17 research outputs found
Épica, crónicas y genealogías. En torno a la historicidad de la Leyenda de los infantes de Lara
[ES] Este trabajo analiza la historicidad de la narración épica conocida como Leyenda de los Infantes de Lara. Frente a la visión tradicional, que atribuía a este relato una gran fidelidad a los hechos históricos, se sugiere una imagen más compleja, que mezcla elementos nuevos y más antiguos: 1) Un posible núcleo histórico consistente en la historia de Ruy Velázquez; 2) Una parte más compacta formada por la trama de la
venganza de sangre, que enlaza la traición con la venganza de Mudarra. Frente a la idea tradicional de que la venganza es una
completa ficción elaborada mucho tiempo después, se sugiere que traición y venganza constituyen una unidad lógica, aunque no
se relacione con hechos históricos concretos. Es muy probable que el núcleo central de la leyenda, tal y como nos ha llegado, sea más bien un conjunto amplio de temas y motivos entretejidos con hechos
históricos más o menos desfigurados.
Finalmente, todas estas piezas cobran sentido en su contexto geográfico: la leyenda parece estar reflejando un
conflicto entre Lara y Salas, leído desde el punto de vista de Salas, con una clara
hostilidad hacia Lara.Peer reviewe
A new design for in-vivo-tissue engineering of musculoskeletal tissue using the inferior epigastric artery central anastomosable vessel of a 3-dimensional construct
Transcatheter Aortic Valve Implantation With or Without Pre-implantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta-analysis
Objectives: Pre-implantation balloon-aortic valvuloplasty (BAV) is considered routine procedure during transcatheter aortic valve implantation (TAVI) to facilitate prosthesis implantation and expansion; however, it has been speculated that fewer embolic events and/or hemodynamic instability may occur if TAVI is performed without pre-implantation BAV. Hence, the aim of the study was to systematically review the clinical outcomes associated with TAVI undertaken without pre-implantation BAV. Methods and Results: We conducted a search of MEDLINE and EMBASE to identify studies that evaluated patients who underwent TAVI with/without pre-implantation BAV for predilation. Pooled analysis and random effects meta-analyses were used to estimate the rate and risk of adverse outcomes. Sixteen studies involving 1395 patients (674/721 with/without preimplantation BAV) fulfilled the inclusion criteria. Crude device success was achieved in 94% (1311/1395) and 30-day all-cause mortality occurred in 6% (72/1282) of patients. Meta-analyses evaluating outcomes between pre-implantation BAV versus without BAV strategies showed no statistically significant differences in terms of mortality (risk ratio [RR]: 0.61, 95% confidence interval [CI]: 0.32-1.14, P=0.12), safety composite endpoint (RR: 0.85, 95%CI: 0.62-1.18, P=0.34), moderate-to-severe paravalvular leaks (RR: 0.68, 95%CI: 0.23-1.99, P=0.48), need for postdilation (RR: 0.86, 95%CI: 0.66-1.13, P=0.58), stroke and/or transient ischemic attack (RR: 0.72, 95%CI: 0.30-1.71, P=0.45), and permanent pacemaker implantation (RR: 0.80, 95%CI: 0.49-1.30, P=0.37). Conclusion: Our analysis suggests that TAVI procedures with or without pre-implantation BAV were associated with similar outcomes in a number of clinically relevant endpoints. Further Disclaimer: The manuscript and its contents are confidential, intended for journal review purposes only, and not to be further disclosed. JAHA/2015/003191-R1 3 studies including a significant number of patients are needed to ascertain the impact of TAVI without pre-implantation BAV as a standard practice