Optimization of Energy Consumption in The Residential Sector, Using Automated Control Systems

With limited energy resources for sustainable and balanced national development it is becoming more and more important to solve tasks of optimization of energy consumption. This optimization is important not only for major Russian companies (which provide major share of tax inflows for the state budget), but also for homes in order toreduce the energy consumption. This article discusses a complex approach in the field monitoring and energy management of apartment buildings as part of the energy management program using an automated thermal and electrical energy management system developed by NGO VEST in Tomsk. It is shown that the power monitoring data allow to make economically effective decisions in reducing energy consumption costs in residential buildings. The creation of the Analytical Center and the use of an automated energy management system give the opportunity to reduce costs of heat consumption in apartment buildings and, as a consequence, increase the efficiency of use of budgetary funds, used for subsidizing the northern regions of Russia

Pathogenetic features of acute naphazoline poisoning in children

Acute poisoning by nasal decongestants is an important issue in pediatrics due to physiological and anatomical characteristics of the child’s body and pharmacokinetics of drugs in early childhoo

Tourism as a means of forming a social health of students

The article discusses the problems of health improvement and social adaptation of the most promising and active category of society – students. Various aspects of the ecologization of the consciousness of a young person, the social and health essence of mass youth tourism are shown. The arguments for the intensification of the interpenetration of the spheres of education, recreation and sports-health tourism are givenВ статье обсуждаются проблемы оздоровления и социальной адаптации наиболее перспективной и активной категории общества – учащейся молодёжи. Показываются различные аспекты экологизации сознания молодого человека, социально-оздоровительной сущности массового молодёжного туризма. Приводятся доводы к активизации взаимопроникновения сфер образования, рекреации и спортивно-оздоровительного туриз

A clinical case of the development of cardiomyopathy in a patient in the postpartum period

The purpose of the study was to analyze the algorithm of etiological diagnosis and the effectiveness of therapy for cardiomyopathy (CMP) using the example of a clinical case of the development of heart failure in a woman in the postpartum period.Цель исследования – на примере клинического случая развития сердечной недостаточности у женщины в послеродовом периоде проанализировать алгоритм этиологической диагностики и эффективность терапии кардиомиопатии (КМП)

Breastfeeding challenges in infants with nasal breathing difficulties: alternative supplemental feeding methods

This review article highlights the features of breastfeeding in case of obstructed nasal breathing in infants, special attention is paid to non-sucking or alternative methods of bottle feeding with expressed breast milk for the period when breastfeeding is not possible or formula supplementation is necessary as an addition to breastfeeding.Breathing through the mouth is considered a pathological adaptation due to difficulty in nasal breathing and is associated with the development of many pathological conditions. There is an evidence base that prolonged breastfeeding is associated with nasal breathing at an older age, as well as the correct formation of the bite. The anatomical and physiological features of the structure of the upper respiratory tract in infants predispose to a more frequent occurrence of difficult nasal breathing compared to adults, which causes difficulties in breastfeeding, up to the refusal of the child’s breast. Therefore, knowledge of modern methods of supplementary feeding with expressed breast milk for this period, as well as ways to effectively and safely deal with nasal congestion in infants, will help doctors and parents to overcome the difficult period of the disease, accompanied by nasal congestion without loss and maintain breastfeeding for as long as possible, in the light of modern data on influence of breast milk on the subsequent life of mother and child.The main method of treatment for nasal congestion of various etiologies is irrigation-elimination therapy. According to the literature, good tolerability and no side effects were found when using a nasal aspirator used in conjunction with isotonic saline

Long-term variability of the optical spectra of NGC 4151: I. Light curves and flux correlations

