Foix Alajouanine Syndrome Mimicking Longitudinally Extensive Transverse Myelitis

Objective: To describe an interesting case of Foix-Alajouanine Syndrome presenting as a longitudinally extensive transverse myelitis (LETM). Background: Foix-Alajouanine Syndrome is caused by a spinal dural arteriovenous malformation and presents as paraparesis and progressive walking impairment. It most commonly involves the thoracolumbar region and affects elderly men. Though treatable, it is a cause of progressive myelopathy often misdiagnosed or missed. Case Discussion: A 77-year-old man with a history of coronary artery disease presented with a one-year history of progressive lower extremity paresthesia, weakness, gait instability, and recurrent falls. He had no lumbar or lower extremity pain. He had no bladder incontinence. His symptoms were attributed to lumbar spinal stenosis and he underwent L3-L4 lumbar decompression at an outside hospital with no improvement. MRI of the lumbar spine without contrast done at the outside facility was reviewed and it showed an LETM from T8 through the tip of the conus medullaris. MRI of the entire spine was repeated with gadolinium. MRI lumbar spine with gadolinium showed flow voids at the dorsal aspect of T8-T9 consistent with a Type I spinal dural AV fistula. This was confirmed by the spinal angiogram. The patient had a negative MRI brain and cervical spine imaging. The spinal fluid analysis was unremarkable. Aquaporin-4 antibody and anti-MOG antibody tests were negative. He underwent a laminectomy with microsurgical obliteration of the AV fistula and regained 50% of his lower extremity strength within 48 hours of his surgery and continues to improve with physical therapy. Conclusion: Foix-Alajouanine Syndrome should be considered in the differential diagnosis of LETM. It is a reversible cause of progressive myelopathy and needs a careful review of imaging, laboratory data, and clinical findings.https://scholarlycommons.henryford.com/merf2020caserpt/1106/thumbnail.jp

