Insulator superconductor transition on solid inert gas substrates

We present observations of the insulator-superconductor transition in ultrathin films of Bi on solid xenon condensed on quartz and on Ge on quartz. The relative permeability $\epsilon_{r}$ ranges from 1.5 for Xe to 15 for Ge. Though we find screening effects as expected, the I-S transition is robust, and unmodified by the substrate. The resistance separatrix is found to be close to $h/4e^2$ and the crossover thickness close to 25 $\AA$ for all substrates. I-V studies and Aslamazov-Larkin analyses indicate superconductivity is inhomogeneous. The transition is best described in terms of a percolation model.Comment: Submitted to LT23 Proceeding

Verb Use in Parkinson\u27s Disease

Verb-specific impairments in their use and comprehension are well documented in persons with Parkinson’s disease (PD). The grammatical and the motor theories have been proposed as possible explanations for verb impairments. The purpose of this study is to describe the use of low-motion and high-motion content verbs in PD in everyday conversation and to determine which theory best supports these findings. In this cross-sectional prospective study, conversation samples were collected and analyzed from participants with PD and their spouses in a mealtime context. Results indicated that total verb use on a proportional basis was not significantly different between persons with PD vs. control participants. Participants with PD produced significantly fewer high-motion verbs compared to low-motion content verbs. However, control participants also produced significantly fewer high-motion verbs compared to low-motion content verbs. The findings do not support the motor theory or the grammatical theory of verb processing in participants with PD

Involvement of CytochromeP4504a in Adenosine A1 receptor mediated regulation of vascular tone

Cardiovascular diseases are one of the leading causes of morbidity and mortality worldwide. The regulation of vascular tone plays an important role in normal cardiovascular function. Adenosine, an autacoid has several physiological and pathophysiological roles, apart from the regulation of vascular tone. Adenosine receptor (AR) contracts and relaxes blood vessels through all four subtypes (A1, A2A, A2B, and A3) linked to different signaling mechanisms. Deciphering complex tissue responses remains difficult because relationships of individual receptor subtypes and various end-effectors (e.g., ion channels) are yet to be identified. Apart from adenosine, 20-HETE, a cytochrome P4504a (Cyp4a) metabolite of arachidonic acid (AA) is a potent vasoconstrictor.;We hypothesized that A1AR induced contraction of the smooth muscle involves Cyp4a, with Protein Kinase C (PKC)-alpha, extracellular regulated kinase (ERK) 1/2 contributing to the downstream signaling events. Another key question we addressed were the ion channel(s) contributing to smooth muscle contraction. Experiments included isometric tension recordings of aortic contraction and western blots. In addition, patch clamp experiments were done with freshly isolated smooth muscle cells from wild type (WT) and A1 knockout (A1KO) mice aortae. We found that inhibition of Cyp4a led to lesser contraction in the adenosine agonists\u27 mediated responses. 20-HETE induced contraction in both WT and A1KO, but this response was lower in A1KO. Inhibition of PKC-alpha and ERK1/2 attenuated the 20-HETE-induced contraction in both WT and A1KO. These findings suggest that A1AR couples with 20-HETE and negatively modulates vascular tone through PKC-alpha and ERK1/2. Furthermore, electrophysiological experiments revealed that non-selective adenosine agonist increased the BK current in A1KO as compared to the WT. This suggests A1 receptors have a negative regulatory effect on BK current. On the other hand, A1 selective agonist decreased the BK current in WT, with no effect on A1KO. PKC-alpha inhibitor abolished the effect of the A 1 selective agonist on BK current. These findings suggest that A 1AR regulates contraction of the aortic smooth muscle through inhibition of BK channels in a PKC-alpha dependent manner. From these data, we conclude that A1AR negatively couples with 20-HETE and by inhibiting BK channels mediates smooth muscle contraction via PKC-alpha

Trapped Between Modernism and Postmodernism: A Critical Study of Philip Larkin's Poetry

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A comparison of pain on intravenous injection to two formulations of Propofol, one containing medium chain and long chain triglycerides and the other without medium chain and long chain triglycerides

Background: To assess and compare the Visual Analog Scale (VAS) for pain on intravenous injection in patients receiving the two different formulations of Propofol.Methods: Total 170 eligible patients were randomized into Group A receiving Propofol MCT/LCT and Group B receiving Propofol LCT. After standard pre-anaesthetic preparation and baseline values recording, the blinded investigator recorded pain intensity after injection of 1mL study drug propofol, using Visual Analog Scale (0-10). Haemodynamic parameters were recorded every minute for 5 minutes. Calculated Propofol dose was injected in 20 seconds, and signs of pain (hand withdrawal, grimacing) were noted. After patient regained full consciousness, recall of injection pain was asked for.Results: The proportion of patients who experienced pain was similar in both groups (group A: 76/85 =89.41%, group B: 81/85 = 95.29%; statistically not significant (p value=0.247). Patients in group A had longer time for pain onset (11.3 seconds-group A Vs 9.8 seconds-group B; statistically significant, p value =0.008). Pain on injection was higher in Propofol LCT group as compared to Propofol MCT/LCT (VAS scores of group A=3.94±2.0 vs group B = 5.49±1.96; statistically significant; p value = 0.0018). Full dose of Propofol MCT/LCT produced significantly less pain when compared to Propofol LCT (p value = 0.0424). Recall of pain was comparable between the groups. Haemodynamic parameters (Heart rate and Mean Arterial Pressure) remained comparable in both groups.Conclusions: Pain on injection was higher and statistically significant in Propofol LCT group as compared to Propofol MCT/LCT

