5 research outputs found
Enhancement of Amygdaloid Neuronal Dendritic Arborization by Fresh Leaf Juice of Centella asiatica (Linn) During Growth Spurt Period in Rats
Centella asiatica (CeA) is a creeping herb, growing in moist places in India and other Asian Countries. Ayurvedic system of medicine, an alternate system of medicine in India, uses leaves of CeA for memory enhancement. Here, we have investigated the role of CeA fresh leaf juice treatment during growth spurt period of rats on dendritic morphology of amygdaloid neurons, one of the regions concerned with learning and memory. The present study was conducted on neonatal rat pups. The rat pups (7-days-old) were fed with 2, 4 and 6 ml/kg body of fresh leaf juice of CeA for 2, 4 and 6 weeks. After the treatment period, the rats were killed, brains removed and amygdaloid neurons impregnated with Silver nitrate (Golgi staining). Amygdaloid neurons were traced using camera lucida and dendritic branching points (a measure of dendritic arborization) and intersections (a measure dendritic length) quantified. These data were compared with those of age-matched control rats. The results showed a significant increase in dendritic length (intersections) and dendritic branching points along the length of dendrites of the amygdaloid neurons of rats treated with 4 and 6 ml/kg body weight/day of CeA for longer periods of time (i.e. 4 and 6 weeks). We conclude that constituents/active principles present in CeA fresh leaf juice has neuronal dendritic growth stimulating property; hence it can be used for enhancing neuronal dendrites in stress and other neurodegenerative and memory disorders
Centella asiatica (L.) Leaf Extract Treatment During the Growth Spurt Period Enhances Hippocampal CA3 Neuronal Dendritic Arborization in Rats
Centella asiatica (CeA) is a creeping plant growing in damp places in India and other Asian countries. The leaves of CeA are used for memory enhancement in the Ayurvedic system of medicine, an alternative system of medicine in India. In this study, we have investigated the effect during the rat growth spurt period of CeA fresh leaf extract treatment on the dendritic morphology of hippocampal CA3 neurons, one of the regions of the brain concerned with learning and memory. Neonatal rat pups (7 days old) were fed with 2, 4 or 6 ml kgβ1 body weight of fresh leaf extract of CeA for 2, 4 or 6 weeks. After the treatment period the rats were killed, their brains were removed and the hippocampal neurons were impregnated with silver nitrate (Golgi staining). Hippocampal CA3 neurons were traced using a camera lucida, and dendritic branching points (a measure of dendritic arborization) and intersections (a measure of dendritic length) were quantified. These data were compared with data for age-matched control rats. The results showed a significant increase in the dendritic length (intersections) and dendritic branching points along the length of both apical and basal dendrites in rats treated with 4 and 6 ml kgβ1 body weight per day of CeA for longer periods of time (i.e. 4 and 6 weeks). We conclude that the constituents/active principles present in CeA fresh leaf extract have a neuronal dendritic growth stimulating property; hence, the extract can be used for enhancing neuronal dendrites in stress and neurodegenerative and memory disorders
Enhanced wound contraction and epithelization period in steroid treated rats: Role of pyramid environment
902-904Contribution and role of a pyramid/square
box on the wound healing suppressant effect of dexamethasone was studied in
rats of either sex using excision wound model to record the wound contraction
rate and epithelization period. The results showed enhanced wound contraction
rate and decreased epithelization period in the pyramid-exposed rats as
compared to controls. Thus, it appears that pyramid environment facilitates the
process of wound healing. Also, the wound healing suppressant effects of
dexamethasone were significantly reduced
Pyramid environment reduces the wound healing suppressant properties of dexamethasone in albino rats
645-648<span style="font-size:
16.0pt;mso-bidi-font-size:9.0pt;font-family:" times="" new="" roman","serif""="">With a
view to investigate the contribution and role of environment within a wooden
pyramid model on the wound healing suppressant effect of dexamethasone in rats,
wound breaking strength, dry weight, hydroxyproli.ne content. And histology of
granulation tissue of the dead space wound were studied in rats. The results
indicate that the environment within the wooden pyramid not only promotes
significant wound healing but also reduces the wound healing suppressant effect
of
<span style="font-size:
16.0pt;mso-bidi-font-size:9.0pt;font-family:" times="" new="" roman","serif""="">dexamethasone.
Histological studies also confirmed the results.
</span