Continuous safe water monitoring using 3G telemetry in IDP camp water supply systems: Iraq trial

Water quality monitoring for disinfection using chlorine in humanitarian settings is predominantly measured through low-resolution manual sampling and analysis methods, that is subject to human error, as well as being highly dependent on accessibility of sites, capacity and availability of human resources. The Chloroclam, a small high-resolution chlorine analyser that transmits continuous real-time data through a 2G/3G mobile network, was trialled over a 7-month period in an IDP camp in Northern Iraq to determine its functionality and ease of use in a crisis context. The results validated the data produced by the Chloroclam, with datasets highlighting significant seasonal and diurnal variances in chlorine concentrations and noting that manual sampling was not representative of the functionality of the water supply system. The data was able to suggest adjustments to dosing regimes to ensure sufficient levels of chlorine is available throughout collection periods and across the year

Novel spectrophotometric method for determination of cinacalcet hydrochloride in its tablets via derivatization with 1,2-naphthoquinone-4-sulphonate

This study represents the first report on the development of a novel spectrophotometric method for determination of cinacalcet hydrochloride (CIN) in its tablet dosage forms. Studies were carried out to investigate the reaction between CIN and 1,2-naphthoquinone-4-sulphonate (NQS) reagent. In alkaline medium (pH 8.5), an orange red-colored product exhibiting maximum absorption peak (λmax) at 490 nm was produced. The stoichiometry and kinetic of the reaction were investigated and the reaction mechanism was postulated. This color-developing reaction was employed in the development of a simple and rapid visible-spectrophotometric method for determination of CIN in its tablets. Under the optimized reaction conditions, Beer's law correlating the absorbance with CIN concentration was obeyed in the range of 3 - 100 μg/ml with good correlation coefficient (0.9993). The molar absorptivity (ε) was 4.2 × 105 l/mol/cm. The limits of detection and quantification were 1.9 and 5.7 μg/ml, respectively. The precision of the method was satisfactory; the values of relative standard deviations (RSD) did not exceed 2%. No interference was observed from the excipients that are present in the tablets. The proposed method was applied successfully for the determination of CIN in its pharmaceutical tablets with good accuracy and precisions; the label claim percentage was 100.80 - 102.23 ± 1.27 - 1.62%. The results were compared favorably with those of a reference pre-validated method. The method is practical and valuable in terms of its routine application in quality control laboratories

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Study of concentration of lactic acid obtained in the process of lactic fermentation of lactose contained in the spent whey using Lactobacillus

Serwatka kwaśna jest groźnym ekologicznie odpadem, będącym produktem ubocznym powstającym w przemyśle mleczarskim. Z uwagi na wysoką zawartość laktozy, odpad ten może być wykorzystywany jako surowiec w procesie fermentacji mlekowej, w którym ulega dalszej przemianie do kwasu mlekowego, przy udziale bakterii fermentacji mlekowej. Niniejsza publikacja stanowi przegląd literaturowy dotyczący procesu fermentacji mlekowej oraz opis badań własnych nad efektywnością procesu fermentacji mlekowej laktozy, pozyskanej z serwatki poprodukcyjnej, do kwasu mlekowego.Acid whey is an environmentally hazardous waste which is a by-product produced in the dairy industry. Due to the high lactose content, the waste can be used as a raw material for lactic fermentation process, where it is converted further to lactic acid using lactic acid bacteria. This publication is a literature review on lactic acid fermentation process and includes description of own research on efficiency of lactic acid fermentation of lactose, obtained from spent whey, to lactic acid

EXOME REPORT: Novel mutation in ATP6V1B2 segregating with autosomal dominant epilepsy, intellectual disability and mild gingival and nail abnormalities

Mutations in ATP6V1B2, which encodes the B2 subunit of the vacuolar H + ATPase have previously been associated with Zimmermann-Laband syndrome 2 (ZLS2) and deafness-onychodystrophy (DDOD) syndrome. Recently epilepsy has also been described as a potentially associated phenotype. Here we further uncover the role of ATP61VB2 in epilepsy and report autosomal dominant inheritance of a novel missense variant in ATP6V1B2 in a large Polish family with relatively mild gingival and nail problems, no phalangeal hypoplasia and with generalized epilepsy. In light of our findings and review of the literature, we propose that the ATP6V1B2 gene should be considered in families with autosomal dominant epilepsy both with or without intellectual disability, and that presence of subtle gingival and nail problems may be another characteristic calling card of affected individuals with ATP6V1B2 mutations.Marie Shawa, Anna Winczewska-Wiktor, Magdalena Badura-Stronka, Sunita Koirala ... Alison Gardner ... Jozef Gecz ... et al