The Influence of Seed Mix and Management on the Performance and Persistence of Sown Forbs in Buffer Strips

A popular option under agri-environmental schemes throughout Europe has been the introduction of buffer strips adjacent to field boundaries. Buffer strips are usually established using grass-only seed mixes, or through natural regeneration. As a consequence, their function and biodiversity value might be limited due to a low presence of desirable forb species. Given the financial barrier of using forb-rich seed mixes, there is a need to identify species that establish reliably in parallel with management options that encourage their persistence. In a 5-year study across three different sites we investigated the responses of 32 different forb species sown in two different grass-based seed mixes tailored to soil type. Generally, there was an increase in sown forb cover with time, and this effect was greatest in plots sown with fine-grasses treated with an application of graminicide or an annual cut. We have identified a suite of ten forb species that are likely to establish and persist in buffer strip habitats

Clinical academic career pathway for nursing and allied health professionals: clinical academic role descriptors

The clinical academic pathway outlined highlights the range of typical practice and research-focused activities that a practitioner on a clinical academic career pathway might normally engage in at different levels and points along this career path. The activities are intended as a guide for practitioners interested in learning more about the practice and research components of a clinical academic career, as well as those already employed in clinical academic roles. They may also be useful for health care organisations and Higher Education Institutions as a tool for developing clinical academic roles

Primality-testing Mersenne numbers

Report of a systematic review of Mersenne numbers 2^p-1 for p < 62982

A real-time articulatory visual feedback approach with target presentation for second language pronunciation learning

International audienceArticulatory information can support learning or remediating pronunciation of a second language (L2). This paper describes an electromagnetic articulometer-based visual-feedback approach using an articulatory target presented in real-time to facilitate L2 pronunciation learning. This approach trains learners to adjust articulatory positions to match targets for a L2 vowel estimated from productions of vowels that overlap in both L1 and L2. Training of Japanese learners for the American English vowel /ae/ that included visual training improved its pronunciation regardless of whether audio training was also included. Articulatory visual feedback is shown to be an effective method for facilitating L2 pronunciation learning

Tongue-surface movement patterns during speech and swallowing

The tongue has been frequently characterized as being composed of several functionally independent articulators. The question of functional regionality within the tongue was examined by quantifying the strength of coupling among four different tongue locations across a large number of consonantal contexts and participants. Tongue behavior during swallowing was also described. Vertical displacements of pellets affixed to the tongue were extracted from the x-ray microbeam database. Forty-six participants recited 20 vowel-consonant-vowel (VCV) combinations and swallowed 10 ccs of water. Tongue-surface movement patterns were quantitatively described by computing the covariance between the vertical time-histories of all possible pellet pairs. Phonemic differentiation in vertical tongue motions was observed as coupling varied predictably across pellet pairs with place of articulation. Moreover, tongue displacements for speech and swallowing clustered into distinct groups based on their coupling profiles. Functional independence of anterior tongue regions was evidenced by a wide range of movement coupling relations between anterior tongue pellets. The strengths and weaknesses of the covariance-based analysis for characterizing tongue movement are considered

Reynolds-number Dependence of Streamwise Velocity Fluctuations in Turbulent Pipe Flow

Statistics of the streamwise velocity component in fully-developed pipe flow are examined for Reynolds numbers in the range 5.5 x 10^4 < Re_D < 5.7 x 10^6. The second moment exhibits two maxima: one in the viscous sublayer is Reynolds-number dependent while the other, near the lower edge of the log region, is also Reynolds-number dependent and follows roughly the peak in Reynolds shear stress. The behaviour of both peaks is consistent with the concept of inactive motion which increases with increasing Reynolds number and decreasing distance from the wall. No simple scaling is apparent, and in particular, so-called "mixed" scaling is no better than wall scaling in the viscous sublayer and is actually worse than wall scaling in the outer region. The second moment is compared with empirical and theoretical scaling laws and some anomalies are apparent. The scaling of spectra using y, R and u_τ is examined. It appears that even at the highest Reynolds number, they exhibit incomplete similarity only: while spectra do collapse with either inner or outer scales for limited ranges of wave number, these ranges do not overlap. Thus similarity may not be described as complete and any apparent k_1^(-1) range does not attract any special significance and does not involve universal constants. It is suggested that this is because of the influence of inactive motion. Spectra also show the presence of very long structures close to the wall

The potential for wildflower interventions to enhance natural enemies and pollinators in commercial apple orchards is limited by other management practices

