309 research outputs found
The role of aquaporins in the kidney of euryhaline teleosts
Water balance in teleost fish is maintained with contributions from the major osmoregulatory organs: intestine, gills and kidney. Overall water fluxes have been studied in all of these organs but not until recently has it become possible to approach the mechanisms of water transport at the molecular level. This mini-review addresses the role of the kidney in osmoregulation with special emphasis on euryhaline teleosts. After a short review of current knowledge of renal functional morphology and regulation, we turn the focus to recent molecular investigations of the role of aquaporins in water and solute transport in the teleost kidney. We conclude that there is much to be achieved in understanding water transport and its regulation in the teleost kidney and that effort should be put into systematic mapping of aquaporins to their tubular as well as cellular localization
Effect of the attachment of ferromagnetic contacts on the conductivity and giant magnetoresistance of graphene nanoribbons
Carbon-based nanostructures and graphene, in particular, evoke a lot of
interest as new promising materials for nanoelectronics and spintronics. One of
the most important issue in this context is the impact of external electrodes
on electronic properties of graphene nanoribbons (GNR). The present theoretical
method is based on the tight-binding model and a modified recursive procedure
for Green's functions. The results show that within the ballistic transport
regime, the so called end-contacted geometry (of minimal GNR/electrode
interface area), is usually more advantageous for practical applications than
its side-contacted counterpart (with a larger coverage area), as far as the
electrical conductivity is concerned. As regards the giant magnetoresistance
coefficient, however, the situation is exactly opposite, since spin- splitting
effects are more pronounced in the lower conductive side-contacted setups.Comment: 8 pages, 4 figure
Water Transport and the Functional Dynamics of Aquaporins in Osmoregulatory Organs of Fishes
Aquaporins play distinct roles for water transport in fishes as they do in mammals—both at the cellular, organ, and organismal levels. However, with over 32,000 known species of fishes inhabiting almost every aquatic environment, from tidal pools, small mountain streams, to the oceans and extreme salty desert lakes, the challenge to obtain consensus as well as specific knowledge about aquaporin physiology in these vertebrate clades is overwhelming. Because the integumental surfaces of these animals are in intimate contact with the surrounding milieu, passive water loss and uptake represent two of the major osmoregulatory challenges that need compensation. However, neither obligatory nor regulatory water transport nor their mechanisms have been elucidated to the same degree as, for example, ion transport in fishes. Currently fewer than 60 papers address fish aquaporins. Most of these papers identify “what is present” and describe tissue expression patterns in various teleosts. The agnathans, chondrichthyans, and functionality of fish aquaporins generally have received little attention. This review emphasizes the functional physiology of aquaporins in fishes, focusing on transepithelial water transport in osmoregulatory organs in euryhaline species – primarily teleosts, but covering other taxonomic groups as well. Most current knowledge comes from teleosts, and there is a strong need for related information on older fish clades. Our survey aims to stimulate new, original research in this area and to bring together new collaborations across disciplines
Water Transport and the Functional Dynamics of Aquaporins in Osmoregulatory Organs of Fishes
Aquaporins play distinct roles for water transport in fishes as they do in mammals—both at the cellular, organ, and organismal levels. However, with over 32,000 known species of fishes inhabiting almost every aquatic environment, from tidal pools, small mountain streams, to the oceans and extreme salty desert lakes, the challenge to obtain consensus as well as specific knowledge about aquaporin physiology in these vertebrate clades is overwhelming. Because the integumental surfaces of these animals are in intimate contact with the surrounding milieu, passive water loss and uptake represent two of the major osmoregulatory challenges that need compensation. However, neither obligatory nor regulatory water transport nor their mechanisms have been elucidated to the same degree as, for example, ion transport in fishes. Currently fewer than 60 papers address fish aquaporins. Most of these papers identify “what is present” and describe tissue expression patterns in various teleosts. The agnathans, chondrichthyans, and functionality of fish aquaporins generally have received little attention. This review emphasizes the functional physiology of aquaporins in fishes, focusing on transepithelial water transport in osmoregulatory organs in euryhaline species – primarily teleosts, but covering other taxonomic groups as well. Most current knowledge comes from teleosts, and there is a strong need for related information on older fish clades. Our survey aims to stimulate new, original research in this area and to bring together new collaborations across disciplines
The fluctuation energy balance in non-suspended fluid-mediated particle transport
Here we compare two extreme regimes of non-suspended fluid-mediated particle
transport, transport in light and heavy fluids ("saltation" and "bedload",