Results of a long-term spectral monitoring of the active galactic nucleus of NGC 4151 are presented (11 years, from 1996 to 2006). High quality spectra (S/N>50 in the continuum near Halpha and Hbeta) were obtained in the spectral range ~4000 to 7500 \AA, with a resolution between 5 and 15 A, using the 6-m and the 1-m SAO's telescopes (Russia), the GHAO's 2.1-m telescope (Cananea, Mexico), and the OAN-SPM's 2.1-m telescope (San-Pedro, Mexico). The observed fluxes of the Halpha, Hbeta, Hgamma and HeII emission lines and of the continuum at the observed wavelength 5117 A, were corrected for the position angle, the seeing and the aperture effects. We found that the continuum and line fluxes varied strongly (up to a factor 6) during the monitoring period. The emission was maximum in 1996-1998, and there were two minima, in 2001 and in 2005. The Halpha, Hgamma and He II fluxes were well correlated with the Hbeta flux. We considered three characteristic periods during which the Hbeta and Halpha profiles were similar: 1996-1999, 2000-2001 and 2002-2006. The line to continuum flux ratios were different; in particular during the first period, the lines were not correlated with the continuum and saturated at high fluxes. In the second and third period, where the continuum flux was small, the Halpha and Hbeta fluxes were well correlated to the continuum flux, meaning that the ionizing continuum was a good extrapolation of the optical continuum. The CCFs are often asymmetrical and the time lags between the lines and the continuum are badly defined indicating the presence of a complex BLR, with dimensions from 1 to 50 light-days.Comment: A&A, accepte

Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety

<p>Background: Melatonin is extensively used in the USA in a non-regulated manner for sleep disorders. Prolonged release melatonin (PRM) is licensed in Europe and other countries for the short term treatment of primary insomnia in patients aged 55 years and over. However, a clear definition of the target patient population and well-controlled studies of long-term efficacy and safety are lacking. It is known that melatonin production declines with age. Some young insomnia patients also may have low melatonin levels. The study investigated whether older age or low melatonin excretion is a better predictor of response to PRM, whether the efficacy observed in short-term studies is sustained during continued treatment and the long term safety of such treatment.</p> <p>Methods: Adult outpatients (791, aged 18-80 years) with primary insomnia, were treated with placebo (2 weeks) and then randomized, double-blind to 3 weeks with PRM or placebo nightly. PRM patients continued whereas placebo completers were re-randomized 1:1 to PRM or placebo for 26 weeks with 2 weeks of single-blind placebo run-out. Main outcome measures were sleep latency derived from a sleep diary, Pittsburgh Sleep Quality Index (PSQI), Quality of Life (World Health Organzaton-5) Clinical Global Impression of Improvement (CGI-I) and adverse effects and vital signs recorded at each visit.</p> <p>Results: On the primary efficacy variable, sleep latency, the effects of PRM (3 weeks) in patients with low endogenous melatonin (6-sulphatoxymelatonin [6-SMT] ≤8 μg/night) regardless of age did not differ from the placebo, whereas PRM significantly reduced sleep latency compared to the placebo in elderly patients regardless of melatonin levels (-19.1 versus -1.7 min; P = 0.002). The effects on sleep latency and additional sleep and daytime parameters that improved with PRM were maintained or enhanced over the 6-month period with no signs of tolerance. Most adverse events were mild in severity with no clinically relevant differences between PRM and placebo for any safety outcome.</p> <p>Conclusions: The results demonstrate short- and long-term efficacy and safety of PRM in elderly insomnia patients. Low melatonin production regardless of age is not useful in predicting responses to melatonin therapy in insomnia. The age cut-off for response warrants further investigation.</p&gt

Novel Biodegradable Polymeric Microparticles Facilitate Scarless Wound Healing by Promoting Re-epithelialization and Inhibiting Fibrosis

Despite decades of research, the goal of achieving scarless wound healing remains elusive. One of the approaches, treatment with polymeric microcarriers, was shown to promote tissue regeneration in various in vitro models of wound healing. The in vivo effects of such an approach are attributed to transferred cells with polymeric microparticles functioning merely as inert scaffolds. We aimed to establish a bioactive biopolymer carrier that would promote would healing and inhibit scar formation in the murine model of deep skin wounds. Here we characterize two candidate types of microparticles based on fibroin/gelatin or spidroin and show that both types increase re-epithelialization rate and inhibit scar formation during skin wound healing. Interestingly, the effects of these microparticles on inflammatory gene expression and cytokine production by macrophages, fibroblasts, and keratinocytes are distinct. Both types of microparticles, as well as their soluble derivatives, fibroin and spidroin, significantly reduced the expression of profibrotic factors Fgf2 and Ctgf in mouse embryonic fibroblasts. However, only fibroin/gelatin microparticles induced transient inflammatory gene expression and cytokine production leading to an influx of inflammatory Ly6C+ myeloid cells to the injection site. The ability of microparticle carriers of equal proregenerative potential to induce inflammatory response may allow their subsequent adaptation to treatment of wounds with different bioburden and fibrotic content