30,500 research outputs found
Criteria for generalized macroscopic and mesoscopic quantum coherence
We consider macroscopic, mesoscopic and "S-scopic" quantum superpositions of
eigenstates of an observable, and develop some signatures for their existence.
We define the extent, or size of a superposition, with respect to an
observable \hat{x}, as being the range of outcomes of \hat{x} predicted by that
superposition. Such superpositions are referred to as generalized -scopic
superpositions to distinguish them from the extreme superpositions that
superpose only the two states that have a difference in their prediction
for the observable. We also consider generalized -scopic superpositions of
coherent states. We explore the constraints that are placed on the statistics
if we suppose a system to be described by mixtures of superpositions that are
restricted in size. In this way we arrive at experimental criteria that are
sufficient to deduce the existence of a generalized -scopic superposition.
The signatures developed are useful where one is able to demonstrate a degree
of squeezing. We also discuss how the signatures enable a new type of
Einstein-Podolsky-Rosen gedanken experiment.Comment: 15 pages, accepted for publication in Phys. Rev.
Validation of a bovine rectal palpation simulator for training veterinary students
No abstract available
Dynamical preparation of EPR entanglement in two-well Bose-Einstein condensates
We propose to generate Einstein-Podolsky-Rosen (EPR) entanglement between
groups of atoms in a two-well Bose-Einstein condensate using a dynamical
process similar to that employed in quantum optics. The local nonlinear S-wave
scattering interaction has the effect of creating a spin squeezing at each
well, while the tunneling, analogous to a beam splitter in optics, introduces
an interference between these fields that results in an inter-well
entanglement. We consider two internal modes at each well, so that the
entanglement can be detected by measuring a reduction in the variances of the
sums of local Schwinger spin observables. As is typical of continuous variable
(CV) entanglement, the entanglement is predicted to increase with atom number,
and becomes sufficiently strong at higher numbers of atoms that the EPR paradox
and steering non-locality can be realized. The entanglement is predicted using
an analytical approach and, for larger atom numbers, stochastic simulations
based on truncated Wigner function. We find generally that strong tunnelling is
favourable, and that entanglement persists and is even enhanced in the presence
of realistic nonlinear losses.Comment: 15 pages, 19 figure
Tripartite entanglement from interlinked parametric interactions
We examine the tripartite entanglement properties of an optical system using
interlinked interactions, recently studied experimentally in terms
of its phase-matching properties by Bondani et al [M. Bondani, A. Allevi, E.
Gevinti, A. Agliati, and A. Andreoni, arXiv:quant-ph/0604002.]. We show that
the system does produce output modes which are genuinely tripartite entangled
and that detection of this entanglement depends crucially on the correlation
functions which are measured, with a three-mode Einstein-Podolsky-Rosen
inequality being the most sensitive.Comment: 15 pages, 5 figure
Unified criteria for multipartite quantum nonlocality
Wiseman and co-workers (Phys. Rev. Lett. 98, 140402, 2007) proposed a
distinction between the nonlocality classes of Bell's nonlocality, steering and
entanglement based on whether or not an overseer trusts each party in a
bipartite scenario where they are asked to demonstrate entanglement. Here we
extend that concept to the multipartite case and derive inequalities that
progressively test for those classes of nonlocality, with different thresholds
for each level. This framework includes the three classes of nonlocality above
in special cases and introduces a family of others.Comment: V2: corrected image display; V3: substantial changes including new
proofs, arguments, and result
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Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver.
We administered an adenoviral vector, Onyx-015, into the hepatic artery of patients with metastatic colorectal cancer involving the liver. Thirty-five patients enrolled in this multi-institutional phase I/II trial received up to eight arterial infusions of up to 2 x 10(12) viral particles. Hepatic toxicity was the primary dose-limiting toxicity observed in preclinical models. However, nearly 200 infusions of this adenoviral vector were administered directly into the hepatic artery without significant toxicity. Therefore, we undertook this analysis to determine the impact of repeated adenoviral exposure on hepatic function. Seventeen patients were treated at our institution, providing a detailed data set on the changes in hepatic function following repeated exposure to adenovirus. No changes in hepatic function occurred with the first treatment of Onyx-015 among these patients. Transient increases in transaminase levels occurred in one patient starting with the second infusion and transient increases in bilirubin was observed in two patients starting with the fifth treatment. These changes occurred too early to be explained by viral-mediated lysis of hepatocytes. In addition, viremia was observed starting 3-5 days after the viral infusion in half of the patient, but was not associated with hepatic toxicity. To further understand the basis for the minimal hepatic toxicity of adenoviral vectors, we evaluated the replication of adenovirus in primary hepatocytes and tumor cells in culture and the expression of the coxsackie-adenoviral receptor (CAR) in normal liver and colon cancer metastatic to the liver. We found that adenovirus replicates poorly in primary hepatocytes but replicates efficiently in tumors including tumors derived from hepatocytes. In addition, we found that CAR is localized at junctions between hepatocytes and is inaccessible to hepatic blood flow. CAR is not expressed on tumor vasculature but is expressed on tumor cells. Spatial restriction of CAR to the intercellular space in normal liver and diminished replication of adenovirus in hepatocytes may explain the minimal toxicity observed following repeated hepatic artery infusions with Onyx-015
Bell inequalities for continuous-variable correlations
We derive a new class of correlation Bell-type inequalities. The inequalities
are valid for any number of outcomes of two observables per each of n parties,
including continuous and unbounded observables. We show that there are no
first-moment correlation Bell inequalities for that scenario, but such
inequalities can be found if one considers at least second moments. The
derivation stems from a simple variance inequality by setting local commutators
to zero. We show that above a constant detector efficiency threshold, the
continuous variable Bell violation can survive even in the macroscopic limit of
large n. This method can be used to derive other well-known Bell inequalities,
shedding new light on the importance of non-commutativity for violations of
local realism.Comment: 4 pages, 1 figure. v2: New results on detector efficiencies and
macroscopic limit, new co-author, changed title and abstract, changed figure,
added journal reference and DO
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