Cognitive modeling of informatization influence on socio-economic indicators of the region

The article discusses topical issues of the influence of informatization on the development of the country’s regions in the conditions of the modern unstable world. The nature of the development of a region can be reflected and understood on the basis of qualitative and quantitative information about its socio-economic indicators, about their relationship and trends in their changes under the influence of internal and external factors. At the same time, information can most often be incomplete, difficult to access, untimely, contradictory, etc. Therefore, in this paper, it is proposed to use a cognitive approach and cognitive modeling of complex systems to overcome the problems of information deficiency by imitating cognitive modeling of the structure and behavior of a complex regional system. The simulation was carried out using the author’s CMCS (Cognitive Modeling Complex System) software system. The results of multi-stage cognitive modeling, consisting in the development of cognitive maps “Influence of ICT on the state of the region” and “Digitalization of the republic” (according to the socio-economic state of the Republic of Dagestan), analysis of structural properties and modeling scenarios for the development of situations on the model are presented. Scenarios make it possible to foresee the ways of possible development of the system under the influence of various factors, including the factor of informatization

Association of angiotensinogen and angiotensin II receptor type I polymorphisms with biomarkers of carbohydrate and lipid metabolism in Dagestan residents with type 2 diabetes and hypertension

Aim. To study the associations of angiotensinogen (AGT) (s4762(С521Т), rs699(Т704C)) and angiotensin II receptor type I (AGTR1) (rs5186(A1166C)) genetic polymorphisms with serum levels of insulin, glucagon, C-peptide, leptin, as well as with dyslipidemia and glycemic levels in Dagestan residents with combination of type 2 diabetes (T2D) and hypertension (HTN), as well as with isolated T2D/HTN.Material and methods. We examined 16 patients with isolated T2D, 59 patients with T2D+HTN and 51 patients with isolated HTN from Dagestan. Genetic polymorphisms of the AGT and AGTR1 genes were studied. The levels of insulin, glucagon, C-peptide, and leptin were studied by enzyme-linked immunosorbent assay (ELISA), while lipid and carbohydrate metabolism — by biochemical methods.Results. In patients with T2D, the association of CC genotype of AGT gene rs4762(С521Т) polymorphism with a leptin decrease was determined, while its CT genotype was associated with an increase in serum level of triglycerides. The TC genotype of AGT gene rs699(Т704C) polymorphism was associated with an increase in leptin, triglyceride and glucose levels. The AA genotype of AGTR1 gene rs5186(A1166C) polymorphism was associated with an increase in insulin and glucose levels, as well as a decrease in leptin level. In patients with a combination of T2D and HTN, CC and CT genotypes of AGT gene rs4762(С521Т) polymorphism was associated with a decrease in glucagon level. The TT genotype of AGT gene rs699(Т704C) polymorphism was associated with an increase in insulin, triglyceride, glucose and body mass index (BMI) levels. In isolated HTN, the CC and CT genotypes of AGT gene rs4762(С521Т) polymorphism were associated ith a decrease in glucagon level. The TT genotype of AGT gene rs699(Т704C) polymorphism was associated with increased levels of insulin, low density lipoproteins, and BMI.Conclusion. Associations of AGT (s4762(С521Т), rs699(Т704C)) and AGTR1 (rs5186(A1166C)) genetic polymorphisms with carbohydrate and lipid metabolism changes are an important pathogenetic link of T2D and HTN, which allows developing an individual prognosis of these diseases in Dagestan residents

Accounting of motivators and demotivators under introduction of the brc system

Рассматривается необходимость учета демотиваторов при работе с балльно-рейтинговой системой оцениванияThe article considers the need to take into account demotivators when working with the BRS syste

