SENTENTIA MITIOR E LIMITI DEL DECISUM: UN CONFINE INVALICABILE?

This thesis focus on the possibility to review a final conviction upon a new and more favorable judicial interpretation. The work begins with the analysis of an Italian case law, which put the problem of the retroactivity of the judicial interpretation in the middle of the scientific and judicial debate. In particular, the case was related to the abolition of the crime of omission of the exhibition of the documents by a foreign person. In this case, both the Constitutional Court and the Court of Cassation dealt with the problem of the retroactivity of a new judicial interpretation, adopting two very different models: one based on the acknowledgment of the judicial law-making; the other one based on the assumption that only the Parliament can abolish a crime. So that, according to the first model, it would be always impossible to review a final conviction upon a new judicial interpretation; on the other hand, according to the second model, it would be possible to reverse a final decision only if the judge didn't expressly consider that question of law (with which the new interpretation is related). Therefore, in both the cases, the Italian jurisprudence admits the possibility to execute the sentence for a fact which is considered no longer a crime. The Author tries to follow a third path, based on the assumption that the jurisprudence is not a source of law, but it can change its interpretation in order to correct a former one and to reaffirm the Parliament willingness

Near Infrared Spectroscopy to Assess Feeding Value and Antinutritional Compounds in Legume Species

There is an increasing demand for information on the quality characteristics and chemical composition of forages in order to meet the demands of dietary specifications for feeding animals. Near Infrared (NIR) spectroscopy provides a tool for rapid and non-destructive analysis in agronomic and breeding programs of a number of chemical components of forages and grains. NIR spectroscopy in particular has the advantage of being able to simultaneously evaluate the samples for a number of qualitative traits of whole plants and seeds. In two experiments here presented, NIR Spectroscopy was used to predict: i) qualitative characteristics of field pea seeds and, as regards secondary metabolites responsible of detrimental or beneficial effects on animal nutrition ii) condensed tannins in legume forages, based on calibration sets of samples previously chemically analysed

Mito-nuclear genetic comparison in a Wolbachia infected weevil: insights on reproductive mode, infection age and evolutionary forces shaping genetic variation

<p>Abstract</p> <p>Background</p> <p>Maternally inherited endosymbionts like <it>Wolbachia pipientis </it>are in linkage disequilibrium with the mtDNA of their hosts. Therefore, they can induce selective sweeps, decreasing genetic diversity over many generations. This sex ratio distorter, that is involved in the origin of parthenogenesis and other reproductive alterations, infects the parthenogenetic weevil <it>Naupactus cervinus</it>, a serious pest of ornamental and fruit plants.</p> <p>Results</p> <p>Molecular evolution analyses of mitochondrial (<it>COI</it>) and nuclear (<it>ITS1</it>) sequences from 309 individuals of <it>Naupactus cervinus </it>sampled over a broad range of its geographical distribution were carried out. Our results demonstrate lack of recombination in the nuclear fragment, non-random association between nuclear and mitochondrial genomes and the consequent coevolution of both genomes, being an indirect evidence of apomixis. This weevil is infected by a single <it>Wolbachia </it>strain, which could have caused a moderate bottleneck in the invaded population which survived the initial infection.</p> <p>Conclusions</p> <p>Clonal reproduction and <it>Wolbachia </it>infection induce the coevolution of bacterial, mitochondrial and nuclear genomes. The time elapsed since the <it>Wolbachia </it>invasion would have erased the traces of the demographic crash in the mtDNA, being the nuclear genome the only one that retained the signal of the bottleneck. The amount of genetic change accumulated in the mtDNA and the high prevalence of <it>Wolbachia </it>in all populations of <it>N. cervinus </it>agree with the hypothesis of an ancient infection. <it>Wolbachia </it>probably had great influence in shaping the genetic diversity of <it>N. cervinus</it>. However, it would have not caused the extinction of males, since sexual and asexual infected lineages coexisted until recent times.</p

Exon 3 of the NUMB Gene Emerged in the Chordate Lineage Coopting the NUMB Protein to the Regulation of MDM2

MDM2 regulates a variety of cellular processes through its dual protein:protein interaction and ubiquitin ligase activities. One major function of MDM2 is to bind and ubiquitinate P53, thereby regulating its proteasomal degradation. This function is in turn controlled by the cell fate determinant NUMB, which binds to and inhibits MDM2 via a short stretch of 11 amino acids, contained in its phosphotyrosine-binding (PTB) domain, encoded by exon 3 of the NUMB gene. The NUMB-MDM2-P53 circuitry is relevant to the specification of the stem cell fate and its subversion has been shown to be causal in breast cancer leading to the emergence of cancer stem cells. While extensive work on the evolutionary aspects of the MDM2/P53 circuitry has provided hints as to how these two proteins have evolved together to maintain conserved and linked functions, little is known about the evolution of the NUMB gene and, in particular, how it developed the ability to regulate MDM2 function. Here, we show that NUMB is a metazoan gene, which acquired exon 3 in the common ancestor of the Chordate lineage, first being present in the Cephalochordate and Tunicate subphyla, but absent in invertebrates. We provide experimental evidence showing that since its emergence, exon 3 conferred to the PTB domain of NUMB the ability to bind and to regulate MDM2 functions

