39 research outputs found
Effect of ras-blockers and no-cycle metabolites on the renal functions of rats exposed to thyroxine injections
Dolomatov S. I., Sataieva T. P. Effect of ras-blockers and no-cycle metabolites on the renal functions of rats exposed to thyroxine injections. Journal of Education, Health and Sport. 2015;5(1):41-55. ISSN 2391-8306. DOI: 10.5281/zenodo.13902http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%281%29%3A41-55https://pbn.nauka.gov.pl/works/522594http://dx.doi.org/10.5281/zenodo.13902Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 β 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archiveΒ Deklaracja.Specyfika i zawartoΕΔ merytoryczna czasopisma nie ulega zmianie.Zgodnie z informacjΔ
MNiSW z dnia 2 czerwca 2014 r., ΕΌe w roku 2014 nie bΔdzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktΓ³w co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).Β© The Author (s) 2015;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 15.06.2014. Revised 05.10.2014. Accepted: 12.01.2015.Β EFFECT OF RAS-BLOCKERS AND NO-CYCLE METABOLITES ON THE RENAL FUNCTIONS OF RATS EXPOSED TO THYROXINE INJECTIONSΒ S. I. Dolomatov, T. P. SataievaΒ Crimea State Medical UniversitySimferopol, Russian FederationCorrespondingΒ author:Sergei DolomatovE-mail: [email protected]. Evaluating the role of RAS and NO-dependent pathogenic mechanisms of formation of renal dysfunction in disorders of the thyroid status. Methods. First 2 groups of experimental white male outbredrats was administered thyroxine (T4) in a dose of 50 g / 100 g per body weight injected intraperitoneally on 1% starch gel base once or during 7 days. In addition, rats were administered non-selective NO-synthase inhibitor NΟ-NLA. Β Those rats were exposed to single administration of the combined T4 (intraperitoneally, 50mg/100g body weight in 24 hours before water loading) and NΟ-NLA (intraperitoneally 1 mg / 100 g body weight 30 min before water loading). As a comparison we studied a group of animals received only an equivalent dose only or T4 NΟ-NLA only 1 mg / 100 g body weight in 30 min before water loading. After 7-days. of T4 administration the same rats received water solution of losartan (10 mg / l) or water solution of captopril (20 mg / l) for 24 hours after the last administration of T4. Another group of rats was treated with T4 for 7 days and afterwards Β was administered L-arginine in a dose 2 mg / 100 g bw per day or water solution (20 mg / l) of sodium nitrite. Rats in the control group for 7 days. was administered intragastrically gel containing no T4. Kidney function was studiedΒ in 24h after administration of T4 in terms of water 5% loading on kidneys. Results. It was found out that administaration of RAS-blockers increases creatinine clearance value after either a single or prolonged administration of T4 in rats. However, decreased renal excretion of endogenous nitrates and protein as well as prevented retention of endogenous nitrite was registered in rats only after administration of losartan after 7 days of T4 administration. Prolonged administration of T4 to the rats Β was accompanied by Β weakened Β renal effects of NO and activated the arginine dependent pathway of NO synthesis into the nitrite reduction, Β evidenced by the increase of endogenous nitrite level in blood plasma of rats treated with T4 continuously along with no pronounced corrective effect of exogenous arginine in hyperthyroid animals and elevated creatinine clearance under the influence of exogenous sodium nitrite in the hyperthyroid animals. Conclusion. Discovered Β effects of RAS blockers allow us to recommend this pharmacological agents as an effective way to slow down the progression of renal dysfunction inthyroid pathlogy.Β Keywords: rat, hyperthyroidism, renal function, RAS- inhibitors, nitrites, nitrates
Proteomics
Proteomics is a branch of molecular biology that deals with the identification and quantification of proteins in living objects, as well as the analysis of protein functions and their interactions.
Proteomics is studied by proteins that are expressed in a given cell, tissue or organism over a period of time (under certain conditions).