ОСОБЕННОСТИ РОСТА И РАЗВИТИЯ МОРКОВИ ПРИ РАЗЛИЧНЫХ СРОКАХ ПОСЕВА В УСЛОВИЯХ РАВНИННОГО ДАГЕСТАНА

Vegetable production in Dagestan is the one of the smallscale, where elementary techniques are used, therefore the vegetable commodity output does not reach a third from total volume produced. With appearance of new irrigation technologies the perspective occurred to raise the productivity of vegetable growing. The use of the drop irrigation improved the vegetable production and yield as well as carrot production. The influence of sowing terms and plant density on features in vegetation phases, photosynthesis activity and water consumption in drip irrigation was studied in carrot ‘Chantenay 2461’ grown on the meadowchestnut soils medium loamy soils of plain areas in Dagestan. Spring sowing time and summer sowing time with plant density of 0.6; 0.8 and 1.0 million plants per hectare have been studied in accordance with the two-factor experiment. In the course of experiment, it has been shown that not the plant density but sowing terms have essentially influenced upon interphase vegetation period in carrot. It has been also revealed that sowing terms have influenced upon photosynthetic activity, increasing the leaf area by 15.1%, while photosynthesis activety and dry matter content have increased by 7.5% and 4.2% respectively. The maximal parameters of photosynthetic activity were obtained when sowing in the second ten-day period of March with density of 0.8 million plants per hectare, and a yield of 42.2 t/ha. To produce such yield, there is a requirement of irrigation rate should be 2600-2700 m3/ha, on average with 18 watering at rates between 87-165 m3 /ha. Calculations of energy and economic efficiency have shown that when sown in the 2nd decade of March density of 0.8 million plants per hectare gave maximum energy efficiency 6.14, whereas the level of profitability of production expenses was equal to 73.5%.Овощеводство Республики Дагестан в основном мелкотоварное, базирующееся на применении примитивных технологий, отсюда и товарность выращиваемых овощей не превышает трети от производимого объема. С появлением новых технологий в орошении открываются хорошие перспективы повышения продуктивности овощеводства. Применение капельного орошения позволит поднять технологичность отрасли на новый уровень и повысить урожайность овощных культур, в том числе и столовой моркови. На лугово-каштановых среднесуглинистых почвах равниной зоны Дагестана изучено влияние сроков и густоты посевов столовой моркови сорта Шантенэ 2461 на особенности прохождения фаз вегетации, показатели фотосинтетической деятельности, водопотребление и режим орошения при капельном орошении. В соответствии с этим был заложен двухфакторный полевой опыт, в котором изучали весенние и летние сроки посева и густоту стояния 0,6; 0,8 и 1,0 млн шт./га. Результатами исследований установлено, что на продолжительность межфазных периодов наибольшее влияние оказывают сроки, а не густота посевов моркови. Выявлено, что сроки посева оказывают существенное влияние на фотосинтетическую деятельность посевов, увеличивая площадь листьев на 15,1%, фотосинтетический потенциал – на 7,5% и массу сухого вещества – на 4,2%. Максимальные показатели фотосинтетической деятельности получены при посеве во 2 декаде марта и густоте 0,8 млн шт./га, обеспечивая урожайность 42,2 т/га. Для формирования такого урожая в среднем требуется оросительная норма на уровне 2600…2700 м3/га при 18 поливах нормами 87 и 165 м3/га. Расчеты энергетической и экономической эффективности показали, что при посеве во 2 декаде марта густотой 0,8 млн шт./га обеспечивается максимальный коэффициент энергетической эффективности – 6,14 и уровень рентабельности производственных затрат 73,5%.

Check of knowleadge using score-rating system and independent test control

Анализируется проблема дублирования балльно-рейтинговой системы оценивания и независимого тестового контроля в системе подготовки специалистов. Предложены мероприятия по устранению недостатковIn article it is told about duplication of score-rating system and independent test controlin training system of specialists. Actions for elimination of shortcomingsare offere

Real World Effectiveness of fixed combination of glargine 100 U/ml and lixisenatide therapy in outpatients with Type 2 Diabetes: A Retrospective Cohort Study SOLO

Background: The effectiveness and safety of a fixed combination of insulin glargine 100 ME/ml and lixisenatide for treatment of patients with type 2 diabetes (T2DM) has been demonstrated in randomized clinical trials, but there are still not enough data of it`s usage of it real clinical practice.Aim: To describe the baseline characteristics of patients with T2DM who started treatment with a fixed ratio combination of insulin glargine 100 ME/ml and lixisenatide in the period from November 2018 to July 2020, and to evaluate the effectiveness of using fixed combination of insulin glargine 100 ME/ml and lixisenatide in for 6–12 months of therapy in a real outpatient practice.Materials and methods: SOLO was a retrospective cohort multicentre study conducted in Russia, Moscow. Adults (≥18 years) with T2DM and HbA1c≥7% in case of availability of medical records during ≥180 days before and ≥1 HbA1c level during 150–210 days after start of treatment with Soliqua SoloStar® were eligible.Results: A total of 383 people with T2DM were included. Baseline characteristics were the following (mean±SD): age 59.9±8.3 years; BMI 36.4±6.3 kg/m2; proportion of patients with BMI≥35 kg/m2 — 52.2%; HbA1c 9.14±1.08%. 65% of patients received oral antidiabetic drugs (OAD) before start of treatment with fixed combination of insulin glargine 100 ME/ml and lixisenatide ; 31.3% of patients were switched from combination of OAD with basal insulin, 1.04% of patients received other therapy (GLP-1 RA, basal-bolus insulin treatment, basal insulin monotherapy), and 2.61% of patients did not receive any hypoglycemic therapy. HbA1c level was 7.78±0.8% after 6 months of treatment and 7.4±0.61% after 12 months. There was a significant decrease of body weight from the baseline value 101.62±20.64 kg by 1.96±4.03 kg at month 6 and by 3.13±4.71 kg at month 12 (p<0.001) Overall, 4 patients (1.04%) reported symptomatic hypoglycemia (glycemia ≤3.9 mmol/L); no episodes of severe hypoglycemia were registered.Conclusion: In a real-life setting in Russia, initiation of a fixed combination of insulin glargine 100 ME/ ml and lixisenatide in people with T2DM uncontrolled on OADs or combination of OADs with basal insulin resulted resulted in an improved glycemic control and body weight change with low risk of hypoglycemia compared to baselin