Nonstationary statistical theory for multipactor

[EN] This work presents a new and general approach to the real dynamics of the multipactor process: the nonstationary statistical multipactor theory. The nonstationary theory removes the stationarity assumption of the classical theory and, as a consequence, it is able to adequately model electron exponential growth as well as absorption processes, above and below the multipactor breakdown level. In addition, it considers both double-surface and single-surface interactions constituting a full framework for nonresonant polyphase multipactor analysis. This work formulates the new theory and validates it with numerical and experimental results with excellent agreement. (C) 2010 American Institute of Physics.The authors would like to thank ESA/ESTEC for having funded this research activity through the Contract "Study of High Order Modes and Fringing Fields in Multipactor Effect" (Contract No. 1-5918/08/NL/GLC) and to the Ministerio de Ciencia e Innovacion (Spain) for the support through the "Programa Torres Quevedo" Contract No. PTQ05-02-02759.Anza, S.; Vicente, C.; Gil, J.; Boria Esbert, VE.; Gimeno, B.; Raboso, D. (2010). Nonstationary statistical theory for multipactor. Physics of Plasmas. 17(6):1-11. https://doi.org/10.1063/1.3443128S111176Farnsworth, P. T. (1934). Television by electron image scanning. Journal of the Franklin Institute, 218(4), 411-444. doi:10.1016/s0016-0032(34)90415-4Starting potentials of high-frequency gas discharges at low pressure. (1948). Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences, 192(1030), 446-463. doi:10.1098/rspa.1948.0018Vaughan, J. R. M. (1988). Multipactor. IEEE Transactions on Electron Devices, 35(7), 1172-1180. doi:10.1109/16.3387Hatch, A. J., & Williams, H. B. (1954). The Secondary Electron Resonance Mechanism of Low‐Pressure High‐Frequency Gas Breakdown. Journal of Applied Physics, 25(4), 417-423. doi:10.1063/1.1721656Hatch, A. J., & Williams, H. B. (1958). Multipacting Modes of High-Frequency Gaseous Breakdown. Physical Review, 112(3), 681-685. doi:10.1103/physrev.112.681H. M. Wachowski, El Segundo Technical Operations Aerospace Corporation, Technical Report No. TDR-269(9990)-5, El Segundo, California, 1964.Furman, M., & Pivi, M. (2002). Probabilistic model for the simulation of secondary electron emission. Physical Review Special Topics - Accelerators and Beams, 5(12). doi:10.1103/physrevstab.5.124404A. Woode and J. Petit, ESTEC Technical Report No. 1556, Noordwijk, 1989.Riyopoulos, S., Chernin, D., & Dialetis, D. (1995). Theory of electron multipactor in crossed fields. Physics of Plasmas, 2(8), 3194-3213. doi:10.1063/1.871151Kishek, R. A., Lau, Y. Y., Ang, L. K., Valfells, A., & Gilgenbach, R. M. (1998). Multipactor discharge on metals and dielectrics: Historical review and recent theories. Physics of Plasmas, 5(5), 2120-2126. doi:10.1063/1.872883Gilardini, A. L. (1992). New breakdown modes of the multipacting discharge. Journal of Applied Physics, 71(9), 4629-4631. doi:10.1063/1.350767Kryazhev, A., Buyanova, M., Semenov, V., Anderson, D., Lisak, M., Puech, J., … Sombrin, J. (2002). Hybrid resonant modes of two-sided multipactor and transition to the polyphase regime. Physics of Plasmas, 9(11), 4736-4743. doi:10.1063/1.1514969Semenov, V. E., Rakova, E., Udiljak, R., Anderson, D., Lisak, M., & Puech, J. (2008). Conformal mapping analysis of multipactor breakdown in waveguide irises. Physics of Plasmas, 15(3), 033501. doi:10.1063/1.2884712Semenov, V. E., Rakova, E. I., Anderson, D., Lisak, M., & Puech, J. (2007). Multipactor in rectangular waveguides. Physics of Plasmas, 14(3), 033501. doi:10.1063/1.2480678Woo, R. (1968). Multipacting Discharges between Coaxial Electrodes. Journal of Applied Physics, 39(3), 1528-1533. doi:10.1063/1.1656390Vdovicheva, N. K., Sazontov, A. G., & Semenov, V. E. (2004). Statistical Theory of Two-Sided Multipactor. Radiophysics and Quantum Electronics, 47(8), 580-596. doi:10.1023/b:raqe.0000049556.18329.e9Vdovicheva, N. K., Sazontov, A. G., Sazontov, V. A., & Semenov, V. E. (2006). Influence of the angular anisotropy of secondary emission on the characteristics of a two-sided multipactor. Radiophysics and Quantum Electronics, 49(5), 368-376. doi:10.1007/s11141-006-0069-2Sazontov, A. G., Sazontov, V. A., & Vdovicheva, N. K. (2008). Multipactor Breakdown Prediction in a Rectangular Waveguide: Statistical Theory and Simulation Results. Contributions to Plasma Physics, 48(4), 331-346. doi:10.1002/ctpp.200810057Sazontov, A., Buyanova, M., Semenov, V., Rakova, E., Vdovicheva, N., Anderson, D., … Lapierre, L. (2005). Effect of emission velocity spread of secondary electrons in two-sided multipactor. Physics of Plasmas, 12(5), 053102. doi:10.1063/1.1881532Kossyi, I. A., Lukyanchikov, G. S., Semenov, V. E., Rakova, E. I., Anderson, D., Lisak, M., & Puech, J. (2008). Polyphase (non-resonant) multipactor in rectangular waveguides. Journal of Physics D: Applied Physics, 41(6), 065203. doi:10.1088/0022-3727/41/6/065203Vaughan, J. R. M. (1989). A new formula for secondary emission yield. IEEE Transactions on Electron Devices, 36(9), 1963-1967. doi:10.1109/16.34278C. Vicente, M. Mattes, D. Wolk, H. L. Hartnagel, J. R. Mosig, and D. Raboso, Proceedings of the 5th International Workshop on Multipactor, RF and DC Corona and Passive Intermodulation in Space RF Hardware (ESTEC, Noordwijk, The Netherlands, 2005), pp. 11–17.Gilardini, A. L. (1995). Multipacting discharges: Constant‐ktheory and simulation results. Journal of Applied Physics, 78(2), 783-795. doi:10.1063/1.360336A. Kryazhev, M.S. thesis, Chalmers University of Technology, Göteborg, Sweden, 2002.Anza, S., Vicente, C., Gimeno, B., Boria, V. E., & Armendáriz, J. (2007). Long-term multipactor discharge in multicarrier systems. Physics of Plasmas, 14(8), 082112. doi:10.1063/1.2768019P. Zuccarello, A. González, G. Piñero, and M. de Diego, Proceedings of the 4th International Workshop on Multipactor, RF and DC Corona and Passive Intermodulation in Space RF Hardware (ESTEC, Noordwijk, The Netherlands, 2003), pp. 469–473.Polyanin, A. (1998). Handbook of Integral Equations. doi:10.1201/9781420050066S. Anza, C. Vicente, D. Raboso, J. Gil, B. Gimeno, and V. E. Boria, IEEE International Microwave Symposium (IEEE, Atlanta, 2008), pp. 1095–1098.C. Vicente, M. Mattes, D. Wolk, H. L. Hartnagel, J. R. Mosig, and D. Raboso, Microwave Symposium Digest, IEEE MTT-S International (IEEE, Long Beach, California, 2005), Vol. 2, pp. 1055–1058

