The effect of the Ti (IV)-citrate complex on Staphylococcus aureus growth and biofilm formation

The primary objective of this study was to investigate the influence of the Ti (IV)-citrate complex on growth dynamics and biofilm formation of S. aureus. Speciation analysis was performed in order to estimate the structure of the Ti complex existing in citrate solutions at near-physiological pH. It is estimated that the fully deprotonated tris(citrate) titanate ion [Ti(C6H4O7)3]8- predominates in solution at pH 6.46-7.44, and that this is most probably the biologically active form of Ti(IV)-citrate. In in vitro experiments, increasing concentrations of citric acid solutions (0.05, 0.005, 0.0005 M), served as positive controls, while the effects of respective concentrations of Ti(IV)-citrate were examined. The obtained results indicate that citrate decreased S. aureus 48 growth at all studied concentrations, whereas S. aureus 44 growth was decreased only by high concentrations of citrate (0.05M). Incubation of S. aureus culture with Ti(IV)-citrate significantly potentiated citrate-induced effects. Ti(IV)-citrate significantly altered specific bacterial growth rate in a similar manner. The most significant growth reduction was observed at the initial period of bacterial growth. At the same time, the opposite effect was detected in investigations of the effect of citrate and Ti(IV)-citrate on S. aureus biofilm formation. Citric acid suppressed S. aureus biofilm formation, whereas Ti(IV)-citrate displayed a significant stimulatory effect. Our findings suggest that Ti(IV)-citrate possesses a more pronounced biological effect than citrate. The proposed mechanism of this action is activation of complex transport into the cell and induction of oxidative stress. However, the exact mechanism of Ti(IV)-citrate biological action on bacterial cultures remains unknown

Hypobaric hypoxia in treatment of metabolic menopausal syndrom

The aim of the research was to evaluate effectiveness of intermittent hypobaric hypoxic adaptation (IHHA) in treatment menopausal metabolic syndrome. The technique hypobaric hypoxia in a pressure chamber 'Ural -1 ‘ at simulated altitude of 3500 m (460 mm.Hg.) 22 three hours IHHA daily session course is used at treatment of 68 women (mean age 52,8+1,1) with metabolic menopausal syndrome. Influence of the given not medicamentous method of treatment on clinical displays menopausal syndrome, weight of a body, a level hormones, parameters lipid and a carbohydrate exchange was estimated. Om completion of the IHHA course redused modified menopause index by 39,9%, systolic arterial pressure by 13,4% and diastolic arterial pressure by 7,3%, body mass decrease by 6,1%. Follicle stimulating hormone and luteinizing hormone levels to decrease by 33,1 % and 27,8% accordingly. Estradiol level and degidroepiandrosteron increase by 15,2% and 17,2% accordingly; reduction of total holesterol by 19,5%, glucosae by 21,3%, insulin by 20,2%. In result high efficiency of use of a method of adaptation to periodic hypoxia in correction of metabolic infringements in postmenopause is revealed.Цель работы - выявить эффективность метода адаптации к периодической барокамерной гипоксии в лечении менопаузального метаболического синдрома. Использован метод адаптации к гипобарической гипоксии в барокамере «Урал-1»: 22 трехчасовых сеанса, проводимых ежедневно на «высоте» 3500 метров (460 мм.рт.ст.) в лечении 68 женщин (средний возраст 52,8+1,1) с менопаузальным метаболическим синдромом. Оценивалось влияние данного немедикаментозного метода на клинические проявления менопаузального синдрома, массу тела, уровень гормонов, показатели липидного и углеводного обмена. В результате адаптации к периодической барокамерной гипоксии выявлено снижение модифицированного менопаузального индекса на 39,9%, массы тела на 6,1%, систолического АД на 13,4% и диастолического АД на 7,3%. Уменьшился уровень фолликулостимулирующего и лютеинизирующего гормонов на 33,1 % и 27,8% соответственно, повысился уровень эстрадиола и дегидрозпиандростерона-сульфата на 15,2% и 17,2% соответственно; снизился уровень холестерина на 19,5%, глюкозы на 21,3%, инсулина на 20,2%. В результате исследования выявлена эффективность метода адаптации к периодической барокамерной гипоксии в коррекции метаболических нарушений у женщин в постменопаузе

Hypobarotherapy in correction clinical disorders of menopausal syndrom in women with natural and surgical menopause

