A dataset of neonatal EEG recordings with seizure annotations

Neonatal seizures are a common emergency in the neonatal intensive care unit (NICU). There are many questions yet to be answered regarding the temporal/spatial characteristics of seizures from different pathologies, response to medication, effects on neurodevelopment and optimal detection. The dataset presented in this descriptor contains EEG recordings from human neonates, the visual interpretation of the EEG by the human experts, supporting clinical data and codes to assist access. Multi-channel EEG was recorded from 79 term neonates admitted to the NICU at the Helsinki University Hospital. The median recording duration was 74 min (IQR: 64 to 96 min). The presence of seizures in the EEGs was annotated independently by three experts. An average of 460 seizures were annotated per expert in the dataset; 39 neonates had seizures and 22 were seizure free, by consensus. The dataset can be used as a reference set of neonatal seizures, in studies of inter-observer agreement and for the development of automated methods of seizure detection and other EEG analyses.Peer reviewe

Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1 – secondary analysis of a randomized controlled trial

Abstract Background Gestational diabetes mellitus (GDM) is characterized by disturbed glucose metabolism and activation of low-grade inflammation. We studied whether metformin treatment has favorable or unfavorable effects on inflammatory markers and insulin-like growth factor-binding protein 1 (IGFBP-1) in GDM patients compared with insulin, and whether these markers associate with major maternal or fetal clinical outcomes. Methods This is a secondary analysis of a previous randomized controlled trial comparing metformin (n = 110) and insulin (n = 107) treatment of GDM. Fasting serum samples were collected at the time of diagnosis (baseline, mean 30 gestational weeks [gw]) and at 36 gw. Inflammatory markers serum high-sensitivity CRP (hsCRP), interleukin-6 (IL-6), matrix metalloproteinase-8 (MMP-8) and glycoprotein acetylation (GlycA) as well as three IGFBP-1 phosphoisoform concentrations were determined. Results In the metformin and insulin groups combined, hsCRP decreased (p = 0.01), whereas IL-6 (p = 0.002), GlycA (p < 0.0001) and all IGFBP-1 phosphoisoforms (p < 0.0001) increased from baseline to 36 gw. GlycA (p = 0.02) and non-phosphorylated IGFBP-1 (p = 0.008) increased more in patients treated with metformin than those treated with insulin. Inflammatory markers did not clearly associate with pregnancy outcomes but non-phosphorylated IGFBP-1 was inversely associated with gestational weight gain. Conclusions Metformin had beneficial effects on maternal serum IGFBP-1 concentrations compared to insulin, as increased IGFBP-1 related to lower total and late pregnancy maternal weight gain. GlycA increased more during metformin treatment compared to insulin. The significance of this observation needs to be more profoundly examined in further studies. There were no evident clinically relevant relations between inflammatory markers and pregnancy outcome measures. Trial registration The trial comparing metformin and insulin treatment was registered in ClinicalTrials.gov ( NCT01240785 ) November 3, 2010. Retrospectively registered

Metformin and insulin treatment of gestational diabetes : effects on inflammatory markers and IGF-binding protein-1-secondary analysis of a randomized controlled trial

Background: Gestational diabetes mellitus (GDM) is characterized by disturbed glucose metabolism and activation of low-grade inflammation. We studied whether metformin treatment has favorable or unfavorable effects on inflammatory markers and insulin-like growth factor-binding protein 1 (IGFBP-1) in GDM patients compared with insulin, and whether these markers associate with major maternal or fetal clinical outcomes. Methods: This is a secondary analysis of a previous randomized controlled trial comparing metformin (n = 110) and insulin (n = 107) treatment of GDM. Fasting serum samples were collected at the time of diagnosis (baseline, mean 30 gestational weeks [gw]) and at 36 gw. Inflammatory markers serum high-sensitivity CRP (hsCRP), interleukin-6 (IL-6), matrix metalloproteinase-8 (MMP-8) and glycoprotein acetylation (GlycA) as well as three IGFBP-1 phosphoisoform concentrations were determined. Results: In the metformin and insulin groups combined, hsCRP decreased (p = 0.01), whereas IL-6 (p = 0.002), GlycA (p <0.0001) and all IGFBP-1 phosphoisoforms (p <0.0001) increased from baseline to 36 gw. GlycA (p = 0.02) and non-phosphorylated IGFBP-1 (p = 0.008) increased more in patients treated with metformin than those treated with insulin. Inflammatory markers did not clearly associate with pregnancy outcomes but non-phosphorylated IGFBP-1 was inversely associated with gestational weight gain. Conclusions: Metformin had beneficial effects on maternal serum IGFBP-1 concentrations compared to insulin, as increased IGFBP-1 related to lower total and late pregnancy maternal weight gain. GlycA increased more during metformin treatment compared to insulin. The significance of this observation needs to be more profoundly examined in further studies. There were no evident clinically relevant relations between inflammatory markers and pregnancy outcome measures.Peer reviewe

