191 research outputs found
Об изучении иностранными студентами-медиками лексической синонимии в процессе усвоения языка специальности
This paper considers design issues for microvalves for large gas flow control. It introduces out-of-plane knife-gate microvalves as a novel design concept and a proportional microvalve concept for pressure control applications. The design of three different actuator-gate configurations and first prototypes are presented. The first valve prototypes feature thermal silicon-aluminum bimorph actuators and the pressure-flow performance per chip area of the demonstrator valve presented is greatly increased using out-of-plane actuation and an out-of-plane orifice. The characterization of the actuators and of the pressure-flow performance is presented. The prototype valve allows for a flow change of Delta Q = 3.4 standard liters per minute (SLPM) at a pressure change of Delta P = 95 kPa (P-in = 196.3 kPa, P-out = 101.3 kPa) on an active chip area of only 2.3 x 3.7 mm(2).QC20100727</p
Лекарственное обеспечение медицинских учреждений и населения Россонского района Витебской области в период национализации аптек и новой экономической политики (1918-1929 гг.)
АПТЕКИИСТОРИЯ МЕДИЦИНЫЛЕКАРСТВЕННОГО ОБЕСПЕЧЕНИЯ СИСТЕМЫФАРМАЦИ
Controlling the quality factor of a tuning-fork resonance between 9 K and 300 K for scanning-probe microscopy
We study the dynamic response of a mechanical quartz tuning fork in the
temperature range from 9 K to 300 K. Since the quality factor Q of the
resonance strongly depends on temperature, we implement a procedure to control
the quality factor of the resonance. We show that we are able to dynamically
change the quality factor and keep it constant over the whole temperature
range. This procedure is suitable for applications in scanning probe
microscopy.Comment: 5 pages, 6 figure
Regulation and splicing of scavenger receptor class B type I in human macrophages and atherosclerotic plaques
BACKGROUND: The protective role of high-density lipoprotein (HDL) in the cardiovascular system is related to its role in the reverse transport of cholesterol from the arterial wall to the liver for subsequent excretion via the bile. Scavenger receptor class B type I (SR-BI) binds HDL and mediates selective uptake of cholesterol ester and cellular efflux of cholesterol to HDL. The role of SR-BI in atherosclerosis has been well established in murine models but it remains unclear whether SR-BI plays an equally important role in atherosclerosis in humans. The aim of this study was to investigate the expression of SR-BI and its isoforms in human macrophages and atherosclerotic plaques. METHODS: The effect of hypoxia and minimally modified low-density lipoprotein (mmLDL), two proatherogenic stimuli, on SR-BI expression was studied in human monocyte-derived macrophages from healthy subjects using real-time PCR. In addition, SR-BI expression was determined in macrophages obtained from subjects with atherosclerosis (n = 15) and healthy controls (n = 15). Expression of SR-BI isoforms was characterized in human atherosclerotic plaques and macrophages using RT-PCR and DNA sequencing. RESULTS: SR-BI expression was decreased in macrophages after hypoxia (p < 0.005). In contrast, SR-BI expression was increased by exposure to mmLDL (p < 0.05). There was no difference in SR-BI expression in macrophages from patients with atherosclerosis compared to controls. In both groups, SR-BI expression was increased by exposure to mmLDL (p < 0.05). Transcripts corresponding to SR-BI and SR-BII were detected in macrophages. In addition, a third isoform, referred to as SR-BIII, was discovered. All three isoforms were also expressed in human atherosclerotic plaque. Compared to the other isoforms, the novel SR-BIII isoform was predicted to have a unique intracellular C-terminal domain containing 53 amino acids. CONCLUSION: We conclude that SR-BI is regulated by proatherogenic stimuli in humans. However, we found no differences between subjects with atherosclerosis and healthy controls. This indicates that altered SR-BI expression is not a common cause of atherosclerosis. In addition, we identified SR-BIII as a novel isoform expressed in human macrophages and in human atherosclerotic plaques
Defects in Regulation of Local Immune Responses Resulting in Atherosclerosis
Atherosclerosis is nowadays generally accepted as an inflammatory disease
but the mechanism of its origin and development have not yet been fully clarified.
The present review focuses on the role of the local immune system as one of the
key players in the pathogenesis of the complex process. Its part represented by
vascular-associated lymphoid tissue (VALT) within the arterial wall participates
directly in the vascular wall's homeostatis. Its inordinate activation during
ontogenic development of an individual, this formerly defensive and physiologic
mechanism transform into a pathological process resulting in an impairing
inflammation. Hsp60, CRP and oxidized or otherwise modified LDL are serious
candidates for triggering these pathological changes. The principal role is played
by anti-Hsp60 antibodies and by shear stress originating on the surface of
endothelium due to blood flow. The experimental and clinical data
supporting this immunological hypothesis of atherosclerosis are discussed
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