SYNTHESIS OF 1-O-TOLYL-3-SUBSTITUTED-2,6-DITHIO-4-AMINO -[(2-O-TOLYLTHIOCARBAMIDO)-1,3-BENZOTHIAZOLO] -1,3,5-TRIAZINE

We reported synthesis of 1-o-tolyl-3-substituted-2,6-dithio-4-amino-[(2-o-tolylthiocarbamido)-1,3-benzothiazolo] -1,3,5-triazines by isomerisation of 2-substituted-imino-6-o-tolylimino-4-[(2-o-tolylthiocarbamido)-1,3 -benzothiazolo]-1,3,5-dithiazines in 10 % aqueous ethanolic sodium bicarbonate mixture in ethanol solvent. The structure determination and justification of the synthesized compounds were done on the basis of elemental analysis, chemical characteristics and spectral studies. Keywords:2-substituted-imino-6-o-tolylimino-4-[(2-o-tolylthiocarbamido)-1,3-benzothiazolo]-1,3,5-dithiazines, Isomerisazation, Sodium bicarbonate, Ethano

SYNTHESIS OF 2-SUBSTITUTEDGUANIDINO-4-SUBSTITUTED-IMINE-6-SUBSTITUTEDIMINO-1,3,5-THIADIAZINES

A novel series of 2-substitutedguanidino-4-substitutedimine-6-sub-stitutedimino-1,3,5- thiadiazines (IIIa1 -e 5 ) have been recently synthesized by refluxing N-methylformamidino-N’- phenyliminothiocarbamide also called as 1-(N-substitutedcarbamimidoyl)3-{N-(E)- substitutedmethylidinecar-bamimidoyl}thiourea (Ia-e) with various isocyanodichloride (II1-5) in acetone-ethanol medium in 1:1 molar proportion. The structure of all the synthesized compounds was justified on the basis of chemical characteristics, elemental analysis and IR, NMR and mass spectral analysis. Keywords: Guanidine, 1,3,5-thiadiazines, acetone, ethanol et

Effect of Psoralea corylifolia on dexamethasone-induced insulin resistance in mice

AbstractThe whole plant of Psoralea corylifolia (PC) is traditionally used in the treatment of diabetes. Mice were treated with prestandardised dose of dexamethasone for 22days and effect of PC at the doses of 100, 200 and 300mg/kg, p.o. on plasma blood glucose level, serum triglyceride level, glucose uptake in skeletal muscle, levels of hepatic antioxidant enzymes (GSH, SOD, catalase and LPO), and body weight were observed. PC showed significant decrease in plasma glucose and serum triglyceride levels (p<0.01) at the dose of 100 and 200mg/kg, p.o. and also stimulated glucose uptake in skeletal muscle. The levels of antioxidant enzymes GSH, SOD, and catalase were significantly increased (p<0.01) and there was significant decrease (p<0.01) in level of LPO.Hence it can be concluded that Psoralea carylifolia may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance

SYNTHESIS OF 1-SUBSTITUTED-2-SUBSTITUTEDGUANIDINO-4-SUBSTITUTEDIMINE-6-THIO-1,3,5-TRIAZINES

2-Substitutedguanidino-4-substitutedimine-6-substitutedimino-1,3,5-thia-diazines (VIIIa-r) were successfully isomerised into 1-substituted-2-sub-stitutedguanidino-4-substitutedimine-6-thio-1,3,5-triazines or 1-methyl-3-(1- substituted-4-{[(E)-substitutedmethylidene]amino}-6-thioxo-1,6-dihydro-1,3,5-triazin-2-yl)guanidines (IXa-r) by refluxing with 10% aqueous ethanolic sodium bicarbonate medium. The structure of all the synthesized compounds was justified on the basis of chemical characteristics, elemental analysis and spectral analysis

Bianchi Type III Cosmological Model with Binary Mixture of Perfect Fluid and Dark Energy

