Chemical burns of the eye: epidemiology and treatment

Purpose: Chemical injuries of the eye may produce exten-sive damage to the ocular surface, resulting in transient or per-manent visual impairment. Purposes: To obtain data about epidemiology and inicial treatment aplied to patients who have suffered from ocular chemical burns and have arrived at a universitary hospital. Methods: An ocular evaluation was performed 47 patients with ocular chemical burns in the ophthalmological emer-gency room of the Hospital São Paulo -- Escola Paulista de Medicina / Universidade Federal de São Paulo (UNIFESP). Results: Most victims were young male adults and industrial accidents were quite frequent (46.8%). Alkaline agents were more often involved (55.32%). The cornea was affected in 95.7% of the cases and grade I and II of Hughes' classification were the most seen. Initial treatment of these patients was performed in 89.4% of the cases (ocular irrigation with physiological saline and debris removal) and 21 patients (44.68%) received topical medication. Conclusions: Several mistakes in the patients' initial approach were observed which may have influenced the prognosis of some patients.Introdução: Queimaduras oculares químicas podem produzir danos importantes à superfície ocular, resultando em incapacidade visual transitória ou permanente. Objetivos: Levantar dados acerca da epidemiologia e do tratamento inicial aplicado aos pacientes vítimas de queimaduras oculares químicas que chegam a um hospital-escola. Métodos: Foi realizado exame oftalmológico em 47 pacientes vítimas de queimaduras oculares químicas no pronto- socorro do Hospital São Paulo - Escola Paulista de Medicina / Universidade Federal de São Paulo (UNIFESP). Resultados: A maioria das vítimas era de jovens do sexo masculino e acidentes de trabalho foram bastante freqüentes (46,8%). Agentes de natureza básica (alcalina) foram envolvidos em 55,32% dos casos. A córnea foi afetada em 95,7% dos casos. Os graus I (78,8%) e II (12,8%) da classificação de Hughes foram os mais observados. O tratamento inicial dos pacientes foi realizado em 89,4% dos casos (irrigação copiosa do olho afetado com solução salina e remoção de debris) e 21 (44,68%) casos receberam medicações tópicas. Conclusões: Foram observados vários erros na abordagem inicial dos pacientes, o que pode ter influenciado o prognóstico de alguns pacientes.UNIFESP-EPM curso de especialização em oftalmologiaUNIFESP-EPM departamento de oftalmologiaUNIFESP, EPM, curso de especialização em oftalmologiaUNIFESP, EPM Depto. de oftalmologiaSciEL

Safrinha recorde o Brasil.

bitstream/item/67631/1/Safrinha-recorde.pd

High precision fundamental constants at the TeV scale

This report summarizes the proceedings of the 2014 Mainz Institute for Theoretical Physics (MITP) scientific program on "High precision fundamental constants at the TeV scale". The two outstanding parameters in the Standard Model dealt with during the MITP scientific program are the strong coupling constant $\alpha_s$ and the top-quark mass $m_t$. Lacking knowledge on the value of those fundamental constants is often the limiting factor in the accuracy of theoretical predictions. The current status on $\alpha_s$ and $m_t$ has been reviewed and directions for future research have been identified.Comment: 57 pages, 24 figures, pdflate

Milho Bt: vantagens para a cadeia produtiva e a viabilidade da coexistência.

bitstream/item/35648/1/milho-bt.pd

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have emerged as critical signalling molecules and therapeutic targets. Here we characterize the molecular mechanism of G-protein activation by a family of non-receptor GEFs containing a Gα-binding and -activating (GBA) motif. We combine NMR spectroscopy, computational modelling and biochemistry to map changes in Gα caused by binding of GBA proteins with residue-level resolution. We find that the GBA motif binds to the SwitchII/α3 cleft of Gα and induces changes in the G-1/P-loop and G-2 boxes (involved in phosphate binding), but not in the G-4/G-5 boxes (guanine binding). Our findings reveal that G-protein-binding and activation mechanisms are fundamentally different between GBA proteins and GPCRs, and that GEF-mediated perturbation of nucleotide phosphate binding is sufficient for Gα activation

Magma displacements under insular volcanic fields, applications to eruption forecasting: El Hierro, Canary Islands, 2011-2013

Significant deformations, followed by increased seismicity detected since 2011 July at El Hierro, Canary Islands, Spain, prompted the deployment of additional monitoring equipment. The climax of this unrest was a submarine eruption first detected on 2011 October 10, and located at about 2 km SW of La Restinga, southernmost village of El Hierro Island. The eruption ceased on 2012 March 5, after the volcanic tremor signals persistently weakened through 2012 February. However, the seismic activity did not end with the eruption, as several other seismic crises followed. The seismic episodes presented a characteristic pattern: over a few days the number and magnitude of seismic event increased persistently, culminating in seismic events severe enough to be felt all over the island. Those crises occurred in 2011 November, 2012 June and September, 2012 December to 2013 January and in 2013 March-April. In all cases the seismic unrest was preceded by significant deformations measured on the island's surface that continued during the whole episode. Analysis of the available GPS and seismic data suggests that several magma displacement processes occurred at depth from the beginning of the unrest. The first main magma movement or 'injection' culminated with the 2011 October submarine eruption. A model combining the geometry of the magma injection process and the variations in seismic energy release has allowed successful forecasting of the new-vent opening.CSIC [2011-30E070]; MINECO [CGL2011-28682-C02-01]; bilateral UNAM (Mexico) - CSIC (Spain) program; Mayor's Office of El Pinar de El Hierroinfo:eu-repo/semantics/publishedVersio

Fusarium proliferatum isolated from garlic in Spain: Identification, toxigenic potential and pathogenicity on related Allium species

Fusarium proliferatum has been reported on garlic in the Northwest USA, Spain and Serbia, causing water-soaked tan-colored lesions on cloves. In this work, Fusarium proliferatum was isolated from 300 symptomatic garlic bulbs. Morphological identification of Fusarium was confirmed using species-specific PCR assays and EF-1α sequencing. Confirmation of pathogenicity was conducted with eighteen isolates. Six randomly selected F. proliferatum isolates from garlic were tested for specific pathogenicity and screened for fusaric acid production. Additionally, pathogenicity of each F. proliferatum isolate was tested on healthy seedlings of onion (Allium cepa), leek (A. porrum), scallions (A. fistulosum), chives (A. schoenoprasum) and garlic (A. sativum). A disease severity index (DSI) was calculated as the mean severity on three plants of each species with four test replicates. Symptoms on onion and garlic plants were observed three weeks after inoculation. All isolates tested produced symptoms on all varieties inoculated. Inoculation of F. proliferatum isolates from diseased garlic onto other Allium species provided new information on host range and pathogenicity. The results demonstrated differences in susceptibility with respect to host species and cultivar. The F. proliferatum isolates tested all produced fusaric acid (FA); correlations between FA production and isolate pathogenicity are discussed. Additionally, all isolates showed the presence of the FUM1 gene suggesting the ability of Spanish isolates to produce fumonisins

On the static solutions in gravity with massive scalar field in three dimensions

We investigate circularly symmetric static solutions in three-dimensional gravity with a minimally coupled massive scalar field. We integrate numerically the field equations assuming asymptotic flatness, where black holes do not exist and a naked singularity is present. We also give a brief review on the massless cases with cosmological constant.Comment: 11 pages, LaTeX, 1 Postscript figure. Some changes were don