Increased maternal TSH and decreased maternal FT4 are associated with a higher operative delivery rate in low-risk pregnancies:A prospective cohort study

Background:  The increasing number of operative deliveries is a topic of major concern in modern obstetrics. Maternal thyroid function is of known influence on many obstetric parameters. Our objective was to investigate a possible relation between maternal thyroid function, and operative deliveries. Secondary aim was to explore whether thyroid function was related to specific reasons for operative deliveries. Methods:  In this prospective cohort study, low-risk Caucasian women, pregnant of a single cephalic fetus were included. Women with known auto-immune disease, a pre-labour Caesarean section, induction of labour, breech presentation or preterm delivery were excluded. In all trimesters of pregnancy the thyroid function was assessed. Differences in mean TSH and FT4 were assessed using t-test. Mean TSH and FT4 levels for operative deliveries were determined by one way ANOVA. Repeated measurement analyses were performed (ANOVA), adjusting for BMI, partiy, maternal age and gestational age at delivery. Results:  In total 872 women were included, of which 699 (80.2 %) had a spontaneous delivery. At 36 weeks gestation women who had an operative delivery had a significantly higher mean TSH (1.63mIU/L versus 1.46mIU/L, p = 0.025) and lower mean FT4 (12.9pmol/L versus 13.3pmol/L, p = 0.007)) compared to women who had a spontaneous delivery. Mean TSH was significantly higher (p = 0.026) and mean FT4 significantly lower (p = 0.030) throughout pregnancy for women with an operative delivery due to failure to progress in second stage of labour, compared to women with a spontaneous delivery or operative delivery for other reasons. Conclusion:  Increased TSH and decreased FT4 seem to be associated with more operative vaginal deliveries and Caesarean sections. After adjusting for several confounders the association remained for operative deliveries due to failure to progress in second stage of labour, possibly to be explained by less efficient uterine action

Earth Through the Eyes of NAPA-1: Commissioning Results and the Next Steps in CubeSat Earth Observation

Disruptive CubeSat technology has brought scientific missions within reach that were previously only achievable through larger spacecraft. Satellite Earth Observation is now the new frontier for governments, private industry, and academia. With the recent launch of the Napa-1 satellite the Royal Thai Airforce (RTAF) has joined the ranks by having its first ever Earth Observation CubeSat in space. Its design, launch, early operations (LEOPS), and commissioning have been carried out by ISISpace, supporting the market’s need for imagery from space. Napa-1, meaning firmament in Thai, is a 6U CubeSat with the Gecko Imager from SCS Space as its primary payload, capable of taking RGB snapshot images with a 39-meter ground sampling distance (GSD) from 500 km altitude. In addition, the TriScape camera from Simera Sense flies onboard as an in-orbit technology demonstrator and is capable of delivering high-quality images with a GSD of 5 meter in the RGB bands. With well over 200 images taken by the primary payload this paper will look back on this exciting first period of Napa-1’s operational life and proudly present the very first images taken by the satellite and the lessons learnt throughout this turnkey mission. With that many images taken and that much data generated, the implemented onboard- and on ground data handling systems have been put to the test. ISISpace has made use of KUBOS’ Major Tom for command and control and having integrated a low-level processing tool, also for image data preview and delivery. Insight is provided into the systems and tools in place for image target planning, image acquisition, satellite command and control, and data delivery to the customer. How is it ensured targets are successfully captured? How is the usefulness of the image data efficiently validated? Subsequently, how is knowledge transfer to the customer accomplished to ensure successful routine operations? ISISpace will share the valuable lessons learnt from the mission planning, data handling, operations, and training points of view and show relevant in-orbit data on, for example, attitude behavior and temperature. In parallel, ISISpace has taken the next step in CubeSat Earth observation by using Napa-1 as a baseline while accommodating larger data streams and leveraging a higher level of automation. Together with the companies Simera Sense and Pinkmatter Solutions, multispectral images with automated on ground data processing (L0 up to L3) are to be delivered by the follow-up mission, Napa-2, to be launched in the summer of 2021. Details on this mission, including a further outlook at how CubeSat imagery and on ground processing will be shaped in the next few years will be provided

A comprehensive MRI investigation to identify potential biomarkers of Osgood Schlatter disease in adolescents: A cross sectional study comparing Osgood Schlatter disease with controls