It is known that information about the primary structure of a protein (the sequence of amino acid residues in a protein) is contained in a structural gene in the form of a codon sequence (genetic code). On the other hand, less than 10% of genes are functionally active (expressed) in the somatic cells of our body. Moreover, a distinct tissue-specific expression of genes is observed. This, in turn, leads to the peculiarities of the qualitative composition of the synthesized proteins in various tissues. No less important is the fact that the total amount of proteins synthesized by our tissues is much greater than the total number of structural genes containing information about their original structure. This phenomenon is explained by the activity of such mechanisms as alternative splicing and a wide variety of post-translational peptide processing pathways (covalent modification of a polypeptide synthesized on the ribosome) in health and disease. Thus, even a brief review of the semantic content of the term "proteomics" indicates an extremely complex system of protein molecules in our body, which plays a fundamental role in maintaining homeostasis and is involved in the formation of adaptive responses in response to adverse changes in the internal and external environment
Π ΠΎΠ»Ρ ΡΠ΅Π½ΠΈΠ½-Π°Π½Π³ΠΈΠΎΡΠ΅Π½Π·ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈ ΡΠΈΠΊΠ»Π° ΠΎΠΊΡΠΈΠ΄Π° Π°Π·ΠΎΡΠ° Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ Π³ΠΈΠΏΠ΅ΡΡΠΈΡΠ΅ΠΎΠΈΠ΄Π½ΠΎΠΉ ΠΏΠΎΡΠΊΠΈ
ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ»ΠΈ ΡΠ΅Π½ΠΈΠ½ Π°Π½Π³ΠΈΠΎΡΠ΅Π½Π·ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈ ΡΠΈΠΊΠ»Π° ΠΎΠΊΡΠΈΠ΄Π° Π°Π·ΠΎΡΠ° Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ Π³ΠΈΠΏΠ΅ΡΡΠΈΡΠ΅ΠΎΠΈΠ΄Π½ΠΎΠΉ ΠΏΠΎΡΠΊΠΈ Π½Π° ΡΠ°Π½Π½Π΅ΠΌ Π²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΠΎΡΡΠ΅Π·ΠΊΠ΅ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π³ΠΈΠΏΠ΅ΡΡΠΈΡΠ΅ΠΎΠ·Π° Ρ Π±Π΅Π»ΡΡ
ΠΊΡΡΡ, Π²ΡΠ·Π²Π°Π½Π½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ ΡΠΈΡΠΎΠΊΡΠΈΠ½Π°.Π’ΠΈΡΠΎΠΊΡΠΈΠ½ (Π’4) ΠΏΠΎ 50 ΠΌΠΊΠ³/100 Π³ ΠΌ.Ρ. Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ Π²Π½ΡΡΡΠΈΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎ Π½Π° 1% ΠΊΡΠ°Ρ
ΠΌΠ°Π»ΡΠ½ΠΎΠΌ Π³Π΅Π»Π΅ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎ ΠΈΠ»ΠΈ Π½Π° ΠΏΡΠΎΡΡΠΆΠ΅Π½ΠΈΠΈ 5 ΠΈ 7 ΡΡΡ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, Π½Π° ΡΠΎΠ½Π΅ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Π’4 Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΠ°ΡΡΠ²ΠΎΡ Π°ΡΠΊΠΎΡΠ±ΠΈΠ½ΠΎΠ²ΠΎΠΉ ΠΊΠΈΡΠ»ΠΎΡΡ (0,2 ΠΌΠ³/100 Π³ ΠΌ.Ρ.) Π·Π° 30 ΠΌΠΈΠ½ Π΄ΠΎ Π²ΠΎΠ΄Π½ΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠΈ ΠΈΠ»ΠΈ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 24 Ρ Ρ ΠΌΠΎΠΌΠ΅Π½ΡΠ° Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Π’4 Π²ΡΠΏΠ°ΠΈΠ²Π°Π»ΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠΎΠΌ ΠΊΠ°ΠΏΡΠΎΠΏΡΠΈΠ»Π° (50 ΠΌΠ³/Π»). ΠΠΎΡΠ»Π΅ 5 ΡΡΡ. Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Π’4 ΠΊΡΡΡ ΡΠ°ΠΊΠΆΠ΅ Π²ΡΠΏΠ°ΠΈΠ²Π°Π»ΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠΎΠΌ Π»ΠΎΠ·Π°ΡΡΠ°Π½Π° (10 ΠΌΠ³/Π») Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 24 Ρ Ρ ΠΌΠΎΠΌΠ΅Π½ΡΠ° ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Π’4. ΠΡΡΡΠ°ΠΌ, ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
