Solar Pumping of Fiber Lasers with Solid-State Luminescent Concentrators: Design Optimization by Ray Tracing

Solar-pumped lasers (SPLs) typically couple sunlight into the laser cavity using focusing optics and solar tracking. Luminescent solar concentrators (LSC) are an alternative, fully planar, scalable pump source that can concentrate diffuse light. For liquid LSC-based SPLs, reflective cavities have been used to trap light and pump a Nd$^{3+}$-doped silica fiber. Here, three solid-state LSC-based SPL designs, in addition to the reflective cavity making use of total internal reflection, are analyzed by ray-tracing simulations. Results are compared to a liquid LSC reference, also used for validating simulations. Substituting the liquid-state LSC for a solid-state LSC (with the fiber placed inside) allows a 7-fold enhancement of the gain coefficient, corresponding to a 30-fold enhancement of the laser output power. An additional 4-fold increase of the output power is possible with a fiber of kilometers length. These results show a roadmap for realizing SPLs with output powers on the order of 2.8 W m$^{-2}$ under terrestrial sunlight, while keeping an identical reflective cavity used for the liquid LSC design. In addition, room-temperature operation should be possible with certain solid LSC designs, and the necessity for a reflective cavity comprised of costly dielectric mirrors may be relieved

Finite grand unified theories and inflation

A class of finite GUTs in curved spacetime is considered in connection with the cosmological inflation scenario. It is confirmed that the use of the running scalar-gravitational coupling constant in these models helps realizing a successful chaotic inflation. The analyses are made for some different sets of the models

A fully planar solar pumped laser based on a luminescent solar collector

A solar-pumped laser (SPL) that converts sunlight directly into a coherent and intense laser beam generally requires a large concentrating lens and precise solar tracking, thereby limiting its potential utility. Here, we demonstrate a fully-planar SPL without a lens or solar tracking. A Nd3+-doped silica fiber is coiled into a cylindrical chamber filled with a sensitizer solution, which acts as a luminescent solar collector. The body of the chamber is highly reflective while the top window is a dichroic mirror that transmits incoming sunlight and traps the fluorescence emitted by the sensitizer. The laser-oscillation threshold was reached at a natural sunlight illumination of 60% on the top window. Calculations indicated that a solar-to-laser power-conversion efficiency could eventually reach 8%. Such an SPL has potential applications in long-term renewable-energy storage or decentralised power supplies for electric vehicles and Internet-of-Things devices

Substrate interconnect technologies for 3-DMEMS packaging

We report the development of 3-dimensional silicon substrate interconnect technologies, specifically for reducing the package size of a MOSFET relay. The ability to interconnect multiple chips at d on a single substrate can significantly improve device performance and size. We present the process development of through-hole interconnects fabricated using deep reactive ion etching (DRIE), with an emphasis on achieving positively tapered, smooth sidewalls to ease deposition of a seed layer for subsequent Cu electroplating. Gray-scale technology is integrated on the same substrate to provide smooth inclined surfaces between multiple vertical levels (>100 lm apart), enabling interconnection between the two levels via simple metal evaporation and lithography. The developments discussed for each technique may be used together or independently to address future packaging and integration needs

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism.

It is unclear whether mutations in fused in sarcoma (FUS) cause familial amyotrophic lateral sclerosis via a loss-of-function effect due to titrating FUS from the nucleus or a gain-of-function effect from cytoplasmic overabundance. To investigate this question, we generated a series of independent Caenorhabditis elegans lines expressing mutant or wild-type (WT) human FUS. We show that mutant FUS, but not WT-FUS, causes cytoplasmic mislocalization associated with progressive motor dysfunction and reduced lifespan. The severity of the mutant phenotype in C. elegans was directly correlated with the severity of the illness caused by the same mutation in humans, arguing that this model closely replicates key features of the human illness. Importantly, the mutant phenotype could not be rescued by overexpression of WT-FUS, even though WT-FUS had physiological intracellular localization, and was not recruited to the cytoplasmic mutant FUS aggregates. Our data suggest that FUS mutants cause neuronal dysfunction by a dominant gain-of-function effect related either to neurotoxic aggregates of mutant FUS in the cytoplasm or to dysfunction in its RNA-binding functions

Support for UNRWA's survival

The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) provides life-saving humanitarian aid for 5·4 million Palestine refugees now entering their eighth decade of statelessness and conflict. About a third of Palestine refugees still live in 58 recognised camps. UNRWA operates 702 schools and 144 health centres, some of which are affected by the ongoing humanitarian disasters in Syria and the Gaza Strip. It has dramatically reduced the prevalence of infectious diseases, mortality, and illiteracy. Its social services include rebuilding infrastructure and homes that have been destroyed by conflict and providing cash assistance and micro-finance loans for Palestinians whose rights are curtailed and who are denied the right of return to their homeland

Sophisticated Framework between Cell Cycle Arrest and Apoptosis Induction Based on p53 Dynamics

The tumor suppressor, p53, regulates several gene expressions that are related to the DNA repair protein, cell cycle arrest and apoptosis induction, which activates the implementation of both cell cycle arrest and induction of apoptosis. However, it is not clear how p53 specifically regulates the implementation of these functions. By applying several well-known kinetic mathematical models, we constructed a novel model that described the influence that DNA damage has on the implementation of both the G2/M phase cell cycle arrest and the intrinsic apoptosis induction via its activation of the p53 synthesis process. The model, which consisted of 32 dependent variables and 115 kinetic parameters, was used to examine interference by DNA damage in the implementation of both G2/M phase cell cycle arrest and intrinsic apoptosis induction. A low DNA damage promoted slightly the synthesis of p53, which showed a sigmoidal behavior with time. In contrast, in the case of a high DNA damage, the p53 showed an oscillation behavior with time. Regardless of the DNA damage level, there were delays in the G2/M progression. The intrinsic apoptosis was only induced in situations where grave DNA damage produced an oscillation of p53. In addition, to wreck the equilibrium between Bcl-2 and Bax the induction of apoptosis required an extreme activation of p53 produced by the oscillation dynamics, and was only implemented after the release of the G2/M phase arrest. When the p53 oscillation is observed, there is possibility that the cell implements the apoptosis induction. Moreover, in contrast to the cell cycle arrest system, the apoptosis induction system is responsible for safeguarding the system that suppresses malignant transformations. The results of these experiments will be useful in the future for elucidating of the dominant factors that determine the cell fate such as normal cell cycles, cell cycle arrest and apoptosis