Idiopathic neonatal haemochromatosis: A case report

A case of neonatal hemochromatosis is reported in a premature 35-week infant who presented at birth with coffee ground vomiting and gradual appearance of grayish icter and colorless stool. Neonatal hemochromatosis was confirmed by elevated ferritin levels and extrahepatic siderosis detected in liver biopsy

A case report of cornelia de lange syndrome in Northern Iran; a clinical and diagnostic study

As a rare multisystem congenital anomaly disorder, Cornelia de Lange syndrome (CdLS) is featured by delayed growth and development, distinct facial dimorphism, limb malformations and multiple organ defects. CdLS is a genetic syndrome affecting 1/10000-1/60000 neonates with unknown genetic basis. Delayed growth and development, hirsute, structural anomalies of the limbs and distinct facial dimorphism are considered as its main clinical characteristics. Introducing CdLS cases of different ethnic backgrounds could add distinctions to the phenotypic picture of the syndrome and be useful in diagnosis. Early diagnosis and decreased death rates are achievable through enhanced awareness on this syndrome. We present here a 45-day-old girl, as the first case of Cornelia in Golestan (Northern Iran), referred to our hospital with the symptoms as mentioned above. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved

All-dielectric reciprocal bianisotropic nanoparticles

The study of high-index dielectric nanoparticles currently attracts a lot of attention. They do not suffer from absorption but promise to provide control on the properties of light comparable to plasmonic nanoparticles. To further advance the field, it is important to identify versatile dielectric nanoparticles with unconventional properties. Here, we show that breaking the symmetry of an all-dielectric nanoparticle leads to a geometrically tunable magneto-electric coupling, i.e. an omega-type bianisotropy. The suggested nanoparticle exhibits different backscatterings and, as an interesting consequence, different optical scattering forces for opposite illumination directions. An array of such nanoparticles provides different reflection phases when illuminated from opposite directions. With a proper geometrical tuning, this bianisotropic nanoparticle is capable of providing a $2\pi$ phase change in the reflection spectrum while possessing a rather large and constant amplitude. This allows creating reflectarrays with near-perfect transmission out of the resonance band due to the absence of an usually employed metallic screen.Comment: 7 pages, 6 figure

Waveform Design for 4D-Imaging mmWave PMCW MIMO Radars with Spectrum Compatibility

4D-imaging mmWave radars offer high angular resolution in both azimuth and elevation, but achieving this requires a large antenna aperture size and a significant number of transmit and/or receive channels. This presents a challenge for designing transmit waveforms that are both orthogonal and separable on the receive side, as well as have low auto-correlation sidelobes. This paper focuses on designing an orthogonal set of sequences for 4D-imaging radar sensors based on PMCW technology. We propose an iterative optimization framework based on Coordinate Descent, which considers the Regions Of Interest (ROI) and optimizes a phase-modulated constant modulus waveform set based on weighted integrated sidelobe level on the required ROI and spectrum shaping. The optimization also accounts for the radar working adjacent to communication systems and other radar sensors. Simulation results are provided to demonstrate the effectiveness of the proposed method, which achieves low sidelobe levels and is compatible with spectrum constraints

In vitro evaluation of a double-stranded self-complementary adeno-associated virus type2 vector in bone marrow stromal cells for bone healing

Background: Both adenoviral and lentiviral vectors have been successfully used to induce bone repair by over-expression of human bone morphogenetic protein 2 (BMP-2) in primary rat bone marrow stromal cells in pre-clinical models of ex vivo regional gene therapy. Despite being a very efficient means of gene delivery, there are potential safety concerns that may limit the adaptation of these viral vectors for clinical use in humans. Recombinant adeno-associated viral (rAAV) vector is a promising viral vector without known pathogenicity in humans and has the potential to be an effective gene delivery vehicle to enhance bone repair. In this study, we investigated gene transfer in rat and human bone marrow stromal cells in order to evaluate the effectiveness of the self-complementary AAV vector (scAAV) system, which has higher efficiency than the single-stranded AAV vector (ssAAV) due to its unique viral genome that bypasses the rate-limiting conversion step necessary in ssAAV.Methods: Self-complementaryAAV2 encoding GFP and BMP-2 (scAAV2-GFP and scAAV2-BMP-2) were used to transduce human and rat bone marrow stromal cells in vitro, and subsequently the levels of GFP and BMP-2 expression were assessed 48 hours after treatment. In parallel experiments, adenoviral and lentiviral vector mediated over-expression of GFP and BMP-2 were used for comparison.Results: Our results demonstrate that the scAAV2 is not capable of inducing significant transgene expression in human and rat bone marrow stromal cells, which may be associated with its unique tropism.Conclusions: In developing ex vivo gene therapy regimens, the ability of a vector to induce the appropriate level of transgene expression needs to be evaluated for each cell type and vector used. © 2011 Alaee et al; licensee BioMed Central Ltd

