Demon-like Algorithmic Quantum Cooling and its Realization with Quantum Optics

The simulation of low-temperature properties of many-body systems remains one of the major challenges in theoretical and experimental quantum information science. We present, and demonstrate experimentally, a universal cooling method which is applicable to any physical system that can be simulated by a quantum computer. This method allows us to distill and eliminate hot components of quantum states, i.e., a quantum Maxwell's demon. The experimental implementation is realized with a quantum-optical network, and the results are in full agreement with theoretical predictions (with fidelity higher than 0.978). These results open a new path for simulating low-temperature properties of physical and chemical systems that are intractable with classical methods.Comment: 7 pages, 5 figures, plus supplementarity material

Brownian Carnot engine

The Carnot cycle imposes a fundamental upper limit to the efficiency of a macroscopic motor operating between two thermal baths. However, this bound needs to be reinterpreted at microscopic scales, where molecular bio-motors and some artificial micro-engines operate. As described by stochastic thermodynamics, energy transfers in microscopic systems are random and thermal fluctuations induce transient decreases of entropy, allowing for possible violations of the Carnot limit. Despite its potential relevance for the development of a thermodynamics of small systems, an experimental study of microscopic Carnot engines is still lacking. Here we report on an experimental realization of a Carnot engine with a single optically trapped Brownian particle as working substance. We present an exhaustive study of the energetics of the engine and analyze the fluctuations of the finite-time efficiency, showing that the Carnot bound can be surpassed for a small number of non-equilibrium cycles. As its macroscopic counterpart, the energetics of our Carnot device exhibits basic properties that one would expect to observe in any microscopic energy transducer operating with baths at different temperatures. Our results characterize the sources of irreversibility in the engine and the statistical properties of the efficiency -an insight that could inspire novel strategies in the design of efficient nano-motors.Comment: 7 pages, 7 figure

Cosmic Background Bose Condensation (CBBC)

Degeneracy effects for bosons are more important for smaller particle mass, smaller temperature and higher number density. Bose condensation requires that particles be in the same lowest energy quantum state. We propose a cosmic background Bose condensation, present everywhere, with its particles having the lowest quantum energy state, A c/lambda, with lambda about the size of the visible universe, and therefore unlocalized. This we identify with the quantum of the self gravitational potential energy of any particle, and with the bit of information of minimum energy. The entropy of the universe (similar to 10(122) bits) has the highest number density (similar to 10(36) bits/cm(3)) of particles inside the visible universe, the smallest mass, similar to 10(-66) g, and the smallest temperature, similar to 10(-29) K. Therefore it is the best candidate for a Cosmic Background Bose Condensation (CBBC), a completely calmed fluid, with no viscosity, in a superfluidity state, and possibly responsible for the expansion of the universe.Alfonso-Faus, A.; Fullana Alfonso, MJ. (2013). Cosmic Background Bose Condensation (CBBC). Astrophysics and Space Science. 347(1):193-196. doi:10.1007/s10509-013-1500-8S1931963471Alfonso-Faus, A.: Universality of the self gravitational potential energy of any fundamental particle. Astrophys. Space Sci. 337, 363 (2010a)Alfonso-Faus, A.: The case for the Universe to be a quantum black hole. Astrophys. Space Sci. 325, 113 (2010b)Alfonso-Faus, A.: Galaxies: kinematics as a proof of the existence of a universal field of minimum acceleration. arXiv:0708.0308 (2010c, preprint)Alfonso-Faus, A.: Quantum gravity and information theories linked by the physical properties of the bit. arXiv:1105.3143 (2011, preprint)Anderson, J.D., et al.: Indication, from Pioneer 10/11, Galileo, and Ulysses data, of an apparent anomalous, weak, long-range acceleration. Phys. Rev. Lett. 81, 2858 (1998)Bekenstein, J.D.: Phys. Rev. D 23(2), 287 (1981)Bérut, A., et al.: Experimental verification of Landauer’s principle linking information and thermodynamics. Nature 483, 187 (2012)Drees, M., Chung-Lin, S.: Theoretical interpretation of experimental data from direct dark matter detection. J. Cosmol. Astropart. Phys. 0706, 011 (2007)Eisberg, R., Resnick, R.: Quantum Physics of Atoms, Molecules, Solids, Nuclei and Particles, 2nd edn. Wiley, New York (1985)Funo, K., Watanabe, Y., Ueda, M.: Thermodynamic work gain from entanglement. arXiv:1207.6872 [quant-ph] (2012, preprint)Hawking, S.W.: Black hole explosions? Nature 248, 30 (1974)Landauer, R.: Irreversibility and heat generation in the computing process. IBM J. Res. Dev. 5, 183 (1961)Landauer, R.: Dissipation and noise immunity in computation and communication. Nature 335, 779 (1988)Lloyd, S.: Computational capacity of the universe. Phys. Rev. Lett. 88, 237901 (2002)Misner, C.W., Thorne, K.S., Wheeler, J.A.: Gravitation. Freeman, Reading (1973), p. 466 (“Why the energy of the gravitational field cannot be localized”)Scarpa, R., Falomo, R.: Testing Newtonian gravity in the low acceleration regime with globular clusters: the case of omega Centauri revisited. Astron. Astrophys. 523, A43 (2010)Sivaram, C.: Cosmological and quantum constraint on particle masses. Am. J. Phys. 50, 279 (1982)Susskind, L.: The World as a hologram. J. Math. Phys. 36, 6377 (1995)’t Hooft, G.: Dimensional reduction in quantum gravity. arXiv:gr-qc/9310026 (1993, preprint)Toyabe, S., et al.: Experimental demonstration of information-to-energy conversion and validation of the generalized Jarzynski equality. Nat. Phys. 6, 988 (2010)Unruh, W.G.: Notes on black-hole evaporation. Phys. Rev. D, Part. Fields 14(4), 870 (1976)Weinberg, S.: Gravitation and Cosmology: Principles and Applications of the General Theory of Relativity p. 619. Wiley, New York (1972

