30 research outputs found
Global Research Priorities to Better Understand the Burden of Iatrogenic Harm in Primary Care: An International Delphi Exercise
There is a need to identify and reach agreement on key foci for patient safety research in primary care contexts and understand how these priorities differ between low-, middle-, and high-income settings.
We conducted a modified Delphi exercise, which was distributed to an international panel of experts in patient safety and primary care.
Family practice and pharmacy were considered the main contexts on which to focus attention in order to advance patient safety in primary care across all income categories. Other clinical contexts prioritised included community midwifery and nursing in low-income countries and care homes in high-income countries.
The sources of patient safety incidents requiring further study across all economic settings that were identified were communication between health care professionals and with patients, teamwork within the health care team, laboratory and diagnostic imaging investigations, issues relating to data management, transitions between different care settings, and chart/patient record com- pleteness.
This work lays the foundation for a range of research initiatives that aim to promote a more comprehensive appreciation of the burden of unsafe primary care, develop understanding of the main areas of risk, and identify interventions that can enhance the safety of primary care provision internationall
UVA/UVA1 phototherapy and PUVA photochemotherapy in connective tissue diseases and related disorders: a research based review
BACKGROUND: Broad-band UVA, long-wave UVA1 and PUVA treatment have been described as an alternative/adjunct therapeutic option in a number of inflammatory and malignant skin diseases. Nevertheless, controlled studies investigating the efficacy of UVA irradiation in connective tissue diseases and related disorders are rare. METHODS: Searching the PubMed database the current article systematically reviews established and innovative therapeutic approaches of broad-band UVA irradiation, UVA1 phototherapy and PUVA photochemotherapy in a variety of different connective tissue disorders. RESULTS: Potential pathways include immunomodulation of inflammation, induction of collagenases and initiation of apoptosis. Even though holding the risk of carcinogenesis, photoaging or UV-induced exacerbation, UVA phototherapy seems to exhibit a tolerable risk/benefit ratio at least in systemic sclerosis, localized scleroderma, extragenital lichen sclerosus et atrophicus, sclerodermoid graft-versus-host disease, lupus erythematosus and a number of sclerotic rarities. CONCLUSIONS: Based on the data retrieved from the literature, therapeutic UVA exposure seems to be effective in connective tissue diseases and related disorders. However, more controlled investigations are needed in order to establish a clear-cut catalogue of indications
Effektivität und Patientensicherheit bei Protonenpumpeninhibitoren bei älteren Menschen - von der Evidenz zur Entwicklung von Empfehlungen
Funktionsintegrierte Konstruktionsglaeser - Entwicklung, Herstellung, Verarbeitung und Anwendung Schlussbericht
SIGLEAvailable from TIB Hannover: F03B116 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekForschungszentrum Juelich GmbH (Germany); Bundesministerium fuer Bildung und Forschung, Berlin (Germany)DEGerman
Quality improvement in preoperative assessment by implementation of an electronic decision support tool
Fisheries Ethics, or What Do You Want To Do with Your Scientific Knowledge in Addition to Earning a Living?
Relations between glycemia and glucose-6-phosphatase activity in the kidney and liver of normal and alloxan-diabetic dogs
Current practice of transitional care for adolescents and young adults in Swiss paediatric and adult rheumatology centres.
About half of all children with rheumatic diseases need continuous medical care during adolescence and adulthood. A good transition into adult rheumatology is essential. Guidelines for a structured transition process have therefore been recommended by the European League Against Rheumatism (EULAR) and the Paediatric Rheumatology European Society (PReS). However, implementation of these guidelines requires resources often not available in a busy clinical practice.
To assess the current practice of transitional care in Switzerland in relation to EULAR/PReS recommendations and to describe gaps and challenges in following the recommendations.
All paediatric Swiss rheumatology centres and their collaborating adult centres offering a transition service to adult care were invited to participate in this survey. The responsible paediatric and adult rheumatologist of each centre was interviewed separately using a structured manual addressing the EULAR/PReS transitional care recommendations.
All 10 paediatric and 9 out of 10 adult rheumatologists agreed to participate. Centres varied in the number of patients in transition, from n = 0 to n = 111. The following EULAR/PReS recommendations were implemented and applied in most centres: continuity in the healthcare team, consultations focused on adolescents and young adults, joint consultations between the paediatric and adult rheumatologist, and access to the EULAR website. Only rarely did a centre have a written transition policy or evaluate their transitional care programme. The vast majority of the interviewees had no specific training in adolescent health. Most centres rated their transitional care performance as very good.
Transition in Switzerland is not uniform and consequently the implementation of the EULAR/PReS recommendations is variable in Swiss rheumatology centres. Skills of healthcare professionals, continuity between clinical settings, size of the centres, and hospital focus on the needs of adolescents and young adults may represent key predictors of successful transitional care for patients with chronic rheumatic diseases. Future studies should examine these variables
Large herbivore migration plasticity along environmental gradients in Europe: life-history traits modulate forage effects
The most common framework under which ungulate migration is studied
predicts that it is driven by spatio-temporal variation in plant phenology,
yet other hypotheses may explain differences within and between species.
To disentangle more complex patterns than those based on single species/
single populations, we quantified migration variability using two sympatric
ungulate species differing in their foraging strategy, mating system and
physiological constraints due to body size. We related observed variation to
a set of hypotheses. We used GPS-collar data from 537 individuals in 10
roe (Capreolus capreolus) and 12 red deer (Cervus elaphus) populations
spanning environmental gradients across Europe to assess variation in
migration propensity, distance and timing. Using time-to-event models, we
explored how the probability of migration varied in relation to sex,
landscape (e.g. topography, forest cover) and temporally-varying
environmental factors (e.g. plant green-up, snow cover). Migration
propensity varied across study areas. Red deer were, on average, three
times more migratory than roe deer (56% vs. 18%). This relationship was
mainly driven by red deer males which were twice as migratory as females
(82% vs. 38%). The probability of roe deer migration was similar between
sexes. Roe deer (both sexes) migrated earliest in spring. While territorial
male roe deer migrated last in autumn, male and female red deer migrated
around the same time in autumn, likely due to their polygynous mating
system. Plant productivity determined the onset of spring migration in both
species, but if plant productivity on winter ranges was sufficiently high, roe
deer were less likely to leave. In autumn, migration coincided with reduced
plant productivity for both species. This relationship was stronger for red
deer. Our results confirm that ungulate migration is influenced by plant
phenology, but in a novel way, that these effects appear to be modulated
by species-specific traits, especially mating strategies