59 research outputs found
Asymmetric Faraday Effect in a Magnetophotonic Crystal
It is widely known that the magneto-optical Faraday effect is linear in
magnetization and therefore the Faraday angles for the states with opposite
magnetizations are of opposite sign but equal in modulus. Here we
experimentally study propagation of light through a one-dimensional all-garnet
magnetophotonic crystal to demonstrate an asymmetric Faraday effect (AFE) for
which Faraday angles for opposite magnetic states differ not only in sign but
in the absolute value as well. AFE appears in the vicinity of the cavity
resonance for an oblique incidence of light which plane of polarization is
inclined to the incidence plane. Under proper incidence and polarization angles
the magnitude of AFE could be very large reaching 30% of the absolute value of
the Faraday effect. The effect originates from the difference in Q-factors for
p- and s- polarized cavity modes that breaks the symmetry between the two
opposite directions of polarization rotation. The discovered AFE is of prime
importance for nanoscale magnonics and optomagnetism.Comment: Supplementary information provided after the main tex
Practices of Protest in the Conditions of the Developing Academic Capitalism
The article focuses on the problem of professional motivation of University teaching staff in the context of developing βacademic capitalismβ and presents the results of the empirical study carried out by the authors at the North-Western Institute of management of RANEPA in MarchβJune 2020. Based on the data obtained, it is revealed that teachers, experiencing deep deprivation of their social needs β the needs for respect, recognition and honor, are trying to find their place in the modern system, get out of the grip of double pressure, on the one hand, from the administration, which purposefully imposes rating systems and effective contracts, increasing competition between teachers, and on the other hand β students, who are now positioned as clients of universities. In the context of developing academic capitalism, teachers choose one of two adaptation strategies: 1) conformism as an opportunity to integrate into a constantly changing situation; 2) the practice of quiet protest as an opportunity to demonstrate the inefficiency of the entrepreneurial model of higher education, at least in its current version, and 3) neutral position to protect the classical values of the academic community
Pulsation in the atmosphere of the roAp star HD 24712. I. Spectroscopic observations and radial velocity measurements
We have investigated the structure of the pulsating atmosphere of one of the
best studied rapidly oscillating Ap stars, HD 24712. For this purpose we
analyzed spectra collected during 2001-2004. An extensive data set was obtained
in 2004 simultaneously with the photometry of the Canadian MOST mini-satellite.
This allows us to connect directly atmospheric dynamics observed as radial
velocity variations with light variations seen in photometry. We directly
derived for the first time and for different chemical elements, respectively
ions, phase shifts between photometric and radial velocity pulsation maxima
indicating, as we suggest, different line formation depths in the atmosphere.
This allowed us to estimate for the first time the propagation velocity of a
pulsation wave in the outer stellar atmosphere of a roAp star to be slightly
lower than the sound speed. We confirm large pulsation amplitudes (150-400 m/s)
for REE lines and the Halpha core, while spectral lines of the other elements
(Mg, Si, Ca, and Fe-peak elements) have nearly constant velocities. We did not
find different pulsation amplitudes and phases for the lines of rare-earth
elements before and after the Balmer jump, which supports the hypothesis of REE
concentration in the upper atmosphere above the hydrogen line-forming layers.