Π’4 Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 7 ΡΡΡ., Π½Π°Π·Π½Π°ΡΠ°Π»ΠΈ L Π°ΡΠ³ΠΈΠ½ΠΈΠ½ ΠΏΠΎ 2 ΠΌΠ³/100 Π³ ΠΌ.Ρ. Π² ΡΡΡ., ΠΈΠ»ΠΈ Π²ΡΠΏΠ°ΠΈΠ²Π°Π»ΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠΎΠΌ (20 ΠΌΠ³/Π») Π½ΠΈΡΡΠΈΡΠ° Π½Π°ΡΡΠΈΡ. ΠΡΡΡΠ°ΠΌ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ 7 ΡΡΡ. Π²Π½ΡΡΡΠΈΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ Π³Π΅Π»Ρ, Π½Π΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠΉ Π’4. ΠΠ΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΏΠΎΡΠ΅ΠΊ ΠΈΠ·ΡΡΠ°Π»ΠΈ ΡΠ΅ΡΠ΅Π· 24 Ρ ΠΏΠΎΡΠ»Π΅ Π·Π°Π²Π΅ΡΡΠ΅Π½ΠΈΡ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Π’4 Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
5% Π²ΠΎΠ΄Π½ΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠΈ. Π ΠΠΠ£ΠΠ¬Π’ΠΠ’Π«. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π±Π»ΠΎΠΊΠ°ΡΠΎΡΡ Π ΠΠ‘ ΠΏΠΎΠ²ΡΡΠ°ΡΡ Π²Π΅Π»ΠΈΡΠΈΠ½Ρ ΠΊΠ»ΠΈΡΠ΅Π½ΡΠ° ΠΊΡΠ΅Π°ΡΠΈΠ½ΠΈΠ½Π° ΠΏΠΎΡΠ»Π΅ ΠΎΠ΄Π½ΠΎΠΊΡΠ°ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ ΠΊΡΡΡΠ°ΠΌ Π’4, ΠΎΠ΄Π½Π°ΠΊΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΡ ΠΏΠΎΡΠΊΠ°ΠΌΠΈ ΠΊΡΡΡ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΡ
Π½ΠΈΡΡΠ°ΡΠΎΠ² ΠΈ Π±Π΅Π»ΠΊΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ΅Π΄ΠΎΡΠ²ΡΠ°ΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΡΠ΅Π½ΡΠΈΠΈ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΡ
Π½ΠΈΡΡΠΈΡΠΎΠ² ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΠ΅ΡΡΡ ΡΠΎΠ»ΡΠΊΠΎ ΠΏΡΠΈ Π½Π°Π·Π½Π°ΡΠ΅Π½ΠΈΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΠΌ Π»ΠΎΠ·Π°ΡΡΠ°Π½Π° ΡΠ΅ΡΠ΅Π· 5 ΡΡΡ. ΠΏΠΎΡΠ»Π΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΡ Π’4. ΠΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΊΡΡΡΠ°ΠΌ Π’4 ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΠΎΡΠ»Π°Π±Π»Π΅Π½ΠΈΠ΅ΠΌ ΡΠ΅Π½Π°Π»ΡΠ½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² NO ΠΈ ΠΏΠ΅ΡΠ΅ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π°ΡΠ³ΠΈΠ½ΠΈΠ½ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΠ³ΠΎ ΠΏΡΡΠΈ ΡΠΈΠ½ΡΠ΅Π·Π° NO Π½Π° Π½ΠΈΡΡΠΈΡΡΠ΅Π΄ΡΠΊΡΠ°Π·Π½ΡΠΉ, ΠΎ ΡΠ΅ΠΌ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΡ
Π½ΠΈΡΡΠΈΡΠΎΠ² Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΊΡΡΡ, ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
Π’4, ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠΎΡΡΠΈΠ³ΠΈΡΡΡΡΠ΅Π³ΠΎ Π½Π΅ΡΡΠΎΡΡΠΎΠΏΠ½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ Π°ΡΠ³ΠΈΠ½ΠΈΠ½Π° Ρ Π³ΠΈΠΏΠ΅ΡΡΠΈΡΠ΅ΠΎΠΈΠ΄Π½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΈ Π½Π°ΡΠ°ΡΡΠ°Π½ΠΈΠ΅ ΠΊΠ»ΠΈΡΠ΅Π½ΡΠ° ΠΊΡΠ΅Π°ΡΠΈΠ½ΠΈΠ½Π° ΠΏΠΎΠ΄ Π²Π»ΠΈΡΠ½ΠΈΠ΅ΠΌ ΡΠΊΠ·ΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ Π½ΠΈΡΡΠΈΡΠ° Π½Π°ΡΡΠΈΡ Π² Π³ΡΡΠΏΠΏΠ΅ Π³ΠΈΠΏΠ΅ΡΡΠΈΡΠ΅ΠΎΠΈΠ΄Π½ΡΡ
ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
.The aim of the investigation was to study the role of renin angiotensine system (RAS) and nitrogen oxide cycle in pathogenesis of hyperthyroid kidney at an early time period of modeling experimental hyperthyroidism in albino rats caused by administration of thyroxin.It was established that RAS blockers increased the value of creatinin clearance after a single and continuous administration of T4 to rats, but decreased excretion by the ratsβ kidneys of endogenous nitrates and protein as well as prevention of endogenous nitrites retention was registered only when the animals were given Lozartan in 5 days after administration of T4. Continuous administration of T4 to rats was followed by weaker effects of NO and redirection of the arginine dependent way of NO synthesis to the nitrite reductase one, which is shown by increased level of endogenous nitrites in blood plasma of the rats continuously given T4, the absence of a pronounced correcting nephrotropic effect of exogenous arginin in hyperthyroid animals and growth of creatinin clearance under the influence of exogenous sodium nitrite in the group of hyperthyroid animals
