Facing fear: Expression of fear facilitates processing of emotional information

Evidence shows that manipulating the expressive component of fear can influence the processing of emotional information. Participants unobtrusively produced the expressive behaviors typical of fear, anger or happiness. Participants producing the expression of fear were faster at classifying verbal material with emotional content than participants producing the expressions of happiness or anger. These effects were especially pronounced for participants who were generally sensitive to their own bodily cues, as indicated by their degree of field-dependence measured by the Rod-and-Frame Task (Witkin &amp; Asch, 1948). The results suggest that one way of eliciting the cognitive consequences of fear is by inducing the embodied expressive behavior.</jats:p

Quantum buoyancy, generalized second law, and higher-dimensional entropy bounds

Bekenstein has presented evidence for the existence of a universal upper bound of magnitude $2\pi R/\hbar c$ to the entropy-to-energy ratio $S/E$ of an arbitrary {\it three} dimensional system of proper radius $R$ and negligible self-gravity. In this paper we derive a generalized upper bound on the entropy-to-energy ratio of a $(D+1)$-dimensional system. We consider a box full of entropy lowered towards and then dropped into a $(D+1)$-dimensional black hole in equilibrium with thermal radiation. In the canonical case of three spatial dimensions, it was previously established that due to quantum buoyancy effects the box floats at some neutral point very close to the horizon. We find here that the significance of quantum buoyancy increases dramatically with the number $D$ of spatial dimensions. In particular, we find that the neutral (floating) point of the box lies near the horizon only if its length $b$ is large enough such that $b/b_C>F(D)$, where $b_C$ is the Compton length of the body and $F(D)\sim D^{D/2}\gg1$ for $D\gg1$. A consequence is that quantum buoyancy severely restricts our ability to deduce the universal entropy bound from the generalized second law of thermodynamics in higher-dimensional spacetimes with $D\gg1$. Nevertheless, we find that the universal entropy bound is always a sufficient condition for operation of the generalized second law in this type of gedanken experiments.Comment: 6 page

Sustainable deathstyles? The geography of green burials in Britain

In the context of a wider literature on ‘deathscapes’, we map the emergence of a new mode of burial and remembrance in Britain. Since a ‘green’ burial ground was established in Carlisle in 1993, sites for so-called ‘green, ‘natural’ or ‘woodland’ funerals have proliferated. There are now over 270 such sites in Britain. Drawing on a postal and email survey sent to all managers/owners and visits to 15 green burial grounds (enabling observations and semi-structured interviews with their managers), we chart their growth, establishment and regulation and describe the landscapes associated with them. This requires, and leads to, wider reflections on nature, capital, consumption, culture and the body

The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane.

The signal recognition particle receptor (SR) is required for the cotranslational targeting of both secretory and membrane proteins to the endoplasmic reticulum (ER) membrane. During targeting, the SR interacts with the signal recognition particle (SRP) which is bound to the signal sequence of the nascent protein chain. This interaction catalyzes the GTP-dependent transfer of the nascent chain from SRP to the protein translocation apparatus in the ER membrane. The SR is a heterodimeric protein comprised of a 69-kD subunit (SR alpha) and a 30-kD subunit (SR beta) which are associated with the ER membrane in an unknown manner. SR alpha and the 54-kD subunits of SRP (SRP54) each contain related GTPase domains which are required for SR and SRP function. Molecular cloning and sequencing of a cDNA encoding SR beta revealed that SR beta is a transmembrane protein and, like SR alpha and SRP54, is a member of the GTPase superfamily. Although SR beta defines its own GTPase subfamily, it is distantly related to ARF and Sar1. Using UV cross-linking, we confirm that SR beta binds GTP specifically. Proteolytic digestion experiments show that SR alpha is required for the interaction of SRP with SR. SR alpha appears to be peripherally associated with the ER membrane, and we suggest that SR beta, as an integral membrane protein, mediates the membrane association of SR alpha. The discovery of its guanine nucleotide-binding domain, however, makes it likely that its role is more complex than that of a passive anchor for SR alpha. These findings suggest that a cascade of three directly interacting GTPases functions during protein targeting to the ER membrane

Improved Algorithms for Decremental Single-Source Reachability on Directed Graphs

Recently we presented the first algorithm for maintaining the set of nodes reachable from a source node in a directed graph that is modified by edge deletions with $o(mn)$ total update time, where $m$ is the number of edges and $n$ is the number of nodes in the graph [Henzinger et al. STOC 2014]. The algorithm is a combination of several different algorithms, each for a different $m$ vs. $n$ trade-off. For the case of $m = \Theta(n^{1.5})$ the running time is $O(n^{2.47})$, just barely below $mn = \Theta(n^{2.5})$. In this paper we simplify the previous algorithm using new algorithmic ideas and achieve an improved running time of $\tilde O(\min(m^{7/6} n^{2/3}, m^{3/4} n^{5/4 + o(1)}, m^{2/3} n^{4/3+o(1)} + m^{3/7} n^{12/7+o(1)}))$. This gives, e.g., $O(n^{2.36})$ for the notorious case $m = \Theta(n^{1.5})$. We obtain the same upper bounds for the problem of maintaining the strongly connected components of a directed graph undergoing edge deletions. Our algorithms are correct with high probabililty against an oblivious adversary.Comment: This paper was presented at the International Colloquium on Automata, Languages and Programming (ICALP) 2015. A full version combining the findings of this paper and its predecessor [Henzinger et al. STOC 2014] is available at arXiv:1504.0795

Phagosome-lysosome fusion is a calcium-independent event in macrophages.

