397 research outputs found
A quantum Monte-Carlo method for fermions, free of discretization errors
In this work we present a novel quantum Monte-Carlo method for fermions,
based on an exact decomposition of the Boltzmann operator . It
can be seen as a synthesis of several related methods. It has the advantage
that it is free of discretization errors, and applicable to general
interactions, both for ground-state and finite-temperature calculations. The
decomposition is based on low-rank matrices, which allows faster calculations.
As an illustration, the method is applied to an analytically solvable model
(pairing in a degenerate shell) and to the Hubbard model.Comment: 5 pages, 4 figures, submitted to Phys. Rev. Let
Continuous Time Quantum Monte Carlo Method for Fermions: Beyond Auxiliary Field Framework
Numerically exact continuous-time Quantum Monte Carlo algorithm for finite
fermionic systems with non-local interactions is proposed. The scheme is
particularly applicable for general multi-band time-dependent correlations
since it does not invoke Hubbard-Stratonovich transformation. The present
determinantal grand-canonical method is based on a stochastic series expansion
for the partition function in the interaction representation. The results for
the Green function and for the time-dependent susceptibility of multi-orbital
super-symmetric impurity model with a spin-flip interaction are presented
Loss of ‘Small-World’ Networks in Alzheimer's Disease: Graph Analysis of fMRI Resting-State Functional Connectivity
BACKGROUND: Local network connectivity disruptions in Alzheimer's disease patients have been found using graph analysis in BOLD fMRI. Other studies using MEG and cortical thickness measures, however, show more global long distance connectivity changes, both in functional and structural imaging data. The form and role of functional connectivity changes thus remains ambiguous. The current study shows more conclusive data on connectivity changes in early AD using graph analysis on resting-state condition fMRI data. METHODOLOGY/PRINCIPAL FINDINGS: 18 mild AD patients and 21 healthy age-matched control subjects without memory complaints were investigated in resting-state condition with MRI at 1.5 Tesla. Functional coupling between brain regions was calculated on the basis of pair-wise synchronizations between regional time-series. Local (cluster coefficient) and global (path length) network measures were quantitatively defined. Compared to controls, the characteristic path length of AD functional networks is closer to the theoretical values of random networks, while no significant differences were found in cluster coefficient. The whole-brain average synchronization does not differ between Alzheimer and healthy control groups. Post-hoc analysis of the regional synchronization reveals increased AD synchronization involving the frontal cortices and generalized decreases located at the parietal and occipital regions. This effectively translates in a global reduction of functional long-distance links between frontal and caudal brain regions. CONCLUSIONS/SIGNIFICANCE: We present evidence of AD-induced changes in global brain functional connectivity specifically affecting long-distance connectivity. This finding is highly relevant for it supports the anterior-posterior disconnection theory and its role in AD. Our results can be interpreted as reflecting the randomization of the brain functional networks in AD, further suggesting a loss of global information integration in disease
Test your surrogate data before you test for nonlinearity
The schemes for the generation of surrogate data in order to test the null
hypothesis of linear stochastic process undergoing nonlinear static transform
are investigated as to their consistency in representing the null hypothesis.
In particular, we pinpoint some important caveats of the prominent algorithm of
amplitude adjusted Fourier transform surrogates (AAFT) and compare it to the
iterated AAFT (IAAFT), which is more consistent in representing the null
hypothesis. It turns out that in many applications with real data the
inferences of nonlinearity after marginal rejection of the null hypothesis were
premature and have to be re-investigated taken into account the inaccuracies in
the AAFT algorithm, mainly concerning the mismatching of the linear
correlations. In order to deal with such inaccuracies we propose the use of
linear together with nonlinear polynomials as discriminating statistics. The
application of this setup to some well-known real data sets cautions against
the use of the AAFT algorithm.Comment: 14 pages, 15 figures, submitted to Physical Review
Level density and thermal properties in rare earth nuclei
A convergent method to extract the nuclear level density and the gamma-ray
strength function from primary gamma-ray spectra has been established.