BackgroundOsgood–Schlatter disease (OSD) is the most common knee pain complaint among adolescents playing sports. Despite this, there remains controversy over the pathophysiology and whether specific anatomical characteristics are associated with OSD.PurposeThis study aimed to systematically and comprehensively characterize adolescents with OSD using magnetic resonance imaging (MRI) compared to pain-free controls, including both tissue abnormalities that may be associated with OSD, as well as anatomical characteristics. A secondary objective was to identify potential imaging biomarkers associated with pain.Study DesignCross-sectional study.MethodsAdolescents with OSD and controls were recruited from 2020 to 2022. Following a clinical exam, demographics, pain, sports participation, and Tanner stage were collected. Knee MRI was conducted on the participants' most symptomatic knee (OSD) or the dominant leg (controls).ResultsSixty-seven adolescents (46 with OSD and 30 controls) were included. 80% of participants with OSD had at least one tissue alteration compared to 54% of controls. Compared to controls, OSD had 36.3 (95%CI 4.5 to 289.7) higher odds of bony oedema at the tibial tuberosity, and 32.7 (95%CI 4.1 to 260.6) and 5.3 (95%CI 0.6 to 46.2) higher odds of bony oedema at the tibial epiphysis and metaphysis respectively. Participants with OSD also had higher odds of fluid/oedema at the patellar tendon (12.3 95%CI 3.3 to 46.6), and superficial infrapatellar bursitis (7.2). Participants with OSD had a more proximal tendon attachment (mean tibial attachment portion difference, −0.05, 95% CI: −0.1 to 0.0, p = 0.02), tendon thickness (proximal mean difference, −0.09, 95% CI: −0.4 to 0.2, p = 0.04; distal mean difference, −0.6, 95% CI: −0.9 to −0.2, p = 0.01). Those with bony/tendon oedema had 1.8 points (95% CI: 0.3 to 3.2) higher pain on palpation than those without (t = −2.5, df = 26.6, p = 0.019), but there was no difference between these groups in a functional single leg pain provocation.ConclusionAdolescents with OSD present with tissue and structural abnormalities on MRI that differed from age-matched controls. The majority had findings in the patellar tendon and bone, which often co-occurred. However, a small proportion of OSD also presents without alterations. It appears these findings may be associated with clinical OSD-related pain on palpation of the tibial tuberosity.Clinical RelevanceOur highlight the pathophysiology on imaging, which has implications for understanding the mechanism and treatment of OSD

The Relationship Between Irrational Beliefs and Depressed Mood in Clinically Depressed Outpatients

Studies into the relationship between irrational beliefs and severity of depression have yielded variable results. Furthermore, there is a lack of information on the nature of this relationship within clinically depressed patients. The paper explores the relationship between BDI scores and individual irrational beliefs as measured by the Irrational Beliefs Test (IBT) in a clinical outpatient group (N=63) with major and minor depressive disorders diagnosed according to Research Diagnostic Criteria and in a comparison group of university students (N=43). The results of MANOVA analyses showed that the two groups differed significantly in overall level of irrational beliefs and in their endorsement of 7 out of 10 irrational belief scales. They also differed as to which irrational belief scale scores were predictive of BDI score. Findings suggested that several rational emotive therapy constructs lack explanatory and predictive power with respect to depressive relationships

