3,238 research outputs found
Inelastic nucleon contributions in nuclear response functions
We estimate the contribution of inelastic nucleon excitations to the
inclusive cross section in the CEBAF kinematic range.
Calculations are based upon parameterizations of the nucleon structure
functions measured at SLAC. Nuclear binding effects are included in a
vector-scalar field theory, and are assumed have a minimal effect on the
nucleon excitation spectrum. We find that for q\lsim 1 GeV the elastic and
inelastic nucleon contributions to the nuclear response functions are
comparable, and can be separated, but with roughly a factor of two uncertainty
in the latter from the extrapolation from data. In contrast, for q\rsim 2 GeV
this uncertainty is greatly reduced but the elastic nucleon contribution is
heavily dominated by the inelastic nucleon background.Comment: 20 pages, 7 figures available from the authors at Department of
Physics and Astronomy, University of Rochester, Rochester NY 1462
Relativistic Effects in the Electromagnetic Current at GeV Energies
We employ a recent approach to the non-relativistic reduction of the
electromagnetic current operator in calculations of electronuclear reactions.
In contrast to the traditional scheme, where approximations are made for the
transferred momentum, transferred energy and initial momentum of the struck
nucleon in obtaining an on-shell inspired form for the current, we treat the
problem exactly for the transferred energy and transferred momentum. We
calculate response functions for the reaction at CEBAF (TJNAF)
energies and find large relativistic corrections. We also show that in Plane
Wave Impulse Approximation, it is always possible to use the full operator, and
we present a comparison of such a limiting case with the results incorporating
relativistic effects to the first order in the initial momentum of the struck
nucleon.Comment: 31 pages, 8 figures, Revte
Origin of Relativistic Effects in the Reaction D(e,e'p)n at GeV Energies
In a series of recent publications, a new approach to the non-relativistic
reduction of the electromagnetic current operator in calculations of
electro-nuclear reactions has been introduced. In one of these papers, the
conjecture that at energies of a few GeV, the bulk of the relativistic effects
comes from the current and not from the nuclear dynamics was made, based on the
large relativistic effects in the transverse-longitudinal response. Here, we
explicitly compare a fully relativistic, manifestly covariant calculation
performed with the Gross equation, with a calculation that uses a
non-relativistic wave function and a fully relativistic current operator. We
find very good agreement up to missing momenta of 400 MeV/c, thus confirming
the previous conjecture. We discuss slight deviations in cross sections for
higher missing momenta and their possible origin, namely p-wave contributions
and off-shell effects.Comment: 25 pages, 11 figure
Electromagnetic form factors of the bound nucleon
We calculate electromagnetic form factors of the proton bound in specified
orbits for several closed shell nuclei. The quark structure of the nucleon and
the shell structure of the finite nuclei are given by the QMC model. We find
that orbital electromagnetic form factors of the bound nucleon deviate
significantly from those of the free nucleon.Comment: 12 pages including 4 ps figure
Relativistic Structure of the Deuteron: 1.Electro-disintegration and y-scaling
Realistic solutions of the spinor-spinor Bethe-Salpeter equation for the
deuteron with realistic interaction kernel including the exchange of pi, sigma,
omega, rho, eta and delta mesons, are used to systematically investigate
relativistic effects in inclusive quasi-elastic electron-deuteron scattering
within the relativistic impulse approximation. Relativistic y-scaling is
considered by generalising the non relativistic scaling function to the
relativistic case, and it is shown that y-scaling does occur in the usual
relativistic scaling variable resulting from the energy conservation in the
instant form of dynamics. The present approach of y-scaling is fully covariant,
with the deuteron being described by eight components, viz. the 3S_1^{++},
3S_1^{--}, 3D_1^{++}, 3D_1^{--}, 3P_1^{+-}, 3P_1^{-+}, 1P_1^{+-}, 1P_1^{-+}
waves. It is demonstrated that if the negative relative energy states 1P_1,
3P_1 are disregarded, the concept of covariant momentum distributions N(p_0,p),
with p_0=M_D/2-\sqrt{p^2+m^2}, can be introduced, and that calculations of
lectro-disintegration cross section in terms of these distributions agree
within few percents with the exact calculations which include the 1P_1, 3P_1
states, provided the nucleon three momentum |p|\<= 1 GeV/c; in this momentum
range, the asymptotic relativistic scaling function is shown to coincide with
the longitudinal covariant momentum distribution.Comment: 32 LaTeX pages, 18 eps-figures. Final version to appear in Phys. Rev.