Thermodynamical quantities have been obtained within the microcanonical and
canonical ensemble theory. Structures in the caloric curve and in the heat
capacity curve are interpreted as fingerprints of breaking of Cooper pairs and
quenching of pairing correlations. The strength function can be described using
models and common parameterizations for the E1, M1 and pygmy resonance
strength. However, a significant decrease of the pygmy resonance strength at
finite temperatures has been observed.Comment: 15 pages including 8 figures. Proceedings article for the conference
Nuclear Structure and Related Topics, Dubna, Russia, June 6-10, 200
Pairing in nuclear systems: from neutron stars to finite nuclei
We discuss several pairing-related phenomena in nuclear systems, ranging from
superfluidity in neutron stars to the gradual breaking of pairs in finite
nuclei. We focus on the links between many-body pairing as it evolves from the
underlying nucleon-nucleon interaction and the eventual experimental and
theoretical manifestations of superfluidity in infinite nuclear matter and of
pairing in finite nuclei. We analyse the nature of pair correlations in nuclei
and their potential impact on nuclear structure experiments. We also describe
recent experimental evidence that points to a relation between pairing and
phase transitions (or transformations) in finite nuclear systems. Finally, we
discuss recent investigations of ground-state properties of random two-body
interactions where pairing plays little role although the interactions yield
interesting nuclear properties such as 0+ ground states in even-even nuclei.Comment: 74 pages, 33 figs, uses revtex4. Submitted to Reviews of Modern
Physic
Electronic Structure Calculation by First Principles for Strongly Correlated Electron Systems
Recent trends of ab initio studies and progress in methodologies for
electronic structure calculations of strongly correlated electron systems are
discussed. The interest for developing efficient methods is motivated by recent
discoveries and characterizations of strongly correlated electron materials and
by requirements for understanding mechanisms of intriguing phenomena beyond a
single-particle picture. A three-stage scheme is developed as renormalized
multi-scale solvers (RMS) utilizing the hierarchical electronic structure in
the energy space. It provides us with an ab initio downfolding of the global
band structure into low-energy effective models followed by low-energy solvers
for the models. The RMS method is illustrated with examples of several
materials. In particular, we overview cases such as dynamics of semiconductors,
transition metals and its compounds including iron-based superconductors and
perovskite oxides, as well as organic conductors of kappa-ET type.Comment: 44 pages including 38 figures, to appear in J. Phys. Soc. Jpn. as an
invited review pape
Glucocorticoids Decrease Hippocampal and Prefrontal Activation during Declarative Memory Retrieval in Young Men
Glucocorticoids (GCs, cortisol in human) are associated with impairments in declarative memory retrieval. Brain regions hypothesized to mediate these effects are the hippocampus and prefrontal cortex (PFC). Our aim was to use fMRI in localizing the effects of GCs during declarative memory retrieval. Therefore, we tested memory retrieval in 21 young healthy males in a randomized placebo-controlled crossover design. Participants encoded word lists containing neutral and emotional words 1 h prior to ingestion of 20 mg hydrocortisone. Memory retrieval was tested using an old/new recognition paradigm in a rapid event-related design. It was found that hydrocortisone decreased brain activity in both the hippocampus and PFC during successful retrieval of neutral words. These observations are consistent with previous animal and human studies suggesting that glucocorticoids modulate both hippocampal and prefrontal brain regions that are crucially involved in memory processing
Comparative characterization of mesenchymal stem cells from eGFP transgenic and non-transgenic mice
Abstract Background Adipose derived- and bone marrow-derived murine mesenchymal stem cells (mMSCs) may be used to study stem cell properties in an in vivo setting for the purposes of evaluating therapeutic strategies that may have clinical applications in the future. If these cells are to be used for transplantation, the question arises of how to track the administered cells. One solution to this problem is to transplant cells with an easily identifiable genetic marker such as enhanced green fluorescent protein (eGFP). This protein is fluorescent and therefore does not require a chemical substrate for identification and can be visualized in living cells. This study seeks to characterize and compare adipose derived- and bone marrow-derived stem cells from C57Bl/6 mice and eGFP transgenic C57Bl/6 mice. Results The expression of eGFP does not appear to affect the ability to differentiate along adipogenic or osteogenic lineages; however it appears that the tissue of origin can influence differentiation capabilities. The presence of eGFP had no effect on cell surface marker expression, and mMSCs derived from both bone marrow and adipose tissue had similar surface marker profiles. There were no significant differences between transgenic and non-transgenic mMSCs. Conclusion Murine adipose derived and bone marrow derived mesenchymal stem cells from non-transgenic and eGFP transgenic C57Bl/6 mice have very similar characterization profiles. The availability of mesenchymal stem cells stably expressing a genetic reporter has important applications for the advancement of stem cell research.</p
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