The basal dunite of the Precambrian mafic-ultramafic Narankavaara intrusion : Petrogenetic considerations and implications to exploration

Several mafic-ultramafic layered intrusions were emplaced in the Fennoscandian Shield during wide-spread mantle-sourced magmatism at 2.5-2.4 Ga. The Narankavaara intrusion (surface area 5 x 30 km(2)), northeastern Finland, contains a 1.5-2 km thick basal dunite (not dated), and a 1.5 km thick layered series (2436 +/- 5 Ma). A newly discovered marginal series between the basal dunite and the layered series indicates that the basal dunite is older, and highlights the need for further study on their relationship. Along its southern basement contact, the basal dunite contains a 200-300 m thick zone of olivine ortho- and mesocumulates, but the bulk of it is composed of olivine adcumulates and lesser olivine-orthopyroxene heteradcumulates. Based on whole-rock geochemistry, the basal dunite is divided into a low-Fe zone (average FeOt 10.2 wt% and Ni 2250 ppm) and a high-Fe zone (average FeOt 12.5 wt% and Ni 1700 ppm). Both zones have high MgO (32-47 wt%) and varying Cr (830-5160 ppm) and Al2O3/TiO2 (16-26). Textural and geochemical layering is similar along the 30 km strike of the basal dunite. A LREE-enriched high-MgO basaltic parental magma composition (13-18 wt% MgO) is inferred for the basal dunite from olivine-melt mixing trends in orthocumulates. The dunite exhibits at least two geochemical reversals as well as abundant low-porosity adcumulates, poikilitic chromite, and bimodal olivine, suggesting formation in a high-volume open magmatic system. Significant similarity in major and trace element compositions with the Narankavaara layered series and the Burakovsky intrusion and Vetreny belt extrusives in Russian Karelia suggests that the basal dunite belongs to the Fennoscandian 2.5-2.4 Ga mafic layered intrusions. An Archean komatiitic origin for the dunite body cannot be completely ruled out, however. Distinct Ni-depletion in olivine is found in the basal dunite from the low-Fe zone to the high-Fe zone (3200 versus 2200 ppm). This depletion does not correlate with Fo contents, which suggests that it is not related to olivine fractionation. The basal dunite may thus have potential for Ni-(Cu-Co-PGE) sulfide mineralization.Peer reviewe

Pohjois-Suomen varhaisproterotsooisen Näränkävaaran kerrosintruusion petrogeneesi, osa I: pohjoisen peridotiitit ja niiden suhde kerrossarjaan ja uusiin magmapulsseihin

The Paleoproterozoic Näränkävaara layered intrusion, northern Finland, has a surface area of 25 km x 5 km and a stratigraphic thickness of ~3 km. The main body of the intrusion includes a 1.5–2 km thick basal dunite series and a 1.3 km thick peridotitic-dioritic layered series, the latter with two peridotitic reversals related to magma recharge. In addition, a series of poorly known elongate poikilitic harzburgitic intrusions (the northern peridotites) are found along the NE contact between the intrusion and the granite-gneiss basement complex. We investigate new mineral and whole-rock geochemical data from the northern peridotites, with the aim of clarifying their petrogenetic relationship to the main layered body of the intrusion. The northern peridotites form a 200–400 m thick cumulate series grading from olivine orthocumulates (OC) at the northern basement complex contact to olivine-orthopyroxene heteradcumulates (HAC) towards the main intrusion body in the south. The OC show whole-rock and mineral chemical trends consistent with origin as rapidly cooled olivine-melt mixtures. The HAC have crystallized in situ from a relatively Cr- and SiO2-rich magma. Based on lithological and stratigraphical correlations, the northern peridotites are linked to the emplacement of the magma that caused the first reversal in the layered series: marginal orthocumulates were formed at the initial emplacement of a new pulse of LREE-enriched siliceous high-MgO basaltic (SHMB) magma into the Näränkävaara chamber, followed by heteradcumulate formation from a fractionating magma with added external SiO2 and fluid. Ubiquitous granite-gneiss xenoliths and felsic veins in drill core suggest assimilation may have been a local process. The northern peridotite parental magma shows undepleted metal ratios suggesting no sulfide saturation occurred prior to emplacement.Peer reviewe

Yield, Quality and Nitrogen Use of Forage Maize under Different Nitrogen Application Rates in Two Boreal Locations

