Anti-glycation agent comprising a Garcinia kola extract or fraction

This invention relates to an anti-glycation agent comprising a Garcinia kola extract or fraction. The compositions comprising the extract or the fraction are used to inhibit the glycation of proteins, in particular the glycation of skin proteins involved in cutaneous aging. This invention also relates to a method for determining the activity of compounds for inhibiting the glycation of cutaneous proteins, in particular for inhibiting the glycation of collagen

Metformin overdose: A serious iatrogenic complication-Western France Poison Control Centre Data Analysis

INTRODUCTION: The prevalence of type 2 diabetes (T2D) continues to rise across the world. Metformin is still considered the "gold standard" and is, therefore, increasingly prescribed. Monitoring of metformin continues to be debated because of its association with lactic acidosis (MALA), a rare but life-threatening complication. The aim of this study was to identify the main individual characteristics associated with severe poisoning in self-poisonings and therapeutic accidents reported at the Western France Poison Control Centre (PCC). METHODS: Retrospective study of metformin poisoning from September 1999 to September 2016 at the Western France PCC recorded in the French PCC\u27s database (SICAP). The end-point was clinically high severity (mortality and/or cardiovascular shock and/or GCS ≤ 7/15). RESULTS: Of the 382 cases included, 197 concerned acute accidental exposures, 127 self-poisonings and 58 therapeutic accidents. MALA concerned 63 patients: 44 therapeutic accidents and 19 self-poisonings. High severity concerned 59 patients: 47 therapeutic accidents and 12 self-poisonings. T2D and age > 60 significantly increase the risk of high severity (OR 7.7, CI [1.54-38.41]; P = 0.013; OR 3.5, CI [1.60-7.84]; P = 0.002, respectively). CONCLUSIONS: Metformin may lead to MALA and severe poisoning in therapeutic accidents but also in self-poisoning circumstances. Among reported cases, T2D history and age >60 increase the risk of serious poisoning. Monitoring of their treatment should be taken seriously especially in the event of digestive symptoms such as diarrhoea

Primary School Teachers’ Knowledge Regarding Emergency Management of Avulsed Permanent Incisors

Objective: The goal of this study was to evaluate primary school teachers' knowledge regarding emergency management of avulsed permanent incisors.Materials and Methods: The study was conducted in fifty randomly chosen primary schools from Casablanca, Morocco. All teachers of the selected schools were included in the study. The data were collected by self administered questionnaires. The questions focusedon the teachers' general characteristics, experience of avulsed teeth and the importance of emergency management. The data were analyzed using chi square test.Results: A total of 501 teachers, of which 23.6% were male and 75.4% were female, answered the questionnaire. The results showed that 44.5 % of the teachers had an experience of avulsed tooth at school, 82.82% of them knew the importance of emergency managementand 32.6% would look for a dentist for treatment of the cases. Only 15.8% would reimplant the tooth themselves. Regarding the storage media, 21.95% would keep the avulsed tooth in milk. There was no significant difference between gender and education level (p>0.05).Conclusion: This study shows school teachers' lack of knowledge regarding dental trauma and especially tooth avulsion. Therefore, the results indicated that educational programs are necessary for improvement in their level of knowledge

Influence de quelques facteurs environnementaux sur la germination d'Euphorbia heterophylla L. (Euphorbiaceae)

Influence of some Environmental Factors on Euphorbia heterophylla L. (Euphorbiaceae) Seeds Germination. In Ivory Coast, Euphorbia heterophylla appears as a weed in cotton fields. Effects of temperature, light and burying levels on its seed germination were tested. Temperature effects were monitored by means of 4 procedures, using a range of temperatures between 20 and 35 °C. The germination latency period can vary between 1 and 2 days, according to the temperature. After 4 days, germination rates were not longer related to temperature and were very similar. Germination can not happen without light. In order to measure the effect of burying levels, six series of 100 seeds were buried; the first at ground level, the others respectively 2, 4, 6, 8 and 9 cm deeper. Optimal germination rates were found for seeds that were buried between 0 and 6 cm

Key traveller groups of relevance to spatial malaria transmission: a survey of movement patterns in four sub-Saharan African countries

