Reply to "Comment on 'Scalar-tensor gravity coupled to a global monopole and flat rotation curves' "

In Brans-Dicke theory of gravity we explain how the extra constant value in the formula for rotation velocities of stars in a galactic halo can be obtained due to the global monopole field. We argue on a few points of the preceding Comment and discuss improvement of our model.Comment: 4 pages, RevTeX4 fil

Discovery of a massive X-ray luminous galaxy cluster at z=1.579

We report on the discovery of a very distant galaxy cluster serendipitously detected in the archive of the XMM-Newton mission, within the scope of the XMM-Newton Distant Cluster Project (XDCP). XMMUJ0044.0-2033 was detected at a high significance level (5sigma) as a compact, but significantly extended source in the X-ray data, with a soft-band flux f(r<40")=(1.5+-0.3)x10^(-14) erg/s/cm2. Optical/NIR follow-up observations confirmed the presence of an overdensity of red galaxies matching the X-ray emission. The cluster was spectroscopically confirmed to be at z=1.579 using ground-based VLT/FORS2 spectroscopy. The analysis of the I-H colour-magnitude diagram shows a sequence of red galaxies with a colour range [3.7 < I-H < 4.6] within 1' from the cluster X-ray emission peak. However, the three spectroscopic members (all with complex morphology) have significantly bluer colours relative to the observed red-sequence. In addition, two of the three cluster members have [OII] emission, indicative of on-going star formation. Using the spectroscopic redshift we estimated the X-ray bolometric luminosity, Lbol = 5.8x10^44 erg/s, implying a massive galaxy cluster. This places XMMU J0044.0-2033 at the forefront of massive distant clusters, closing the gap between lower redshift systems and recently discovered proto- and low-mass clusters at z >1.6.Comment: letter to appear in A&

Simcluster: clustering enumeration gene expression data on the simplex space

Transcript enumeration methods such as SAGE, MPSS, and sequencing-by-synthesis EST &#x22;digital northern&#x22;, are important high-throughput techniques for digital gene expression measurement. As other counting or voting processes, these measurements constitute compositional data exhibiting properties particular to the simplex space where the summation of the components is constrained. These properties are not present on regular Euclidean spaces, on which hybridization-based microarray data is often modeled. Therefore, pattern recognition methods commonly used for microarray data analysis may be non-informative for the data generated by transcript enumeration techniques since they ignore certain fundamental properties of this space.&#xd;&#xa;&#xd;&#xa;Here we present a software tool, Simcluster, designed to perform clustering analysis for data on the simplex space. We present Simcluster as a stand-alone command-line C package and as a user-friendly on-line tool. Both versions are available at: http://xerad.systemsbiology.net/simcluster.&#xd;&#xa;&#xd;&#xa;Simcluster is designed in accordance with a well-established mathematical framework for compositional data analysis, which provides principled procedures for dealing with the simplex space, and is thus applicable in a number of contexts, including enumeration-based gene expression data

Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants

Purpose: Based on recovered metabolite ratios in urine, it has been concluded that paracetamol glucuronidation may be up-regulated upon multiple dosing. This study investigates paracetamol clearance in neonates and infants after single and multiple dosing using a population modelling approach. Methods: A population pharmacokinetic model was developed in NONMEM VI, based on paracetamol plasma concentrations from 54 preterm and term neonates and infants, and on paracetamol, paracetamol-glucuronide and paracetamol-sulphate amounts in urine from 22 of these patients. Patients received either a single intravenous propacetamol dose or up to 12 repeated doses. Results: Paracetamol and metabolite disposition was best described with one-compartment models. The formation clearance of paracetamol-sulphate was 1.46 mL/min/kg1.4, which was about 5.5 times higher than the formation clearance of the glucuronide of 0.266 mL/min/kg. The renal excretion rate constants of both met

N=8 SCFT and M Theory on AdS_4 x RP^7

We study M theory on AdS_4 \times \RP^7 corresponding to 3 dimensional ${\cal N}=8$ superconformal field theory which is the strong coupling limit of 3 dimensional super Yang-Mills theory. For SU(N) theory, a wrapped M5 brane on \RP^5 can be interpreted as baryon vertex. For $SO(N)/Sp(2N)$ theory, by using the property of (co-)homology of \RP^7, we classify various wrapping branes and consider domain walls and the baryon vertex.Comment: 17 pages, Changed baryon like operator as M5 branes in M theory rather than D6 brane in IIA theory. To appear in Phys.Rev.

Couplings of the Rho Meson in a Holographic dual of QCD with Regge Trajectories

The couplings $g_{\rho HH}$ of the $\rho$ meson with any hadron H are calculated in a holographic dual of QCD where the Regge trajectories for mesons are manifest. The resulting couplings grow linearly with the exciting number of H, thus are far from universal. A simple argument has been given for this behavior based on quasi-classical picture of excited hadrons. It seems that in holographic duals with exact Regge trajectories the $g_{\rho HH}$ universality should be violated. The $\rho$-dominance for the electromagnetic form factors of H are also strongly violated, except for the lowest state, the pion. Quite unexpected, the form factor of the pion is completely saturated by the contribution of the $\rho$. The asymptotic behavior of the form factors are also calculated, and are found to be perfectly accordant with the prediction of conformal symmetry and pertubative QCD.Comment: 9 page

SO/Sp Monopoles and Branes with Orientifold 3 Plane

We study BPS monopoles in 4 dimensional N=4 SO(N) and $Sp(N)$ super Yang-Mills theories realized as the low energy effective theory of $N$ (physical and its mirror) parallel D3 branes and an {\it Orientifold 3 plane} with D1 branes stretched between them in type IIB string theory. Monopoles on D3 branes give the natural understanding by embedding in SU(N) through the constraints on both the asymptotic Higgs field (corresponding to the horizontal positions of D3 branes) and the magnetic charges (corresponding to the number of D1 branes) imposed by the O3 plane. The compatibility conditions of Nahm data for monopoles for these groups can be interpreted very naturally through the D1 branes in the presence of O3 plane.Comment: 18 pages, Latex with RevTex, 1 table, 4 figures, v2: Clarified the introduction and improved on the supersymmetric theory on D1 branes in page 7 and 8 and this final version to appear in Phys.Rev.

Holographic Charged Fluid with Anomalous Current at Finite Cutoff Surface in Einstein-Maxwell Gravity

The holographic charged fluid with anomalous current in Einstein-Maxwell gravity has been generalized from the infinite boundary to the finite cutoff surface by using the gravity/fluid correspondence. After perturbing the boosted Reissner-Nordstrom (RN)-AdS black brane solution of the Einstein-Maxwell gravity with the Chern-Simons term, we obtain the first order perturbative gravitational and Maxwell solutions, and calculate the stress tensor and charged current of the dual fluid at finite cutoff surfaces which contains undetermined parameters after demanding regularity condition at the future horizon. We adopt the Dirichlet boundary condition and impose the Landau frame to fix these parameters, finally obtain the dependence of transport coefficients in the dual stress tensor and charged current on the arbitrary radical cutoff $r_c$. We find that the dual fluid is not conformal, but it has vanishing bulk viscosity, and the shear viscosity to entropy density ratio is universally $1/4\pi$. Other transport coefficients of the dual current turns out to be cutoff-dependent. In particular, the chiral vortical conductivity expressed in terms of thermodynamic quantities takes the same form as that of the dual fluid at the asymptotic AdS boundary, and the chiral magnetic conductivity receives a cutoff-dependent correction which vanishes at the infinite boundary.Comment: 19 pages, v2: references added, v3: typos corrected, v5: typos corrected, version accepted for publication in JHE