GAMMA RAYS INDUCED MUTAGENIC STUDIES IN CATHARANTHUS ROSEUS (L.) G. DON., AN IMPORTANT ORNAMENTAL PLANT

A study was conducted to estimate the effect of gamma rays on growth and yield traits in periwinkle (Catharanthus roseus (L.) G. Don), an important horticulture plant. The seeds were treated with different levels of gamma rays (20, 25 and 30). Morphological parameters were analysed on the 30th day, like plant height, days of first flower, plant height, fresh weight per plant, dry weight per plant, root fresh weight per plant and root dry weight per plant. The morphological parameters were decreased with increasing levels of gamma rays doses

Initiating and Managing Patients with Venous Thromboembolism on Anticoagulant Drugs: A Practical Overview

Several new oral anticoagulants have recently been approved for the treatment of venous thromboembolism (VTE). In this review, we discuss the currently approved drugs and the factors that influence the choice of anticoagulant in a given patient. Once anticoagulation is initiated, periodic monitoring of adequacy of anticoagulation may be necessary depending on the choice of anticoagulant and patient-related factors, such as renal function. Situations that may warrant need for monitoring and the tests available for this purpose are discussed. We review reversal of anticoagulation in urgent/emergent situations as well as perioperative anticoagulation interruption in the elective setting. The data on use of direct oral anticoagulants in patients with compromised renal function, obesity and bariatric surgery, and in the treatment of cancer-associated thrombosis are discussed. The review aims to provide the clinician with the essential information to allow effective and safe use of anticoagulants for the treatment of VTE

Woven design data transmission using TTL logic for 128 hooks electronic cardless jacquard

A new electronic cardless handloom weaving apparatus which is an alternate to mechanical jacquard has been developed in order to improve the productivity and to reduce the occupational stress of the handloom weaver. The main objective of this development is to retain the features of the handloom with comfortable weaving and reduced laborious work. This development is based on embedded system to control the warp yarn vertical movement. The conventional punched cards are replaced by multimedia memory card file system. The shedding effect is programmatically controlled through miniature stepper motors. The new apparatus is found to be highly versatile for introducing variety of weaving patterns

THE IMPACT OF LIBRARY AWARENESS AMONG PUBLIC IN DISTRICT CENTRAL LIBRARY, TIRUNELVELI

The current review examines about the utilization and mindfulness Library Awareness among public In District Central Library, Tirunelveli. .The Public library is a framework that gives admittance to the information data and work of administrations and similarly accessible to all individuals from the local area of identity, Language, business status and instructive accomplishment. An overview technique was directed by utilizing organized questionnaire, which were circulated among 150 public library clients, among them 120 filled poll were gotten with reaction pace of 80%. The review uncovers that greater part 79% of clients of male, about40% of respondents are four year college education holders and it is trailed by post graduates. More number respondents bookkeeping 55% are fall between 20-30 years old gathering, larger part of clients visit the library day to day and they are keen on understanding papers and magazines. The concentrate additionally uncovers that, clients don\u27t know about news section and copy administrations of the library and they are not happy with the assortment of e-assets in the library

Deep Feature Representation and Similarity Matrix based Noise Label Refinement Method for Efficient Face Annotation

Face annotation is a naming procedure that assigns the correct name to a person emerging from an image. Faces that are manually annotated by people in online applications include incorrect labels, giving rise to the issue of label ambiguity. This may lead to mislabelling in face annotation. Consequently, an efficient method is still essential to enhance the reliability of face annotation. Hence, in this work, a novel method named the Similarity Matrix-based Noise Label Refinement (SMNLR) is proposed, which effectively predicts the accurate label from the noisy labelled facial images. To enhance the performance of the proposed method, the deep learning technique named Convolutional Neural Networks (CNN) is used for feature representation. Several experiments are conducted to evaluate the effectiveness of the proposed face annotation method using the LFW, IMFDB and Yahoo datasets. The experimental results clearly illustrate the robustness of the proposed SMNLR method in dealing with noisy labelled faces

Association between Tumor Markers and Macro Metals – Calcium and Magnesium

AbstractMonoclonal antibodies are used to detect serum antigens associated with malignancies. The tumor markers are most useful for monitoring response to therapy and detecting early relapse. Tumor markers are special molecules released by tumor cells, found in high levels in patients with malignancies. Each tumor marker is organ specific and is elevated in specific type of malignancy and its level in circulating blood provide a clue about the type and severity of the disease. The blood level is very useful for diagnosis, prognosis and to check recurrence after treatment. Experiments were performed to investigate and establish if there are any associations between the principle tumor markers viz CEA (colon caner) , CA125 (ovarian cancer) and CA15.3 (breast cancer) to the diagnostically useful macro-metals Calcium and Magnesium and to suggest if the above two metals need to be analyzed along with the tumor markers for the diagnostic purposes. The study was done with the blood serum sample of suspected or established cancer patients (both men and women). For the samples, biochemical assay using electro-chemiluminescence technique (for CEA, CA 125 and CA 15.3) was used; Calcium and Magnesium were analyzed using manual dye-binding methods and the readings were acquired using a semi auto analyzer. Appropriate statistical methods were used to conclude that, there exists a very strong relationship between CA 125 and CA 15.3; and proved that CA 15.3 is linked to both metals Calcium and Magnesium; whereas CEA shows an inverse correlation with CA 125.1Head of Biochemistry, Apollo Specialty Hospitals, Chennai; 2School Biosciences and Technology, VIT, Vellore-632001, Tamil Nadu, IndiaPlease Cite This Artilce As:S.  Swaminathan, Kasthuri Prakash and C. Ramalingam. 2010. Association between Tumor Markers and Macro Metals – Calcium and Magnesium. J. Exp. Sci. 1(4) 14-20. Â