Research focusing on the nitrogen (N) application and N use of forage maize (Zea mays L.) in the boreal region is either limited or non-existent. The aim of this study was to investigate the response of yield, quality and N recovery efficiency (NRE) of forage maize to an increase in the N application rate and different climatic conditions in two locations in Finland. The field experiment was conducted in southern (Helsinki; 60° N) and central (Maaninka; 63° N) Finland in 2019 and 2020. Dry matter (DM) yield, forage quality and NRE were determined for N application rates of 100, 150 and 200 N kg ha−1. The DM yield was similar to all studied N application rates. Moreover, there were no marked differences in the studied forage quality traits or the NRE following the N application rates. However, the NRE of maize was generally low at 45%. The current study recommends a N application rate of 100–150 N kg ha−1 for forage maize in the boreal region. There is no need to increase the N application from current recommendations since climate conditions seem to limit the growth, development and NRE of forage maize. The observed low NRE of forage maize warrants further research in the future

Yield, Quality and Nitrogen Use of Forage Maize under Different Nitrogen Application Rates in Two Boreal Locations

Research focusing on the nitrogen (N) application and N use of forage maize (Zea mays L.) in the boreal region is either limited or non-existent. The aim of this study was to investigate the response of yield, quality and N recovery efficiency (NRE) of forage maize to an increase in the N application rate and different climatic conditions in two locations in Finland. The field experiment was conducted in southern (Helsinki; 60° N) and central (Maaninka; 63° N) Finland in 2019 and 2020. Dry matter (DM) yield, forage quality and NRE were determined for N application rates of 100, 150 and 200 N kg ha−1. The DM yield was similar to all studied N application rates. Moreover, there were no marked differences in the studied forage quality traits or the NRE following the N application rates. However, the NRE of maize was generally low at 45%. The current study recommends a N application rate of 100–150 N kg ha−1 for forage maize in the boreal region. There is no need to increase the N application from current recommendations since climate conditions seem to limit the growth, development and NRE of forage maize. The observed low NRE of forage maize warrants further research in the future

Serum lipids and their association with birth weight in metformin and insulin treated patients with gestational diabetes

AimsTo compare the effects of metformin and insulin treatment on maternal serum lipids in patients with gestational diabetes (GDM), and to analyse the associations between individual lipids and birth weight (BW).MethodsThis is a secondary analysis of a randomized trial comparing metformin (n = 110) and insulin (n = 107) treatment of GDM. Fasting serum lipidome was measured at baseline (the time of diagnosis, mean 30 gestational weeks, gw) and at 36 gw using nuclear magnetic resonance spectroscopy.ResultsTotal and VLDL triglycerides, and VLDL cholesterol increased from baseline to 36 gw in both treatment groups. The rise in triglycerides was greater in the metformin treated patients (p ConclusionCompared to insulin, metformin treatment of GDM led to higher maternal serum concentrations of triglyceride-rich lipoproteins. Especially triglycerides and cholesterol in VLDL were positively associated with BW. Women with high VLDL cholesterol or high apoB/apoA-1 may benefit from insulin treatment over metformin with respect to offspring BW.</p

Ympäristömelun vaikutukset

Ympäristöministeriö julkaisi vuonna 1977 kansainvälisten meluvaikutusten asiantuntijoiden Maailman terveysjärjestöille (WHO) kokoaman selvityksen pohjalta julkaisun "Ympäristömelun vaikutukset". Tämän jälkeen tietämys melunvaikutuksista on syventynyt ja laajentunut, minkä takia julkaisun päivitys on tarpeen. Uusi julkaisu käsittelee melun vaikutuksia käyttämällä samaa ryhmittelyä, jota WHO käyttää ulkoisista tai sisäisistä syistä johtuvien sairauksien ja niiden seurannaisvaikutusten yhteydessä. Vaikutuksia ovat kudos- ja elinvaurion lisäksi toiminnallinen vaurio, toiminnanvajaus ja haitta. Julkaisussa lähtökohtana ovat nimenomaan melun vaikutukset eivätkä melun akustiset äänipiirteet, kuten äänekkyys. Julkaisu esittelee ympäristömelun eri vaikutukset painottaen niiden yleisyyttä ja merkitystä. Niistä häiritsevyys on merkityksellisin. Sen ohella käsitellään melun haitallisia vaikutuksia uneen, kognitiivisiin toimintoihin erityisesti lapsilla, puheviestintään, sydän- ja verenkiertoelimistön toimintoihin sekä joskus aiheutuvaa kuulovauriota. Uusimman tutkimustiedon mukaan pitkäaikaisen altistumisen ympäristömelulle on todettu lisäävän riskiä verisuonisairauksiin. Julkaisussa kiinnitetään lisäksi huomiota meluherkkyyteen, jota ei ole aiemmin otettu riittävästi huomioon. Julkaisun liitteenä ovat WHO:n suositukset ympäristömelusta vuodelta 2000