The alpha 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits <i>Porphyromonas gingivalis</i>-induced expression of interleukin-8 by oral keratinocytes

Objective: The alpha 7 nicotinic receptor (α7nAChR) is expressed by oral keratinocytes. α7nAChR activation mediates anti-inflammatory responses. The objective of this study was to determine if α7nAChR activation inhibited pathogen-induced interleukin-8 (IL-8) expression by oral keratinocytes.&lt;p&gt;&lt;/p&gt; Materials and methods: Periodontal tissue expression of α7nAChR was determined by real-time PCR. OKF6/TERT-2 oral keratinocytes were exposed to &lt;i&gt;Porphyromonas gingivalis&lt;/i&gt; in the presence and absence of a α7nAChR agonist (PHA-543613 hydrochloride) alone or after pre-exposure to a specific α7nAChR antagonist (α-bungarotoxin). Interleukin-8 (IL-8) expression was measured by ELISA and real-time PCR. Phosphorylation of the NF-κB p65 subunit was determined using an NF-κB p65 profiler assay and STAT-3 activation by STAT-3 in-cell ELISA. The release of ACh from oral keratinocytes in response to &lt;i&gt;P. gingivalis&lt;/i&gt; lipopolysaccharide was determined using a GeneBLAzer M3 CHO-K1-blacell reporter assay.&lt;p&gt;&lt;/p&gt; Results: Expression of α7nAChR mRNA was elevated in diseased periodontal tissue. PHA-543613 hydrochloride inhibited &lt;i&gt;P. Gingivalis&lt;/i&gt;-induced expression of IL-8 at the transcriptional level. This effect was abolished when cells were pre-exposed to a specific α7nAChR antagonist, α-bungarotoxin. PHA-543613 hydrochloride downregulated NF-κB signalling through reduced phosphorylation of the NF-κB p65-subunit. In addition, PHA-543613 hydrochloride promoted STAT-3 signalling by maintenance of phosphorylation. Furthermore, oral keratinocytes upregulated ACh release in response to &lt;i&gt;P. Gingivalis&lt;/i&gt; lipopolysaccharide.&lt;p&gt;&lt;/p&gt; Conclusion: These data suggest that α7nAChR plays a role in regulating the innate immune responses of oral keratinocytes.&lt;p&gt;&lt;/p&gt

Experimental free energy measurements of kinetic molecular states using fluctuation theorems

Recent advances in non-equilibrium statistical mechanics and single molecule technologies make it possible to extract free energy differences from irreversible work measurements in pulling experiments. To date, free energy recovery has been focused on native or equilibrium molecular states, whereas free energy measurements of kinetic states (i.e. finite lifetime states that are generated dynamically and are metastable) have remained unexplored. Kinetic states can play an important role in various domains of physics, such as nanotechnology or condensed matter physics. In biophysics, there are many examples where they determine the fate of molecular reactions: protein and peptide-nucleic acid binding, specific cation binding, antigen-antibody interactions, transient states in enzymatic reactions or the formation of transient intermediates and non-native structures in molecular folders. Here we demonstrate that it is possible to obtain free energies of kinetic states by applying extended fluctuation relations. This is shown by using optical tweezers to mechanically unfold and refold DNA structures exhibiting intermediate and misfolded kinetic states.Comment: main paper (16 pages, 5 figures) and supplementary information (22 pages, 14 figures

