626 research outputs found
Large-scale Ferrofluid Simulations on Graphics Processing Units
We present an approach to molecular-dynamics simulations of ferrofluids on
graphics processing units (GPUs). Our numerical scheme is based on a
GPU-oriented modification of the Barnes-Hut (BH) algorithm designed to increase
the parallelism of computations. For an ensemble consisting of one million of
ferromagnetic particles, the performance of the proposed algorithm on a Tesla
M2050 GPU demonstrated a computational-time speed-up of four order of magnitude
compared to the performance of the sequential All-Pairs (AP) algorithm on a
single-core CPU, and two order of magnitude compared to the performance of the
optimized AP algorithm on the GPU. The accuracy of the scheme is corroborated
by comparing the results of numerical simulations with theoretical predictions
Nonlinear evolution of short-wavelength torsional AlfvΓ©n waves
We analyze nonlinear evolution of torsional AlfvΓ©n waves in a straight magnetic flux tube filled in with a low-Ξ² plasma, and surrounded with a plasma of lower density. Such magnetic tubes model, in particular, a segment of a coronal loop or a polar plume. The wavelength is taken comparable to the tube radius. We perform a numerical simulation of the wave propagation using ideal magnetohydrodynamics. We find that a torsional wave nonlinearly induces three kinds of compressive flows: the parallel flow at the AlfvΓ©n speed, which constitutes a bulk plasma motion along the magnetic field, the tube wave, and also transverse flows in the radial direction, associated with sausage fast magnetoacoustic modes. In addition, the nonlinear torsional wave steepens and its propagation speed increases. The latter effect leads to the progressive distortion of the torsional wave front, i.e., nonlinear phase mixing. Because of the intrinsic non-uniformity of the torsional wave amplitude across the tube radius, the nonlinear effects are more pronounced in regions with higher wave amplitudes. They are always absent at the axes of the flux tube. In the case of a linear radial profile of the wave amplitude, the nonlinear effects are localized in an annulus region near the tube boundary. Thus, the parallel compressive flows driven by torsional AlfvΓ©n waves in the solar and stellar coronae, are essentially non-uniform in the perpendicular direction. The presence of additional sinks for the wave energy reduces the efficiency of the nonlinear parallel cascade in torsional AlfvΓ©n waves
Colonization by higher plants of iron-ore dumps of Krivyi Rig basin
ΠΠΏΠΈΡΠ°Π½ΠΎ ΠΏΡΠΈΡΠΎΠ΄Π½Π΅ Π·Π°ΡΠΎΡΡΠ°Π½Π½Ρ Π²ΠΈΡΠΈΠΌΠΈ ΡΠΎΡΠ»ΠΈΠ½Π°ΠΌΠΈ Π²ΡΠ΄Π²Π°Π»ΡΠ² Π³ΡΡΠ½ΠΈΡΠΎΠ·Π±Π°Π³Π°ΡΡΠ²Π°Π»ΡΠ½ΠΈΡ
ΠΊΠΎΠΌΠ±ΡΠ½Π°ΡΡΠ² ΠΡΠΈΠ²Π±Π°ΡΡ Π·Π°Π»Π΅ΠΆΠ½ΠΎ Π²ΡΠ΄ ΡΡ
Π²ΡΠΊΡ, Π΅ΠΊΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
ΡΠΌΠΎΠ² Ρ ΡΡΠ±ΡΡΡΠ°ΡΡ. ΠΡΠ°ΡΠ΅ Π·Π°ΡΠΎΡΡΠ°ΡΡΡ Π²ΡΠ΄Π²Π°Π»ΠΈ, ΡΠΊΠ»Π°Π΄Π΅Π½Ρ Π»Π΅ΡΠΎΠ²ΠΈΠ΄Π½ΠΈΠΌΠΈ ΡΡΠ³Π»ΠΈΠ½ΠΊΠ°ΠΌΠΈ, ΠΏΠΎΡΡΠΌ β ΠΊΠ²Π°ΡΡΠΈΡΠ°ΠΌΠΈ, ΡΡΠΌΡΡΡΡ ΡΠΈΡ
ΡΡΠ±ΡΡΡΠ°ΡΡΠ², Π²Π°ΠΏΠ½ΡΠΊΠ°ΠΌΠΈ. Π₯Π°ΡΠ°ΠΊΡΠ΅Ρ ΡΡΠΊΡΠ΅ΡΡΠΉ, Π½Π° Π΄ΡΠΌΠΊΡ Π°Π²ΡΠΎΡΡΠ², Π·Π°Π»Π΅ΠΆΠΈΡΡ ΡΠ°ΠΊΠΎΠΆ Π²ΡΠ΄ Π²ΠΏΠ»ΠΈΠ²Ρ Π°Π»Π΅Π»ΠΎΠΏΠ°ΡΠΈΡΠ½ΠΈΡ
ΡΠΈΠ½Π½ΠΈΠΊΡΠ².ΠΠΏΠΈΡΠ°Π½ΠΎ Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π·Π°ΡΠ°ΡΡΠ°Π½ΠΈΠ΅ Π²ΡΡΡΠΈΠΌΠΈ ΡΠ°ΡΡΠ΅Π½ΠΈΡΠΌΠΈ ΠΎΡΠ²Π°Π»ΠΎΠ² Π³ΠΎΡΠ½ΠΎΠΎΠ±ΠΎΠ³Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΎΠ² ΠΡΠΈΠ²Π±Π°ΡΡΠ° Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΈΡ
Π²ΠΎΠ·ΡΠ°ΡΡΠ°, ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ»ΠΎΠ²ΠΈΠΉ ΠΈ ΡΡΠ±ΡΡΡΠ°ΡΠ°. ΠΡΡΡΠ΅ Π·Π°ΡΠ°ΡΡΠ°ΡΡ ΠΎΡΠ²Π°Π»Ρ, ΡΠ»ΠΎΠΆΠ΅Π½Π½ΡΠ΅ Π»Π΅ΡΡΠΎΠ²ΠΈΠ΄Π½ΡΠΌΠΈ ΡΡΠ³Π»ΠΈΠ½ΠΊΠ°ΠΌΠΈ, Π·Π°ΡΠ΅ΠΌ β ΠΊΠ²Π°ΡΡΠΈΡΠ°ΠΌΠΈ, ΡΠΌΠ΅ΡΡΡ ΡΡΠΈΡ
