The Size of Stable International Environmental Agreements in the case of Stock Pollution

Most of the literature on stability of International Environmental Agreements is essen- tially static and can therefore not identify changes in the size of the stable coalition in connection with changes in the stock of pollutants. This is a relevant issue because most global pollution problems are dynamic with stock externalities. This paper shows that the incentives for membership indeed change with changes in the stock of pollutants and that technology choice is an important factor when considering the consequences.

Optimal Management with Potential Regime Shifts

We analyze how the threat of a potential future regime shift affects optimal management. We use a simple general growth model to analyze four cases that involve combinations of stock collapse versus changes in system dynamics, and exogenous versus endogenous probabilities of regime shift. Prior work has focused on stock collapse with endogenous probabilities and reaches ambiguous conclusions about the effect of potential regime shift on optimal management. We show that all other cases yield unambiguous results. In particular, with endogenous probability of regime shift that affects system dynamics the potential for regime shift causes optimal management to become precautionary.

The ESO Spectroscopic facility

We present the concept of a novel facility dedicated to massively-multiplexed spectroscopy. The telescope has a very wide field Cassegrain focus optimised for fibre feeding. With a Field of View (FoV) of 2.5 degrees diameter and a 11.4m pupil, it will be the largest etendue telescope. The large focal plane can easily host up to 16.000 fibres. In addition, a gravity invariant focus for the central 10 arc-minutes is available to host a giant integral field unit (IFU). The 3 lenses corrector includes an ADC, and has good performance in the 360-1300 nm wavelength range. The top level science requirements were developed by a dedicated ESO working group, and one of the primary cases is high resolution spectroscopy of GAIA stars and, in general, how our Galaxy formed and evolves. The facility will therefore be equipped with both, high and low resolution spectrographs. We stress the importance of developing the telescope and instrument designs simultaneously. The most relevant R\&D aspect is also briefly discussed.Comment: 6 pages 4 figures , presented at IAU Symposium 334 "rediscovering our galaxy

Cerebellar and Extracerebellar Involvement in Mouse Eyeblink Conditioning: the ACDC Model

Over the past decade the advent of mouse transgenics has generated new perspectives on the study of cerebellar molecular mechanisms that are essential for eyeblink conditioning. However, it also appears that results from eyeblink conditioning experiments done in mice differ in some aspects from results previously obtained in other mammals. In this review article we will, based on studies using (cell-specific) mouse mutants and region-specific lesions, re-examine the general eyeblink behavior in mice and the neuro-anatomical circuits that might contribute to the different peaks in the conditioned eyeblink trace. We conclude that the learning process in mice has at least two stages: An early stage, which includes short-latency responses that are at least partly controlled by extracerebellar structures such as the amygdala, and a later stage, which is represented by well-timed conditioned responses that are mainly controlled by the pontocerebellar and olivocerebellar systems. We refer to this overall concept as the Amygdala-Cerebellum-Dynamic-Conditioning Model (ACDC model)

Resonant Orbits in Triaxial Galaxies

Box orbits in triaxial potentials are generically thin, that is, they lie close in phase space to a resonant orbit satisfying a relation of the form l\omega_1 +m\omega_2+n\omega_3=0 between the three fundamental frequencies. Resonant orbits are confined to a membrane; they play roughly the same role, in three dimensions, that closed orbits play in two. Stable resonant orbits avoid the center of the potential; orbits that are thick enough to pass near the center are typically stochastic. Very near the center, where the gravitational potential is dominated by the black hole, resonant orbits continue to exist, including at least one family whose elongation is parallel to the long axes of the triaxial figure.Comment: 20 Latex pages, 11 Postscript figures. Submitted to The Astronomical Journa

Region-specific Foxp2 deletions in cortex, striatum or cerebellum cannot explain vocalization deficits observed in spontaneous global knockouts

FOXP2 has been identified as a gene related to speech in humans, based on rare mutations that yield significant impairments in speech at the level of both motor performance and language comprehension. Disruptions of the murine orthologue Foxp2 in mouse pups have been shown to interfere with production of ultrasonic vocalizations (USVs). However, it remains unclear which structures are responsible for these deficits. Here, we show that conditional knockout mice with selective Foxp2 deletions targeting the cerebral cortex, striatum or cerebellum, three key sites of motor control with robust neural gene expression, do not recapture the profile of pup USV deficits observed in mice with global disruptions of this gene. Moreover, we observed that global Foxp2 knockout pups show substantive reductions in USV production as well as an overproduction of short broadband noise “clicks”, which was not present in the brain region-specific knockouts. These data indicate that deficits of Foxp2 expression in the cortex, striatum or cerebellum cannot solely explain the disrupted vocalization behaviours in global Foxp2 knockouts. Our findings raise the possibility that the impact of Foxp2 disruption on USV is mediated at least in part by effects of this gene on the anatomical prerequisites for vocalizing

Forward Signaling by Unipolar Brush Cells in the Mouse Cerebellum

Unipolar brush cells (UBCs) are glutamatergic interneurons prominently present in the granular layer of the vestibulocerebellum. UBCs engage in extensive synaptic contact with a single presynaptic mossy fiber and signal to downstream granule cells through an elaborate network of mossy fiber-like axons. Ultrastructural examinations and electrophysiological recordings in organotypic slice cultures have indicated that UBCs target not only granule cells but also other UBCs, thus forming chains of two or perhaps more interconnected UBCs. In this report, we show recordings of spontaneous and evoked (di)synaptic events in granule cells and UBCs in fresh cerebellar slices from juvenile mice (5–7 weeks). The patterns of arrival of synaptic events were consistent with the presence of a presynaptic UBC, and recordings from UBCs displayed spontaneous protracted synaptic events characteristic of UBC excitatory synaptic transmission. These results highlight that chains of UBCs could further extend the temporal range of delayed and protracted signaling in the cerebellar cortical network

Reply to "Comment on 'Scalar-tensor gravity coupled to a global monopole and flat rotation curves' "

In Brans-Dicke theory of gravity we explain how the extra constant value in the formula for rotation velocities of stars in a galactic halo can be obtained due to the global monopole field. We argue on a few points of the preceding Comment and discuss improvement of our model.Comment: 4 pages, RevTeX4 fil