Neural network interpolation of the magnetic field for the LISA Pathfinder Diagnostics Subsystem

LISA Pathfinder is a science and technology demonstrator of the European Space Agency within the framework of its LISA mission, which aims to be the first space-borne gravitational wave observatory. The payload of LISA Pathfinder is the so-called LISA Technology Package, which is designed to measure relative accelerations between two test masses in nominal free fall. Its disturbances are monitored and dealt by the diagnostics subsystem. This subsystem consists of several modules, and one of these is the magnetic diagnostics system, which includes a set of four tri-axial fluxgate magnetometers, intended to measure with high precision the magnetic field at the positions of the test masses. However, since the magnetometers are located far from the positions of the test masses, the magnetic field at their positions must be interpolated. It has been recently shown that because there are not enough magnetic channels, classical interpolation methods fail to derive reliable measurements at the positions of the test masses, while neural network interpolation can provide the required measurements at the desired accuracy. In this paper we expand these studies and we assess the reliability and robustness of the neural network interpolation scheme for variations of the locations and possible offsets of the magnetometers, as well as for changes in environmental conditions. We find that neural networks are robust enough to derive accurate measurements of the magnetic field at the positions of the test masses in most circumstances

Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments.

Impairments in cognitive function, mood, and sleep quality occur following ascent to high altitude. Low oxygen (hypoxia) and poor sleep quality are both linked to impaired cognitive performance, but their independent contributions at high altitude remain unknown. Adaptive servoventilation (ASV) improves sleep quality by stabilizing breathing and preventing central apneas without supplemental oxygen. We compared the efficacy of ASV and supplemental oxygen sleep treatments for improving daytime cognitive function and mood in high-altitude visitors (N = 18) during acclimatization to 3,800 m. Each night, subjects were randomly provided with ASV, supplemental oxygen (SpO2 > 95%), or no treatment. Each morning subjects completed a series of cognitive function tests and questionnaires to assess mood and multiple aspects of cognitive performance. We found that both ASV and supplemental oxygen (O2) improved daytime feelings of confusion (ASV: p < 0.01; O2: p < 0.05) and fatigue (ASV: p < 0.01; O2: p < 0.01) but did not improve other measures of cognitive performance at high altitude. However, performance improved on the trail making tests (TMT) A and B (p < 0.001), the balloon analog risk test (p < 0.0001), and the psychomotor vigilance test (p < 0.01) over the course of three days at altitude after controlling for effects of sleep treatments. Compared to sea level, subjects reported higher levels of confusion (p < 0.01) and performed worse on the TMT A (p < 0.05) and the emotion recognition test (p < 0.05) on nights when they received no treatment at high altitude. These results suggest that stabilizing breathing (ASV) or increasing oxygenation (supplemental oxygen) during sleep can reduce feelings of fatigue and confusion, but that daytime hypoxia may play a larger role in other cognitive impairments reported at high altitude. Furthermore, this study provides evidence that some aspects of cognition (executive control, risk inhibition, sustained attention) improve with acclimatization

Subtraction of test mass angular noise in the LISA Technology Package interferometer