Production and transfer of energy and information in Hamiltonian systems

We present novel results that relate energy and information transfer with sensitivity to initial conditions in chaotic multi-dimensional Hamiltonian systems. We show the relation among Kolmogorov-Sinai entropy, Lyapunov exponents, and upper bounds for the Mutual Information Rate calculated in the Hamiltonian phase space and on bi-dimensional subspaces. Our main result is that the net amount of transfer from kinetic to potential energy per unit of time is a power-law of the upper bound for the Mutual Information Rate between kinetic and potential energies, and also a power-law of the Kolmogorov-Sinai entropy. Therefore, transfer of energy is related with both transfer and production of information. However, the power-law nature of this relation means that a small increment of energy transferred leads to a relatively much larger increase of the information exchanged. Then, we propose an ?experimental? implementation of a 1-dimensional communication channel based on a Hamiltonian system, and calculate the actual rate with which information is exchanged between the first and last particle of the channel. Finally, a relation between our results and important quantities of thermodynamics is presented

Validity of the Falls Risk for Older People in the Community (FROP‑Com) tool to predict falls and fall injuries for older people presenting to the emergency department after falling

The aims of this study were to (1) externally validate the accuracy of the Falls Risk for Older People in the Community (FROP-Com) falls risk assessment tool in predicting falls and (2) undertake initial validation of the accuracy of the FROPCom to predict injurious falls (requiring medical attention) in people aged ≥ 60 years presenting to emergency departments (EDs) after falling. Two hundred and thirteen participants (mean age = 72.4 years; 59.2% women) were recruited (control group of a randomised controlled trial). A FROP-Com assessment was completed at a home visit within 2 weeks of ED discharge. Data on falls and injurious falls requiring medical attention were collected via monthly falls calendars for the next 12 months. Predictive accuracy was evaluated using sensitivity and specificity of a high-risk FROP-Com classification (score ≥ 19) in predicting a fall and injurious falls requiring medical attention. Fifty per cent of participants fell, with 60.4% of falls requiring medical attention. Thirty-two per cent were classified as high, 49% as moderate and 19% low falls risk. Low sensitivity was achieved for the FROP-Com high-risk classification for predicting falls (43.4%) and injurious falls (34.4%), although specificity was high (79.4% and 78.6%, respectively). Despite the FROP-Com’s low predictive accuracy, the high fall rate and high falls risk of the sample suggest that older people who fall, present to ED and are discharged home are at high risk of future falls. In high-falls-risk populations such as in this study, the FROP-Com is not a valid tool for classifying risk of falls or injurious falls. Its potential value may instead be in identifying risk factors for falling to direct tailoring of falls prevention interventions to reduce future falls

Quasispecies Spatial Models for RNA Viruses with Different Replication Modes and Infection Strategies

Empirical observations and theoretical studies suggest that viruses may use different replication strategies to amplify their genomes, which impact the dynamics of mutation accumulation in viral populations and therefore, their fitness and virulence. Similarly, during natural infections, viruses replicate and infect cells that are rarely in suspension but spatially organized. Surprisingly, most quasispecies models of virus replication have ignored these two phenomena. In order to study these two viral characteristics, we have developed stochastic cellular automata models that simulate two different modes of replication (geometric vs stamping machine) for quasispecies replicating and spreading on a two-dimensional space. Furthermore, we explored these two replication models considering epistatic fitness landscapes (antagonistic vs synergistic) and different scenarios for cell-to-cell spread, one with free superinfection and another with superinfection inhibition. We found that the master sequences for populations replicating geometrically and with antagonistic fitness effects vanished at low critical mutation rates. By contrast, the highest critical mutation rate was observed for populations replicating geometrically but with a synergistic fitness landscape. Our simulations also showed that for stamping machine replication and antagonistic epistasis, a combination that appears to be common among plant viruses, populations further increased their robustness by inhibiting superinfection. We have also shown that the mode of replication strongly influenced the linkage between viral loci, which rapidly reached linkage equilibrium at increasing mutations for geometric replication. We also found that the strategy that minimized the time required to spread over the whole space was the stamping machine with antagonistic epistasis among mutations. Finally, our simulations revealed that the multiplicity of infection fluctuated but generically increased along time

Description of quantum coherence in thermodynamic processes requires constraints beyond free energy

Recent studies have developed fundamental limitations on nanoscale thermodynamics, in terms of a set of independent free energy relations. Here we show that free energy relations cannot properly describe quantum coherence in thermodynamic processes. By casting time-asymmetry as a quantifiable, fundamental resource of a quantum state, we arrive at an additional, independent set of thermodynamic constraints that naturally extend the existing ones. These asymmetry relations reveal that the traditional Szilárd engine argument does not extend automatically to quantum coherences, but instead only relational coherences in a multipartite scenario can contribute to thermodynamic work. We find that coherence transformations are always irreversible. Our results also reveal additional structural parallels between thermodynamics and the theory of entanglement