Long Gamma-Ray Burst Progenitors: Boundary Conditions and Binary Models

The observed association of Long Gamma-Ray Bursts (LGRBs) with peculiar Type Ic supernovae gives support to Woosley`s collapsar/hypernova model, in which the GRB is produced by the collapse of the rapidly rotating core of a massive star to a black hole. The association of LGRBs with small star-forming galaxies suggests low-metallicity to be a condition for a massive star to evolve to the collapsar stage. Both completely-mixed single star models and binary star models are possible. In binary models the progenitor of the GRB is a massive helium star with a close companion. We find that tidal synchronization during core-helium burning is reached on a short timescale (less than a few millennia). However, the strong core-envelope coupling in the subsequent evolutionary stages is likely to rule out helium stars with main-sequence companions as progenitors of hypernovae/GRBs. On the other hand, helium stars in close binaries with a neutron-star or black-hole companion can, despite the strong core-envelope coupling in the post-helium burning phase, retain sufficient core angular momentum to produce a hypernova/GRB.Comment: 8 pp., 2 figs, Proceedings of 5th Stromlo Symposiu

Beam Energy Considerations for Gold Nano-Particle Enhanced Radiation Treatment

Purpose: A novel approach using nano technology enhanced radiation modalities is investigated. The proposed methodology uses antibodies labeled with organically inert metals with a high atomic number. Irradiation using photons with energies in the kilo--electron volt (keV) range show an increase in dose due to a combination of an increase in photo-electric interactions and a pronounced generation of Auger and/or Coster-Kronig (A-CK) electrons. Methods: The dependency of the dose deposition on various factors is investigated using Monte Carlo simulation models. The factors investigated include: agent concentration, spectral dependency looking at mono--energetic sources as well as classical bremsstrahlung sources. The optimization of the energy spectrum is performed in terms of physical dose enhancement as well as the dose deposited by Auger and/or Coster-Kronig electrons and their biological effectiveness. Results: A quasi-linear dependency on concentration and an exponential decrease within the target medium is observed. The maximal dose enhancement is dependent on the position of the target in the beam. Apart from irradiation with low photon energies (10 - 20 keV) there is no added benefit from the increase in generation of Auger electrons. Interestingly, a regular 110kVp bremsstrahlung spectrum shows a comparable enhancement in comparison with the optimized mono--energetic sources. Conclusions: In conclusion we find that the use of nano-particle enhanced shows promise to be implemented quite easily in regular clinic on a physical level due to the advantageous properties in classical beams.Comment: Preprint submitted to Phys Med Bio

Discovery of Two Relativistic Neutron Star-White Dwarf Binaries

We have discovered two recycled pulsars in relativistic orbits as part of the first high-frequency survey of intermediate Galactic latitudes. PSR J1157-5112 is a 44 ms pulsar and the first recycled pulsar with an ultra-massive (M > 1.14 Mo) white dwarf companion. Millisecond pulsar J1757-5322 is a relativistic circular-orbit system which will coalesce due to the emission of gravitational radiation in less than 9.5 Gyr. Of the ~40 known circular orbit pulsars, J1757-5322 and J1157-5112 have the highest projected orbital velocities. There are now three local neutron-star/white-dwarf binaries that will coalesce in less than a Hubble time, implying a large coalescence rate for these objects in the local Universe. Systems such as J1141-6545 (Kaspi et al. 2000) are potential gamma-ray burst progenitors and dominate the coalescence rate, whilst lighter systems make excellent progenitors of millisecond pulsars with planetary or ultra-low mass companions.Comment: 4 pages, to appear in ApJ Letters. Uses aastex v 5.0, emulateapj5.sty, apjfonts.st

Neutrino-Driven Jets and Rapid-Process Nucleosynthesis

We have studied whether the jet in a collapse-driven supernova can be a key process for the rapid-process (r-process) nucleosynthesis. We have examined the features of a steady, subsonic, and rigidly rotating jet in which the centrifugal force is balanced by the magnetic force. As for the models in which the magnetic field is weak and angular velocity is small, we found that the r-process does not occur because the final temperature is kept to be too high and the dynamical timescale becomes too long when the neutrino luminosities are set to be high. Even if the luminosities of the neutrinos are set to be low, which results in the low final temperature, we found that the models do not give a required condition to produce the r-process matter. Furthermore, the amount of the mass outflow seems to be too little to explain the solar-system abundance ratio in such low-luminosity models. As for the models in which the magnetic field is strong and angular velocity is large, we found that the entropy per baryon becomes too small and the dynamical timescale becomes too long. This tendency is, of course, a bad one for the production of the r-process nuclei. As a conclusion, we have to say that it is difficult to cause a successful r-process nucleosynthesis in the jet models in this study.Comment: 34 pages and 6 postscript figures. submitted to Astrophysical Journa