We present recent sensitivity measurements of the LISA Technology Package interferometer with articulated mirrors as test masses, actuated by piezo-electric transducers. The required longitudinal displacement resolution of 9 pm/sqrt[Hz] above 3 mHz has been demonstrated with an angular noise that corresponds to the expected in on-orbit operation. The excess noise contribution of this test mass jitter onto the sensitive displacement readout was completely subtracted by fitting the angular interferometric data streams to the longitudinal displacement measurement. Thus, this cross-coupling constitutes no limitation to the required performance of the LISA Technology Package interferometry.Comment: Applied Physics B - Lasers and Optics (2008

On-ground tests of LISA PathFinder thermal diagnostics system

Thermal conditions in the LTP, the LISA Technology Package, are required to be very stable, and in such environment precision temperature measurements are also required for various diagnostics objectives. A sensitive temperature gauging system for the LTP is being developed at IEEC, which includes a set of thermistors and associated electronics. In this paper we discuss the derived requirements applying to the temperature sensing system, and address the problem of how to create in the laboratory a thermally quiet environment, suitable to perform meaningful on-ground tests of the system. The concept is a two layer spherical body, with a central aluminium core for sensor implantation surrounded by a layer of polyurethane. We construct the insulator transfer function, which relates the temperature at the core with the laboratory ambient temperature, and evaluate the losses caused by heat leakage through connecting wires. The results of the analysis indicate that, in spite of the very demanding stability conditions, a sphere of outer diameter of the order one metre is sufficient. We provide experimental evidence confirming the model predictions.Comment: 18 pages, 5 figures, LaTeX2e (compile with pdflatex), sumbitted to CQG. This paper is a significant extension of gr-qc/060109

Relationships Between Chemoreflex Responses, Sleep Quality, and Hematocrit in Andean Men and Women.

Andean highlanders are challenged by chronic hypoxia and many exhibit elevated hematocrit (Hct) and blunted ventilation compared to other high-altitude populations. While many Andeans develop Chronic Mountain Sickness (CMS) and excessive erythrocytosis, Hct varies markedly within Andean men and women and may be driven by individual differences in ventilatory control and/or sleep events which exacerbate hypoxemia. To test this hypothesis, we quantified relationships between resting ventilation and ventilatory chemoreflexes, sleep desaturation, breathing disturbance, and Hct in Andean men and women. Ventilatory measures were made in 109 individuals (n = 63 men; n = 46 women), and sleep measures in 45 of these participants (n = 22 men; n = 23 women). In both men and women, high Hct was associated with low daytime SpO2 (p < 0.001 and p < 0.002, respectively) and decreased sleep SpO2 (mean, nadir, and time <80%; all p < 0.02). In men, high Hct was also associated with increased end-tidal PCO2 (p < 0.009). While ventilatory responses to hypoxia and hypercapnia did not predict Hct, decreased hypoxic ventilatory responses were associated with lower daytime SpO2 in men (p < 0.01) and women (p < 0.009) and with lower nadir sleep SpO2 in women (p < 0.02). Decreased ventilatory responses to CO2 were associated with more time below 80% SpO2 during sleep in men (p < 0.05). The obstructive apnea index and apnea-hypopnea index also predicted Hct and CMS scores in men after accounting for age, BMI, and SpO2 during sleep. Finally, heart rate response to hypoxia was lower in men with higher Hct (p < 0.0001). These data support the idea that hypoventilation and decreased ventilatory sensitivity to hypoxia are associated with decreased day time and nighttime SpO2 levels that may exacerbate the stimulus for erythropoiesis in Andean men and women. However, interventional and longitudinal studies are required to establish the causal relationships between these associations

Thermal diagnostic of the Optical Window on board LISA Pathfinder

Vacuum conditions inside the LTP Gravitational Reference Sensor must comply with rather demanding requirements. The Optical Window (OW) is an interface which seals the vacuum enclosure and, at the same time, lets the laser beam go through for interferometric Metrology with the test masses. The OW is a plane-parallel plate clamped in a Titanium flange, and is considerably sensitive to thermal and stress fluctuations. It is critical for the required precision measurements, hence its temperature will be carefully monitored in flight. This paper reports on the results of a series of OW characterisation laboratory runs, intended to study its response to selected thermal signals, as well as their fit to numerical models, and the meaning of the latter. We find that a single pole ARMA transfer function provides a consistent approximation to the OW response to thermal excitations, and derive a relationship with the physical processes taking place in the OW. We also show how system noise reduction can be accomplished by means of that transfer function.Comment: 20 pages, 14 figures; accepted for publication in Class. Quantum Gra

