A Godel-Friedman cosmology?

Based on the mathematical similarity between the Friedman open metric and Godel's metric in the case of nearby distances, we investigate a new scenario for the Universe's evolution, where the present Friedman universe originates from a primordial Godel universe by a phase transition during which the cosmological constant vanishes. Using Hubble's constant and the present matter density as input, we show that the radius and density of the primordial Godel universe are close, in order of magnitude, to the present values, and that the time of expansion coincides with the age of the Universe in the standard Friedman model. In addition, the conservation of angular momentum provides, in this context, a possible origin for the rotation of galaxies, leading to a relation between the masses and spins corroborated by observational data.Comment: Extended version, accepted for publication in Physical Review

Spacetime Splitting, Admissible Coordinates and Causality

To confront relativity theory with observation, it is necessary to split spacetime into its temporal and spatial components. The (1+3) timelike threading approach involves restrictions on the gravitational potentials $(g_{\mu \nu})$, while the (3+1) spacelike slicing approach involves restrictions on $(g^{\mu \nu})$. These latter coordinate conditions protect chronology within any such coordinate patch. While the threading coordinate conditions can be naturally integrated into the structure of Lorentzian geometry and constitute the standard coordinate conditions in general relativity, this circumstance does not extend to the slicing coordinate conditions. We explore the influence of chronology violation on wave motion. In particular, we consider the propagation of radiation parallel to the rotation axis of stationary G\"odel-type universes characterized by parameters $\eta > 0$ and $\lambda > 0$ such that for $\eta 1$) chronology is protected (violated). We show that in the WKB approximation such waves can freely propagate only when chronology is protected.Comment: 25 pages, 3 figures; v2: minor typos corrected, accepted for publication in Phys. Rev.

A point mutation in cpsE renders Streptococcus pneumoniae nonencapsulated and enhances its growth, adherence and competence.

BACKGROUND: The polysaccharide capsule is a major virulence factor of the important human pathogen Streptococcus pneumoniae. However, S. pneumoniae strains lacking capsule do occur. RESULTS: Here, we report a nasopharyngeal isolate of Streptococcus pneumoniae composed of a mixture of two phenotypes; one encapsulated (serotype 18C) and the other nonencapsulated, determined by serotyping, electron microscopy and fluorescence isothiocyanate dextran exclusion assay.By whole genome sequencing, we demonstrated that the phenotypes differ by a single nucleotide base pair in capsular gene cpsE (C to G change at gene position 1135) predicted to result in amino acid change from arginine to glycine at position 379, located in the cytoplasmic, enzymatically active, region of this transmembrane protein. This SNP is responsible for loss of capsule production as the phenotype is transferred with the capsule operon. The nonencapsulated variant is superior in growth in vitro and is also 117-fold more adherent to and more invasive into Detroit 562 human epithelial cells than the encapsulated variant.Expression of six competence pathway genes and one competence-associated gene was 11 to 34-fold higher in the nonencapsulated variant than the encapsulated and transformation frequency was 3.7-fold greater. CONCLUSIONS: We identified a new single point mutation in capsule gene cpsE of a clinical S. pneumoniae serotype 18C isolate sufficient to cause loss of capsule expression resulting in the co-existence of the encapsulated and nonencapsulated phenotype. The mutation caused phenotypic changes in growth, adherence to epithelial cells and transformability. Mutation in capsule gene cpsE may be a way for S. pneumoniae to lose its capsule and increase its colonization potential

The evolution of optical networking

C3 - Journal Articles Unrefereed Letters or Note

Improved optical switching extinction in three-electrode Ti:LiNbO3 directional couplers

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