Abstract. The paper deals with Bianchi type III cosmological models filled with perfect fluid and dark energy components. The two sources are assumed to interact minimally so that their energy momentum tensors are conserved separately. The exact solution of Einstein&apos;s field equations is obtained by assuming the expansion θ in the model is proportional to the shear (σ). This condition leads to A = B m , where A and B are metric coefficients and m is a constant. The physical and geometrical behaviors of the models are also discussed

PHARMACEUTICAL AND BIOPHARMACEUTICAL ASPECTS OF QUANTUM DOTS-AN OVERVIEW

In the twenty-first century, nanotechnology has become cutting-edge technology. It is interdisciplinary and multidisciplinary, covering numerous fields such as medicine, engineering, biology, physics, material sciences, and chemistry. The present work aims to cover the optical properties, method of preparations, surface modifications, bio-conjugation, characterization, stability, and cytotoxicity of quantum dots (QDs). Articles were reviewed in English literature reporting the pharmaceutical and bio-pharmaceutical aspects of QDs which were indexed in Scopus, web of science, google scholar and PubMed without applying the year of publication criterion. One significant value of utilizing nanotechnology is that one can alter and control the properties in a genuinely unsurprising way to address explicit applications' issues. In science and biomedicine, the usage of functional nanomaterials has been broadly investigated and has become one of the quick-moving and stimulating research directions. Different types of nanomaterial (silicon nanowires, QDs, carbon nanotubes, nanoparticles of gold/silver) were extensively utilized for biological purposes. Nanomedicine shows numerous advantages in the natural characteristics of targeted drug delivery and therapeutics. For instance, protection of drugs against degradation, improvement in the drug's stability, prolonged circulation time, deceased side effects, and enhanced distribution in tissues. The present review article deals with the quantum dots, their optical properties, method of preparations, surface modifications, bio-conjugation, characterization, stability, and cytotoxicity of quantum dots. The review also discusses various biomedical applications of QDs. The QDs-based bio-nanotechnology will always be in the growing list of unique applications, with progress being made in specialized nanoparticle development, the detection of elegant conjugation methods, and the discovery of new targeting ligands

Network slicing to enable scalability and flexibility in 5G mobile networks

We argue for network slicing as an efficient solution that addresses the diverse requirements of 5G mobile networks, thus provid-ing the necessary flexibility and scalability associated with future network implementations. We elaborate on the challenges that emerge when we design 5G networks based on network slicing. We focus on the architectural aspects associated with the coexistence of dedicated as well as shared slices in the network. In particular, we analyze the realization options of a flexible radio access network with focus on network slicing and their impact on the design of 5G mobile networks. In addition to the technical study, this paper provides an investigation of the revenue potential of network slicing, where the applications that originate from such concept and the profit capabilities from the network operator's perspective are put forward.This work has been performed in the framework of the H2020-ICT-2014-2 project 5G NORMA

A balancing act: RNA binding protein HuR/TTP axis in endometriosis patients

Endometriosis, a major reproductive pathology affecting 8-10% of women is characterized by chronic inflammation and immune dysfunction. Human antigen R (HuR) and Tristetraprolin (TTP) are RNA binding proteins that competitively bind to cytokines involved in inflammation including: tumor necrosis factor alpha (TNF-α), granulocyte macrophage colony stimulating factor (GM-CSF), interleukin 6 (IL-6) among others, and stabilize and destabilize them, respectively. The aim of this study was to examine RNA binding protein (RNABP) HuR/TTP axis in endometriosis patients compared to menstrual stage matched healthy fertile controls in hopes of better understanding their contribution to the pathogenesis of endometriosis. Additionally, using a targeted in vitro siRNA approach, we examined whether knock-down of TTP can play a functional role on other RNABPs that competitively bind to inflammatory targets of TTP in both endometriotic and endometrial epithelial cell lines. Our results suggest that RNABPs TTP and HuR are dysregulated in endometriotic lesions compared to matched eutopic patient samples as well endometrium from healthy controls. Silencing of TTP in endometriotic and endometrial epithelial cells revealed differential response to inflammatory cytokines and other RNABPs. Our results suggest potential involvement of HuR/TTP RNA binding protein axis in regulation of inflammation in endometriosis