respectively), regarding their particle fluctuation energy balance. From direct
numerical simulations, we surprisingly find that the ratio between collisional
and fluid drag dissipation of fluctuation energy is significantly larger in
saltation than in bedload, even though the contribution of interparticle
collisions to transport of momentum and energy is much smaller in saltation due
to the low concentration of particles in the transport layer. We conclude that
the much higher frequency of high-energy particle-bed impacts ("splash") in
saltation is the cause for this counter-intuitive behavior. Moreover, from a
comparison of these simulations to Particle Tracking Velocimetry measurements
which we performed in a wind tunnel under steady transport of fine and coarse
sand, we find that turbulent fluctuations of the flow produce particle
fluctuation energy at an unexpectedly high rate in saltation even under
conditions for which the effects of turbulence are usually believed to be
small
Aerothermoelastic analysis of a NASP demonstrator model
The proposed National Aerospace Plane (NASP) is designed to travel at speeds up to Mach 25. Because aerodynamic heating during high-speed flight through the atmosphere could destiffen a structure, significant couplings between the elastic and rigid body modes could result in lower flutter speeds and more pronounced aeroelastic response characteristics. These speeds will also generate thermal loads on the structure. The purpose of this research is to develop methodologies applicable to the NASP and to apply them to a representative model to determine its aerothermoelastic characteristics when subjected to these thermal loads. This paper describes an aerothermoelastic analysis of the generic hypersonic vehicle configuration. The steps involved in this analysis were: generating vehicle surface temperatures at the appropriate flight conditions; applying these temperatures to the vehicle's structure to predict changes in the stiffness resulting from material property degradation; predicting the vibration characteristics of the heated structure at the various temperature conditions; performing aerodynamic analyses; and conducting flutter analysis of the heated vehicle. Results of these analyses and conclusions representative of a NASP vehicle are provided in this paper
Functional Characterization of Water Transport and Cellular Localization of Three Aquaporin Paralogs in the Salmonid Intestine
Intestinal water absorption is greatly enhanced in salmonids upon acclimation from freshwater (FW) to seawater (SW); however, the molecular mechanism for water transport is unknown. We conducted a pharmacological characterization of water absorption in the rainbow trout intestine along with an investigation of the distribution and cellular localization of three aquaporins (Aqp1aa, -1ab, and -8ab) in pyloric caeca, middle (M), and posterior (P) intestine of the Atlantic salmon. In vitro iso-osmotic water absorption (Jv) was higher in SW than FW-trout and was inhibited by (mmol L−1): 0.1 KCN (41%), 0.1 ouabain (72%), and 0.1 bumetanide (82%) suggesting that active transport, Na+, K+-ATPase and Na+, K+, 2Cl−-co-transport are involved in establishing the driving gradient for water transport. Jv was also inhibited by 1 mmol L−1 HgCl2, serosally (23% in M and 44% in P), mucosally (27% in M), or both (61% in M and 58% in P), suggesting involvement of both apical and basolateral aquaporins in water transport. The inhibition was antagonized by 5 mmol L−1 mercaptoethanol. By comparison, 10 mmol L−1 mucosal tetraethylammonium, an inhibitor of certain aquaporins, inhibited Jv by 20%. In the presence of glucose, mucosal addition of phloridzin inhibited water transport by 20%, suggesting that water transport is partially linked to the Na+-glucose co-transporter. Using polyclonal antibodies against salmon Aqp1aa, -1ab, and -8ab, we detected Aqp1aa, and -1ab immunoreactivity in the brush border and sub-apical region of enterocytes in all intestinal segments. The Aqp8ab antibody showed a particularly strong immunoreaction in the brush border and sub-apical region of enterocytes throughout the intestine and also stained lateral membranes and peri-nuclear regions though at lower intensity. The present localization of three aquaporins in both apical and lateral membranes of salmonid enterocytes facilitates a model for transcellular water transport in the intestine of SW-acclimated salmonids
Multi-functional annular fairing for coupling launch abort motor to space vehicle
An annular fairing having aerodynamic, thermal, structural and acoustic attributes couples a launch abort motor to a space vehicle having a payload of concern mounted on top of a rocket propulsion system. A first end of the annular fairing is fixedly attached to the launch abort motor while a second end of the annular fairing is attached in a releasable fashion to an aft region of the payload. The annular fairing increases in diameter between its first and second ends
The Dynamics of a Meandering River
We present a statistical model of a meandering river on an alluvial plane
which is motivated by the physical non-linear dynamics of the river channel
migration and by describing heterogeneity of the terrain by noise. We study the
dynamics analytically and numerically. The motion of the river channel is
unstable and we show that by inclusion of the formation of ox-bow lakes, the
system may be stabilised. We then calculate the steady state and show that it
is in agreement with simulations and measurements of field data.Comment: Revtex, 12 pages, 2 postscript figure
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