Phagosome-lysosome membrane fusion is a highly regulated event that is essential for intracellular killing of microorganisms. Functionally, it represents a form of polarized regulated secretion, which is classically dependent on increases in intracellular ionized calcium ([Ca2+]i). Indeed, increases in [Ca2+]i are essential for phagosome-granule (lysosome) fusion in neutrophils and for lysosomal fusion events that mediate host cell invasion by Trypanosoma cruzi trypomastigotes. Since several intracellular pathogens survive in macrophage phagosomes that do not fuse with lysosomes, we examined the regulation of phagosome-lysosome fusion in macrophages. Macrophages (M phi) were treated with 12.5 microM bis-(2-amino-S-methylphenoxy) ethane-N,N,N',N',-tetraacetic acid tetraacetoxymethyl ester (MAPT/AM), a cell-permeant calcium chelator which reduced resting cytoplasmic [Ca2+]; from 80 nM to &lt; or = 20 nM and completely blocked increases in [Ca2+]i in response to multiple stimuli, even in the presence of extracellular calcium. Subsequently, M phi phagocytosed serum-opsonized zymosan, staphylococci, or Mycobacterium bovis. Microbes were enumerated by 4',6-diamidino-2-phenylindole, dihydrochloride (DAPI) staining, and phagosome-lysosome fusion was scored using both lysosome-associated membrane protein (LAMP-1) as a membrane marker and rhodamine dextran as a content marker for lysosomes. Confirmation of phagosome-lysosome fusion by electron microscopy validated the fluorescence microscopy findings. We found that phagosome-lysosome fusion in M phi occurs noramlly at very low [Ca2+]i (&lt; or = 20 nM). Kinetic analysis showed that in M phi none of the steps leading from particle binding to eventual phagosome-lysosome fusion are regulated by [Ca2+]i in a rate-limiting way. Furthermore, confocal microscopy revealed no difference in the intensity of LAMP-1 immunofluorescence in phagolysosome membranes in calcium-buffered vs. control macrophages. We conclude that neither membrane recognition nor fusion events in the phagosomal pathway in macrophages are dependent on or regulated by calcium

A simultaneous generalization of independence and disjointness in boolean algebras

We give a definition of some classes of boolean algebras generalizing free boolean algebras; they satisfy a universal property that certain functions extend to homomorphisms. We give a combinatorial property of generating sets of these algebras, which we call n-independent. The properties of these classes (n-free and omega-free boolean algebras) are investigated. These include connections to hypergraph theory and cardinal invariants on these algebras. Related cardinal functions, $n$Ind, which is the supremum of the cardinalities of n-independent subsets; i_n, the minimum size of a maximal n-independent subset; and i_omega, the minimum size of an omega-independent subset, are introduced and investigated. The values of i_n and i_omega on P(omega)/fin are shown to be independent of ZFC.Comment: Sumbitted to Orde

Effective temperature for black holes

The physical interpretation of black hole's quasinormal modes is fundamental for realizing unitary quantum gravity theory as black holes are considered theoretical laboratories for testing models of such an ultimate theory and their quasinormal modes are natural candidates for an interpretation in terms of quantum levels. The spectrum of black hole's quasinormal modes can be re-analysed by introducing a black hole's effective temperature which takes into account the fact that, as shown by Parikh and Wilczek, the radiation spectrum cannot be strictly thermal. This issue changes in a fundamental way the physical understanding of such a spectrum and enables a re-examination of various results in the literature which realizes important modifies on quantum physics of black holes. In particular, the formula of the horizon's area quantization and the number of quanta of area result modified becoming functions of the quantum "overtone" number n. Consequently, the famous formula of Bekenstein-Hawking entropy, its sub-leading corrections and the number of microstates are also modified. Black hole's entropy results a function of the quantum overtone number too. We emphasize that this is the first time that black hole's entropy is directly connected with a quantum number. Previous results in the literature are re-obtained in the limit n \to \infty.Comment: 10 pages,accepted for publication in Journal of High Energy Physics. Comments are welcom

DBpedia's triple pattern fragments: usage patterns and insights

Queryable Linked Data is published through several interfaces, including SPARQL endpoints and Linked Data documents. In October 2014, the DBpedia Association announced an official Triple Pattern Fragments interface to its popular DBpedia dataset. This interface proposes to improve the availability of live queryable data by dividing query execution between clients and servers. In this paper, we present a usage analysis between November 2014 and July 2015. In 9 months time, the interface had an average availability of 99.99 %, handling 16,776,170 requests, 43.0% of which were served from cache. These numbers provide promising evidence that low-cost Triple Pattern Fragments interfaces provide a viable strategy for live applications on top of public, queryable datasets