Evaluating extracts of spondias mombin for antimicrobial activitie

The plant Spondias mombin Linn. also called yellow mombin in English, Igongo/Ichankla in Idoma, and Uchakuru in Igbo, is common in the forest and savanna regions of Nigeria. It is used in several countries of the world to treat various ailments including infectious diseases. Water, chloroform, methanol, and petroleum ether extracts of leaf, root, and bark of the mature plant were screened for antimicrobial activity using an indicator-based microdilution technique. Inhibition was measured as minimal inhibitory concentration (MIC). The growth of Streptococcus pyogenes (mean MIC = 0.139 mg), Candida albicans (mean MIC = 0.148 mg), Salmonella typhi (mean MIC = 0.226 mg), Escherichia coli (mean MIC = 0.265 mg), and Staphylococcus aureus (mean MIC = 0.289 mg) in broth cultures were inhibited. Inhibition was significantly correlated with plant parts (r = -0.435; p < 0.05), leaf extracts having the greatest inhibitory effect (mean MIC = 0.060 mg), and the bark extracts the least (mean MIC = 0.389 mg). Statistical tests show that the mean MICs of leaf and bark extracts differ significantly (

Antibacterial Activity of Ethanolic Extract of Acalypha wilkesiana Leaves Growing in Jos, Plateau State, Nigeria

Antibacterial activity of ethanolic extract of Acalypha wilkesiana leaves growing in Vom, Jos, Plateau state, Nigeria was carried out to verify claims by the locals of its medicinal properties. We tested the extract for activity against Staphylococcus aureus (G+), Yersinia enterocolitica, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa and Klebsiella aerogenes (G-). The extract exhibited activity against the organisms in varying degrees. In the agar diffusion test, Y. enterocolitica showed the highest zone of inhibition (18 mm) at the highest concentration of extract tested (20 mg/mL) while E. coli, S. aureus, S. typhi, P. aeruginosa and K. aerogenes showed zones of inhibition of 17, 16, 15, 14 and 16 mm respectively. At extract concentration of 2.5 mg/mL, Y. enterocolitica and P. aeruginosa did not show any zones of inhibition while E.coli, S. aureus, S. typhi, and K. aerogenes showed zones of inhibition of 7, 6, 6 and 7 mm respectively. Below extract concentration of 2.5 mg/mL, there was no zone of inhibition observed with any organism. The MIC of the extract against the organisms was 5 mg/mL except on S. aureus where the MIC was 2.5 mg/mL. The MBC of the extract was 10 mg/mL against Y. enterocolitica, S. typhi, P. aeruginosa and K. aerogenes, 5 mg/mL against E. coli and S. aureus. Preliminary phytochemical testing revealed the presence of tannins, steroids, flavonoids and cardiac glycosides while saponins, alkaloids and anthraquinones were not present. The result gives scientific backing to the use of the leaves by the local people in the treatment of conditions usually associated with the organisms tested

Antimicrobial activities of honey from different geographical locations on gram negative and positive organisms

Honey samples were obtained from the different agro-ecological zones of Nigeria including: the tropical rainforest, mangrove swamp, plateau grassland, guinea savannah and sudan savannah. The antimicrobial activities of these differently sourced honeys were assessed against six bacteria organisms (Staphylococcus aureaus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Klebsiella aerogenes and Proteus mirabilis). The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were studied using standard methods. Results obtained showed that geographical locations had effects on the antibacterial activities of the different honeys at different concentrations (6.25-100%). Honey originating from Vom, Plateau State showed the highest antimicrobial activity. All the honeys showed varied bacteriostatic and bactericidal activities. None of the honeys produced any effect on Klebsiella aerogenes and Proteus mirabilis. Further work is encouraged

Causes and Measures for Controlling Loan Default among Agricultural Cooperatives in Bune State, Nigeria

The studies analyzed the causes and measures for controlling loan default among agricultural co-operatives in Benue State of Nigeria. Data were collected from 130 respondents using structured questionnaire, and was analyzed using descriptive statistics. The result shows that factors responsible for loan default were classified into Institutional, Client-related, Geo-economical, and Market related factors. Late disbursement of (92.31%), lack of loan monitoring (76.92%), inadequate loan appraisals (69.23%), and lack of clear cut policy on lending (69.23) were the institutional factors responsible for loan default. Lack of integrity (80.77%), poor business practice (78.46%), and loan diversion (50.0%) were client-related factors. Death of client (70.77%), economic downturn (55.38%), and natural calamity (52.31%) were geo-economic factors, while, lack of market information (81.54%), market location (49.23%) and wrong economic decision (40.77) were market related factors. The result also showed that obtaining information on borrowers\u27 integrity (92.23%), and training of borrowers on the terms and conditions (82.54%) were main measures to control loan default in the study area. Information on client integrity, and training of borrowers on terms and condition of loan before loan are granted were found to be best measures to control loan default. It was recommended that sound and flexible lending policies measures which must be reviewed frequently by the Central Bank of Nigeria (CBN) and Bank for Agriculture and Agricultural Co-operatives (BAAC) be put in place in order to curtail bureaucracies involved in the management approvals and disbursement of agricultural loan should be formulated. This will ensure early disbursement of funds to co-operative members