Background: As malaria prevalence declines in many parts of the world due to widescale control efforts and as drug-resistant parasites begin to emerge, a quantitative understanding of human movement is becoming increasingly relevant to malaria control. However, despite its importance, significant knowledge gaps remain regarding human movement, particularly in sub-Saharan Africa. Methods: A quantitative survey of human movement patterns was conducted in four countries in sub-Saharan Africa: Mali, Burkina Faso, Zambia, and Tanzania, with three to five survey locations chosen in each country. Questions were included on demographic and trip details, malaria risk behaviour, children accompanying travellers, and mobile phone usage to enable phone signal data to be better correlated with movement. A total of 4352 individuals were interviewed and 6411 trips recorded. Results: A cluster analysis of trips highlighted two distinct traveller groups of relevance to malaria transmission: women travelling with children (in all four countries) and youth workers (in Mali). Women travelling with children were more likely to travel to areas of relatively high malaria prevalence in Mali (OR = 4.46, 95 % CI = 3.42–5.83), Burkina Faso (OR = 1.58, 95 % CI = 1.23–1.58), Zambia (OR = 1.50, 95 % CI = 1.20–1.89), and Tanzania (OR = 2.28, 95 % CI = 1.71–3.05) compared to other travellers. They were also more likely to own bed nets in Burkina Faso (OR = 1.77, 95 % CI = 1.25–2.53) and Zambia (OR = 1.74, 95 % CI = 1.34 2.27), and less likely to own a mobile phone in Mali (OR = 0.50, 95 % CI = 0.39–0.65), Burkina Faso (OR = 0.39, 95 % CI = 0.30–0.52), and Zambia (OR = 0.60, 95 % CI = 0.47–0.76). Malian youth workers were more likely to travel to areas of relatively high malaria prevalence (OR = 23, 95 % CI = 17–31) and for longer durations (mean of 70 days cf 21 days, p < 0.001) compared to other travellers. Conclusions: Women travelling with children were a remarkably consistent traveller group across all four countries surveyed. They are expected to contribute greatly towards spatial malaria transmission because the children they travel with tend to have high parasite prevalence. Youth workers were a significant traveller group in Mali and are expected to contribute greatly to spatial malaria transmission because their movements correlate with seasonal rains and hence peak mosquito densities. Interventions aimed at interrupting spatial transmission of parasites should consider these traveller groups

Physicochemical and Nutritional Properties of Varieties of Carrot (Daucus carota) grown in Region of Korhogo, North of Côte d’Ivoire

Very popular for its therapeutic and nutritional virtues, culture of carrot (Daucus carota) has developed in temperate zones of Asia and Europe but also in some tropical regions of Africa including Côte d'Ivoire. Agronomic factors, commercial and food requirements require selection of varieties with good nutritional values. In this study, physicochemical properties and nutritional values of four carrot varieties namely Amazonia, Bahia, Madona and Pamela+ were compared after cultivation and harvest in region of Korhogo. Results showed that, Amazonia, the control carrot variety stands out for its acidity and minerals levels. Bahia is the richest variety with high levels of carbohydrate and protein. Madona is the most basic, wettest and fatest carrot. For a long storage, Pamela is most interesting variety. To our knowledge, it is the first time that physicochemical and nutritional parameters of carrot varieties in region of Korhogo have been studied. Future research on these carrot varieties will be studied of their post-harvest conservation, their sensory analysis and their transformation

Synthesis of Perfectly Oriented MAPb0.93Cr0.07Br3 Perovskite Crystals for Thin-Film Photovoltaic Applications

[EN] Wide band gap methylammonium lead halide perovskites (CH3NH3PbX3, X=halogen; CH3NH3: MA) are interesting materials for photovoltaic applications. They have recently gained substantial attention because of their high efficiency, low cost, superior optical properties. The most attractive and representative perovskites are methylammonium lead halides (CH3NH3PbX3,) denoted as MAPbX3, X = Br, Cl, I. usually the optical and structural properties of CH3NH3PbBr3 can be adjusted by introducing other extrinsic ions such as chloride and bromide. In this work, instead of replacing the halogens I or Cl with bromine (Br) as usual, we preferred to act on the post-transition metal (Pb). To this end, we replaced lead with chromium (Cr) which is a transition metal and may have the same oxidation state (+2) as lead. MAPb0.93Cr0.07Br3 thin films were deposited on ITO substrate by the spin coating process. X-ray diffraction analyses indicated the formation of a cubic perovskite with space group Pm3 m. The structural analysis reveals films with (110) and (220) as main peaks. Deposited films showed a strong absorbance in the UV¿vis range. The band gap values were estimated from absorbance measurements. It was found between 1.60 and 1.80 eV. SEM analysis shows a morphology with good coverage and no apparent crystal orientation.Soro, D.; Sidibé, M.; Fassinou, W.; Marí, B.; Sall, T.; Fofana, B.; Boko, A.... (2017). Synthesis of Perfectly Oriented MAPb0.93Cr0.07Br3 Perovskite Crystals for Thin-Film Photovoltaic Applications. International Journal of Innovative Research in Science, Engineering and Technology. IJIRSET (Online). 6(6):10170-10176. doi:10.15680/IJIRSET.2017.0606007S10170101766