Concentration of paramagnetic centres at low-temperature thermal destruction of asphaltenes of heavy petroleum distillates
Β© Kazan Federal University (KFU).Changes of paramagnetic centers (PC) concentration in dispersed petroleum systems were studied in the process of low-temperature thermolysis. The kinetic model of PC concentration dynamics based on the processes of unpaired electrons formation during singlet-triplet transitions, weak chemical bonds dissociation and recombination of free radicals is proposed. PACS: 75.20.-g, 96.20.Dt, 02.30.H
EPR study of spectra transformations of the intrinsic vanadyl-porphyrin complexes in heavy crude oils with temperature to probe the asphaltenes' aggregation
Β© 2018 Elsevier B.V. Temperature dependencies of electron paramagnetic resonance spectra of intrinsic paramagnetic vanadyl complexes and dynamical viscosity for two heavy crude oils and asphalt samples are measured. Transitions between the different motional conditions (from the rigid to the fast motion regimes) are observed. The rotational correlation times (in the model of the isotropic diffusion) are extracted. It is shown that the characteristic temperatures for the motional regime transitions are mainly defined by the asphaltenesβ content. From our analysis it follows that the thermal treatment leads to the destruction of the asphaltene complexes onto the 4β5 small pieces. The results indicate that paramagnetic vanadyl complexes are the sensitive intrinsic probes to study qualitatively and quantitatively structural transformations of aspahltenes of heavy crude oils in-situ
EPR study of spectra transformations of the intrinsic vanadyl-porphyrin complexes in heavy crude oils with temperature to probe the asphaltenes' aggregation
Temperature dependencies of electron paramagnetic resonance spectra of intrinsic paramagnetic vanadyl complexes
and dynamical viscosity for two heavy crude oils and asphalt samples are measured. Transitions between
the different motional conditions (from the rigid to the fast motion regimes) are observed. The rotational correlation
times (in the model of the isotropic diffusion) are extracted. It is shown that the characteristic temperatures
for the motional regime transitions are mainly defined by the asphaltenes' content. From our analysis it
follows that the thermal treatment leads to the destruction of the asphaltene complexes onto the 4-5 small pieces.
The results indicate that paramagnetic vanadyl complexes are the sensitive intrinsic probes to study qualitatively
and quantitatively structural transformations of aspahltenes of heavy crude oils in-situ
The practical significanse of determination of the osmolality of the saliva in healthy and ill patients
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΎΡΠΌΠΎΠ»ΡΠ»ΡΠ½ΠΎΡΡΠΈ ΡΠ»ΡΠ½Ρ ΠΆΠ΅Π½ΡΠΈΠ½ Ρ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ Π±Π΅ΡΠ΅ΠΌΠ΅Π½ Π½ΠΎΡΡΠΈ ΠΈ ΠΏΡΠΈ ΠΏΠ°ΡΠ°Π΄ΠΎΠ½ΡΠΈΡΠ΅ Π½Π° ΡΠΎΠ½Π΅ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠ»ΡΠ½Π° ΡΠ²Π»ΡΠ΅ΡΡΡ Π³ΠΈΠΏΠΎΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΡΡ, Π° ΠΏΠΎΠ»ΠΎΡΠΊΠ°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΎΡΡΠΈ ΡΡΠ° 0,9% ΡΠ°ΡΡΠ²ΠΎΡΠΎΠΌ Ρ