We also discuss radial velocity amplitudes and phases measured for individual
spectral lines as tools for a 3D tomography of the atmosphere of HD 24712.Comment: accepted by A&
Protecting Mice from H7 Avian Influenza Virus by Immunisation with a Recombinant Adenovirus Encoding Influenza A Virus Conserved Antigens
Influenza is a highly contagious disease that causes annual epidemics and occasional pandemics. Birds are believed to be the source of newly emerging pandemic strains, including highly pathogenic avian influenza viruses of the subtype H7. The aim of the study: to evaluate the ability of the recombinant human adenovirus, serotype 5, which expresses genes of influenza A highly conserved antigens (ion channel M2 and nucleoprotein NP), to provide protection to laboratory mice against infection with a lethal dose of avian influenza virus, subtype H7. To achieve this goal, it was necessary to adapt influenza A virus, subtype H7 for reproduction in the lungs of mice, to characterise it, and to use it for evaluation of the protective properties of the recombinant adenovirus. Materials and methods: avian influenza virus A/Chicken/NJ/294508-12/2004 (H7N2) was adapted for reproduction in the lungs of mice by repeated passages. The adapted strain was sequenced and assessed using hemagglutination test, EID50 and LD50 for laboratory mice. BALB/c mice were immunised once with Ad5-tet-M2NP adenovirus intranasally, and 21 days after the immunisation they were infected with a lethal dose (5 LD50) of influenza virus A/Chicken/NJ/294508-12/2004 (H7N2) in order to assess the protective properties of the recombinant adenovirus. The level of viral shedding from the lungs of the infected mice was evaluated by titration of the lung homogenates in MDCK cell culture on days 3 and 6 after infection. The level of specific antibodies to H7 avian influenza virus was determined by indirect enzyme immunoassay. Results: the use of Ad5-tet-M2NP adenovirus for immunisation of the mice ensured 100% survival of the animals that had disease symptoms (weight loss) after their infection with the lethal dose (5 LD50) of H7 avian influenza virus. The study demonstrated a high post-vaccination level of humoral immune response to H7 avian influenza virus. The virus titer decreased significantly by day 6 in the lungs of mice that had been immunised with Ad5-tet-M2NP compared to the control group. Conclusion: the Ad5-tetM2NP recombinant adenovirus can be used to create a candidate pandemic influenza vaccine that would protect against avian influenza viruses, subtype H7, in particular
The adaptive potential of North American subtype H7N2 avian influenza viruses to mammals
Introduction. H7 subtype avian influenza viruses causing severe epizootics among birds are phylogenetically different in the Eastern and Western hemispheres. Numerous human infections caused by these viruses in the Eastern hemisphere indicate that H7 viruses can overcome the interspecies barrier and pose a potential threat of a new pandemic.The H7N2 viruses with deletion of amino acids 221β228 (H3 numbering) in hemagglutinin (HA) had been circulating among poultry in the Western Hemisphere during 1996β2006, and had once again been detected in 2016 in an animal shelter, where they caused cat diseases.
The objective of this study is to elucidate the mechanism of adaptation to mammals of North American H7N2 influenza viruses with deletion in HA.
Materials and methods. The A/chicken/New Jersey/294598-12/2004 (H7N2) virus was adapted to mice by the lung passages. Complete genomes of original and mouse-adapted viruses were analyzed. The receptor specificity and thermostability of viruses, HA activation pH and virulence for mice were determined.
Results. The non-pathogenic H7N2 avian influenza virus became pathogenic after 10 passages in mice. Amino acid substitutions occurred in five viral proteins: one in PB2 (E627K), NA (K127N), NEP (E14Q), four in HA and six in NS1. Mutations in HA slightly changed receptor specificity but increased the pH of HA activation by 0.4 units. The NS1 protein undergone the greatest changes in the positions (N73T, S114G, K118R, G171A, F214L and G224R), where amino acid polymorphisms were observed in the original virus, but only minor amino acid variants have been preserved in the mouse adapted variant.