Host-Based Treatments for Severe COVID-19

COVID-19 has been a global health problem since 2020. There are different spectrums of manifestation of this disease, ranging from asymptomatic to extremely severe forms requiring admission to intensive care units and life-support therapies, mainly due to severe pneumonia. The progressive understanding of this disease has allowed researchers and clinicians to implement different therapeutic alternatives, depending on both the severity of clinical involvement and the causative molecular mechanism that has been progressively explored. In this review, we analysed the main therapeutic options available to date based on modulating the host inflammatory response to SARS-CoV-2 infection in patients with severe and critical illness. Although current guidelines are moving toward a personalised treatment approach titrated on the timing of presentation, disease severity, and laboratory parameters, future research is needed to identify additional biomarkers that can anticipate the disease course and guide targeted interventions on an individual basis

Microvascular Alteration in COVID-19 Documented by Nailfold Capillaroscopy

COVID-19 is a multisystemic disease that mainly affects and causes dysregulation of the endothelium, causing systemic manifestations. A nailfold video capillaroscopy is a safe, easy, and noninvasive method to evaluate microcirculation alteration. In this review, we analyzed the literature available to date regarding the object of nailfold video capillaroscopy (NVC) use in patients with a SARS-CoV-2 infection, both in the acute phase and after discharge. The scientific evidence pointed out the main alterations in capillary circulation shown by NVC, so reviewing the findings of each article allowed us to define and analyze the future prospects and needs for possibly including NVC within the management of patients with COVID-19, both during and after the acute phase

Exploration of virtual body-representation in adolescence : the role of age and sex in avatar customization

The malleable nature of the self led researchers to investigate the meaning of virtual identity by exploring virtual self-representation through avatars and its association with users\u2019 identity. The present study aims to investigate the changes in virtual body-representation in adolescence related to age levels and sex and the association with adolescents\u2019 self-esteem and body esteem. Anthropometric features, body esteem and self-esteem were used to assess adolescents\u2019 body image and identity. The scoring code of the \u201cDrawing Me\u201d graphical test was used to evaluate the avatars. The sample is composed of 63 adolescents of different ages\u2014early, middle and late adolescence\u2014balanced by sex. Results show that the creation of a digital avatar changes with age and is partially associated with adolescents\u2019 perceptions in terms of body esteem and self-esteem. Moreover, the creation of avatars occurs differently for boys, who enrich their avatars with many sexual features, than for girls, who prefer to detail their avatars\u2019 clothing to enrich them. Critical reflections and implications for psychological interventions that may use avatars to investigate adolescents\u2019 identity in integration with other tools will be discussed

Functional Progression after Dose Suspension or Discontinuation of Nintedanib in Idiopathic Pulmonary Fibrosis: A Real-Life Multicentre Study

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with rapidly progressive evolution and an unfavorable outcome. Nintedanib (NTD) is an antifibrotic drug that has been shown to be effective in slowing down the progression of the disease. The aim of our study was to examine the efficacy, especially in terms of the functional decline, and the safety profile of NTD in patients treated with the recommended dose and subjects who reduced or suspended the therapy due to the occurrence of adverse reactions. Methods: We conducted a real-life retrospective study based on the experience of NTD use in two centers between 2015 and 2022. Clinical data were evaluated at baseline, at 6 and 12 months after the NTD introduction in the whole population and in subgroups of patients who continued the full-dose treatment, at a reduced dosage, and at the discontinuation of treatment. The following data were recorded: the demographic features, IPF clinical features, NTD therapeutic dosage, tolerability and adverse events, pulmonary function tests (PFTs), the duration of treatment upon discontinuation, and the causes of interruption. Results: There were 54 IPF patients who were included (29.6% females, with a median (IQR) age at baseline of 75 (69.0-79.0) years). Twelve months after the introduction of the NTD therapy, 20 (37%) patients were still taking the full dose, 11 (20.4%) had reduced it to 200 mg daily, and 15 (27.8%) had stopped treatment. Gastrointestinal intolerance predominantly led to the dose reduction (13.0%) and treatment cessation (20.4%). There were two deaths within the initial 6 months (3.7%) and seven (13.0%) within 12 months. Compared to the baseline, the results of the PFTs remained stable at 6 and 12 months for the entire NTD-treated population, except for a significant decline in the DLCO (% predicted value) at both 6 (38.0 ± 17.8 vs. 43.0 ± 26.0; p = 0.041) and 12 months (41.5 ± 15.3 vs. 44.0 ± 26.8; p = 0.048). The patients who continued treatment at the full dose or a reduced dosage showed no significant differences in the FVC and the DLCO at 12 months. Conversely, those discontinuing the NTD exhibited a statistically significant decline in the FVC (% predicted value) at 12 months compared to the baseline (55.0 ± 13.5 vs. 70.0 ± 23.0; p = 0.035). Conclusions: This study highlights the functional decline of the FVC at 12 months after the NTD initiation among patients discontinuing therapy but not among those reducing their dosage

Prediction of the chemical composition and nutritive value of lucerne (Medicago sativa L.) by Near Infrared Spectroscopy

Lucerne is a low input energy efficient crop that improves soil fertility, and its importance is rising with the increase of public interest in sustainable agriculture. Furthermore, it occupies a significant economic position in the animal feed market (i.e. hay, dehydrated forage, pellets and silage products) and deserves a particular interest in the Parmigiano-Reggiano and Grana Padano cheese production areas of Northern Italy (Torricelli et al., 2000)