Cognitive modeling of informatization influence on socio-economic indicators of the region

The article discusses topical issues of the influence of informatization on the development of the country’s regions in the conditions of the modern unstable world. The nature of the development of a region can be reflected and understood on the basis of qualitative and quantitative information about its socio-economic indicators, about their relationship and trends in their changes under the influence of internal and external factors. At the same time, information can most often be incomplete, difficult to access, untimely, contradictory, etc. Therefore, in this paper, it is proposed to use a cognitive approach and cognitive modeling of complex systems to overcome the problems of information deficiency by imitating cognitive modeling of the structure and behavior of a complex regional system. The simulation was carried out using the author’s CMCS (Cognitive Modeling Complex System) software system. The results of multi-stage cognitive modeling, consisting in the development of cognitive maps “Influence of ICT on the state of the region” and “Digitalization of the republic” (according to the socio-economic state of the Republic of Dagestan), analysis of structural properties and modeling scenarios for the development of situations on the model are presented. Scenarios make it possible to foresee the ways of possible development of the system under the influence of various factors, including the factor of informatization

Theory of Spike Spiral Waves in a Reaction-Diffusion System

We discovered a new type of spiral wave solutions in reaction-diffusion systems --- spike spiral wave, which significantly differs from spiral waves observed in FitzHugh-Nagumo-type models. We present an asymptotic theory of these waves in Gray-Scott model. We derive the kinematic relations describing the shape of this spiral and find the dependence of its main parameters on the control parameters. The theory does not rely on the specific features of Gray-Scott model and thus is expected to be applicable to a broad range of reaction-diffusion systems.Comment: 4 pages (REVTeX), 2 figures (postscript), submitted to Phys. Rev. Let

Biodiversity of Prokaryotic Communities Associated with the Ectoderm of Ectopleura crocea (Cnidaria, Hydrozoa)

The surface of many marine organisms is colonized by complex communities of microbes, yet our understanding of the diversity and role of host-associated microbes is still limited. We investigated the association between Ectopleura crocea (a colonial hydroid distributed worldwide in temperate waters) and prokaryotic assemblages colonizing the hydranth surface. We used, for the first time on a marine hydroid, a combination of electron and epifluorescence microscopy and 16S rDNA tag pyrosequencing to investigate the associated prokaryotic diversity. Dense assemblages of prokaryotes were associated with the hydrant surface. Two microbial morphotypes were observed: one horseshoe-shaped and one fusiform, worm-like. These prokaryotes were observed on the hydrozoan epidermis, but not in the portions covered by the perisarcal exoskeleton, and their abundance was higher in March while decreased in late spring. Molecular analyses showed that assemblages were dominated by Bacteria rather than Archaea. Bacterial assemblages were highly diversified, with up to 113 genera and 570 Operational Taxonomic Units (OTUs), many of which were rare and contributed to <0.4%. The two most abundant OTUs, likely corresponding to the two morphotypes present on the epidermis, were distantly related to Comamonadaceae (genus Delftia) and to Flavobacteriaceae (genus Polaribacter). Epibiontic bacteria were found on E. crocea from different geographic areas but not in other hydroid species in the same areas, suggesting that the host-microbe association is species-specific. This is the first detailed report of bacteria living on the hydrozoan epidermis, and indeed the first study reporting bacteria associated with the epithelium of E. crocea. Our results provide a starting point for future studies aiming at clarifying the role of this peculiar hydrozoan-bacterial association

Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices

# The Author(s) 2009. This article is published with open access at Springerlink.com Introduction Dysregulation of neuronal networks has been suggested to underlie the cognitive and perceptual abnor-malities observed schizophrenia. Discussions An in vitro model of psychosis is proposed based on the two different approaches to cause aberrant networ

