Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy

This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations. Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window. The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells. The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled

Phonon arithmetic in a trapped ion system

Single-quantum level operations are important tools to manipulate a quantum state. Annihilation or creation of single particles translates a quantum state to another by adding or subtracting a particle, depending on how many are already in the given state. The operations are probabilistic and the success rate has yet been low in their experimental realization. Here we experimentally demonstrate (near) deterministic addition and subtraction of a bosonic particle, in particular a phonon of ionic motion in a harmonic potential. We realize the operations by coupling phonons to an auxiliary two-level system and applying transitionless adiabatic passage. We show handy repetition of the operations on various initial states and demonstrate by the reconstruction of the density matrices that the operations preserve coherences. We observe the transformation of a classical state to a highly non-classical one and a Gaussian state to a non-Gaussian one by applying a sequence of operations deterministically

Genetic diversity of taraxacum germplasm revealed by sequence-related amplified polymorphism (SRAP) analysis

Sequence-related amplified polymorphism (SRAP) and morphological markers were employed to determine the genetic diversity and relations among 11 population of taraxacum in northeast of China. Data on 34 morphological traits were collected and analyzed. A total of 795 polymorphic SRAP’s bands were scored with 20 combinations of primers. The genetic relationships analyzed with un-weighed pairgroup method with arithmetic mean (UPMGA) showed that 11 population of taraxacum were grouped into three clusters. The results reveal by SRAP molecular markers were consistent with those based on the agronomic traits, suggesting that SRAP markers could be used in the taxonomic analysis of taraxacum germplasm.Key words: Taraxacum, sequence-related amplified polymorphism (SRAP), genetic diversity, un-weighed pairgroup method with arithmetic mean (UPMGA)

M-SSE: an effective searchable symmetric encryption with enhanced security for mobile devices

Searchable Encryption (SE) allows mobile devices with limited computing and storage resources to outsource data to an untrusted cloud server. Users are able to search and retrieve the outsourced, however, it suffers from information and privacy leakage. The reason is that most of the previous works rely on the single cloud model, which allows that the cloud server get all the search information from users. In this paper, we present a new scheme M-SSE that achieves both forward and backward security based on a multi-cloud technique. The new scheme is secure against both adaptive file injection attack and size pattern attack by utilizing multiple cloud servers. Experiment results show that our scheme is effective compared with the other existing schemes

Infrared stability of ABJ-like theories

We consider marginal deformations of the superconformal ABJM/ABJ models which preserve N=2 supersymmetry. We determine perturbatively the spectrum of fixed points and study their infrared stability. We find a closed line of fixed points which is IR stable. The fixed point corresponding to the ABJM/ABJ models is stable under marginal deformations which respect the original SU(2)xSU(2) invariance, while deformations which break this group destabilize the theory which then flows to a less symmetric fixed point. We discuss the addition of flavor degrees of freedom. We prove that in general a flavor marginal superpotential does not destabilize the system in the IR. An exception is represented by a marginal coupling which mixes matter charged under different gauge sectors. Finally, we consider the case of relevant deformations which should drive the system to a strongly coupled IR fixed point recently investigated in arXiv:0909.2036 [hep-th].Comment: 1+11 pages, 4 figures; v2: minor correction