Π»ΠΎΡΠΈΠ΄Π° Π½Π°ΡΡΠΈΡ, Π² Π³ΡΡΠΏΠΏΠ΅ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π½Π΅Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΆΠ΅Π½ΡΠΈΠ½, ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΠΎΡΠΌΠΎΠ»ΡΠ»ΡΠ½ΠΎΡΡΠΈ ΡΠ»ΡΠ½Ρ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π² ΡΠ»ΡΠ½Π΅ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ², Π½ΠΈΡΡΠΈΡΠΎΠ² ΠΈ ΠΎΠ±ΡΠ΅Π³ΠΎ ΠΊΠ°Π»ΡΡΠΈΡ, Π° ΠΏΠΎΠ»ΠΎΡΠΊΠ°Π½ΠΈΠ΅ ΠΏΠΎΠ»ΠΎΡΡΠΈ ΡΡΠ° 0,9% ΡΠ°ΡΡΠ²ΠΎΡΠΎΠΌ Ρ
Π»ΠΎΡΠΈΠ΄Π° Π½Π°ΡΡΠΈΡ Π½Π΅ Π²ΡΠ·ΡΠ²Π°Π΅Ρ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ² Π² ΡΠ»ΡΠ½Π΅. ΠΡΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ Π½Π΅ ΠΏΡΠΎΠΈΡΡ
ΠΎΠ΄ΠΈΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎΠ³ΠΎ Π΄Π»Ρ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΠΏΡΠΎΡΠ΅ΠΊΠ°ΡΡΠ΅ΠΉ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ ΠΏΠΎΠ½ΠΈΠΆΠ΅Π½ΠΈΡ Π²Π΅Π»ΠΈΡΠΈΠ½Ρ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π² ΡΠ»ΡΠ½Π΅ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΈ Π°ΠΊΡΠΈΠ²Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ² ΠΈ Π½ΠΈΡΡΠΈΡΠΎΠ². Π ΡΠ»ΡΠ½Π΅ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
Ρ ΠΏΠ°ΡΠ°Π΄ΠΎΠ½ΡΠΈΡΠΎΠΌ ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΠ΅ΡΡΡ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ Π²ΡΡΠΎΠΊΠΎΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Π½ΠΈΡΡΠΈΡΠΎΠ² ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ» ΡΡΠ΅Π΄Π½Π΅ΠΉ ΠΌΠ°ΡΡΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΎΡΠΌΠΎΠ»ΡΠ»ΡΠ½ΠΎΡΡΠΈ ΡΠ»ΡΠ½Ρ Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ ΡΠΎ Π·Π΄ΠΎΡΠΎΠ²ΡΠΌΠΈ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌΠΈ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΠ°ΡΠ°Π΄ΠΎΠ½ΡΠΈΡΠ° Π½Π° ΡΠΎΠ½Π΅ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΈΠΌ ΡΡΠΎΠ²Π½Π΅ΠΌ Π² ΡΠ»ΡΠ½Π΅ ΠΠΠΠ-ΡΡΠ»ΡΡΠ°ΡΠ° ΠΈ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈ Π΅ΠΌ ΡΡΡΡΠΈΠΎΠ»Π°, Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠ°Π²Π° ΡΠ»ΡΠ½Ρ ΠΌΠΎΠΆΠ΅Ρ Π΄Π°ΡΡ ΡΠ΅Π½Π½ΡΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΠΈ ΠΏΠΎΠ»ΠΎΡΡΠΈ ΡΡΠ° ΠΏΡΠΈ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΈ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΠΈ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΡΠΈ.The aim is the study of the data dynamics of osmolality of saliva of women with pathologic pregnancy and with paradontitis during pregnancy. Was determined that saliva is hyperosmic fluid, and mouth wash with 0,9% saline solution in the group of health nonpregnant women leads to the decrease in osmolality of saliva. Also was noted that physiologic flow of pregnancy leads to the decrease in saliva of omatically active substances, nitrates and total calcium, and the mouth rinse with the 0,9% saline solution does not lead to the decrease in the concentration of osmotically active substances in saliva. In pathologic pregnancy flow the characteristic for the physiological pregnancy decrease of the value of the concentration of osmotically active substances and nitrates does not take place. In the saliva of pregnant women with paradontitis the concentration of nitrates and medium weight molecules are at their highest, and also a stable increase of osmolality of saliva in comparison with health women take place. It was noted that the paradontitis flow during the pregnancy is Ρharacterized by a higher level in saliva of DHEA-sulfate and the decrease of estradiol, in comparison with control group of pregnant women. The investigation of osmotic consistence of saliva can give a valuable information about the state of the mouth cavity state during physiologic and pathologic pregnancy flow