Conclusion. The results show that H7N2 viruses have the potential to adapt to mammals. The increase in virulence is most likely due to the adaptive E627K mutation in PB2 and possibly in HA
ΠΠ°ΡΠΈΡΠ° ΠΌΡΡΠ΅ΠΉ ΠΎΡ Π·Π°ΡΠ°ΠΆΠ΅Π½ΠΈΡ Π²ΠΈΡΡΡΠΎΠΌ Π³ΡΠΈΠΏΠΏΠ° ΠΏΡΠΈΡ ΡΡΠ±ΡΠΈΠΏΠ° H7 Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΈΠΌΠΌΡΠ½ΠΈΠ·Π°ΡΠΈΠΈ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΠΌ Π°Π΄Π΅Π½ΠΎΠ²ΠΈΡΡΡΠΎΠΌ, ΠΊΠΎΠ΄ΠΈΡΡΡΡΠΈΠΌ ΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°ΡΠΈΠ²Π½ΡΠ΅ Π°Π½ΡΠΈΠ³Π΅Π½Ρ Π²ΠΈΡΡΡΠ° Π³ΡΠΈΠΏΠΏΠ° Π
Influenza is a highly contagious disease that causes annual epidemics and occasional pandemics. Birds are believed to be the source of newly emerging pandemic strains, including highly pathogenic avian influenza viruses of the subtype H7. The aim of the study: to evaluate the ability of the recombinant human adenovirus, serotype 5, which expresses genes of influenza A highly conserved antigens (ion channel M2 and nucleoprotein NP), to provide protection to laboratory mice against infection with a lethal dose of avian influenza virus, subtype H7. To achieve this goal, it was necessary to adapt influenza A virus, subtype H7 for reproduction in the lungs of mice, to characterise it, and to use it for evaluation of the protective properties of the recombinant adenovirus. Materials and methods: avian influenza virus A/Chicken/NJ/294508-12/2004 (H7N2) was adapted for reproduction in the lungs of mice by repeated passages. The adapted strain was sequenced and assessed using hemagglutination test, EID50 and LD50 for laboratory mice. BALB/c mice were immunised once with Ad5-tet-M2NP adenovirus intranasally, and 21 days after the immunisation they were infected with a lethal dose (5 LD50) of influenza virus A/Chicken/NJ/294508-12/2004 (H7N2) in order to assess the protective properties of the recombinant adenovirus. The level of viral shedding from the lungs of the infected mice was evaluated by titration of the lung homogenates in MDCK cell culture on days 3 and 6 after infection. The level of specific antibodies to H7 avian influenza virus was determined by indirect enzyme immunoassay. Results: the use of Ad5-tet-M2NP adenovirus for immunisation of the mice ensured 100% survival of the animals that had disease symptoms (weight loss) after their infection with the lethal dose (5 LD50) of H7 avian influenza virus. The study demonstrated a high post-vaccination level of humoral immune response to H7 avian influenza virus. The virus titer decreased significantly by day 6 in the lungs of mice that had been immunised with Ad5-tet-M2NP compared to the control group. Conclusion: the Ad5-tetM2NP recombinant adenovirus can be used to create a candidate pandemic influenza vaccine that would protect against avian influenza viruses, subtype H7, in particular.