Towards the development of the psychosocial impact of assistive devices scale for continence (C-PIADS)

BACKGROUND: Current outcome measures for continence management devices do not adequately address psychosocial impact. The PIADS is an assessment tool that has been shown to reliably predict the adoption and use of assistive technology devices, but it is not widely used for continence devices. OBJECTIVE: To explore whether the PIADS requires modification to address the particular needs of continence device users and to inform any subsequent item development. METHODS: The study used interpretive methods in which qualitative information from semi-structured interviews was combined with the findings from cognitive interviews for questionnaire pre-testing. A total of 40 participants in UK and Canada were interviewed. RESULTS: Few participants had difficulty in understanding or relating to the majority of PIADS items. Several items were not considered relevant to continence and some areas for potential new items were uncovered. Embarrassment and concealment of urinary incontinence from others were common topics. CONCLUSIONS: The PIADS appears to fundamentally address many, but not all, of the important psychosocial concerns of adults who have continence difficulties. A version for continence, the C-PIADS, will require modification of the PIADS and is likely to contain some new items

Joint modeling with time-dependent treatment and heteroskedasticity: Bayesian analysis with application to the Framingham Heart Study

Medical studies for chronic disease are often interested in the relation between longitudinal risk factor profiles and individuals' later life disease outcomes. These profiles may typically be subject to intermediate structural changes due to treatment or environmental influences. Analysis of such studies may be handled by the joint model framework. However, current joint modeling does not consider structural changes in the residual variability of the risk profile nor consider the influence of subject-specific residual variability on the time-to-event outcome. In the present paper, we extend the joint model framework to address these two heterogeneous intra-individual variabilities. A Bayesian approach is used to estimate the unknown parameters and simulation studies are conducted to investigate the performance of the method. The proposed joint model is applied to the Framingham Heart Study to investigate the influence of anti-hypertensive medication on the systolic blood pressure variability together with its effect on the risk of developing cardiovascular disease. We show that anti-hypertensive medication is associated with elevated systolic blood pressure variability and increased variability elevates risk of developing cardiovascular disease.Comment: 34 pages, 4 figure

Collisional Hardening of Compact Binaries in Globular Clusters

We consider essential mechanisms for orbit-shrinkage or "hardening" of compact binaries in globular clusters to the point of Roche-lobe contact and X-ray emission phase, focussing on the process of collisional hardening due to encounters between binaries and single stars in the cluster core. The interplay between this kind of hardening and that due to emission of gravitational radiation produces a characteristic scaling of the orbit-shrinkage time with the single-star binary encounter rate $\gamma$ in the cluster which we introduce, clarify, and explore. We investigate possible effects of this scaling on populations of X-ray binaries in globular clusters within the framework of a simple "toy" scheme for describing the evolution of pre-X-ray binaries in globular clusters. We find the expected qualitative trends sufficiently supported by data on X-ray binaries in galactic globular clusters to encourage us toward a more quantitative study.Comment: 8 pages, 4 figures. Accepted for publication in MNRA

Evolution of Neutron-Star, Carbon-Oxygen White-Dwarf Binaries

At least one, but more likely two or more, eccentric neutron-star, carbon-oxygen white-dwarf binaries with an unrecycled pulsar have been observed. According to the standard scenario for evolving neutron stars which are recycled in common envelope evolution we expect to observe \gsim 50 such circular neutron star-carbon oxygen white dwarf binaries, since their formation rate is roughly equal to that of the eccentric binaries and the time over which they can be observed is two orders of magnitude longer, as we shall outline. We observe at most one or two such circular binaries and from that we conclude that the standard scenario must be revised. Introducing hypercritical accretion into common envelope evolution removes the discrepancy by converting the neutron star into a black hole which does not emit radio waves, and therefore would not be observed.Comment: 25 pages, 1 figure, accepted in Ap