ΡΡΠ±ΡΡΡΠ°ΡΠΎΠ² ΠΈ ΠΈΠ·Π²Π΅ΡΡΠ½ΡΠΊΠ°ΠΌΠΈ. Π₯Π°ΡΠ°ΠΊΡΠ΅Ρ ΡΡΠΊΡΠ΅ΡΡΠΈΠΉ, ΠΏΠΎ ΠΌΠ½Π΅Π½ΠΈΡ Π°Π²ΡΠΎΡΠΎΠ², Π·Π°Π²ΠΈΡΠΈΡ ΡΠ°ΠΊΠΆΠ΅ ΠΎΡ Π²Π»ΠΈΡΠ½ΠΈΡ Π°Π»Π»Π΅Π»ΠΎΠΏΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ².Natural overgrowing of dumps of the Kryvbas ore-dressing and processing enterprises with higher plants depending on the dumpsβ age, ecological conditions and substrate is described. Better overgrowths are found on the dumps composed by the series: loess-like loams, quartzites, mixture of these substrates and limestone. We suppose that the character of successions depends on the effect of allelopathic factors
New treatment options for bladder cancer patients: based on ASCO 2022 materials and beyond
Bladder cancer is the fourth most common cancer worldwide and the eighth leading cause of cancer mortality in men. The advent of new systemic therapies, including PD-1 and PD-L1 inhibitors, and advances in biomarker development have revolutionized the treatment of this disease. The current guidelines of the National Comprehensive Cancer Network (NCCN) support the inclusion of some new therapies in clinical practice. Over the past decade, many approvals for immuno-therapeutic agents have been obtained. Since bladder cancer is characterized by a high frequency of mutations, there has been a widespread introduction of medicines from the group of immune checkpoint inhibitors. All studies from this review were presented at a recent meeting of the American Society of Clinical Oncology (ASCO) and published in reputable journals
Laboratory predictors to intravesical BCG therapy response in patients with non-muscle invasive bladder cancer
Introduction. Transurethral resection of bladder tumor (TURBT) is the gold standard treatment for patients with non-muscle invasive bladder cancer (NMIBC). However, the high recurrence rate after TURBT makes necessary not only regular following to reveal recurrence disease timely, but it also talks about a necessity of adjuvant antitumor therapy in some cases, that allows to prevent disease recurrence and progression. In this regard, patients belonging to high- and sometimes intermediate- risk progression groups are shown to undergo postoperative adjuvant intravesical Bacillus CalmetteβGuΓ©rin (BCG) therapy. Despite the long experience of using BCG therapy for NMIBC treatment the question of the existence of possible prognostic markers and response predictors to intravesical BCG therapy remains open.Objective. To review cutting-edge data on different markers that can be used as predictive response markers to ongoing intravesical BCG therapy in NMIBC-patients.Materials and methods. A literature search was conducted using PubMed/ Medline and Google Scholar databases. We used terms 'bladder cancer', 'non-muscle-invasive bladder cancer' in conjunction with 'recurrence', 'progression', 'BCG', 'intravesical therapy', 'immune response', 'molecular markers' to choose relevant articles published between 2000 and 2022.Results. Clinical and pathological characteristics of the tumor and the patient himself remain leading in predicting the response to intravesical BCG therapy in NMIBC-patients. However, to improve the effectiveness of assessing the risk of developing adverse BC outcomes and choosing the most appropriate strategy for monitoring and treatment in each case, it is necessary to introduce additional assessment parameters. Molecular and genetic markers could be considered as such parameters, make it possible to reveal differences between tumors at a deeper level.Conclusion. Currently, there