ΠΡΠΈΠΏΠΏ β Π²ΡΡΠΎΠΊΠΎΠΊΠΎΠ½ΡΠ°Π³ΠΈΠΎΠ·Π½ΠΎΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅, Π²ΡΠ·ΡΠ²Π°ΡΡΠ΅Π΅ Π΅ΠΆΠ΅Π³ΠΎΠ΄Π½ΡΠ΅ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΈ ΠΈ ΡΠ΅ΡΠ΅Π· Π½Π΅ΡΠ°Π²Π½ΡΠ΅ ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»Ρ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ β ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΠΈ. ΠΡΡΠΎΡΠ½ΠΈΠΊΠΎΠΌ Π²Π½ΠΎΠ²Ρ Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΡ
ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΡΠ½ΡΡ
ΡΡΠ°ΠΌΠΌΠΎΠ², ΠΊΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, ΡΠ²Π»ΡΡΡΡΡ ΠΏΡΠΈΡΡ, Π° Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅Π΅ Π±Π΅ΡΠΏΠΎΠΊΠΎΠΉΡΡΠ²ΠΎ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π²ΡΠ·ΡΠ²Π°ΡΡ Π²ΡΡΠΎΠΊΠΎΠΏΠ°ΡΠΎΠ³Π΅Π½Π½ΡΠ΅ Π²ΠΈΡΡΡΡ Π³ΡΠΈΠΏΠΏΠ° ΠΏΡΠΈΡ ΡΡΠ±ΡΠΈΠΏΠ° H7. Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ: ΠΎΡΠ΅Π½ΠΈΡΡ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π΄Π΅Π½ΠΎΠ²ΠΈΡΡΡΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΏΡΡΠΎΠ³ΠΎ ΡΠ΅ΡΠΎΡΠΈΠΏΠ°, ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΡΡΠ΅Π³ΠΎ Π³Π΅Π½Ρ Π²ΡΡΠΎΠΊΠΎΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°ΡΠΈΠ²Π½ΡΡ
Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠ² Π²ΠΈΡΡΡΠ° Π³ΡΠΈΠΏΠΏΠ° Π (ΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΊΠ°Π½Π°Π»Π° Π2 ΠΈ Π½ΡΠΊΠ»Π΅ΠΎΠΏΡΠΎΡΠ΅ΠΈΠ½Π° NP), ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°ΡΡ Π·Π°ΡΠΈΡΡ ΠΎΡ Π·Π°ΡΠ°ΠΆΠ΅Π½ΠΈΡ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΌΡΡΠ΅ΠΉ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΎΠ·ΠΎΠΉ Π²ΠΈΡΡΡΠ° Π³ΡΠΈΠΏΠΏΠ° ΠΏΡΠΈΡ ΡΡΠ±ΡΠΈΠΏΠ° H7. ΠΠ»Ρ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ ΡΠ΅Π»ΠΈ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ Π±ΡΠ»ΠΎ Π°Π΄Π°ΠΏΡΠΈΡΠΎΠ²Π°ΡΡ Π΄Π»Ρ ΡΠ°Π·ΠΌΠ½ΠΎΠΆΠ΅Π½ΠΈΡ Π² Π»Π΅Π³ΠΊΠΈΡ
ΠΌΡΡΠ΅ΠΉ Π²ΠΈΡΡΡ Π³ΡΠΈΠΏΠΏΠ° Π ΡΡΠ±ΡΠΈΠΏΠ° Π7, ΠΎΡ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°ΡΡ ΠΈ Ρ Π΅Π³ΠΎ ΠΏΠΎΠΌΠΎΡΡΡ ΠΎΡΠ΅Π½ΠΈΡΡ Π·Π°ΡΠΈΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π΄Π΅Π½ΠΎΠ²ΠΈΡΡΡΠ°. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ: Π²ΠΈΡΡΡ Π³ΡΠΈΠΏΠΏΠ° ΠΏΡΠΈΡ A/Chicken/NJ/294508-12/2004 (H7N2) Π±ΡΠ» Π°Π΄Π°ΠΏΡΠΈΡΠΎΠ²Π°Π½ Π΄Π»Ρ ΡΠ°Π·ΠΌΠ½ΠΎΠΆΠ΅Π½ΠΈΡ Π² Π»Π΅Π³ΠΊΠΈΡ
ΠΌΡΡΠ΅ΠΉ ΠΏΡΡΠ΅ΠΌ ΠΌΠ½ΠΎΠ³ΠΎΠΊΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΏΠ°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ. ΠΡΠΎΡ ΡΡΠ°ΠΌΠΌ Π±ΡΠ» ΡΠ΅ΠΊΠ²Π΅Π½ΠΈΡΠΎΠ²Π°Π½ ΠΈ ΠΎΡ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π½ Π² ΡΠ΅Π°ΠΊΡΠΈΠΈ Π³Π΅ΠΌΠ°Π³Π³Π»ΡΡΠΈΠ½Π°ΡΠΈΠΈ, ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ Π΅Π³ΠΎ ΠΠΠ50 ΠΈ ΠΠ50 