A new clinical tool for assessing numerical abilities in neurological diseases: numerical activities of daily living

The aim of this study was to build an instrument, the numerical activities of daily living (NADL), designed to identify the specific impairments in numerical functions that may cause problems in everyday life. These impairments go beyond what can be inferred from the available scales evaluating activities of daily living in general, and are not adequately captured by measures of the general deterioration of cognitive functions as assessed by standard clinical instruments like the MMSE and MoCA. We assessed a control group (n = 148) and a patient group affected by a wide variety of neurological conditions (n = 175), with NADL along with IADL, MMSE, and MoCA. The NADL battery was found to have satisfactory construct validity and reliability, across a wide age range. This enabled us to calculate appropriate criteria for impairment that took into account age and education. It was found that neurological patients tended to overestimate their abilities as compared to the judgment made by their caregivers, assessed with objective tests of numerical abilities

Physical origin of the power-law tailed statistical distributions

Starting from the BBGKY hierarchy, describing the kinetics of nonlinear particle system, we obtain the relevant entropy and stationary distribution function. Subsequently, by employing the Lorentz transformations we propose the relativistic generalization of the exponential and logarithmic functions. The related particle distribution and entropy represents the relativistic extension of the classical Maxwell-Boltzmann distribution and of the Boltzmann entropy respectively and define the statistical mechanics presented in [Phys. Rev. E {\bf 66}, 056125 (2002)] and [Phys. Rev. E {\bf 72}, 036108 (2005). The achievements of the present effort, support the idea that the experimentally observed power law tailed statistical distributions in plasma physics, are enforced by the relativistic microscopic particle dynamics.Comment: 6 pages. arXiv admin note: substantial text overlap with arXiv:1110.3944, arXiv:1012.390

Relativistic coupled-cluster calculations of 20^{20}Ne, 40^{40}Ar, 84^{84}Kr and 129^{129}Xe: correlation energies and dipole polarizabilities

We have carried out a detailed and systematic study of the correlation energies of inert gas atoms Ne, Ar, Kr and Xe using relativistic many-body perturbation theory and relativistic coupled-cluster theory. In the relativistic coupled-cluster calculations, we implement perturbative triples and include these in the correlation energy calculations. We then calculate the dipole polarizability of the ground states using perturbed coupled-cluster theory.Comment: 10 figures, 6 tables, submitted to PR

Comparative fragility methods for seismic assessment of masonry buildings located in Muccia (Italy)

The current paper focuses on a sector of the historic centre of Muccia, in the district of Macerata (Italy), affected by the seismic sequence that involved Central Italy in 2016. The main goal is comparison, in terms of fragility curves, among two vulnerability assessment methodologies (empirical and mechanical). The study area has been structurally and typologically identified according to the Building Typology Matrix (BTM). Physical vulnerability analysis of the urban-sector was performed through application of an index-based method, specifically for masonry building aggregates. An isolated masonry building, damaged after the seismic sequences, has been selected as a case study. For the assessed building, empirical fragility curves are presented according to Guagenti & Petrini’s correlation law. Furthermore, a numerical model has been set up by using the macro-element approach, which has allowed to perform non-linear static analyses. Mechanical properties of masonry were defined according to the New Technical Codes for Constructions (NTC18), assuming a limited knowledge level (LC1). Refined mechanical fragility functions have been derived and compared to the empirical ones. Analysis results have shown that the empirical method tends to overestimate by 5% and 10% the expected damage for slight and moderate thresholds. For PGA values greater than 0,3 g the damage levels decreased by 30% and 20%, with reference to the near collapse and collapse conditions, respectively

Numerical model upgrading of a historical masonry building damaged during the 2016 Italian earthquakes: the case study of the Podestà palace in Montelupone (Italy)

In October 2016, two major earthquakes occurred in Marche region in the Centre of Italy, causing widespread damage. The epicentre of the second one struck Norcia, Visso and Accumoli and a lot of damages to cultural heritage were done in the cities of Tolentino, San Severino, Camerino, Matelica, Macerata and Montelupone, where are located the Podesta` Palace and the Civic Tower investigated in this paper. The main aim of this research is the determination of modal properties of these historical masonry constructions using experimental and numerical studies. The experimental analysis was based on ambient vibration survey, while numerical analysis was based on finite element analysis with solid elements. The results of the experimental study were used to tune the numerical model of the structure. As the most doubtful parameters, the modulus of elasticity of the masonry and the interaction among structural parts were adjusted to achieve the experimental results with numerical model by simple operations. Obtaining good consistency between the experimental and numerical analyses, the study revealed the actual dynamic properties of the damaged palace

Src family kinases as therapeutic targets in advanced solid tumors. What we have learned so far

Src is the prototypal member of Src Family tyrosine Kinases (SFKs), a large non-receptor kinase class that controls multiple signaling pathways in animal cells. SFKs activation is necessary for the mitogenic signal from many growth factors, but also for the acquisition of migratory and invasive phenotype. Indeed, oncogenic activation of SFKs has been demonstrated to play an important role in solid cancers; promoting tumor growth and formation of distant metastases. Several drugs targeting SFKs have been developed and tested in preclinical models and many of them have successfully reached clinical use in hematologic cancers. Although in solid tumors SFKs inhibitors have consistently confirmed their ability in blocking cancer cell progression in several experimental models; their utilization in clinical trials has unveiled unexpected complications against an effective utilization in patients. In this review, we summarize basic molecular mechanisms involving SFKs in cancer spreading and metastasization; and discuss preclinical and clinical data highlighting the main challenges for their future application as therapeutic targets in solid cancer progression

Modal parameters identification with environmental tests and advanced numerical analyses for masonry bell towers: a meaningful case study

Abstract In the first part, a dynamic monitoring for non-destructive evaluation of heritage structures is discussed with reference to a case study, namely the Pomposa Abbey belfry, located in the Ferrara Province (Italy). The main dynamic parameters constitute an important reference to define an advanced numerical model, discussed in the second part, based on Non-Smooth Contact Dynamics (NSCD) method. Schematised as a system of rigid blocks undergoing frictional sliding and plastic impacts, the tower has exhibited complex dynamics, because of both geometrical nonlinearity and the non-smooth nature of the contact laws. First, harmonic oscillations have been applied to the basement of the tower and a systematic parametric study has been conducted, aimed at correlating the system vulnerability to the values of amplitude and frequency of the assigned excitation corroborated by the dynamic identification results. In addition, numerical analyses have been done to highlight the effects of the friction coefficient and of the blocks geometries on the dynamics, in particular on the collapse modes. Finally, a study of the tower stability against seismic excitations has been addressed and 3D simulations have been performed with a real earthquake

Factors influencing on Job decision of Management Undergraduates in North and East Universities of Sri Lanka

This paper attempts to investigate the preferences on taking the decision of Job and to find out the factors influencing on Job decision of the management undergraduate in North and East Universities of Sri Lanka. A closed ended questionnaire was developed as tool for data collection. A total number of 400 third and final year management students from 3 Universities and 2 Campuses located in North and East of Sri Lanka have been responded to the questionnaire. The quantitative analyses were conducted with the help of SPSS. The result reveals that majority of the respondents’ preferred for future career developments are public sector and private sector organizations. One third of the total respondents plan to seek employment in their chosen field specially after obtaining the bachelor's degree. Further Salary, interesting job, job security and educational opportunity are the major factors for the management graduates in Job decision. Keywords: Job decision, Management, Undergraduate, Universit