The Clinical Rationale for the Sentry Bioconvertible Inferior Vena Cava Filter for the Prevention of Pulmonary Embolism

The Sentry inferior vena cava (IVC) filter is designed to provide temporary protection against pulmonary embolism (PE) during transient high-risk periods and then to bioconvert after 60 days after implantation. At the time of bioconversion, the device's nitinol arms retract from the filtering position into the caval wall. Subsequently, the stable stent-like nitinol frame is endothelialized. The Sentry bioconvertible IVC filter has been evaluated in a multicenter investigational-device-exemption pivotal trial (NCT01975090) of 129 patients with documented deep vein thrombosis (DVT) or PE, or at temporary risk of developing DVT or PE, and with contraindications to anticoagulation. Successful filter conversion was observed in 95.7% of patients at 6 months (110/115) and 96.4% at 12 months (106/110). Through 12 months, there were no cases of symptomatic PE. The rationale for development of the Sentry bioconvertible device includes the following considerations: (1) the period of highest risk of PE for the vast majority of patients occurs within the first 60 days after an index event, with most of the PEs occurring in the first 30 days; (2) the design of retrievable IVC filters to support their removal after a transitory high-PE-risk period has, in practice, been associated with insecure filter dynamics and time-dependent complications including tilting, fracture, embolization, migration, and IVC perforation; (3) most retrievable IVC filters are placed for temporary protection, but for a variety of reasons they are not removed in any more than half of implanted patients, and when removal is attempted, the procedure is not always successful even with advanced techniques; and (4) analysis of Medicare hospital data suggests that payment for the retrieval procedure does not routinely compensate for expense. The Sentry device is not intended for removal after bioconversion. In initial clinical use, complications have been limited. Long-term results for the Sentry bioconvertible IVC filter are anticipated soon

The development of air shower in the iron absorber

The iron open-sandwich experiments to observe one dimensional development of individual air showers were carried out at Akeno Observatory. One dimensional energy flow, incident energy and production height of shower is estimated using the data of size and age obtained from the above experiment and simple calculation

The Annual Cycle of SST in the Eastern Tropical Pacific, Diagnosed in an Ocean GCM

The annual onset of the east Pacific cold tongue is diagnosed in an ocean GCM simulation of the tropical Pacific. The model uses a mixed-layer scheme that explicitly simulates the processes of vertical exchange of heat and momentum with the deeper layers of the ocean; comparison with observations of temperature and currents shows that many important aspects of the model fields are realistic. As previous studies have found, the heat balance in the eastern tropical Pacific is notoriously complicated, and virtually every term in the balance plays a significant role at one time or another. However, despite many complications, the three-dimensional ocean advection terms in the cold tongue region tend to cancel each other in the annual cycle and, to first order, the variation of SST can be described as simply following the variation of net solar radiation at the sea surface (sun minus clouds). The cancellation is primarily between cooling due to equatorial upwelling and warming due to tropical instability waves, both of which are strongest in the second half of the year (when the winds are stronger). Even near the equator, where the ocean advection is relatively intense, the terms associated with cloudiness variations are among the largest contributions to the SST balance. The annual cycle of cloudiness transforms the semiannual solar cycle at the top of the atmosphere into a largely 1 cycle yr−1 variation of insolation at the sea surface. However, the annual cycle of cloudiness appears closely tied to SST in coupled feedbacks (positive for low stratus decks and negative for deep cumulus convection), so the annual cycle of SST cannot be fully diagnosed in an ocean-only modeling context as in the present study. Zonal advection was found to be a relatively small influence on annual equatorial cold tongue variations; in particular, there was little direct (oceanic) connection between the Peru coastal upwelling and equatorial annual cycles. Meridional advection driven by cross-equatorial winds has been conjectured as a key factor leading to the onset of the cold tongue. The results suggest that the SST changes due to this mechanism are modest, and if meridional advection is in fact a major influence, then it must be through interaction with another process (such as a coupled feedback with stratus cloudiness). At present, it is not possible to evaluate this feedback quantitatively

Application of thermoluminescence for detection of cascade shower 1: Hardware and software of reader system

A reader system for the detection of cascade showers via luminescence induced by heating sensitive material (BaSO4:Eu) is developed. The reader system is composed of following six instruments: (1) heater, (2) light guide, (3) image intensifier, (4) CCD camera, (5) image processor, (6) microcomputer. The efficiency of these apparatuses and software application for image analysis is reported

Application of thermoluminescence for detection of cascade shower 2: Detection of cosmic ray cascade shower at Mount Fuji

The results of a thermoluminescence (TL) chamber exposed at Mt. Fuji during Aug. '83 - Aug. '84 are reported. The TL signal induced by cosmic ray shower is detected and compared with the spot darkness of X-ray film exposed at the same time

Comparison of absolute intensity between EAS with gamma-families and general EAS at Mount Norikura

Gamma-families with total energy greater than 10 TeV, found in the EX chamber which was cooperated with the EAS array were combined with EAS triggered by big bursts. The absolute intensity of the size spectrum of these combined EAS was compared with that of general EAS obtained by AS trigger. The EAS with sizes greater than 2x1 million were always accompanied by gamma-families with sigma E sub gamma H 10 TeV, n sub gamma, H 2 and Emin=3 TeV, although the rate of EAS accompaning such gamma-families decreases rapidly as their sizes decrease

Cash Transfers, Early Marriage, and Fertility in Malawi and Zambia

There is increasing interest in the ability of cash transfers to facilitate safe transitions to adulthood in low-income settings; however, evidence from scaled-up government programming demonstrating this potential is scarce. Using two experimental evaluations of unconditional cash transfers targeted to ultra-poor and labor-constrained households over approximately three years in Malawi and Zambia, we examine whether cash transfers delayed early marriage and pregnancy among youth aged 14 to 21 years at baseline. Although we find strong impacts on poverty and schooling, two main pathways hypothesized in the literature, we find limited impacts on safe transition outcomes for both males and females. In addition, despite hypotheses that social norms may constrain potential impacts of cash transfer programs, we show suggestive evidence that pre-program variation in social norms across communities does not significantly affect program impact. We conclude with policy implications and suggestions for future research

Observation of direct hadronic pairs in nucleus-nucleus collisions in JACEE emulsion chambers

In a number of high energy ( or = 1 TeV/amu) nucleus-nucleus collisions observed in Japanese-American Cooperative Emulsion Experiment (JACEE) emulsion chambers, nonrandom spatial association of produced charged particles, mostly hadronic pairs, are observed. Similar narrow pairs are observed in about 100 events at much low energy (20 to 60 GeV/amu). Analysis shows that 30 to 50% of Pair abundances are understood by the Hambury-Brown-Twiss effect, and the remainder seems to require other explanations

Heavy nucleus collisions between 20 and 60 GeV/nucleon

Interest in studying relativistic nucleus-nucleus interations arises from the fact that they offer an opportunity to probe nuclear matter at high density and temperature. It is expected that under such extreme conditions a transition from hadronic matter into quark-gluon plasma occurs and that in the interactions of highly relativistic nuclei such conditions are created. Cosmic rays remain a unique source of high energy heavy nuclei. The Japanese-American Cooperative Emulsion Experiment (JACEE-3) was designed to study the collisions of heavy cosmic ray nuclei with different nuclear targets at energies beyond 20 GeV/nucleon. JACEE-3 experiment was carried out using a combined electronic counters and an emulsion chamber detector, which was exposed to the cosmic rays on a balloon at an altitude of 5 g/sq cm