Titanium dioxide nanoparticles catalyzed synthesis of Hantzsch esters and polyhydroquinoline derivatives

1,4-Dihydropyridine and polyhydroquinoline derivatives have been prepared efficiently in a one-pot synthesis via Hantzsch condensation using nanosized titanium dioxide as a heterogeneous catalyst. The present methodology offers several advantages such as excellent yields, short reaction times (30-120 min), environmentally benign, and mild reaction conditions. The catalyst can be readily separated from the reaction products and recovered in excellent purity for direct reuse

Waveform Selection for FMCW and PMCW 4D-Imaging Automotive Radar Sensors

The emerging 4D-imaging automotive MIMO radar sensors necessitate the selection of appropriate transmit waveforms, which should be separable on the receive side in addition to having low auto-correlation sidelobes. TDM, FDM, DDM, and inter-chirp CDM approaches have traditionally been proposed for FMCW radar sensors to ensure the orthogonality of the transmit signals. However, as the number of transmit antennas increases, each of the aforementioned approaches suffers from some drawbacks, which are described in this paper. PMCW radars, on the other hand, can be considered to be more costly to implement, have been proposed to provide better performance and allow for the use of waveform optimization techniques. In this context, we use a block gradient descent approach to designing a waveform set that is optimized based on weighted integrated sidelobe level in this paper, and we show that the proposed waveform outperforms conventional MIMO-FMCW approaches by performing comparative simulations

Parametric Mie resonances and directional amplification in time-modulated scatterers

We provide a theoretical description of light scattering by a spherical particle whose permittivity is modulated in time at twice the frequency of the incident light. Such a particle acts as a finite-sized photonic time crystal and, despite its sub-wavelength spatial extent, can host optical parametric amplification. Conditions of parametric Mie resonances in the sphere are derived. We show that time-modulated materials provide a route to tailor directional light amplification, qualitatively different from that in scatterers made from a gain media. We design two characteristic time-modulated spheres that simultaneously exhibit light amplification and desired radiation patterns, including those with zero backward and/or vanishing forward scattering. The latter sphere provides an opportunity for creating shadow-free detectors of incident light.Comment: 8 pages, 4 figure

Polybrominated Diphenyl Ethers: A Case Study for Using Biomonitoring Data to Address Risk Assessment Questions

The use of biomonitoring data holds promise for characterizing exposure and informing risk assessment. Biomonitoring data have been used successfully to track population trends, identify susceptible populations, and provide indications of emerging environmental health issues. However, there remain challenges associated with interpreting biomonitoring data for risk assessment. An international biomonitoring workshop was convened in September 2004 to explore the use of biomonitoring data in the context of risk assessment. Six compounds were examined as case studies for this workshop, including polybrominated diphenyl ethers (PBDEs). The PBDE case study was developed to provide an example of a persistent compound for which relatively few data are available for human exposure, biomonitoring, and health outcomes. PBDEs are used in hard plastics, electronics, textiles, and polyurethane foam products. The congener pattern downstream of production facilities often resembles the commercial mixture. However, because these compounds persist in the environment and in biota, the patterns of congeners evolve. PBDEs partition into body lipids, and direct measurement of bromodiphenyl ether congeners in biologic specimens provides a good marker of exposure. Data indicate significant variability (> 100-fold range) in lipid-adjusted levels for PBDEs in the general population. It is hypothesized that both exposure and pharmacokinetics may play a role in observed congener profiles. Significant gaps in our ability to interpret PBDE biomonitoring data to address public health and risk assessment questions include limited knowledge of environmental fate and transport of PBDE congeners, limited population-based data for adults, and lack of data for potentially vulnerable populations such as children