Multipactor radiation analysis within a waveguide region based on a frequency-domain representation of the dynamics of charged particles

[EN] A technique for the accurate computation of the electromagnetic fields radiated by a charged particle moving within a parallel-plate waveguide is presented. Based on a transformation of the time-varying current density of the particle into a time-harmonic current density, this technique allows the evaluation of the radiated electromagnetic fields both in the frequency and time domains, as well as in the near- and far-field regions. For this purpose, several accelerated versions of the parallel-plate Green's function in the frequency domain have been considered. The theory has been successfully applied to the multipactor discharge occurring within a two metal-plates region. The proposed formulation has been tested with a particle-in-cell code based on the finite-difference time-domain method, obtaining good agreement.The authors would like to thank ESA/ESTEC for having funded this research activity through the Contract "RF Breakdown in Multicarrier Systems" (Contract No. 19918/06/NL/GLC).Gimeno, B.; Sorolla, E.; Anza, S.; Vicente, C.; Gil, J.; Pérez, AM.; Boria Esbert, VE.... (2009). Multipactor radiation analysis within a waveguide region based on a frequency-domain representation of the dynamics of charged particles. Physical review. E, Statistical, nonlinear, and soft matter physics. 79(4):1-9. https://doi.org/10.1103/PhysRevE.79.046604S19794Figueroa, H., Gai, W., Konecny, R., Norem, J., Ruggiero, A., Schoessow, P., & Simpson, J. (1988). Direct Measurement of Beam-Induced Fields in Accelerating Structures. Physical Review Letters, 60(21), 2144-2147. doi:10.1103/physrevlett.60.2144Ng, K.-Y. (1990). Wake fields in a dielectric-lined waveguide. Physical Review D, 42(5), 1819-1828. doi:10.1103/physrevd.42.1819Rosing, M., & Gai, W. (1990). Longitudinal- and transverse-wake-field effects in dielectric structures. Physical Review D, 42(5), 1829-1834. doi:10.1103/physrevd.42.1829Gai, W., Kanareykin, A. D., Kustov, A. L., & Simpson, J. (1997). Numerical simulations of intense charged-particle beam propagation in a dielectric wake-field accelerator. Physical Review E, 55(3), 3481-3488. doi:10.1103/physreve.55.3481Burov, A., & Danilov, V. (1999). Suppression of Transverse Bunch Instabilities by Asymmetries in the Chamber Geometry. Physical Review Letters, 82(11), 2286-2289. doi:10.1103/physrevlett.82.2286Xiao, L., Gai, W., & Sun, X. (2001). Field analysis of a dielectric-loaded rectangular waveguide accelerating structure. Physical Review E, 65(1). doi:10.1103/physreve.65.016505Jing, C., Liu, W., Xiao, L., Gai, W., Schoessow, P., & Wong, T. (2003). Dipole-mode wakefields in dielectric-loaded rectangular waveguide accelerating structures. Physical Review E, 68(1). doi:10.1103/physreve.68.016502Stupakov, G., Bane, K. L. F., & Zagorodnov, I. (2007). Optical approximation in the theory of geometric impedance. Physical Review Special Topics - Accelerators and Beams, 10(5). doi:10.1103/physrevstab.10.054401Hatch, A. J., & Williams, H. B. (1954). The Secondary Electron Resonance Mechanism of Low‐Pressure High‐Frequency Gas Breakdown. Journal of Applied Physics, 25(4), 417-423. doi:10.1063/1.1721656Hatch, A. J., & Williams, H. B. (1958). Multipacting Modes of High-Frequency Gaseous Breakdown. Physical Review, 112(3), 681-685. doi:10.1103/physrev.112.681Vaughan, J. R. M. (1988). Multipactor. IEEE Transactions on Electron Devices, 35(7), 1172-1180. doi:10.1109/16.3387Gilardini, A. L. (1995). Multipacting discharges: Constant‐ktheory and simulation results. Journal of Applied Physics, 78(2), 783-795. doi:10.1063/1.360336Riyopoulos, S. (1997). Multipactor saturation due to space-charge-induced debunching. Physics of Plasmas, 4(5), 