The aim of the research was to evaluate effectiveness of hypobarotherapy in comparison with hormonal replacement therapy (HRT) in correction clinical disturbances in 216 women with menopausal syndrom. The technique hypobaric hypoxia in a pressure chamber 'Ural -1 ' at simulated altitude of 3500 m (460 mm.Hg.) 22 three hours daily session course is used at treatment women with different type of menopause (natural and surgical menopause). Influence of the given not medicamentous method of treatment, hormonal replacement therapy and complex therapy (hypobarotherapy and HRT) on clinical symptoms of menopausal syndrome in women with different type of menopause was estimated. In result high efficiency of use of a method of hypobarotherapy in correction clinical disturbances in women with natural menopause is revealed.С целью оценки эффективности гипобарической гипокситерапии в коррекции менопаузальных симптомов в сравнении с заместительной гормональной терапией (ЗГТ) проведено обследование 216 женщин с менопаузальным синдромом, разделенных в зависимости от вида менопаузы и варианта лечения на 6 групп. Курс гипобарической гипокситерапии в барокамере «Урал-1» (22 ежедневных трехчасовых сеанса) проведен в группах женщин с естественной и хирургической менопаузой. Оценивалось влияние данного немедикаментозного метода лечения, заместительной гормональной терапии и комплексного лечения (гипобаротерапии и ЗГТ) на клинические проявления менопаузального синдрома. В результате выявлена высокая эффективность гипобаротерапии в коррекции менопаузальных симптомов у женщин с естественной менопаузой

Hair Trace Element and Electrolyte Content in Women with Natural and In Vitro Fertilization-Induced Pregnancy

The objective of the present study was to perform comparative analysis of hair trace element content in women with natural and in vitro fertilization (IVF)-induced pregnancy. Hair trace element content in 33 women with IVF-induced pregnancy and 99 age- and body mass index-matched control pregnant women (natural pregnancy) was assessed using inductively coupled plasma mass spectrometry. The results demonstrated that IVF-pregnant women are characterized by significantly lower hair levels of Cu, Fe, Si, Zn, Ca, Mg, and Ba at p < 0.05 or lower. Comparison of the individual levels with the national reference values demonstrated higher incidence of Fe and Cu deficiency in IVF-pregnant women in comparison to that of the controls. IVF pregnancy was also associated with higher hair As levels (p < 0.05). Multiple regression analysis revealed a significant interrelation between IVF pregnancy and hair Cu, Fe, Si, and As content. Hair Cu levels were also influenced by vitamin/mineral supplementation and the number of pregnancies, whereas hair Zn content was dependent on prepregnancy anthropometric parameters. In turn, planning of pregnancy had a significant impact on Mg levels in scalp hair. Generally, the obtained data demonstrate an elevated risk of copper, iron, zinc, calcium, and magnesium deficiency and arsenic overload in women with IVF-induced pregnancy. The obtained data indicate the necessity of regular monitoring of micronutrient status in IVF-pregnant women in order to prevent potential deleterious effects of altered mineral homeostasis

Key indicators of innovation activity of Russia (From 2011 to 2017)

© 2019, Allied Business Academies. All rights reserved. Innovation as a priority for development Russia's economy became relevant relatively recently. Management of innovation processes federal and regional level requires knowledge of their patterns, problems and the specifics of innovation in Russia, as well as the problems and specifics of the innovation activities of enterprises in the context of economic activities. Official federal statistics contain extremely limited number of indicators characterizing innovative processes in business. The innovation sphere is currently the subject of a study of various branches of scientific knowledge and is actualized in numerous scientific publications. However, they do not have common conceptual foundations, and for the most part they have only economic content. In the literature there is no single definition of the concept of "innovation", we tried to give a single comprehensive definition of the concept of "innovation", consider different points of view, identified two main approaches to the definition of the concept of innovation. In the article we tried to analyze the basic indicators of the innovative development of the Russian Federation over the past 7 years

Key indicators of innovation activity of Russia (From 2011 to 2017)

© 2019, Allied Business Academies. All rights reserved. Innovation as a priority for development Russia's economy became relevant relatively recently. Management of innovation processes federal and regional level requires knowledge of their patterns, problems and the specifics of innovation in Russia, as well as the problems and specifics of the innovation activities of enterprises in the context of economic activities. Official federal statistics contain extremely limited number of indicators characterizing innovative processes in business. The innovation sphere is currently the subject of a study of various branches of scientific knowledge and is actualized in numerous scientific publications. However, they do not have common conceptual foundations, and for the most part they have only economic content. In the literature there is no single definition of the concept of "innovation", we tried to give a single comprehensive definition of the concept of "innovation", consider different points of view, identified two main approaches to the definition of the concept of innovation. In the article we tried to analyze the basic indicators of the innovative development of the Russian Federation over the past 7 years