Eating to exit: autophagy-enabled senescence revealed

Autophagy and senescence are two distinct cellular responses to stress that are also tumor suppression mechanisms. In this issue of Genes & Development, Young and colleagues ( pp. 798-803) discovered that autophagy is induced during and facilitates the process of senescence. Knowing now that these two pathways are functionally intertwined sets the stage for establishing how they function cooperatively in the cancer setting

On Vague Computers

Vagueness is something everyone is familiar with. In fact, most people think that vagueness is closely related to language and exists only there. However, vagueness is a property of the physical world. Quantum computers harness superposition and entanglement to perform their computational tasks. Both superposition and entanglement are vague processes. Thus quantum computers, which process exact data without "exploiting" vagueness, are actually vague computers

Feasibility and tolerability of whole-body, low-intensity vibration and its effects on muscle function and bone in patients with dystrophinopathies: a pilot study.

IntroductionDystrophinopathies are X-linked muscle degenerative disorders that result in progressive muscle weakness complicated by bone loss. This study's goal was to evaluate feasibility and tolerability of whole-body, low-intensity vibration (WBLIV) and its potential effects on muscle and bone in patients with Duchenne or Becker muscular dystrophy.MethodsThis 12-month pilot study included 5 patients (age 5.9-21.7 years) who used a low-intensity Marodyne LivMD plate vibrating at 30-90 Hz for 10 min/day for the first 6 months. Timed motor function tests, myometry, and peripheral quantitative computed tomography were performed at baseline and at 6 and 12 months.ResultsMotor function and lower extremity muscle strength remained either unchanged or improved during the intervention phase, followed by deterioration after WBLIV discontinuation. Indices of bone density and geometry remained stable in the tibia.ConclusionsWBLIV was well tolerated and appeared to have a stabilizing effect on lower extremity muscle function and bone measures. Muscle Nerve 55: 875-883, 2017

Probabilistic Search for Object Segmentation and Recognition

The problem of searching for a model-based scene interpretation is analyzed within a probabilistic framework. Object models are formulated as generative models for range data of the scene. A new statistical criterion, the truncated object probability, is introduced to infer an optimal sequence of object hypotheses to be evaluated for their match to the data. The truncated probability is partly determined by prior knowledge of the objects and partly learned from data. Some experiments on sequence quality and object segmentation and recognition from stereo data are presented. The article recovers classic concepts from object recognition (grouping, geometric hashing, alignment) from the probabilistic perspective and adds insight into the optimal ordering of object hypotheses for evaluation. Moreover, it introduces point-relation densities, a key component of the truncated probability, as statistical models of local surface shape.Comment: 18 pages, 5 figure

Remote sensing in Michigan for land resource management

The Environmental Research Institute of Michigan is conducting a program whose goal is the large-scale adoption, by both public agencies and private interests in Michigan, of NASA earth-resource survey technology as an important aid in the solution of current problems in resource management and environmental protection. During the period from June 1975 to June 1976, remote sensing techniques to aid Michigan government agencies were used to achieve the following major results: (1) supply justification for public acquisition of land to establish the St. John's Marshland Recreation Area; (2) recommend economical and effective methods for performing a statewide wetlands survey; (3) assist in the enforcement of state laws relating to sand and gravel mining, soil erosion and sedimentation, and shorelands protection; (4) accomplish a variety of regional resource management actions in the East Central Michigan Planning and Development Region. Other tasks on which remote sensing technology was used include industrial and school site selection, ice detachment in the Soo Harbor, grave detection, and data presentation for wastewater management programs

Remote sensing in Michigan for land resource management

An extensive program was conducted to establish practical uses of NASA earth resource survey technology in meeting resource management problems throughout Michigan. As a result, a broad interest in and understanding of the usefulness of remote sensing methods was developed and a wide variety of applications was undertaken to provide information needed for informed decision making and effective action

AdS/CFT and the Information Paradox

The information paradox in the quantum evolution of black holes is studied within the framework of the AdS/CFT correspondence. The unitarity of the CFT strongly suggests that all information about an initial state that forms a black hole is returned in the Hawking radiation. The CFT dynamics implies an information retention time of order the black hole lifetime. This fact determines many qualitative properties of the non-local effects that must show up in a semi-classical effective theory in the bulk. We argue that no violations of causality are apparent to local observers, but the semi-classical theory in the bulk duplicates degrees of freedom inside and outside the event horizon. Non-local quantum effects are required to eliminate this redundancy. This leads to a breakdown of the usual classical-quantum correspondence principle in Lorentzian black hole spacetimes.Comment: 16 pages, harvmac, reference added, minor correction

A systematic review of ICD complications in randomised controlled trials versus registries: is our 'real-world' data an underestimation?

Implantable cardioverter defibrillator (ICD) implantation carries a significant risk of complications, however published estimates appear inconsistent. We aimed to present a contemporary systematic review using meta-analysis methods of ICD complications in randomised controlled trials (RCTs) and compare it to recent data from the largest international ICD registry, the US National Cardiovascular Data Registry (NCDR). PubMed was searched for any RCTs involving ICD implantation published 1999-2013; 18 were identified for analysis including 6433 patients, mean follow-up 3 months-5.6 years. Exclusion criteria were studies of children, hypertrophic cardiomyopathy, congenital heart disease, resynchronisation therapy and generator changes. Total pooled complication rate from the RCTs (excluding inappropriate shocks) was 9.1%, including displacement 3.1%, pneumothorax 1.1% and haematoma 1.2%. Infection rate was 1.5%.There were no predictors of complications but longer follow-up showed a trend to higher complication rates (p=0.07). In contrast, data from the NCDR ICD, reporting on 356 515 implants (2006-2010) showed a statistically significant threefold lower total major complication rate of 3.08% with lead displacement 1.02%, haematoma 0.86% and pneumothorax 0.44%. The overall ICD complication rate in our meta-analysis is 9.1% over 16 months. The ICD complication reported in the NCDR ICD registry is significantly lower despite a similar population. This may reflect under-reporting of complications in registries. Reporting of ICD complications in RCTs and registries is very variable and there is a need to standardise classification of complications internationally

Nonsingular Black Hole Evaporation and ``Stable'' Remnants

We examine the evaporation of two--dimensional black holes, the classical space--times of which are extended geometries, like for example the two--dimensional section of the extremal Reissner--Nordstrom black hole. We find that the evaporation in two particular models proceeds to a stable end--point. This should represent the generic behavior of a certain class of two--dimensional dilaton--gravity models. There are two distinct regimes depending on whether the back--reaction is weak or strong in a certain sense. When the back--reaction is weak, evaporation proceeds via an adiabatic evolution, whereas for strong back--reaction, the decay proceeds in a somewhat surprising manner. Although information loss is inevitable in these models at the semi--classical level, it is rather benign, in that the information is stored in another asymptotic region.Comment: 23 pages, 6 figures, harvmac and epsf, RU-93-12, PUPT-1399, NSF-ITP-93-5