Inducing spin triplet superconductivity in a ferromagnet

Combining ferromagnetism and superconductivity can lead to the development of a completely new generation of technology, with unique and powerful characteristics, called superconducting spintronics. The task of developing this, however, is challenging because at the microscopic level the superconducting and ferromagnetic states are intrinsically incompatible. Under certain conditions, however, the conventional (singlet) superconducting state can be converted into the triplet one, with the spins of the electrons forming the Cooper pairs aligned parallel. The triplet state can coexist with ferromagnetism and is very interesting both for applications and from a fundamental point of view. In this thesis we study the electrical properties of small hybrid devices that mainly consist of superconducting and ferromagnetic layers. By measuring the electrical resistance of these devices as a function of parameters such as the temperature or the applied magnetic field, it is possible to indirectly infer important information about the state of the (super)conductivity in the different layers. We investigate different types of devices (multilayers, triplet spin valves and Josephson junctions), in order to address different aspects related to the generation of the triplet state, for a better and better control of the process

Colossal proximity effect in a superconducting triplet spin valve based on halfmetallic ferromagnetic CrO2

Ferromagnets can sustain supercurrents through the formation of equal spin triplet Cooper pairs and the mechanism of odd-frequency pairing. Since such pairs are not broken by the exchange energy of the ferromagnet, superconducting triplet correlations are long-ranged and spin-polarized, with promises for superconducting spintronics devices. The main challenge is to understand how triplets are generated at the superconductor (S)/ ferromagnet (F) interface. Here we use the concept of a so-called triplet spin valve (TSV) to investigate the conversion of singlets in a conventional superconductor to triplets in the halfmetallic ferromagnet CrO_2. TSV's are composed of two ferromagnetic layers (separated by a thin normal metal (N) layer) and a superconductor (F_1/N/F_2/S). The package F_1/N/F_2 generates triplets in F_1 when the magnetization directions of the F_{1,2}-layers are not collinear. This drains singlet pairs from the S-layer, and triplet generation is therefore signalled by a decrease of the critical temperature $T_c$. Recently, experiments with TSV's were reported with Co draining layers, using in-plane fields, and finding T_c-shifts up to 100~mK. Using CrO_2 instead of Co and rotating a magnetic field from in-plane to out-of-plane, we find strong T_c variations of almost a Kelvin up to fields of the order of a Tesla. Such strong drainage is consistent with the large lengths over which supercurrents can flow in CrO_2, which are significantly larger than in conventional ferromagnets. Our results point to the special interest of halfmetals for superconducting spintronics.Comment: 6 pages, 5 figures; supplementary information separat

Triplet generation and upper critical field in superconducting spin valves based on CrO2

Quantum Matter and Optic

Emergence of the stripe-domain phase in patterned permalloy films

The occurrence of stripe domains in ferromagnetic permalloy (Py = Fe20Ni80) is a well-known phenomenon which has been extensively observed and characterized. This peculiar magnetic configuration appears only in films with a thickness above a critical value (dcr), which is strongly determined by the sputtering conditions (i.e., deposition rate, temperature, magnetic field). So far, dcr has usually been presented as the boundary between the homogeneous (H) and stripe-domain (SD) regime, respectively, below and above dcr. In this work we study the transition from the H to the SD regime in thin films and microstructured bridges of Py with different thicknesses. We find there is an intermediate regime, over a quite significant thickness range below dcr, which is signaled in confined structures by a quickly changing domain-wall configuration and by a broadening of the magnetoresistance dip at the coercive field. We call this the emerging stripe-domain (ESD) regime. The transition from the ESD to the SD regime is accompanied by a sharp increase of the magnetoresistance ratio at the thickness where stripes appear in MFM

TRAIL, OPG, and TWEAK in kidney disease: biomarkers or therapeutic targets?