Π΄Π»Ρ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΌΡΡΠ΅ΠΉ. ΠΠ»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π·Π°ΡΠΈΡΠ½ΡΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π΄Π΅Π½ΠΎΠ²ΠΈΡΡΡΠ° ΠΌΡΡΠΈ Π»ΠΈΠ½ΠΈΠΈ BALB/c Π±ΡΠ»ΠΈ ΠΈΠΌΠΌΡΠ½ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ Π°Π΄Π΅Π½ΠΎΠ²ΠΈΡΡΡΠΎΠΌ Ad5-tet-M2NP ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎ ΠΈΠ½ΡΡΠ°Π½Π°Π·Π°Π»ΡΠ½ΠΎ ΠΈ ΡΠ΅ΡΠ΅Π· 21 ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ»Π΅ ΠΈΠΌΠΌΡΠ½ΠΈΠ·Π°ΡΠΈΠΈ Π·Π°ΡΠ°ΠΆΠ΅Π½Ρ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΎΠ·ΠΎΠΉ (5 ΠΠ50) Π²ΠΈΡΡΡΠ° Π³ΡΠΈΠΏΠΏΠ° ΠΏΡΠΈΡ A/Chicken/NJ/294508-12/2004 (H7N2). Π£ΡΠΎΠ²Π΅Π½Ρ Π²ΠΈΡΡΡΠΎΠ²ΡΠ΄Π΅Π»Π΅Π½ΠΈΡ ΠΈΠ· Π»Π΅Π³ΠΊΠΈΡ
ΠΌΡΡΠ΅ΠΉ Π±ΡΠ» ΠΎΡΠ΅Π½Π΅Π½ Π½Π° 3 ΠΈ 6 ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ»Π΅ Π·Π°ΡΠ°ΠΆΠ΅Π½ΠΈΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΈΡΡΠΎΠ²Π°Π½ΠΈΡ Π³ΠΎΠΌΠΎΠ³Π΅Π½Π°ΡΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ
Π½Π° ΠΊΡΠ»ΡΡΡΡΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ MDCK. Π£ΡΠΎΠ²Π΅Π½Ρ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π½ΡΠΈΡΠ΅Π» ΠΊ Π²ΠΈΡΡΡΡ Π³ΡΠΈΠΏΠΏΠ° ΠΏΡΠΈΡ ΡΡΠ±ΡΠΈΠΏΠ° Π7 ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π½Π΅ΠΏΡΡΠΌΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ: ΠΈΠΌΠΌΡΠ½ΠΈΠ·Π°ΡΠΈΡ ΠΌΡΡΠ΅ΠΉ Π°Π΄Π΅Π½ΠΎΠ²ΠΈΡΡΡΠΎΠΌ Ad5-tet-M2NP ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ² Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ (ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π°) ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ»Π° 100% Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΏΠΎΡΠ»Π΅ Π·Π°ΡΠ°ΠΆΠ΅Π½ΠΈΡ Π»Π΅ΡΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΎΠ·ΠΎΠΉ (5 ΠΠ50) Π²ΠΈΡΡΡΠ° Π³ΡΠΈΠΏΠΏΠ° ΠΏΡΠΈΡ ΡΡΠ±ΡΠΈΠΏΠ° H7. ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ Π²ΡΡΠΎΠΊΠΈΠΉ ΠΏΠΎΡΡΠ²Π°ΠΊΡΠΈΠ½Π°Π»ΡΠ½ΡΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Π³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ΠΊ Π²ΠΈΡΡΡΡ Π³ΡΠΈΠΏΠΏΠ° ΠΏΡΠΈΡ ΡΡΠ±ΡΠΈΠΏΠ° H7. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π² Π»Π΅Π³ΠΊΠΈΡ
ΠΌΡΡΠ΅ΠΉ ΠΈΠ· Π³ΡΡΠΏΠΏΡ, ΠΈΠΌΠΌΡΠ½ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Ad5-tet-M2NP, ΡΠΆΠ΅ ΠΊ 6 ΡΡΡΠΊΠ°ΠΌ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΠΈΡΡΠ° Π²ΠΈΡΡΡΠ° Π³ΡΠΈΠΏΠΏΠ° ΠΏΡΠΈΡ ΡΡΠ±ΡΠΈΠΏΠ° H7 ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅: ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΠΉ Π°Π΄Π΅Π½ΠΎΠ²ΠΈΡΡΡ Ad5-tet-M2NP ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ Π΄Π»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΡΠ½ΠΎΠΉ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ³ΡΠΈΠΏΠΏΠΎΠ·Π½ΠΎΠΉ Π²Π°ΠΊΡΠΈΠ½Ρ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΈ ΠΎΡ Π²ΠΈΡΡΡΠΎΠ² Π³ΡΠΈΠΏΠΏΠ° ΠΏΡΠΈΡ ΡΡΠ±ΡΠΈΠΏΠ°Β H7
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