1448-1462. doi:10.1063/1.872319Kryazhev, A., Buyanova, M., Semenov, V., Anderson, D., Lisak, M., Puech, J., … Sombrin, J. (2002). Hybrid resonant modes of two-sided multipactor and transition to the polyphase regime. Physics of Plasmas, 9(11), 4736-4743. doi:10.1063/1.1514969Udiljak, R., Anderson, D., Ingvarson, P., Jordan, U., Jostell, U., Lapierre, L., … Sombrin, J. (2003). New method for detection of multipaction. IEEE Transactions on Plasma Science, 31(3), 396-404. doi:10.1109/tps.2003.811646De Lara, J., Perez, F., Alfonseca, M., Galan, L., Montero, I., Roman, E., & Garcia-Baquero, D. R. (2006). Multipactor prediction for on-board spacecraft RF equipment with the MEST software tool. IEEE Transactions on Plasma Science, 34(2), 476-484. doi:10.1109/tps.2006.872450Torregrosa, G., Coves, A., Vicente, C. P., Perez, A. M., Gimeno, B., & Boria, V. E. (2006). Time evolution of an electron discharge in a parallel-plate dielectric-loaded waveguide. IEEE Electron Device Letters, 27(7), 619-621. doi:10.1109/led.2006.877284Udiljak, R., Anderson, D., Lisak, M., Semenov, V. E., & Puech, J. (2007). Multipactor in a coaxial transmission line. I. Analytical study. Physics of Plasmas, 14(3), 033508. doi:10.1063/1.2710464Semenov, V. E., Zharova, N., Udiljak, R., Anderson, D., Lisak, M., & Puech, J. (2007). Multipactor in a coaxial transmission line. II. Particle-in-cell simulations. Physics of Plasmas, 14(3), 033509. doi:10.1063/1.2710466Anza, S., Vicente, C., Gimeno, B., Boria, V. E., & Armendáriz, J. (2007). Long-term multipactor discharge in multicarrier systems. Physics of Plasmas, 14(8), 082112. doi:10.1063/1.2768019Udiljak, R., Anderson, D., Lisak, M., Puech, J., & Semenov, V. E. (2007). Multipactor in a Waveguide Iris. IEEE Transactions on Plasma Science, 35(2), 388-395. doi:10.1109/tps.2007.892737Burton, R. J., de Jong, M. S., & Funk, L. W. 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Physics of Plasmas, 5(5), 2120-2126. doi:10.1063/1.872883Neuber, A., Hemmert, D., Krompholz, H., Hatfield, L., & Kristiansen, M. (1999). Initiation of high power microwave dielectric interface breakdown. Journal of Applied Physics, 86(3), 1724-1728. doi:10.1063/1.370953Chojnacki, E. (2000). Simulations of a multipactor-inhibited waveguide geometry. Physical Review Special Topics - Accelerators and Beams, 3(3). doi:10.1103/physrevstab.3.032001Cimino, R., Collins, I. R., Furman, M. A., Pivi, M., Ruggiero, F., Rumolo, G., & Zimmermann, F. (2004). Can Low-Energy Electrons Affect High-Energy Physics Accelerators? Physical Review Letters, 93(1). doi:10.1103/physrevlett.93.014801Abe, T., Kageyama, T., Akai, K., Ebihara, K., Sakai, H., & Takeuchi, Y. (2006). Multipactoring zone map of an rf input coupler and its application to high beam current storage rings. 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Acceleration disturbances and requirements for ASTROD I

ASTRODynamical Space Test of Relativity using Optical Devices I (ASTROD I) mainly aims at testing relativistic gravity and measuring the solar-system parameters with high precision, by carrying out laser ranging between a spacecraft in a solar orbit and ground stations. In order to achieve these goals, the magnitude of the total acceleration disturbance of the proof mass has to be less than 10−13 m s−2 Hz−1/2 at 0.1 m Hz. In this paper, we give a preliminary overview of the sources and magnitude of acceleration disturbances that could arise in the ASTROD I proof mass. Based on the estimates of the acceleration disturbances and by assuming a simple controlloop model, we infer requirements for ASTROD I. Our estimates show that most of the requirements for ASTROD I can be relaxed in comparison with Laser Interferometer Space Antenna (LISA).Comment: 19 pages, two figures, accepted for publication by Class. Quantum Grav. (at press