Incidence of acne in adolescents of coastal and non-maritime towns of the Republic of Dagestan

For the purpose of comparative analysis of the incidence acne of teenage in seaside and non-maritime towns, an epidemiological study of 64,451 acne teenage patients (15-17 years), first detected in life in 2004-2012, conducted in the towns of the Republic of Dagestan (RD). The towns of the RD divided into two groups: the seaside 5 towns located off the coast of the Caspian Sea, and the non-maritime 5 towns - at a distance of 30 km and more from the sea. The results of the study show a 7-fold increase in the incidence of acne vulgaris in adolescents compared with children and adults. The critical town for the acne is Khasavyurt, exceeding the average annual rate by 5.2 times compared with the incidence in all towns. In all towns of the RD there is a tendency to increase the incidence of teenage acne. Thus, the growing trend in the incidence of acne among adolescents points to the need to develop a program for the prevention of acne, taking into account the characteristics of disadvantaged towns located far from the sea.С целью сравнительного анализа заболеваемости акне подростков в приморских и неприморских городах проведено эпидемиологическое исследование 64 451 больного акне подростка (15-17 лет), выявленного впервые в жизни за 2004-2012 гг. В городах республики дагестан. Города распределены на 2 группы: приморские 5 городов, расположенные у побережья каспийского моря, и неприморские 5 городов - на расстоянии 30 км и более от побережья моря. Результаты исследования показывают 7-кратное превышение показателя заболеваемости acne vulgaris у подростков по сравнению с детьми и взрослыми. Критическим по заболеваемости акне городом является Хасавюрт с превышением среднемноголетнего показателя в 5,2 раза по сравнению с заболеваемостью по всем городам. Во всех городах наблюдается тенденция к росту заболеваемости акне подростков. Таким образом, возрастающий тренд заболеваемости акне среди подростков указывает на необходимость разработки программы по профилактике акне с учетом особенностей неблагополучных городов, расположенных далеко от моря

Twenty-year clinical progression of dysferlinopathy in patients from Dagestan

© 2017 Umakhanova, Bardakov, Mavlikeev, Chernova, Magomedova, Akhmedova, Yakovlev, Dalgatov, Fedotov, Isaev and Deev.To date, over 30 genes with mutations causing limb-girdle muscle dystrophy have been described. Dysferlinopathies are a form of limb-girdle muscle dystrophy type 2B with an incidence ranging from 1:1,300 to 1:200,000 in different populations. In 1996, Dr. S. N. Illarioshkin described a family from the Botlikhsky district of Dagestan, where limb-girdle muscle dystrophy type 2B and Miyoshi myopathy were diagnosed in 12 members from three generations of a large Avar family. In 2000, a previously undescribed mutation in the DYSF gene (c.TG573/574AT; p. Val67Asp) was detected in the affected members of this family. Twenty years later, in this work, we re-examine five known and seven newly affected family members previously diagnosed with dysferlinopathy. We observed disease progression in family members who were previously diagnosed and noted obvious clinical polymorphism of the disease. A typical clinical case is provided

Corrigendum: Twenty-year clinical progression of dysferlinopathy in patients from Dagestan [Front Neurol, 8, (2017) (77)] doi: 10.3389/fneur.2017.00077

The "Funding" section should be: This work was funded by Human Stem Cells Institute PJSC and Roman V. Deev. Theoretical part of this work was supported by Russian Scientific Foundation grant (14-15-00916). Ivan A. Yakovlev and Mikhail O. Mavlikeev were supported by the Russian Government Program of Competitive Growth of Kazan Federal University. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way

Hybrid ( laser- spark) a method of applying a reinforcement coating

Hybrid spark -laser treatment shows a positive effect on the performance properties of coatings (roughness, thickness, continuity, adhesion).Гибридная электроискровая –лазерная обработка показывает положительное влияние на эксплуатационные свойства покрытий (шероховатость, толщину, сплошность, адгезию)