A Review on GPU Based Parallel Computing for NP Problems

Now a days there are different number of optimization problems are present. Which are NP problems to solve this problems parallel metaheuristic algorithm are required. Graph theories are most commonly studied combinational problems. In this paper providing the new move towards solve this combinational problem with GPU based parallel computing using CUDA architecture. Comparing those problem with relevant to the transfer rate, effective memory utilization and speedup etc. to acquire the paramount possible solution. By applying the different algorithms on the optimization problem to catch the efficient memory exploitation, synchronized execution, saving time and increasing speedup of execution. Due to this the speedup factor is enhance and get the best optimal solution

COGNITIVE, AFFECTIVE AND CONATIVE MODEL FOR ANALYSING HIGHER EDUCATION STUDENTSq

Many models are used in recent years to analyze behavior of the students in the higher education. Analyzing the learning style and student performance in academic studies are very essential to enhance their performance. This research work is focused on analyzing the learners behavior using three dimensions, i.e., cognitive, affective, and conative model. In this paper, we used Moodle learning management system which is a learning platform to create a personalized learning environment and to track learning abilities using activities. This model will be helpful to study the cognitive, conative, and emotions of students.Â

ROLE OF PADA ABHYANGA AS PREVENTIVE ASPECT W.S.R TO EYE DISORDERS: A CONCEPTUAL STUDY

Ayurveda aimed in prevention and cure of physical and mental health. In Ayurveda, Dinacharya is one of the concept which helps to fulfill this aim of Ayurveda. Vitality enhancing technique which is incorporated in massage of the feet is called Padabhyanga. It is one of the prophylactic principles mentioned in Ayurvedic dinacharya. The hectic computerised life style, faulty food habits, stress and strain, irregular sleeping habits and negligence in following daily and seasonal regimen provoke many eye problems. By doing Padaabhyanga, Kharatwa, Stabdata, Rukshata, Shrama, Suptata of pada relieved and Bala, Sthairya improved, Drustiprasaadakara. It also prevents Grudrasi vaata, Pada sputana, Sirasnaayu sankocha.In the centre of the feet 2 Siras are situated which are directly connected to the eyes, these transmit the effect of the medicines applied over the feet in the form of massage. Hence every person should need make use of Padabhyanga. Major cause of blindness for prevalence are cataract, glaucoma, diabetic retinopathy, Age related macular degeneration, refractive errors. There by Paada Abhyanga through its Vaata-ameliorating action is responsible for better function of Chakshurindriya. According to Sushrutacharya, by practice of Snehana karma, which results in Utpatti of Pratyagradhatu – Navadhatu. such that degenerative changes related to eye are antagonized by the Snehana karma. Padaabhyanga is helpful in preventing above said diseases which causes the blindness. Hence this conceptual study is made to explain the mode of action and effect of Pada Abhyanga to increase and maintain the visual acuity

VASANTIKAVAMANA A PREVENTIVE MEASURE FOR KAPHAJA ROGAS

The aims and objective of Ayurveda is of two fold i.e., Prevention of disease in healthy individual and cure of the disease in a diseased person. To fulfil the first aim, our Acharyas have described Dinacharya, Rutucharya. In Dosha chaya, Prakopaavastha, if the person consumes more Apathyakaraahara, Vihara, Doshas will go in Prasaraadiavast has and leads to Vyadhi. Ayurveda emphasized to practise these therapies to eliminate the vitiated Dosha in accordance to the seasonal variation like Vamana in Vasantharutu, Virechana in Sharadrutu, Basti in Pravrutrutu, as a prevention of disease and promotion of health. Person who follows this regimen in each season never suffers from severe disorderAccording to Induteeka, thus neglected, the vitiated Dosha get accumulated over the time to its maximum, and the channels of rasa are being obstructed by the vitiated Dosha (deposition of debries in the inner layers making the lumen narrowed), nourishment to the tissues is not possible. This causes the diseases like Sthoulya, Agnisada, Kusta, Meha etc, which are not amenable for treatment. 4 Maasa (Rutudvaya) for Sanchaya of Kaphadosha, if it is not early evacuated in Chaitramaasa it end up in Rutujaan rogas. Hence, while maintaining health itself one must undergo purifactory measures to prevent from occurrence of the diseases by seasonal factors. Hence this conceptual study is made to explain the effect of Vasantikavamana a preventive measure for Kaphaja rogas.