2,223 research outputs found
Trust and control interrelations: New perspectives on the trust control nexus
This article is the post-print version of the published article that may be accessed at the link below. Copyright @ 2007 Sage Publications.This article introduces the special issue on New Perspectives on the Trust-Control Nexus in Organizational Relations. Trust and control are interlinked processes commonly seen as key to reach effectiveness in inter- and intraorganizational relations. The relation between trust and control is, however, a complex one, and research into this relation has given rise to various and contradictory interpretations of how trust and control relate. A well-known discussion is directed at whether trust and control are better conceived as substitutes, or as complementary mechanisms of governance. The articles in this special issue bring the discussion on the relationship between both concepts a step further by identifying common factors, distinctive mechanisms, and key implications relevant for theory building and empirical research. By studying trust and control through different perspectives and at different levels of analysis, the articles provide new theoretical insights and empirical evidence on the foundations of the trust-control interrelations
ASCORE: an up-to-date cardiovascular risk score for hypertensive patients reflecting contemporary clinical practice developed using the (ASCOT-BPLA) trial data.
A number of risk scores already exist to predict cardiovascular (CV) events. However, scores developed with data collected some time ago might not accurately predict the CV risk of contemporary hypertensive patients that benefit from more modern treatments and management. Using data from the randomised clinical trial Anglo-Scandinavian Cardiac Outcomes Trial-BPLA, with 15 955 hypertensive patients without previous CV disease receiving contemporary preventive CV management, we developed a new risk score predicting the 5-year risk of a first CV event (CV death, myocardial infarction or stroke). Cox proportional hazard models were used to develop a risk equation from baseline predictors. The final risk model (ASCORE) included age, sex, smoking, diabetes, previous blood pressure (BP) treatment, systolic BP, total cholesterol, high-density lipoprotein-cholesterol, fasting glucose and creatinine baseline variables. A simplified model (ASCORE-S) excluding laboratory variables was also derived. Both models showed very good internal validity. User-friendly integer score tables are reported for both models. Applying the latest Framingham risk score to our data significantly overpredicted the observed 5-year risk of the composite CV outcome. We conclude that risk scores derived using older databases (such as Framingham) may overestimate the CV risk of patients receiving current BP treatments; therefore, 'updated' risk scores are needed for current patients
The epidemiology of patellar luxation in dogs attending primary-care veterinary practices in England
Correlates of Complete Childhood Vaccination in East African Countries.
Despite the benefits of childhood vaccinations, vaccination rates in low-income countries (LICs) vary widely. Increasing coverage of vaccines to 90% in the poorest countries over the next 10 years has been estimated to prevent 426 million cases of illness and avert nearly 6.4 million childhood deaths worldwide. Consequently, we sought to provide a comprehensive examination of contemporary vaccination patterns in East Africa and to identify common and country-specific barriers to complete childhood vaccination. Using data from the Demographic and Health Surveys (DHS) for Burundi, Ethiopia, Kenya, Rwanda, Tanzania, and Uganda, we looked at the prevalence of complete vaccination for polio, measles, Bacillus Calmette-Guérin (BCG) and DTwPHibHep (DTP) as recommended by the WHO among children ages 12 to 23 months. We conducted multivariable logistic regression within each country to estimate associations between complete vaccination status and health care access and sociodemographic variables using backwards stepwise regression. Vaccination varied significantly by country. In all countries, the majority of children received at least one dose of a WHO recommended vaccine; however, in Ethiopia, Tanzania, and Uganda less than 50% of children received a complete schedule of recommended vaccines. Being delivered in a public or private institution compared with being delivered at home was associated with increased odds of complete vaccination status. Sociodemographic covariates were not consistently associated with complete vaccination status across countries. Although no consistent set of predictors accounted for complete vaccination status, we observed differences based on region and the location of delivery. These differences point to the need to examine the historical, political, and economic context of each country in order to maximize vaccination coverage. Vaccination against these childhood diseases is a critical step towards reaching the Millennium Development Goal of reducing under-five mortality by two-thirds by 2015 and thus should be a global priority
Low-lying level structure of Cu and its implications on the rp process
The low-lying energy levels of proton-rich Cu have been extracted
using in-beam -ray spectroscopy with the state-of-the-art -ray
tracking array GRETINA in conjunction with the S800 spectrograph at the
National Superconducting Cyclotron Laboratory at Michigan State University.