Inclusive electron scattering in a relativistic Green function approach
A relativistic Green function approach to the inclusive quasielastic (e,e')
scattering is presented. The single particle Green function is expanded in
terms of the eigenfunctions of the nonhermitian optical potential. This allows
one to treat final state interactions consistently in the inclusive and in the
exclusive reactions. Numerical results for the response functions and the cross
sections for different target nuclei and in a wide range of kinematics are
presented and discussed in comparison with experimental data.Comment: 12 pages, 7 figures, REVTeX
Titanium based cranial reconstruction using incremental sheet forming
In this paper, we report recent work in cranial plate manufacturing using incremental sheet forming (ISF) process. With a typical cranial shape, the ISF process was used to manufacture the titanium cranial shape by using different ISF tooling solutions with and without backing plates. Detailed evaluation of the ISF process including material deformation and thinning, geometric accuracy and surface finish was conducted by using a combination of experimental testing and Finite Element (FE) simulation. The results show that satisfactory cranial shape can be achieved with sufficient accuracy and surface finish by using a feature based tool path generation method and new ISF tooling design. The results also demonstrate that the ISF based cranial reconstruction has the potential to achieve considerable lead time reduction as compared to conventional methods for cranial plate manufacturing. This outcome indicates that there is a potential for the ISF process to achieve technological advances and economic benefits as well as improvement to quality of life
Randomised trials comparing different healthcare settings : an exploratory review of the impact of pre-trial preferences on participation, and discussion of other methodological challenges
BACKGROUND: We recently published a systematic review of different healthcare settings (such as outpatient, community or home) for administering intravenous chemotherapy, and concluded that performing conventionally designed randomised trials was difficult. The main problems were achieving adequate trial accrual rates and recruiting a study population which adequately represented the target population of interest. These issues stemmed from the fact that potential participants may have had pre-trial perceptions about the trial settings they may be allocated; such preferences will sometimes be strong enough for patients to decline an invitation to participate in a trial. A patient preference trial design (in which patients can choose, or be randomised to, an intervention) may have obviated these recruitment issues, although none of the trials used such a design. METHODS: In order to gain a better understanding of the broader prevalence and extent of these preference issues (and any other methodological challenges), we undertook an exploratory review of settings trials in any area of healthcare treatment research. We searched The Cochrane Library and Google Scholar and used snowballing methods to identify trials comparing different healthcare settings. RESULTS: Trial accrual was affected by patient preferences for a setting in 15 of the 16 identified studies; birth setting trials were the most markedly affected, with between 68 % and 85 % of eligible women declining to participate specifically because of preference for a particular healthcare setting. Recruitment into substance abuse and chemotherapy setting studies was also notably affected by preferences. Only four trials used a preference design: the proportion of eligible patients choosing to participate via a preference group ranged from between 33 % and 67 %. CONCLUSIONS: In trials of healthcare settings, accrual may be seriously affected by patient preferences. The use of trial designs which incorporate a preference component should therefore strongly be considered. When designing such trials, investigators should consider settings to be complex interventions, which are likely to have linked components which may be difficult to control for. Careful thought is also needed regarding the choice of comparator settings and the most appropriate outcome measures to be used
A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi
Introduction: Cryptococcal meningitis is the most common neurological infection in HIV infected patients in Sub Saharan Africa, where gold standard treatment with intravenous amphotericin B and 5 flucytosine is often unavailable or difficult to administer. Fluconazole monotherapy is frequently recommended in national guidelines but is a fungistatic drug compromised by uncertainty over optimal dosing and a paucity of clinical end-point outcome data.
Methods: From July 2010 until March 2011, HIV infected adults with a first episode of cryptococcal meningitis were
recruited at Queen Elizabeth Central Hospital, Blantyre, Malawi. Patients were treated with oral fluconazole monotherapy 800 mg daily, as per national guidelines. ART was started at 4 weeks. Outcomes and factors associated with treatment failure were assessed 4, 10 and 52 weeks after fluconazole initiation.
Results: Sixty patients were recruited. 26/60 (43%) died by 4 weeks. 35/60 (58.0%) and 43/56 (77%) died or failed treatment by 10 or 52 weeks respectively. Reduced consciousness (Glasgow Coma Score ,14 of 15), moderate/severe neurological disability (modified Rankin Score .3 of 5) and confusion (Abbreviated Mental Test Score ,8 of 10) were all common at baseline and associated with death or treatment failure. ART prior to recruitment was not associated with better outcomes.
Conclusions: Mortality and treatment failure from cryptococcal meningitis following initiation of treatment with 800 mg oral fluconazole is unacceptably high. To improve outcomes, there is an urgent need for better therapeutic strategies and point-of-care diagnostics, allowing earlier diagnosis before development of neurological deficit
Proton Spin Structure in the Resonance Region
We have examined the spin structure of the proton in the region of the
nucleon resonances (1.085 GeV < W < 1.910 GeV) at an average four momentum
transfer of Q^2 = 1.3 GeV^2. Using the Jefferson Lab polarized electron beam, a
spectrometer, and a polarized solid target, we measured the asymmetries
A_parallel and A_perp to high precision, and extracted the asymmetries A_1 and
A_2, and the spin structure functions g_1 and g_2. We found a notably non-zero
A_perp, significant contributions from higher-twist effects, and only weak
support for polarized quark--hadron duality.Comment: 6 pages, 4 figures, REVTeX4, similar to PRL submission, plots
colorized and appenix added, v3: minor edit, matches PR
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