Effect of S-Glass Fibres on the Flexural Strength of Acrylic Resins used for Temporary Restorations: An In Vitro Study

AIM OF THE STUDY: The aim of this in vitro study is to evaluate the effect of S- glass fibre reinforcement on the flexural strength of autopolymerizing PMMA and to analyse the effect of silanization on it. MATERIALS AND METHODS: A stainless steel mould of 25mm (±2.0)×2mm (±0.1)×2mm (±0.1) (according to ISO4049/2000) was used for the fabrication of all specimens and an acrylic jig was fabricated using autopolymerizing poly methyl methacrylate for orienting the split moulds. Autopolymerizing poly methyl methacrylate (Shade: C) was the provisional restorative material that was used in the study. The specimens were fabricated under 5 groups; Group A- control group (Unreinforced autopolymerizing PMMA), Group B- Autopolymerizing PMMA reinforced with short S glass fibres treated with monomer, Group C- Autopolymerizing PMMA reinforced with long S glass fibres treated with monomer, Group D- Autopolymerizing PMMA reinforced with short S glass fibres treated with silane, Group E- Autopolymerizing PMMA reinforced with long S glass fibres treated with silane. For all the reinforced groups, 4wt% of glass fibre (4.75mg) was added. For Groups B and D, short S glass fibres of 2mm length and for Groups C and E, long S glass fibres of 23mm length were used, with the consideration of mould dimension. All the fabricated specimens were stored in distilled water for 24 hrs and maintained at 37 degree Celsius in incubator. The specimens were then subjected for testing using three point bending test in a universal testing machine, to determine the flexural strength of the specimens. RESULTS: The mean and standard deviations of flexural strength of different groups were evaluated and one way ANOVA test was performed to find the statistical significance. On analyzing the results of the ANOVA test, it was seen that the flexural strength differed significantly between the groups (F=29.382, P=0.000), with the highest value shown by Group E (Autopolymerizing PMMA reinforced with long S glass fibres treated with silane) and with the least value shown by Group A (Unreinforced PMMA). Multiple intergroup comparison using Tukey post hoc test revealed that there was no significant difference between groups surface treated with monomer and silane, irrespective of length of the fibre used for reinforcement. CONCLUSION: Within the limitations of the study, reinforcement of autopolymerizing PMMA with S glass fibre had increased the flexural strength significantly. Placement of unidirectional fibre along the tension side had shown improved results when compared to randomly oriented fibres. There was no significant difference between groups surface treated with monomer and silane, irrespective of length of the fibre used for reinforcement. Thus, S- Glass fibre reinforced autopolymerizing PMMA could be considered as a material of choice for long span anterior and short span posterior provisional restorations which needed long term intraoral usage, with the support of results from this study and future clinical studies

Synaptic partner prediction from point annotations in insect brains

High-throughput electron microscopy allows recording of lar- ge stacks of neural tissue with sufficient resolution to extract the wiring diagram of the underlying neural network. Current efforts to automate this process focus mainly on the segmentation of neurons. However, in order to recover a wiring diagram, synaptic partners need to be identi- fied as well. This is especially challenging in insect brains like Drosophila melanogaster, where one presynaptic site is associated with multiple post- synaptic elements. Here we propose a 3D U-Net architecture to directly identify pairs of voxels that are pre- and postsynaptic to each other. To that end, we formulate the problem of synaptic partner identification as a classification problem on long-range edges between voxels to encode both the presence of a synaptic pair and its direction. This formulation allows us to directly learn from synaptic point annotations instead of more ex- pensive voxel-based synaptic cleft or vesicle annotations. We evaluate our method on the MICCAI 2016 CREMI challenge and improve over the current state of the art, producing 3% fewer errors than the next best method

Current Treatment of Venous Thromboembolism

Venous thromboembolism (VTE), comprising deep vein thrombosis and pulmonary embolism, is a common disorder with at least 250,000 new events occurring each year in the United States alone. Treatment of VTE entails anticoagulation, which is achieved initially with the use of a parenterally administered anticoagulant followed by a more prolonged course of treatment with an oral vitamin K antagonist. The duration of anticoagulation depends on the clinical assessment of the benefit-risk ratio of prolonged anticoagulation versus the risk of recurrent events. In this review, we discuss some of the issues that we believe are among the most critical unanswered questions in the management of VTE in the present era

RBC barcoding allows for the study of erythrocyte population dynamics and P. falciparum merozoite invasion.

Plasmodium falciparum invasion of host erythrocytes is essential for the propagation of the blood stage of malaria infection. Additionally, the brief extracellular merozoite stage of P. falciparum represents one of the rare windows during which the parasite is directly exposed to the host immune response. Therefore, efficient invasion of the host erythrocyte is necessary not only for productive host erythrocyte infection, but also for evasion of the immune response. Host traits, such as hemoglobinopathies and differential expression of erythrocyte invasion ligands, can protect individuals from malaria by impeding parasite erythrocyte invasion. Here we combine RBC barcoding with flow cytometry to study P. falciparum invasion. This novel high-throughput method allows for the (i) direct comparison of P. falciparum invasion into different erythrocyte populations and (ii) assessment of the impact of changing erythrocyte population dynamics on P. falciparum invasion