Excited states in Cu serve as resonances in the
Ni(p,)Cu reaction, which is a part of the rp-process in
type I x-ray bursts. To resolve existing ambiguities in the reaction Q-value, a
more localized IMME mass fit is used resulting in ~keV. We derive
the first experimentally-constrained thermonuclear reaction rate for
Ni(p,)Cu. We find that, with this new rate, the
rp-process may bypass the Ni waiting point via the Ni(p,)
reaction for typical x-ray burst conditions with a branching of up to
40. We also identify additional nuclear physics uncertainties that
need to be addressed before drawing final conclusions about the rp-process
reaction flow in the Ni region.Comment: 8 pages, accepted for Phys. Rev.
Half Life of the Doubly-magic r-Process Nucleus 78Ni
Nuclei with magic numbers serve as important benchmarks in nuclear theory. In
addition, neutron-rich nuclei play an important role in the astrophysical rapid
neutron-capture process (r-process). 78Ni is the only doubly-magic nucleus that
is also an important waiting point in the r-process, and serves as a major
bottleneck in the synthesis of heavier elements. The half-life of 78Ni has been
experimentally deduced for the first time at the Coupled Cyclotron Facility of
the National Superconducting Cyclotron Laboratory at Michigan State University,
and was found to be 110 (+100 -60) ms. In the same experiment, a first
half-life was deduced for 77Ni of 128 (+27 -33) ms, and more precise half-lives
were deduced for 75Ni and 76Ni of 344 (+20 -24) ms and 238 (+15 -18) ms
respectively.Comment: 4 pages, 3 figure
Implications of sperm banking for health-related quality of life up to 1 year after cancer diagnosis.
Sperm banking is recommended for all men diagnosed with cancer where treatment is associated with risk of long-term gonadatoxicity, to offer the opportunity of fatherhood and improved quality of life. However, uptake of sperm banking is lower than expected and little is known about why men refuse. Our aims were to determine: (i) demographic and medical variables associated with decisions about banking and (ii) differences in quality of life between bankers and non-bankers at diagnosis (Time 1 (T1)) and 1 year later (Time 2 (T2))
The XMM Cluster Survey: Evidence for energy injection at high redshift from evolution of the X-ray luminosity-temperature relation
We measure the evolution of the X-ray luminosity-temperature (L_X-T) relation
since z~1.5 using a sample of 211 serendipitously detected galaxy clusters with
spectroscopic redshifts drawn from the XMM Cluster Survey first data release
(XCS-DR1). This is the first study spanning this redshift range using a single,
large, homogeneous cluster sample. Using an orthogonal regression technique, we
find no evidence for evolution in the slope or intrinsic scatter of the
relation since z~1.5, finding both to be consistent with previous measurements
at z~0.1. However, the normalisation is seen to evolve negatively with respect
to the self-similar expectation: we find E(z)^{-1} L_X = 10^{44.67 +/- 0.09}
(T/5)^{3.04 +/- 0.16} (1+z)^{-1.5 +/- 0.5}, which is within 2 sigma of the zero
evolution case. We see milder, but still negative, evolution with respect to
self-similar when using a bisector regression technique. We compare our results
to numerical simulations, where we fit simulated cluster samples using the same
methods used on the XCS data. Our data favour models in which the majority of
the excess entropy required to explain the slope of the L_X-T relation is
injected at high redshift. Simulations in which AGN feedback is implemented
using prescriptions from current semi-analytic galaxy formation models predict
positive evolution of the normalisation, and differ from our data at more than
5 sigma. This suggests that more efficient feedback at high redshift may be
needed in these models.Comment: Accepted for publication in MNRAS; 12 pages, 6 figures; added
references to match published versio
Combining estimates of interest in prognostic modelling studies after multiple imputation: current practice and guidelines
Background: Multiple imputation (MI) provides an effective approach to handle missing covariate
data within prognostic modelling studies, as it can properly account for the missing data
uncertainty. The multiply imputed datasets are each analysed using standard prognostic modelling
techniques to obtain the estimates of interest. The estimates from each imputed dataset are then
combined into one overall estimate and variance, incorporating both the within and between
imputation variability. Rubin's rules for combining these multiply imputed estimates are based on
asymptotic theory. The resulting combined estimates may be more accurate if the posterior
distribution of the population parameter of interest is better approximated by the normal
distribution. However, the normality assumption may not be appropriate for all the parameters of
interest when analysing prognostic modelling studies, such as predicted survival probabilities and
model performance measures.
Methods: Guidelines for combining the estimates of interest when analysing prognostic modelling
studies are provided. A literature review is performed to identify current practice for combining
such estimates in prognostic modelling studies.
Results: Methods for combining all reported estimates after MI were not well reported in the
current literature. Rubin's rules without applying any transformations were the standard approach
used, when any method was stated.
Conclusion: The proposed simple guidelines for combining estimates after MI may lead to a wider
and more appropriate use of MI in future prognostic modelling studies
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