Relationship Between Plasma Homocysteine and Vitamin B12 Levels in Clinically Diagnosed Cases of Cardiovascular Accident in Lagos, Nigeria

Vitamin B12 deficiency interferes with the normal pathway for homocysteine metabolism, even in the presence of adequate serum folate and pyridoxine. Homocysteinaemia, is an elevated level of homocysteine in plasma which has been established as a risk factor for the development of cardiovascular disorders. However, there has been conflicting report from various research works on the role of Vitamin B12 in the occurrence of major cardiovascular disorders. The study was set to determine the mean values of homocysteine, and correlate same with mean plasma levels of vitamin B12 in the subjects, and to estimate the prevalence of anaemia in the stroke patients, using Haemoglobin concentration (Hb) and mean corpuscular volume (MCV) as indices. One hundred (100) participants were recruited, comprising 40 clinically diagnosed stroke patients (hemorrhagic or thrombo-embolic), and 60 normal adults as control group. Plasma homocysteine levels were measured by HPLC and plasma vitamin B12 levels by Chemiluminescent Microparticle Immuno-assay method. Anticoagulated whole blood samples were evaluated for Hb, and MCV using automated Advia-60. Mean value of plasma homocysteine for the stroke patients (17.7±4.4umol/l) was significantly higher than values obtained in the control group at 9.5±2.4umol/l (

Sensitivity analysis of the dynamic CO2 storage capacity estimate for the Bunter Sandstone of the UK Southern North Sea

Carbon capture and storage (CCS) in subsurface reservoirs has been identified as a potentially cost-effective way to reduce CO2 emissions to the atmosphere. Global emissions reductions on the gigatonne scale using CCS will require regional or basin-scale deployment of CO2 storage in saline aquifers. Thus the evaluation of both the dynamic and ultimate CO2 storage capacity of formations is important for policy makers to determine the viability of CCS as a pillar of the greenhouse gas mitigation strategy in a particular region. We use a reservoir simulation model representing the large-scale Bunter Sandstone in the UK Southern North Sea to evaluate the dynamics and sensitivities of regional CO2 plume transport and storage. At the basin-scale, we predict hydrogeological changes in the storage reservoir in response to multiple regional carbon sequestration development scenarios. We test the sensitivity of injection capacity to a range of target CO2 injection rates and fluctuations in CO2 supply. Model sensitivities varying the target injection rates indicate that in the absence of pressure management up to 3.7 Gt of CO2 can be stored in the Bunter region over 50 years given the pressure constraints set to avoid fracturing the formation. Long-term (approx. 1000 years), our results show that up to 16 Gt of CO2 can be stored in the Bunter region without pressure management. With pressure management, the estimate rises to 32 Gt. However, consideration must be given to the additional operational and economic requirements of pressure management using brine production

Coccidioidomycosis in Chicken Pullets in Jos, Plateau State, Nigeria: A Case Report

No Abstract

Increasing cassava root yield on farmers’ fields in Nigeria through appropriate weed management

Open Access Article; Published online: 08 Sep 2021Weed competition is the major biological stress affecting cassava production in smallholder farms in West and Central Africa, where yields are low compared with those in Asia and Latin America. Options for improved weed management are crucial in increasing productivity. Selected pre- and post-emergence herbicides, integrated with appropriate tillage and plant spacing, were tested in 96 sites in four locations in Nigeria, 24 in 2016 and 72 in 2017. Trials were split plots with six pre-emergence herbicides and no post-emergence treatment as main plots. Subplot treatments were four post-emergence herbicides, weeding with a motorized rotary weeder, short- and long-handled hoes, and no post-emergence weed control, i.e., regardless of pre-emergence treatments. Indaziflam-based treatments, irrespective of post-emergence treatment, and flumioxazin + pyroxasulfone applied pre-emergence followed by one weeding with a long-handled hoe provided >80% control of major broadleaf and grass weeds. Compared with herbicide use, farmer control practices (53%) were not efficient in controlling weeds. The highest root yield was produced where (1) s-metolachlor was combined with atrazine, and one weeding with a long-handled hoe or clethodim with lactofen, and (2) indaziflam + isoxaflutole was combined with glyphosate. An increase in root yield from 3.41 to 14.2 t ha-1 and from 3.0 to 11.99 t ha-1 was obtained where herbicides were used compared with farmers’ practice and manual hoe weeding. Our results showed that integrating good agronomic practices with safe and effective use of appropriate herbicides can result in root yield >20 t ha−1. i.e., twice the national average root yield of 8–12 t ha−1, with >50% net profit. The use of appropriate herbicides can reduce the amount of manual labor required and improve livelihoods, specifically for women and children. Smallholder cassava farmers would require continuous training on the safe use and handling of herbicides to improve efficiency and prevent adverse effects on humans and the environment