Anti-tumor Activity of N4 [(E)-1-(2-hydroxyphenyl) Methylidene], N4-[(E)-2-Phenylethylidene], N4 [(E,2E)-3-Phenyl-2-propenylidene], and N4 [(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines

Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding N4[(E)-1-(2-hydroxyphenyl) methylidene] (NHPM), N4-[(E)-2-phenylethylidene] (NPI), N4[(E,2E)-3-phenyl-2-propenylidene] (NPPI), and N4[(E) ethylidene] (NEI) isonicotinohydrazide, in high yields, after several minutes, as reported. These new compounds have shown antitumor activity against two kinds of cancer cells, which are K562 (human chronic myeloid leukemia) and Jurkat (human T lymphocyte carcinoma)

Trimethylammonium fluorochromate (TriMAFC): A convenient new and mild reagent for oxidation of organic substrates

564-567Trimethylammonium fluorochromate (TriMAFC) is easily synthesized by addition of a trimethylamine to an aqueous solution of CrO3 and HF and used for quantitative oxidation of several organic substrates. This reagent is a versatile reagent for the effective and selective oxidation of organic substrates, in particular for alcohols, under mild conditions

Synthesis, Characterization, X-ray Structural Analysis and Study of Oxidative Properties of Tetraethylammonium Chlorochromate

Tetraethylammonium chlorochromate(VI), Et4N[CrO3Cl] is easily synthesized in nearly quantitative yield using a direct reaction of chromium(VI) oxide and tetraethylammonium chloride and characterized by elemental analysis, IR, UV/Visible, 1H-NMR and 13C-NMR techniques and single-crystal X-ray diffraction analysis (monoclinic system, space group C2(#5), with a = 12.023(3), b = 7.998(2), c = 14.527(4) Å, β = 114.187(4)°, V = 1274.4(6) Å3 and Z = 4). X-ray data determined the CH ··· O hydrogen bond that forms between the ethyl hydrogen of the cation and oxygen of the anion. This compound is a versatile reagent for efficient and selective oxidation of organic substrates, in particular for alcohols to their corresponding aldehydes or ketones, under mild conditions.link_to_subscribed_fulltex

Synthesis, Characterization, X-ray Structural Analysis and Study of Oxidative Properties of Propyltriphenylphosphonium Bromochromate

The complex of propyltriphenylphosphonium bromochromate(VI), PrPh3P[CrO3Br] is easily synthesized in nearly quantitative yield using a direct reaction of chromium(VI) oxide and propyltriphenylphosphonium bromide. This compound is a versatile reagent for the efficient and selective oxidation of organic substrates, in particular for alcohols to their corresponding aldehydes or ketones, under mild conditions. This compound was characterized by IR, UV/Visible, 13C-n.m.r. and 1H-n.m.r. techniques. It crystallized in the monoclinic form and its crystal and molecular structure have been determined by X-ray crystallography.link_to_subscribed_fulltex

Synthesis, characterization, X-ray structural analysis, and iodination ability of benzyl(triphenyl)phosphonium dichloroiodate.

Benzyl(triphenyl)phosphonium dichloroiodate (BTPPICl2), BnPh3P+(ICl2)−, is easily synthesized in a nearly quantitative yield by the addition of BnPh3P+Cl− to a CH2Cl2 solution of iodine monochloride (ICl). BnPh3P+Cl− can be prepared by the reaction of Ph3P and BnCl. The compound was characterized by physicochemical and spectroscopic methods (elemental analysis, FT-IR, and 1H-NMR). The use of phosphonium counterion improves the quality of the BTPPICl2 crystals. BTPPICl2 crystallizes in the monoclinic system, and its crystal and molecular structure has been determined at 100(1) K by X-ray diffraction. The structure was solved by the direct method and had refined R value of 0.0637 for 699 reflections (I>2σ(I)), space group P21/n with a=12.4700(3), b=13.2196(3), c=14.4580(3) Å, β=102.6340(10)°, V=2325.67(9) Å3, and Z=4. The I-atom is coordinated by two Cl-atoms as ligands in a linear geometry. This compound is a versatile reagent for the efficient and selective iodination of organic substrates, in particular of aromatic phenols to the corresponding iodo compounds, under mild conditions. To assess the generality of method, a wide variety of phenols with electron-donating and electron-withdrawing substituents were studied. BTPPICl2 is a mild iodination reagent, which offers a new avenue for an expeditious iodination of phenols. The inexpensive, relatively non-toxic reagent, and mild conditions are the positive features of the procedure and reagent