Ligands and receptors of the tumor necrosis factor (TNF) superfamily regulate immune responses and homeostatic functions with potential diagnostic and therapeutic implications. Kidney disease represents a global public health problem, whose prevalence is rising worldwide, due to the aging of the population and the increasing prevalence of diabetes, hypertension, obesity, and immune disorders. In addition, chronic kidney disease is an independent risk factor for the development of cardiovascular disease, which further increases kidney-related morbidity and mortality. Recently, it has been shown that some TNF superfamily members are actively implicated in renal pathophysiology. These members include TNF-related apoptosis-inducing ligand (TRAIL), its decoy receptor osteoprotegerin (OPG), and TNF-like weaker inducer of apoptosis (TWEAK). All of them have shown the ability to activate crucial pathways involved in kidney disease development and progression (e.g. canonical and non-canonical pathways of the transcription factor nuclear factor-kappa B), as well as the ability to regulate cell proliferation, differentiation, apoptosis, necrosis, inflammation, angiogenesis, and fibrosis with double-edged effects depending on the type and stage of kidney injury. Here we will review the actions of TRAIL, OPG, and TWEAK on diabetic and non-diabetic kidney disease, in order to provide insights into their full clinical potential as biomarkers and/or therapeutic options against kidney disease

An Intracellular Arrangement of Histoplasma capsulatum Yeast-Aggregates Generates Nuclear Damage to the Cultured Murine Alveolar Macrophages

Histoplasma capsulatum is responsible for a human systemic mycosis that primarily affects lung tissue. Macrophages are the major effector cells in humans that respond to the fungus, and the development of respiratory disease depends on the ability of Histoplasma yeast cells to survive and replicate within alveolar macrophages. Therefore, the interaction between macrophages and H. capsulatum is a decisive step in the yeast dissemination into host tissues. Although the role played by components of cell-mediated immunity in the host's defense system and the mechanisms used by the pathogen to evade the host immune response are well understood, knowledge regarding the effects induced by H. capsulatum in host cells at the nuclear level is limited. According to the present findings, H. capsulatum yeast cells display a unique architectural arrangement during the intracellular infection of cultured murine alveolar macrophages, characterized as a formation of aggregates that seem to surround the host cell nucleus, resembling a crown. This extranuclear organization of yeast-aggregates generates damage on the nucleus of the host cell, producing DNA fragmentation and inducing apoptosis, even though the yeast cells are not located inside the nucleus and do not trigger changes in nuclear proteins. The current study highlights a singular intracellular arrangement of H. capsulatum yeast near to the nucleus of infected murine alveolar macrophages that may contribute to the yeast’s persistence under intracellular conditions, since this fungal pathogen may display different strategies to prevent elimination by the host's phagocytic mechanisms

Disinfection of Ocular Cells and Tissues by Atmospheric-Pressure Cold Plasma

Background: Low temperature plasmas have been proposed in medicine as agents for tissue disinfection and have received increasing attention due to the frequency of bacterial resistance to antibiotics. This study explored whether atmospheric-pressure cold plasma (APCP) generated by a new portable device that ionizes a flow of helium gas can inactivate ocular pathogens without causing significant tissue damage. Methodology and Principal Findings: We tested the APCP effects on cultured Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Candida albicans, Aspergillus fumigatus and Herpes simplex virus-1, ocular cells (conjunctival fibroblasts and keratocytes) and ex-vivo corneas. Exposure to APCP for 0.5 to 5 minutes significantly reduced microbial viability (colony-forming units) but not human cell viability (MTT assay, FACS and Tunel analysis) or the number of HSV-1 plaque-forming units. Increased levels of intracellular reactive oxygen species (ROS) in exposed microorganisms and cells were found using a FACS-activated 2',7'-dichlorofluorescein diacetate probe. Immunoassays demonstrated no induction of thymine dimers in cell cultures and corneal tissues. A transient increased expression of 8-OHdG, genes and proteins related to oxidative stress (OGG1, GPX, NFE2L2) was determined in ocular cells and corneas by HPLC, qRT-PCR and Western blot analysis. Conclusions: A short application of APCP appears to be an efficient and rapid ocular disinfectant for bacteria and fungi without significant damage on ocular cells and tissues, although the treatment of conjunctival fibroblasts and keratocytes caused a time-restricted generation of intracellular ROS and oxidative stress-related responses