PERENCANAAN KEBUTUHAN MATERIAL (PKM) PADA PRODUKSI KINCIR ANGIN KAPASITAS 100 WATT

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Encapsulation of contrast imaging agents by polypropyleneimine-based dendrimers†

International audiencePolypropyleneimines (PPIs) functionalized by glycerol-based entities are prepared and characterized by diffusion-ordered spectroscopy NMR. Showing low cytotoxicity against MRC5 fibroblasts, their encapsulation capacities of gadolinium complexes was evaluated. T1 measurements were performed to determine the relaxivity of the encapsulated gadopentetate dimeglumine (GdBOPTA) in dendrimers of fourth and fifth generation (GD-PPI-4 and GD-PPI-5). Comparison of the GdBOPTA relaxivity and the relaxivity of GdBOPTA-loaded dendrimers showed a slight increase of the gadolinium chelate relaxivit

The Preparation of New Phosphorus-Centered Functional Groups for Modified Oligonucleotides and Other Natural Phosphates

Efforts to develop synthetic methodologies allowing the preparation of α,α– difluorophosphonothioates, α,α–difluorophosphonodithioates, α,α–difluorophosphono- trithioates, and α,α–difluorophosphinates are reviewed in the light of applications in the field of modified oligonucleotides and cyclitol phosphates. Two successful approaches have been developed, based either on the addition of phosphorus-centered radicals onto gem–difluoroalkenes or on a process involving the addition of lithiodifluorophosphono- thioates 91 onto a ketone and the subsequent deoxygenation reaction of the adduct. The radical route successfully developed a practical route to α,α–difluoro–H–phosphinates which proved to be useful intermediates to a variety of phosphate isosters. The ionic route led to the first preparation of phosphonodifluoromethyl analogues of nucleoside– 3’–phosphates

Research data supporting: Iterative reactions of transient boronic acids enable sequential C-C bond formation

NMR filesThis record supports 'Iterative reactions of transient boronic acids enable sequential C-C bond formation', which has been published in Nature Chemistry.This work was supported by the EPSRC [grant numbers EP/K009494/1 and EP/M004120/1]

Continuum Damage Mechanics—Modelling and Simulation

Continuum damage mechanics elaborates the continuum mechanics-based modelling and simulation of mechanical degradation effects. The objective of this contribution is to briefly review different aspects of continuum damage mechanics of solid continua with a focus on general modelling concepts and application to isotropic as well as anisotropic damage approaches on the one hand, and to discuss possible solution strategies in the context of finite element simulations on the other. In particular, viscous regularisation and gradient-enhanced regularisation—as a reduced form of general non-local theories—are considered. Several numerical examples including ductile damage, i.e. the coupling of damage with plasticity related phenomena, are addressed which show the applicability of the particular modelling and simulation frameworks highlighted