An intergalactic medium temperature from a giant radio galaxy

© 2022 The Author(s). Published by Oxford University Press on behalf of Royal Astronomical Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).The warm-hot intergalactic medium (warm-hot IGM, or WHIM) pervades the filaments of the Cosmic Web and harbours half of the Universe's baryons. The WHIM's thermodynamic properties are notoriously hard to measure. Here we estimate a galaxy group - WHIM boundary temperature using a new method. In particular, we use a radio image of the giant radio galaxy (giant RG, or GRG) created by NGC 6185, a massive nearby spiral. We analyse this extraordinary object with a Bayesian 3D lobe model and deduce an equipartition pressure $P_\mathrm{eq} = 6 \cdot 10^{-16}\ \mathrm{Pa}$ -- among the lowest found in RGs yet. Using an X-ray-based statistical conversion for Fanaroff-Riley II RGs, we find a true lobe pressure $P = 1.5\substack{+1.7\\-0.4}\cdot 10^{-15}\ \mathrm{Pa}$. Cosmic Web reconstructions, group catalogues, and MHD simulations furthermore imply an $\mathrm{Mpc}$-scale IGM density $1 + \delta_\mathrm{IGM} = 40\substack{+30\\-10}$. The buoyantly rising lobes are crushed by the IGM at their inner side, where an approximate balance between IGM and lobe pressure occurs: $P_\mathrm{IGM} \approx P$. The ideal gas law then suggests an IGM temperature $T_\mathrm{IGM} = 11\substack{+12\\-5} \cdot 10^6\ \mathrm{K}$, or $k_\mathrm{B}T_\mathrm{IGM} = 0.9\substack{+1.0\\-0.4}\ \mathrm{keV}$, at the virial radius -- consistent with X-ray-derived temperatures of similarly massive groups. Interestingly, the method is not performing at its limit: in principle, estimates $T_\mathrm{IGM} \sim 4 \cdot 10^6\ \mathrm{K}$ are already possible -- rivalling the lowest X-ray measurements available. The technique's future scope extends from galaxy group outskirts to the WHIM. In conclusion, we demonstrate that observations of GRGs in Cosmic Web filaments are finally sensitive enough to probe the thermodynamics of galaxy groups and beyond.Peer reviewe

Finding AGN remnant candidates based on radio morphology with machine learning

Remnant radio galaxies represent the dying phase of radio-loud active galactic nuclei (AGN). Large samples of remnant radio galaxies are important for quantifying the radio galaxy life cycle. The remnants of radio-loud AGN can be identified in radio sky surveys based on their spectral index, or, complementary, through visual inspection based on their radio morphology. However, this is extremely time-consuming when applied to the new large and sensitive radio surveys. Here we aim to reduce the amount of visual inspection required to find AGN remnants based on their morphology, through supervised machine learning trained on an existing sample of remnant candidates. For a dataset of 4107 radio sources, with angular sizes larger than 60 arcsec, from the LOw Frequency ARray (LOFAR) Two-Metre Sky Survey second data release (LoTSS-DR2), we started with 151 radio sources that were visually classified as 'AGN remnant candidate'. We derived a wide range of morphological features for all radio sources from their corresponding Stokes-I images: from simple source catalogue-derived properties, to clustered Haralick-features, and self-organising map (SOM) derived morphological features. We trained a random forest classifier to separate the 'AGN remnant candidates' from the not yet inspected sources. The SOM-derived features and the total to peak flux ratio of a source are shown to be most salient to the classifier. We estimate that $31\pm5\%$ of sources with positive predictions from our classifier will be labelled 'AGN remnant candidates' upon visual inspection, while we estimate the upper bound of the $95\%$ confidence interval for 'AGN remnant candidates' in the negative predictions at $8\%$. Visual inspection of just the positive predictions reduces the number of radio sources requiring visual inspection by $73\%$.Comment: 23 pages; accepted for publication in A&

Type 2 Diabetes Mellitus and Vertebral Fracture Risk

Purpose of Review: The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus. Recent Findings: Vertebral fracture risk is increased in individuals with T2DM. The presence of vertebral fractures in T2DM is associated with increased non-vertebral fracture risk and mortality. TBS could be helpful to estimate vertebral fracture risk in individuals with T2DM. An increased amount of bone marrow fat has been implicated in bone fragility in T2DM. Results from two recent studies show that both teriparatide and denosumab are effective in reducing vertebral fracture risk also in individuals with T2DM. Summary: Individuals with T2DM could benefit from systematic screening in the clinic for presence of vertebral fractures

On Form Factors in nested Bethe Ansatz systems

We investigate form factors of local operators in the multi-component Quantum Non-linear Schr\"odinger model, a prototype theory solvable by the so-called nested Bethe Ansatz. We determine the analytic properties of the infinite volume form factors using the coordinate Bethe Ansatz solution and we establish a connection with the finite volume matrix elements. In the two-component models we derive a set of recursion relations for the "magnonic form factors", which are the matrix elements on the nested Bethe Ansatz states. In certain simple cases (involving states with only one spin-impurity) we obtain explicit solutions for the recursion relations.Comment: 34 pages, v2 (minor modifications