are no markers that have high-evidence in predicting response to intravesical BCG therapy in NMIBC-patients compared with the cliniΡal and pathological characteristics of the tumor and the patient himself. The clearer awareness of molecular genetic pathways of BC pathogenesis, the mechanism of BCG antitumor effect will make it possible to competently select markers that have the highest specificity for BC, which will increase the predictive ability of currently existing tools to assess the risks of BC recurrence and progression
Π’Π°ΠΊΡΠ°Π½Ρ Π² ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠ°ΠΊΠ° ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ: ΠΎΠ±Π·ΠΎΡ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
Prostate cancer is one of the most common causes of death from oncological diseases in men. Taxanes (including docetaxel and cabazitaxel) are microtubule-stabilizing agents which block mitotic cell division leading to apoptosis. Past data have shown promise and good tolerability for different regimens. Recent studies demonstrated that taxanes prolonged the survival both metastatic (hormone sensitive and castrationresistant) locally advanced prostate cancer. In this article, we describe current treatments for Ρrostate cancer in different stages with taxanes.Π Π°ΠΊ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ β ΠΎΠ΄Π½Π° ΠΈΠ· Π²Π΅Π΄ΡΡΠΈΡ
ΠΏΡΠΈΡΠΈΠ½ ΡΠΌΠ΅ΡΡΠΈ ΠΎΡ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Ρ ΠΌΡΠΆΡΠΈΠ½. ΠΠ°ΡΡΡΠ΅Π½ΠΈΠ΅ ΠΆΠΈΠ·Π½Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠΈΠΊΠ»Π° ΠΊΠ»Π΅ΡΠΊΠΈ ΠΈΠΌΠ΅Π΅Ρ ΡΠ΅ΡΠ°ΡΡΠ΅Π΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π΄Π»Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΠΊΠ° ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ. Π’Π°ΠΊΡΠ°Π½Ρ, Π²ΠΊΠ»ΡΡΠ°Ρ Π΄ΠΎΡΠ΅ΡΠ°ΠΊΡΠ΅Π» ΠΈ ΠΊΠ°Π±Π°Π·ΠΈΡΠ°ΠΊΡΠ΅Π», ΡΠ²Π»ΡΡΡΡΡ ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·ΠΈΡΡΡΡΠΈΠΌΠΈ ΠΌΠΈΠΊΡΠΎΡΡΡΠ±ΠΎΡΠΊΠΈ Π°Π³Π΅Π½ΡΠ°ΠΌΠΈ, Π±Π»ΠΎΠΊΠΈΡΡΡΡΠΈΠΌΠΈ ΠΌΠΈΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡΠΈΠΌΠΈ ΠΊ Π°ΠΏΠΎΠΏΡΠΎΠ·Ρ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΡΠΎΡΠ»ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Ρ
ΠΎΡΠΎΡΡΡ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΠΌΠΎΡΡΡ ΡΠ°ΠΊΡΠ°Π½ΠΎΠ² ΠΈ ΠΌΠ½ΠΎΠ³ΠΎΠΎΠ±Π΅ΡΠ°ΡΡΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΠ΅ΠΆΠΈΠΌΠ°Ρ
ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ. Π ΠΏΡΠ΅Π΄ΡΠ΄ΡΡΠΈΡ
ΡΠ°Π±ΠΎΡΠ°Ρ
ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ°ΠΊΡΠ°Π½ΠΎΠ² ΠΏΡΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ (ΠΊΠ°ΠΊ Π³ΠΎΡΠΌΠΎΠ½ΠΎΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌ, ΡΠ°ΠΊ ΠΈ ΠΊΠ°ΡΡΡΠ°ΡΠΈΠΎΠ½Π½ΠΎ-ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΠΌ) ΠΈ ΠΌΠ΅ΡΡΠ½ΠΎ-ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΠΌ (Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ ΠΊΠ°ΠΊ ΡΠ»Π΅ΠΌΠ΅Π½Ρ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ) ΠΏΡΠΎΡΠ΅ΡΡΠ΅. Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΡΠ°ΡΡΠ΅ ΠΎΠΏΠΈΡΡΠ²Π°ΡΡΡΡ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΡΠ°ΠΊΠ° ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ Π½Π° ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΡΡΠ°Π΄ΠΈΡΡ
The impact of the time interval from diagnosis to radical prostatectomy on oncological outcomes in high-risk prostate cancer
