18 research outputs found
Pilot in Vivo Structure–Activity Relationship of Dihydromethysticin in Blocking 4‑(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced <i>O</i><sup>6</sup>‑Methylguanine and Lung Tumor in A/J Mice
No full text(+)-Dihydromethysticin was recently
identified as a promising lung
cancer chemopreventive agent, while (+)-dihydrokavain was completely
ineffective. A pilot in vivo structure–activity relationship
(SAR) was explored, evaluating the efficacy of its analogs in blocking
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced short-term <i>O</i><sup>6</sup>-methylguanine and long-term adenoma formation
in the lung tissues in A/J mice. Both results revealed cohesive SARs,
demonstrating that the methylenedioxy functional group in DHM is essential
while the lactone functional group tolerates modifications
Kava Blocks 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone–Induced Lung Tumorigenesis in Association with Reducing O 6
No full textDietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification
No full textAN EVALUATION OF INVENTORY MANAGEMENT AND PERFORMANCE IN INDIAN MACHINE TOOL SMEs: AN EXPLORATORY STUDY
No full textRapid Identification of Keap1–Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search
No full textSpin orbit torques and Dzyaloshinskii-Moriya interaction in dual-interfaced Co-Ni multilayers
No full text
Polarity-tunable magnetic tunnel junctions based on ferromagnetism at oxide heterointerfaces
No full textDihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice
No full textA new spin for oxide interfaces
No full textInternational audienceThe variety of emergent phenomena occurring at oxide interfaces has made these systems the focus of intense study in recent years. We argue that spin–orbit effects in oxide interfaces provide a versatile handle to generate, control and convert spin currents, with a view towards low-power spintronic
