. Many of the specimens are from extant genera and the species can be identifi ed in some cases. Specimens of two groups of such insect fossils have presentday relatives in the Mediterranean basin (Isoptera; Coleoptera, Chrysomelidae: Dicladispa). The aquatic and shoreline fauna of the lake must have been extremely diverse. The climate in the area was warmer than today. With 18 figures

Differentiation of dementia with Lewy bodies from Alzheimer's disease using a dopaminergic presynaptic ligand

Background: Dementia with Lewy bodies (DLB) is one of the main differential diagnoses of Alzheimer's disease (AD). Key pathological features of patients with DLB are not only the presence of cerebral cortical neuronal loss, with Lewy bodies in surviving neurones, but also loss of nigrostriatal dopaminergic neurones, similar to that of Parkinson's disease (PD). In DLB there is 40-70% loss of striatal dopamine.Objective: To determine if detection of this dopaminergic degeneration can help to distinguish DLB from AD during life.Methods: The integrity of the nigrostriatal metabolism in 27 patients with DLB, 17 with AD, 19 drug naive patients with PD, and 16 controls was assessed using a dopaminergic presynaptic ligand, I-123-labelled 2beta-carbomethoxy-3beta-(4-iodophenyl)-N-(3-fluoropropyl)nortropane (FP-CIT), and single photon emission tomography (SPET). A SPET scan was carried out with a single slice, brain dedicated tomograph (SME 810) 3.5 hours after intravenous injection of 185 MBq FP-CIT. With occipital cortex used as a radioactivity uptake reference, ratios for the caudate nucleus and the anterior and posterior putamen of both hemispheres were calculated. All scans were also rated by a simple visual method.Results: Both DLB and PD patients had significantly lower uptake of radioactivity than patients with (p<0.01) and controls (p<0.001) in the caudate nucleus and the anterior and posterior Putamen.Conclusion: FP-CIT SPET provides a means of distinguishing DLB from AD during life

The effects of salivas on occlusal forces

Contacting surfaces of opposing teeth produce friction that, when altered, changes the contact force direction and/or magnitude. As friction can be influenced by several factors, including lubrication and the contacting materials, the aim of this study was to measure the occlusal load alterations experienced by teeth with the introduction of different salivas and dental restorative materials. Pairs of molar teeth were set into occlusion with a weighted maxillary tooth mounted onto a vertical sliding assembly and the mandibular tooth supported by a load cell. The load components on the mandibular tooth were measured with three opposing pairs of dental restorative materials (plastic denture, all-ceramic and stainless steel), four (human and three artificial) salivas and 16 occlusal configurations. All lateral force component measurements were significantly different (P < 0·0001) from the dry (control) surface regardless of the crown material or occlusal configuration, while the effects of the artificial salivas compared to each other and to human saliva depended on the crown material

Mental health of forced migrants recently granted leave to remain in the United Kingdom

Background: Asylum seekers who are granted leave to remain in the United Kingdom are required to make a rapid transition to housing and welfare benefits. The challenges facing new refugees during this ‘transition period’ can affect their mental health, but this has not been quantified. Aims: To assess the impact of the transition period on new refugees’ mental health in the 12 months after being granted leave to remain in the United Kingdom. Method: A longitudinal survey design was used to measure the mental health of 30 newly recognised refugees at monthly intervals in the first 6 months and again at 1 year after receiving leave to remain in the United Kingdom. There were five outcome measures for symptoms of anxiety, depression, distress, post-traumatic stress disorder (PTSD), post-migration living difficulties (PMLD) and a life events calendar to record key changes in housing and welfare. Results: The results showed that the trajectory of scores across all measures fluctuates, but overall they all improve from baseline to Month 12. Scores for depression and PMLD showed significant improvement at Month 5, and scores for anxiety, depression, distress and PMLD showed significant improvement at Month 12. PTSD scores did not show significant improvement at any month. In months with a high number of stressful life events, participants had worse PMLD and PTSD scores. Conclusion: Overall improvement in mental health could partly be explained by the stability of being granted leave to remain in the United Kingdom, but may also be due to the high level of practical support these participants received. Recommendations are made for those working with clients during the transition period