Modern fruit production has successfully increased yields and fruit quality to meet market demands mainly through intensification and the use of Plant Protection Products (PPPs). Due to the associated environmental impacts and consumers increasingly demanding food produced more sustainably, the tree fruit sector is seeking to reduce its reliance on PPPs. Despite intensification, apple production is still highly dependent on ecosystem services, including pest regulation and pollination. The aim of this study was to investigate the response of natural enemies and pollinators in commercial apple orchards to the provision of a wildflower habitat. It was hypothesised that the abundance and diversity of beneficial invertebrate species would be enhanced leading to an increased control of apple pests and enhanced pollination of apple blossom. We also investigated the effect of orchard pesticide toxicity on natural enemies and pest regulation services and how responses varied between apple cultivars (Jazz and Braeburn). The study was carried out in five orchards of each apple variety across Kent (UK), using a split-plot experimental design. At each site, a one-hectare orchard plot was established with wildflower strips in alleyways between rows of trees and compared with a one-hectare control plot where alleyways were managed conventionally with regular cutting. Responses of natural enemies and pollinators were recorded over a period of three and four years, respectively. The presence of wildflower strips did not contribute significantly towards the delivery of natural pest regulation or pollination services. However, hoverfly diversity and species richness were greater in orchards with wildflower strips, and whilst this was not associated with increased rates of pest regulation, such a response could potentially provide more resilient pest regulation and pollination services. Braeburn orchards had higher bee abundance, and pest predation rates, which were associated with a greater abundance of earwigs, compared to Jazz orchards. Of key significance for growers is that high values of cumulative pesticide toxicity negatively affected natural enemy populations, especially earwigs. If growers want to support natural enemies and wild pollinators in modern apple orchards following the principles of ecological intensification, they need to consider both the types and frequency of pesticide sprays used, in conjunction with interventions aimed at promoting beneficial invertebrates

Intratumoral Hydrogen Peroxide With Radiation Therapy in Locally Advanced Breast Cancer: Results From a Phase 1 Clinical Trial.

Purpose Hydrogen peroxide (H2O2) plays a vital role in normal cellular processes but at supraphysiological concentrations causes oxidative stress and cytotoxicity, a property that is potentially exploitable for the treatment of cancer in combination with radiation therapy (RT). We report the first phase 1 trial testing the safety and tolerability of intratumoral H2O2 + external beam RT as a novel combination in patients with breast cancer and exploratory plasma marker analyses investigating possible mechanisms of action.Methods and materials Twelve patients with breast tumors ≥3 cm (surgically or medically inoperable) received intratumoral H2O2 with either 36 Gy in 6 twice-weekly fractions (n = 6) or 49.5 Gy in 18 daily fractions (n = 6) to the whole breast ± locoregional lymph nodes in a single-center, nonrandomized study. H2O2 was mixed in 1% sodium hyaluronate gel (final H2O2 concentration 0.5%) before administration to slow drug release and minimize local discomfort. The mixture was injected intratumorally under ultrasound guidance twice weekly 1 hour before RT. The primary endpoint was patient-reported maximum intratumoral pain intensity before and 24 hours postinjection. Secondary endpoints included grade ≥3 skin toxicity and tumor response by ultrasound. Blood samples were collected before, during, and at the end of treatment for cell-death and immune marker analysis.Results Compliance with H2O2 and RT was 100%. Five of 12 patients reported moderate pain after injection (grade 2 Common Terminology Criteria for Adverse Events v4.02) with median duration 60 minutes (interquartile range, 20-120 minutes). Skin toxicity was comparable to RT alone, with maintained partial/complete tumor response relative to baseline in 11 of 12 patients at last follow-up (median 12 months). Blood marker analysis highlighted significant associations of TRAIL, IL-1β, IL-4, and MIP-1α with tumor response.Conclusions Intratumoral H2O2 with RT is well tolerated with no additional toxicity compared with RT alone. If efficacy is confirmed in a randomized phase 2 trial, the approach has potential as a cost-effective radiation response enhancer in multiple cancer types in which locoregional control after RT alone remains poor

Apple pollination: demand depends on variety and supply depends on pollinator identity

Insect pollination underpins apple production but the extent to which different pollinator guilds supply this service, particularly across different apple varieties, is unknown. Such information is essential if appropriate orchard management practices are to be targeted and proportional to the potential benefits pollinator species may provide. Here we use a novel combination of pollinator effectiveness assays (floral visit effectiveness), orchard field surveys (flower visitation rate) and pollinator dependence manipulations (pollinator exclusion experiments) to quantify the supply of pollination services provided by four different pollinator guilds to the production of four commercial varieties of apple. We show that not all pollinators are equally effective at pollinating apples, with hoverflies being less effective than solitary bees and bumblebees, and the relative abundance of different pollinator guilds visiting apple flowers of different varieties varies significantly. Based on this, the taxa specific economic benefits to UK apple production have been established. The contribution of insect pollinators to the economic output in all varieties was estimated to be £92.1M across the UK, with contributions varying widely across taxa: solitary bees (£51.4M), honeybees (£21.4M), bumblebees (£18.6M) and hoverflies (£0.7M). This research highlights the differences in the economic benefits of four insect pollinator guilds to four major apple varieties in the UK. This information is essential to underpin appropriate investment in pollination services management and provides a model that can be used in other entomolophilous crops to improve our understanding of crop pollination ecology