Introduction. To date, the impact of the time interval from diagnostic prostate biopsy to radical prostatectomy on treatment outcomes remains a topical issue.Objective. To evaluate the effect of the timespan from diagnosis to radical treatment of prostate cancer (PCa) patients on tumor morphology and long-term oncological outcomes.Materials and methods. A retrospective analysis of the results of treatment of patients with high-risk PCa who underwent radical prostatectomy with extended lymphadenectomy from 2001 to 2019 in three St. Petersburg clinics was performed. The influence of the time interval from prostate biopsy to radical treatment on long-term outcomes was assessed.Results. An increase in the time interval before surgical treatment over three months did not affect the tumor morphology. Five-year biochemical relapse-free survival was 79.7%, 67.8% and 52.5% among patients with time interval from biopsy to surgical treatment less than 30 days, 30 β 90 days and more than 90 days, respectively. The time interval prior to radical treatment did not have any effect on overall and cancer-specific survival.Conclusion. The time interval from prostate biopsy to surgical intervention, not exceeding 3 months, is the most favorable with respect to long-term outcomes
Effect of taxanes on the miR-106 and miR-200c expression in prostate cancer cells in vivo and in vitro
Introduction. A combination of antiandrogen and cytostatic drugs was justified in the neoadjuvant therapy of patients with high-risk prostate cancer (HiRPCa) in some clinical trials. The effectiveness of such therapy in each individual case depends on the sensitivity of cancer cells to the applied drugs. It makes possible the development of the new technologies to personalize therapeutic approach. MicroRNAs (miRNAs) are a class of regulatory molecules whose expression is altered in PCa cells and can be associated with the sensitivity/resistance of cancer cells to specific cytostatics, for instance, taxanes.Objective. To identify the potential-marker miRNAs of PCa cells sensitivity to taxanes.Materials and methods. Samples of PCa tissue (n. 56) obtained from patients underwent neo-adjuvant therapy (antiandrogen and taxanes) and radical prostatectomy; PCa cell lines (PC-3, DU-145, LNCap). Total RNAs isolation was carried out using miRNeasy FFPE Kit, LRU-100-50; miRCURY LNA miRNA Focus PCR Panel, All-MIR kits were used for semi-quantitative analysis of potentially marker microRNA molecules using sequential reverse transcription and PCR.Results. The effect of taxanes on PCa cells is associated with up-regulation of miR-106b expression and down-regulation of miR-200c expression in both in vivo and in vitro conditions.Conclusion. MiR-106b and miR-200c miRNAs are involved in the response of PCa cells to taxanes, and therapeutic modification of these molecules in PCa cells may present a potential strategy to increase their sensitivity to taxane-containing therapy. Appropriate innovative technology may be in demand in the treatment of HiRPCa-patients
The cBio cancer Genomics portal: An open platform for exploring multidimensional cancer genomics data
Cataloged from PDF version of article.The cBio Cancer Genomics Portal (http://cbioportal.org) is an open-access resource for interactive exploration of multidimensional cancer genomics data sets, currently providing access to data from more than 5,000 tumor samples from 20 cancer studies. The cBio Cancer Genomics Portal significantly lowers the barriers between complex genomic data and cancer researchers who want rapid, intuitive, and high-quality access to molecular profiles and clinical attributes from large-scale cancer genomics projects and empowers researchers to translate these rich data sets into biologic insights and clinical applications. Β© 2012 American Association for Cancer Research
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