A thorough dynamic interpretation of residual dipolar couplings in ubiquitin.

dipolar couplings (rdcs), ubiquitin The presence of slow motions with large amplitudes, as detected by measurements based on residual dipola

T−μT {-} \mu quark matter phase transitions and critical end point in nonlocal PNJL models

We study the $T {-} {\mu}$ phase diagram of quark matter under the influence of a strong uniform magnetic field in the framework of a nonlocal extension of the Polyakov Nambu Jona Lasinio model (PNJL). The existence of a critical end point (CEP) is found for the whole considered range of the magnetic field (up to 1 $GeV^{2}$). We analyze the location of this CEP as a function of the external field and discuss the presence of inverse magnetic catalysis for nonzero chemical potentials. Our results show that the temperature of the CEP decreases with the magnetic field, in contrast to the behavior observed in local NJL/PNJL models

Infrared Thermography to an Aluminium Foam Sandwich Structure Subjected to Low Velocity Impact Tests

Abstract This work is the straightforward continuation of previous ones in which vibro-acoustic characteristics of AFS panels were investigated both numerically and experimentally. Herein, the use of infrared thermography (IRT) is exploited to investigate impact damaging of an aluminium foam sandwich panel by monitoring its surface, opposite to the impact, during a low velocity impact test, which is performed with a modified Charpy pendulum. Thermal images, acquired in time sequence during the impact by the infrared camera, are post-processed to get information useful for understanding absorption capabilities and impact damaging mechanisms of this kind of structure

Vandetanib for the Treatment of Metastatic Medullary Thyroid Cancer

Medullary thyroid cancer (MTC) represents an aggressive form of thyroid malignancy. Some may occur spontaneously or can be associated with Multiple Endocrine Neoplasia syndromes, or Familial Medullary Thyroid Cancer syndrome. In these patients, the protooncogene RET (rearranged during transfection) is mutated. In patients who have unresectable or metastatic disease, the long term prognosis is poor. New treatments for this disease have focused on the use of targeted agents that inhibit the receptor tyrosine kinase of RET. One of these treatments, Vandetanib (Caprelsa, Astra Zeneca), recently has received approval from the Food and Drug Administration for the treatment of patients with progressive locally advanced and/or metastatic disease. This review highlights the studies that led to the drug’s approval, and discusses on the potential financial costs of treatment and side effects of this therapy. The main clinical studies evaluating Vandetanib for the treatment of other solid tumors will also be reviewed