КОКЛЮШ У ДЕТЕЙ – КЛИНИКО-ЭПИДЕМИЧЕСКАЯ ХАРАКТЕРИСТИКА В САМАРСКОЙ ОБЛАСТИ

Objective: to study the features of the clinical and epidemiological characteristics of whooping cough in children in the Samara region.Materials and methods: 389 cases of pertussis in the Samara region for 2015–2016 were analyzed.Results: it is shown that in spite of 95–98% vaccination coverage, in recent years there has been an increase in the incidence of whooping cough. Seasonality of morbidity remains. Among the children observed, the youngest children were not vaccinated against pertussis. The clinical picture of the disease remains typical with the classic course of catarrhal and spasmodic periods. Moderately severe forms of the disease predominate. Complications were noted mainly in unvaccinated children of the first year of life. The most frequent complications were pneumonia and apnea. There is a hypodiagnosis of pertussis in outpatient conditions. Infection often occurs under the mask of ARVI, while the sensitivity of the bacteriological method of diagnosis is zero. Of the methods for confirming the diagnosis, the most reliable is ELISA and PCR.Conclusion: these epidemiological and clinical features of pertussis current testify to the need to further improve methods of early diagnosis, especially express methods, etiopathagenetic treatment, specific prevention, antiepidemic measures in the foci of infection.Цель: изучить особенности клинико-эпидемической характеристики коклюша у детей в Самарской области.Материалы и методы: проанализированы 389 случаев коклюша в Самарской области за 2015–2016 гг.Результаты: показано, что, несмотря на 95–98% охват прививками, в течение последних лет наблюдается подъем заболеваемости коклюшем. Сохраняется сезонность. Среди наблюдавшихся детей преобладали дети младшего возраста, не привитые от коклюша. Клиническая картина заболевания остается типичной с классическим течением катарального и спазматического периодов. Преобладают среднетяжелые формы заболевания. Осложнения отмечались в основном у непривитых детей первого года жизни. Наиболее частыми осложнениями являлись пневмонии и апноэ. Имеет место гиподиагностика коклюша в амбулаторных условиях. Инфекция нередко протекает под маской ОРВИ, при этом чувствительность бактериологического метода диагностики равна нулю. Из методов подтверждения диагноза наиболее достоверным является ИФА и ПЦР.Заключение: указанные эпидемиологические и клинические особенности течения коклюша свидетельствуют о необходимости дальнейшего совершенствования методов ранней диагностики, особенно экспресс-методов, этиопатагенетического лечения, специфической профилактики, противоэпидемических мероприятий в очагах инфекции.

The waking brain: an update

Wakefulness and consciousness depend on perturbation of the cortical soliloquy. Ascending activation of the cerebral cortex is characteristic for both waking and paradoxical (REM) sleep. These evolutionary conserved activating systems build a network in the brainstem, midbrain, and diencephalon that contains the neurotransmitters and neuromodulators glutamate, histamine, acetylcholine, the catecholamines, serotonin, and some neuropeptides orchestrating the different behavioral states. Inhibition of these waking systems by GABAergic neurons allows sleep. Over the past decades, a prominent role became evident for the histaminergic and the orexinergic neurons as a hypothalamic waking center

ROLE OF POLYMERASE CHAIN REACTION IN THE COMPLEX DIAGNOSTICS OF UROGENITAL INFECTIONS

Abstract. The present day there is no universally accepted algorithm for the application of PCR for the diagnostics of urogenital infections and interpretation of results. At the same time, the application of PCR for diagnostics of infection by opportunistic such pathogens as M. hominis, U. parvum can make the antibiotictherapy to be unnecessary

Reflective Processes and Social Orientation at Different Stages of Professionalisation (on the Example of Preparation for Medical Activity)

Introduction. In recent decades, competency-based approach is considered to be the leading one in the system of vocational education in Russia. However, the preparation for future employment cannot be limited to competencies. This is particularly true for anthropocentric professions, for example, the training of medical workers. In such fields of employment, the personal qualities of a specialist are extremely important, i. e. his or her ability to communication, productive interaction, which implies a certain type of reflection.The aim of the present research was to identify the role of reflection, when forming the social orientation of physicians at different stages of their specialty training and realisation of oneself in this or that specialty – from university education to the end of career.Methodology and research methods. In the course of the research, psychodiagnostic methods based on the questionnaire “Differential Type of Reflection” by D. A. Leontiev et al. and FIRO – Fundamental Interpersonal Relations Orientation questionnaire by A. Schutz in the adaptation of A. A. Rukavishnikov were employed, taking into account the key provisions of theories concerning personality psychology and social behaviour. Automated neural networks based on the architecture of a multilayer perceptron according to the type of regression analysis and analysis of Kendall’s tau correlation coefficient were used to process the data.Results. Reflective processes among future physicians and physicians-practitioners were studied on the sample of 384 people (aged from 17 to 76 years old) – 169 students of medical universities and 215 employees of stationary and outpatient clinics of Chelyabinsk region. It was revealed that at different stages of mastering the profession, the level of productive (systemic) reflection turned out to be different, but it was growing according to the increased degree of professionalisation. However, this level did not reach normative values in all groups, pointing to the need for psychological correction of self-determination and self-distancing. The identified ways of respondents’ social orientation demonstrate the contradictory nature of relations to oneself and to others; and such relations were mostly expressed at the beginning of training. Along with the fear of being rejected, manifested at an unconscious level, the respondents took the conscious decisions to preserve own individuality and to maintain the distance with other people. This contradiction means the presence of intra-personal conflict, which, like dissatisfaction with individual needs for interpersonal communication, provokes the prevalence of unproductive types of reflection – introspection and quasi-reflection.Scientific novelty. The integration of ideas about the role, structure, content and determinants of reflection can be represented as follows: traditional understanding from the perspective of inter-individual approach as a mechanism of social perception and interpretation from the point of view of intra-individual (personal) and subject-activity approaches as the higher mental process, which is formed in the process of the acquired profession. This integration allowed the authors to identify the relationships between the level of reflection development, personal peculiarities, experience and medical specialisation.Practical significance. The research materials and the authors’ conclusions can serve as a basis for the development of recommendations for the correction and prevention of unproductive forms of reflection at the initial stages of education in a medical university (e.g. specially organised extracurricular classes), as well as in the system of advanced training of practicing physicians